Zhangjun Cheng
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View article: Inhibition of CGRP receptor ameliorates AD pathology by reprogramming lipid metabolism through HDAC11/LXRβ/ABCA1 signaling
Inhibition of CGRP receptor ameliorates AD pathology by reprogramming lipid metabolism through HDAC11/LXRβ/ABCA1 signaling Open
SUMMARY The Calcitonin gene-related peptide (CGRP) receptor has gained attention in Alzheimer’s Disease (AD) research due to its involvement in regulating neuroinflammation. However, its role and mechanism in AD pathology remain unclear. H…
View article: En Bloc Versus Conventional Transurethral Resection for Non-Muscle-Invasive Bladder Cancer: An Expanded and Updated Systematic Review and Meta-Analysis Reconciling Contemporary Evidence onOncological, Pathological, and Safety Outcomes
En Bloc Versus Conventional Transurethral Resection for Non-Muscle-Invasive Bladder Cancer: An Expanded and Updated Systematic Review and Meta-Analysis Reconciling Contemporary Evidence onOncological, Pathological, and Safety Outcomes Open
Background: This systematic review and meta-analysis compares oncological outcomes, pathological quality, and safety profiles between en bloc (ERBT) and conventional transurethral resection (cTURBT) for non-muscle-invasive bladder cancer (…
View article: FKBP9 enhances IGF2BP1-mediated m6A recognition to promote hepatocellular carcinoma progression
FKBP9 enhances IGF2BP1-mediated m6A recognition to promote hepatocellular carcinoma progression Open
Background & Aims: N6-methyladenosine (m6A) modification regulates mRNA stability and translation to promote cancer progression. FK506-binding protein 9 (FKBP9), a peptidyl-prolyl isomerase, is associated with carcinogenesis, but its role …
View article: College students' depression and body image: Unraveling the Link
College students' depression and body image: Unraveling the Link Open
BACKGROUND With the increasing global incidence of mental illness, depression has become a serious problem among college students. AIM To investigate the relationship between depression and its correlates in Chinese adolescents and to iden…
View article: Nomogram based on tumor burden score for prediction of prognosis of patients with hepatocellular carcinoma before hepatectomy
Nomogram based on tumor burden score for prediction of prognosis of patients with hepatocellular carcinoma before hepatectomy Open
Purpose To develop nomogram models predicting the prognosis for patients with hepatocellular carcinoma (HCC) before hepatectomy. Methods Patients treated at the Eastern Hepatobiliary Surgery Hospital and Zhongda Hospital, Southeast Univers…
View article: A Study of the Causes of Tupperware's Financial Distress
A Study of the Causes of Tupperware's Financial Distress Open
In today's market environment, there is still a stable demand for plastic cups, but Tupperware, which was once brilliant for a while, has fallen into a difficult situation, making it difficult to continue. This paper focuses on the causes …
View article: The efficacy of parasacral transcutaneous electrical nerve stimulation for the treatment of overactive bladder in children: a systematic review and meta-analysis
The efficacy of parasacral transcutaneous electrical nerve stimulation for the treatment of overactive bladder in children: a systematic review and meta-analysis Open
Aim Despite the presence of published evidence in recent decades suggesting an improvement in overactive bladder (OAB) with the utilization of parasacral transcutaneous electrical nerve stimulation (PTENS), there is currently a lack of con…
View article: Pharmacotherapy of Liver Fibrosis and Hepatitis: Recent Advances
Pharmacotherapy of Liver Fibrosis and Hepatitis: Recent Advances Open
Liver fibrosis is a progressive scarring process primarily caused by chronic inflammation and injury, often closely associated with viral hepatitis, alcoholic liver disease, metabolic dysfunction-associated steatotic liver disease (MASLD),…
View article: Evaluation of the outcomes of staging laparoscopy in intrahepatic cholangiocarcinoma patients undergoing surgical resection: a multicenter retrospective study in China
Evaluation of the outcomes of staging laparoscopy in intrahepatic cholangiocarcinoma patients undergoing surgical resection: a multicenter retrospective study in China Open
Aim: To evaluate the perioperative outcomes and postoperative survival of applying staging laparoscopy (SL) in intrahepatic cholangiocarcinoma (ICC) patients undergoing surgical resection. Methods: A retrospective analysis was performed on…
