Zhangli Ni
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View article: Post-mitotic transcriptional activation and 3D regulatory interactions show locus- and differentiation-specific sensitivity to cohesin depletion
Post-mitotic transcriptional activation and 3D regulatory interactions show locus- and differentiation-specific sensitivity to cohesin depletion Open
Prior studies showed that structural loops collapse upon acute cohesin depletion, while regulatory enhancer-promoter (E-P) loops largely persist, consistent with minimal transcriptional changes. However, these studies, conducted in asynchr…
View article: The presence of blastocyst within the uteri facilitates lumenal epithelium transformation for implantation via upregulating lysosome proteostasis activity
The presence of blastocyst within the uteri facilitates lumenal epithelium transformation for implantation via upregulating lysosome proteostasis activity Open
The mammalian endometrium is covered by the lumenal epithelium (Le), which directly interacts with the blastocyst and plays an important role in the establishment of reciprocal crosstalk between the embryo and receptive uterus during impla…
View article: Uterine Notch2 facilitates pregnancy recognition and corpus luteum maintenance via upregulating decidual Prl8a2
Uterine Notch2 facilitates pregnancy recognition and corpus luteum maintenance via upregulating decidual Prl8a2 Open
The maternal recognition of pregnancy is a necessary prerequisite for gestation maintenance through prolonging the corpus luteum lifespan and ensuring progesterone production. In addition to pituitary prolactin and placental lactogens, dec…
View article: Sequential activation of uterine epithelial IGF1R by stromal IGF1 and embryonic IGF2 directs normal uterine preparation for embryo implantation
Sequential activation of uterine epithelial IGF1R by stromal IGF1 and embryonic IGF2 directs normal uterine preparation for embryo implantation Open
Embryo implantation in both humans and rodents is initiated by the attachment of a blastocyst to the uterine epithelium. For blastocyst attachment, the uterine epithelium needs to transform at both the structural and molecular levels first…
View article: Epigenetic control of embryo–uterine crosstalk at peri-implantation
Epigenetic control of embryo–uterine crosstalk at peri-implantation Open
View article: Spatiotemporal coordination of trophoblast and allantoic Rbpj signaling directs normal placental morphogenesis
Spatiotemporal coordination of trophoblast and allantoic Rbpj signaling directs normal placental morphogenesis Open
View article: Homeobox genes for embryo implantation: From mouse to human
Homeobox genes for embryo implantation: From mouse to human Open
The proper development of uterus to a state of receptivity and the attainment of implantation competency for blastocyst are 2 indispensable aspects for implantation, which is considered to be a critical event for successful pregnancy. Like…
View article: Involvement of PKCε in FSH-induced connexin43 phosphorylation and oocyte maturation in mouse
Involvement of PKCε in FSH-induced connexin43 phosphorylation and oocyte maturation in mouse Open
Gap junctions (GJs) are indispensable for communication between cumulus cells (CCs) and oocytes in coordinating the gonadotropin-induced meiotic maturation of oocytes. Of all proteins that constitute GJs, phosphorylated connexin43 (pCx43) …
View article: Polycomb subunit BMI1 determines uterine progesterone responsiveness essential for normal embryo implantation
Polycomb subunit BMI1 determines uterine progesterone responsiveness essential for normal embryo implantation Open
Natural and synthetic progestogens have been commonly used to prevent recurrent pregnancy loss in women with inadequate progesterone secretion or reduced progesterone sensitivity. However, the clinical efficacy of progesterone and its anal…
View article: PR-Set7 deficiency limits uterine epithelial population growth hampering postnatal gland formation in mice
PR-Set7 deficiency limits uterine epithelial population growth hampering postnatal gland formation in mice Open