Zhanghai He
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View article: LncRNA ZFPM2-AS1 promotes phyllodes tumor progression by binding to CDC42 and inhibiting STAT1 activation
LncRNA ZFPM2-AS1 promotes phyllodes tumor progression by binding to CDC42 and inhibiting STAT1 activation Open
Breast phyllodes tumor (PT) is a rare fibroepithelial neoplasm with potential malignant behavior. Long non-coding RNAs (lncRNAs) play multifaceted roles in various cancers, but their involvement in breast PT remains largely unexplored. In …
View article: Effect of <scp><sup>1</sup>H‐NMR</scp> serum lipoproteins on immunotherapy response in advanced triple‐negative breast cancer patients
Effect of <span><sup>1</sup>H‐NMR</span> serum lipoproteins on immunotherapy response in advanced triple‐negative breast cancer patients Open
We previously reported the results of a phase II trial of anti‐PD‐1 antibody plus anti‐vascular endothelial growth factor receptor 2 inhibitors and eribulin in heavily pretreated advanced triple‐negative breast cancer with a favorable obje…
View article: lncRNA-WAL Promotes Aggressiveness of Triple-Negative Breast Cancer via inducing β-Catenin nuclear translocation
lncRNA-WAL Promotes Aggressiveness of Triple-Negative Breast Cancer via inducing β-Catenin nuclear translocation Open
Because of its insensitive to existing radiotherapy, chemotherapy and targeted treatments, Triple-negative breast cancer (TNBC) remains a great challenge to overcome. More and more evidence has indicated abnormal wnt/β-catenin pathway acti…
View article: Clinicopathological characteristics of IgG4-related lung disease
Clinicopathological characteristics of IgG4-related lung disease Open
View article: Clinicopathological Characteristics of LgG4-Related Lung Disease
Clinicopathological Characteristics of LgG4-Related Lung Disease Open
Background: Immunoglobulin G4-related lung disease (IgG4-RLD) is a rare entity. The aim of this study is to retrospectively analyzed the clinicopathological characteristics of IgG4-RLD pathologically confirmed in order to improve the diagn…
View article: STEAP3 promotes cancer cell proliferation by facilitating nuclear trafficking of EGFR to enhance RAC1-ERK-STAT3 signaling in hepatocellular carcinoma
STEAP3 promotes cancer cell proliferation by facilitating nuclear trafficking of EGFR to enhance RAC1-ERK-STAT3 signaling in hepatocellular carcinoma Open
View article: Neoadjuvant everolimus plus letrozole versus fluorouracil, epirubicin and cyclophosphamide for ER-positive, HER2-negative breast cancer: a randomized pilot trial
Neoadjuvant everolimus plus letrozole versus fluorouracil, epirubicin and cyclophosphamide for ER-positive, HER2-negative breast cancer: a randomized pilot trial Open
View article: Re-excision or “wait and watch”—a prediction model in breast phyllodes tumors after surgery
Re-excision or “wait and watch”—a prediction model in breast phyllodes tumors after surgery Open
The study model presented more concise and objective variables to evaluate the recurrence-free survival of patients after surgery, which can help deciding whether to do a re-excision or "wait and watch".
View article: Drug-induced Interstitial Lung Disease in Breast Cancer Patients: A Lesson We Should Learn From Multi-Disciplinary Integration
Drug-induced Interstitial Lung Disease in Breast Cancer Patients: A Lesson We Should Learn From Multi-Disciplinary Integration Open
Taxanes represented by paclitaxel and targeted therapy including trastuzumab are two common agents for human epidermal growth factor receptor-2 (HER-2)-positive breast cancer patients. Effectiveness, however, usually comes at the cost of m…
View article: Overexpression of gasdermin D promotes invasion of adenoid cystic carcinoma.
Overexpression of gasdermin D promotes invasion of adenoid cystic carcinoma. Open
Objective: To investigate the relationship between gasdermin D (GSDMD) expression and the invasion of adenoid cystic carcinoma (ACC). Methods: Immunohistochemistry (IHC) was used to examine GSDMD expression in tumours and adjacent non-canc…
View article: PRL-3 facilitates Hepatocellular Carcinoma progression by co-amplifying with and activating FAK
PRL-3 facilitates Hepatocellular Carcinoma progression by co-amplifying with and activating FAK Open
Background: In addition to protein tyrosine kinases, accumulating evidence has shown that protein tyrosine phosphatases (PTPs) are suitable therapeutic targets in cancer. PRL-3 is a PTP member that has been well studied in many mali…
View article: HIF-1α Promotes the Metastasis of Esophageal Squamous Cell Carcinoma by Targeting SP1
HIF-1α Promotes the Metastasis of Esophageal Squamous Cell Carcinoma by Targeting SP1 Open
Background: In microenvironment of malignant tumors, Hypoxia-Inducible Factors (HIF), most importantly HIF-1α, play an important role in regulation of adaptive biological response to hypoxia, promoting angiogenesis and metastasis. H…
View article: circGSK3β promotes metastasis in esophageal squamous cell carcinoma by augmenting β-catenin signaling
circGSK3β promotes metastasis in esophageal squamous cell carcinoma by augmenting β-catenin signaling Open
View article: CCL18-induced HOTAIR upregulation promotes malignant progression in esophageal squamous cell carcinoma through the miR-130a-5p-ZEB1 axis
CCL18-induced HOTAIR upregulation promotes malignant progression in esophageal squamous cell carcinoma through the miR-130a-5p-ZEB1 axis Open
Accumulating evidence indicates that CCL18 and the long non-coding RNA, HOTAIR, have critical roles in cancer progression and metastasis, but the correlation between CCL18 and HOTAIR in esophageal squamous cell carcinoma (ESCC) and their d…
View article: Development and validation of nomograms predicting survival in Chinese patients with triple negative breast cancer
Development and validation of nomograms predicting survival in Chinese patients with triple negative breast cancer Open
View article: Genomic Signature of Driver Genes Identified by Target Next-Generation Sequencing in Chinese Non-Small Cell Lung Cancer
Genomic Signature of Driver Genes Identified by Target Next-Generation Sequencing in Chinese Non-Small Cell Lung Cancer Open
Background Non-small cell lung cancer (NSCLC) is one of the most common human malignancies and the leading cause of cancer-related death. Over the past few decades, genomic alterations of cancer driver genes have been identified in NSCLC, …
View article: LncRNA HOTTIP modulates cancer stem cell properties in human pancreatic cancer by regulating HOXA9
LncRNA HOTTIP modulates cancer stem cell properties in human pancreatic cancer by regulating HOXA9 Open
Our previous study demonstrated that long non-coding RNA (lncRNA) HOTTIP was maximally expressed in PDAC, and promoted cancer cell progression and epithelial to mesenchymal transition (EMT). Numerous studies indicated that lncRNAs or EMT s…