View article: Single-cell landscape identifies the immunophenotypes and microenvironments of HBV-positive and HBV-negative liver cancer
Single-cell landscape identifies the immunophenotypes and microenvironments of HBV-positive and HBV-negative liver cancer Open
Background: HBV infection leads to HCC and affects immunotherapy. We are exploring the tumor ecosystem in HCC to help gain a deeper understanding and design more effective immunotherapy strategies for patients with HCC with or without HBV …
View article: A New TNM T3 Subclassification with Corresponding Prognostic Stage Grouping for Gallbladder Cancer: A Multicenter Retrospective Study
A New TNM T3 Subclassification with Corresponding Prognostic Stage Grouping for Gallbladder Cancer: A Multicenter Retrospective Study Open
View article: Hepatocellular Brg1 promotes CCl4-induced liver inflammation, ECM accumulation and fibrosis in mice
Hepatocellular Brg1 promotes CCl4-induced liver inflammation, ECM accumulation and fibrosis in mice Open
Introduction Hepatic fibrosis is a progressive pathological process involving the exhaustion of hepatocellular regenerative capacity and ultimately leading to the development of cirrhosis and even hepatocellular carcinoma. Brg1, the core s…
View article: miR-552 promotes the proliferation and metastasis of intrahepatic cholangiocarcinoma by targeting FOXO1
miR-552 promotes the proliferation and metastasis of intrahepatic cholangiocarcinoma by targeting FOXO1 Open
Intrahepatic cholangiocarcinoma (ICC) is a relatively rare but highly malignant cancer. Few effective systemic targeted therapies are available for patients with unresectable ICC, but there exists an urgent need to explore mechanisms under…
View article: STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages
STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages Open
The liver is the main site of colorectal cancer (CRC) metastasis. Tumor-associated macrophages (TAMs) play a key role in tumor metastasis. Therefore, modulating the function of tumor-associated macrophages is a potential therapeutic strate…
View article: Editorial: Extracellular vesicles in gastrointestinal cancers
Editorial: Extracellular vesicles in gastrointestinal cancers Open
EDITORIAL article Front. Oncol., 04 July 2023Sec. Molecular and Cellular Oncology Volume 13 - 2023 | https://doi.org/10.3389/fonc.2023.1240002
View article: <scp>LncRNA HClnc1</scp> facilitates hepatocellular carcinoma progression by regulating <scp>PKM2</scp> signaling and indicates poor survival outcome after hepatectomy
<span>LncRNA HClnc1</span> facilitates hepatocellular carcinoma progression by regulating <span>PKM2</span> signaling and indicates poor survival outcome after hepatectomy Open
Aim Long noncoding RNAs (lncRNAs) are key mediators with a wide range of pathophysiological functions, but their role in human hepatocellular carcinoma (HCC) is still unclear. Methods An unbiased microarray study evaluated a novel lncRNA, …
View article: Early Experience of TACE Combined with Atezolizumab plus Bevacizumab for Patients with Intermediate-Stage Hepatocellular Carcinoma beyond Up-to-Seven Criteria: A Multicenter, Single-Arm Study
Early Experience of TACE Combined with Atezolizumab plus Bevacizumab for Patients with Intermediate-Stage Hepatocellular Carcinoma beyond Up-to-Seven Criteria: A Multicenter, Single-Arm Study Open
Aim. Locoregional treatment, such as TACE, in combination with immunotherapy may elicit a synergistic anticancer effect. However, TACE combined with atezolizumab plus bevacizumab (atezo/bev) has not been investigated for patients with inte…
View article: A new TNM T3 subclassification with corresponding prognostic stage grouping for gallbladder cancer: a multicenter retrospective study
A new TNM T3 subclassification with corresponding prognostic stage grouping for gallbladder cancer: a multicenter retrospective study Open
View article: N<sup>6</sup>-Methyladenosine Modification of ANLN Enhances Hepatocellular Carcinoma Bone Metastasis
N<sup>6</sup>-Methyladenosine Modification of ANLN Enhances Hepatocellular Carcinoma Bone Metastasis Open
Bones are categorized as the second most prevalent location of extra-hepatic metastasis in Hepatocellular Carcinoma (HCC), which is linked to an extremely poor prognosis due to limited therapeutic options. N6-methyladenosine (m<…
View article: Liver resection versus liver transplantation for hepatocellular carcinoma within the Milan criteria based on estimated microvascular invasion risks
Liver resection versus liver transplantation for hepatocellular carcinoma within the Milan criteria based on estimated microvascular invasion risks Open
Background Preoperative prediction of microvascular invasion (MVI) in hepatocellular carcinoma (HCC) may optimize individualized treatment decision-making. This study aimed to investigate the prognostic differences between HCC patients und…
View article: A Nomogram Model to Predict Early Recurrence of Patients With Intrahepatic Cholangiocarcinoma for Adjuvant Chemotherapy Guidance: A Multi-Institutional Analysis
A Nomogram Model to Predict Early Recurrence of Patients With Intrahepatic Cholangiocarcinoma for Adjuvant Chemotherapy Guidance: A Multi-Institutional Analysis Open
Background The influence of different postoperative recurrence times on the efficacy of adjuvant chemotherapy (ACT) for intrahepatic cholangiocarcinoma (ICC) remains unclear. This study aimed to investigate the independent risk factors and…
View article: Recurrence and prognosis in intrahepatic cholangiocarcinoma patients with different etiology after radical resection: a multi-institutional study
Recurrence and prognosis in intrahepatic cholangiocarcinoma patients with different etiology after radical resection: a multi-institutional study Open
View article: A Novel Nomogram for Predicting Postoperative Liver Failure After Major Hepatectomy for Hepatocellular Carcinoma
A Novel Nomogram for Predicting Postoperative Liver Failure After Major Hepatectomy for Hepatocellular Carcinoma Open
Background Post-hepatectomy liver failure (PHLF) is the most common cause of mortality after major hepatectomy in hepatocellular carcinoma (HCC) patients. We aim to develop a nomogram to preoperatively predict grade B/C PHLF defined by the…
View article: Downregulation of MUC15 by miR-183-5p.1 promotes liver tumor-initiating cells properties and tumorigenesis via regulating c-MET/PI3K/AKT/SOX2 axis
Downregulation of MUC15 by miR-183-5p.1 promotes liver tumor-initiating cells properties and tumorigenesis via regulating c-MET/PI3K/AKT/SOX2 axis Open
View article: Chinese Expert Consensus on Immunotherapy for Hepatocellular Carcinoma (2021 Edition)
Chinese Expert Consensus on Immunotherapy for Hepatocellular Carcinoma (2021 Edition) Open
Background: Hepatocellular carcinoma (HCC) is one of the most common malignancies in China. Most HCC patients are first diagnosed at an advanced stage, and systemic treatments are the mainstay of treatment. Summary:…
View article: Recurrence and Prognosis in Intrahepatic Cholangiocarcinoma Patients with Different Etiology After Radical Resection: A Multi-Institutional Study
Recurrence and Prognosis in Intrahepatic Cholangiocarcinoma Patients with Different Etiology After Radical Resection: A Multi-Institutional Study Open
Objective We aimed to evaluate the prognosis and adjuvant chemotherapy (ACT) in intrahepatic cholangiocarcinoma (ICC) patients with different etiology after radical resection. Methods A total of 448 patients with ICC who underwent radical …
View article: An RNA–RNA crosstalk network involving HMGB1 and RICTOR facilitates hepatocellular carcinoma tumorigenesis by promoting glutamine metabolism and impedes immunotherapy by PD-L1+ exosomes activity
An RNA–RNA crosstalk network involving HMGB1 and RICTOR facilitates hepatocellular carcinoma tumorigenesis by promoting glutamine metabolism and impedes immunotherapy by PD-L1+ exosomes activity Open
View article: Prediction Efficacy of Prognostic Nutritional Index and Albumin–Bilirubin Grade in Patients With Intrahepatic Cholangiocarcinoma After Radical Resection: A Multi-Institutional Analysis of 535 Patients
Prediction Efficacy of Prognostic Nutritional Index and Albumin–Bilirubin Grade in Patients With Intrahepatic Cholangiocarcinoma After Radical Resection: A Multi-Institutional Analysis of 535 Patients Open
Background The preoperative nutritional status and the immunological status have been reported to be independent prognostic factors of patients with intrahepatic cholangiocarcinoma (ICC). This study aimed to investigate whether prognostic …
View article: Prognostic value and predication model of microvascular invasion in patients with intrahepatic cholangiocarcinoma: a multicenter study from China
Prognostic value and predication model of microvascular invasion in patients with intrahepatic cholangiocarcinoma: a multicenter study from China Open
View article: Prolonged oral ingestion of microplastics induced inflammation in the liver tissues of C57BL/6J mice through polarization of macrophages and increased infiltration of natural killer cells
Prolonged oral ingestion of microplastics induced inflammation in the liver tissues of C57BL/6J mice through polarization of macrophages and increased infiltration of natural killer cells Open