Zhangming Pei
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View article: <i>Akkermansia muciniphila</i>‐Derived <i>N</i>‐Acetylspermidine Modulates the Localization of Intestinal α1,2‐Fucosylated Proteins to Maintain Gut Homeostasis
<i>Akkermansia muciniphila</i>‐Derived <i>N</i>‐Acetylspermidine Modulates the Localization of Intestinal α1,2‐Fucosylated Proteins to Maintain Gut Homeostasis Open
The growing incidence of inflammatory bowel diseases, including colitis and Crohn's disease, poses a critical challenge for global healthcare. Current development of α1,2‐fucosylation‐enhancing strategies shows significant potential as a c…
View article: <i>Bifidobacterium longum</i> increases serum vitamin D metabolite levels and modulates intestinal flora to alleviate osteoporosis in mice
<i>Bifidobacterium longum</i> increases serum vitamin D metabolite levels and modulates intestinal flora to alleviate osteoporosis in mice Open
The elderly population is prone to osteoporosis, owing to the deterioration of the skin, liver, and kidney functions. Vitamin D (VD) supplementation has a limited effect, and VD deficiency is mostly treated with medication. Several studies…
View article: Combined Analysis of Transcriptomes and Metabolomes Reveals Key Genes and Substances That Affect the Formation of a Multi-Species Biofilm by Nine Gut Bacteria
Combined Analysis of Transcriptomes and Metabolomes Reveals Key Genes and Substances That Affect the Formation of a Multi-Species Biofilm by Nine Gut Bacteria Open
Biofilms are one of the ways microorganisms exist in natural environments. In recent years, research has gradually shifted its focus to exploring the complexity and interactions of multi-species biofilms. A study showed that nine gut bacte…
View article: Effect of Lactobacillus helveticus DYNDL_20-5 and Fucose on the Quality and Metabolism of Fermented Milk
Effect of Lactobacillus helveticus DYNDL_20-5 and Fucose on the Quality and Metabolism of Fermented Milk Open
View article: Multi-Omics Reveals Gut Microbial and Metabolic Changes Associated with Ruminococcus Torques–Mediated Weight Recovery in Food-Restricted Mice
Multi-Omics Reveals Gut Microbial and Metabolic Changes Associated with Ruminococcus Torques–Mediated Weight Recovery in Food-Restricted Mice Open
View article: Uncovering the mechanisms underlying the efficacy of probiotic strains in mitigating food allergies: an emphasis on gut microbiota and indoleacrylic acid
Uncovering the mechanisms underlying the efficacy of probiotic strains in mitigating food allergies: an emphasis on gut microbiota and indoleacrylic acid Open
Food allergies manifest as systemic or digestive allergic responses induced by food allergens, and their progression has been demonstrated to be intimately associated with the host’s gut microbiota. Our preceding investigation has revealed…
View article: Gut microbiota metabolism of branched‐chain amino acids and their metabolites can improve the physiological function of aging mice
Gut microbiota metabolism of branched‐chain amino acids and their metabolites can improve the physiological function of aging mice Open
The metabolism of branched‐chain amino acids by gut microbiota can improve overall health and may reverse aging. In this study, we investigated Parabacteroides merdae, a gut microbe that is known to catabolise branched‐chain amino acids (B…
View article: Lacticaseibacillus rhamnosus CCFM1060 Modulates gut microbiota and intestinal barrier Function: Alcoholic liver disease Mitigation through Nrf2/HO-1 and NF-κB Pathways
Lacticaseibacillus rhamnosus CCFM1060 Modulates gut microbiota and intestinal barrier Function: Alcoholic liver disease Mitigation through Nrf2/HO-1 and NF-κB Pathways Open
Long-term and/or excessive ethanol intake can lead to alcoholic liver disease (ALD). Gut dysbiosis contributes to a critical role in the pathogenesis of ALD. Here, we explored the impact of viable and dead Lacticaseibacillus rhamnosus CCFM…
View article: A newly constructed Chinese gut phageome catalog
A newly constructed Chinese gut phageome catalog Open
All documents in this project are process documents generated from the manuscript "Expanding the horizon of the intestinal bacteriophages from a newly constructed Chinese gut phageome catalog: the overall landscape, bacteria-phage interact…
View article: Effect of Mixed Probiotics on Alleviating H1N1 Influenza Infection and Regulating Gut Microbiota
Effect of Mixed Probiotics on Alleviating H1N1 Influenza Infection and Regulating Gut Microbiota Open
Influenza and other respiratory infections cause annual epidemics worldwide, with high incidence and mortality rates reported among immunocompromised infants and elderly individuals. Probiotics can modulate the immune system through their …
View article: A universe of human gut-derived bacterial prophages: unveiling the hidden viral players in intestinal microecology
A universe of human gut-derived bacterial prophages: unveiling the hidden viral players in intestinal microecology Open
Prophages, which are an existing form of temperate phages that integrate into host genomes, have been found extensively present in diverse bacterial species. The human gut microbiome, characterized by its complexity, dynamism, and intercon…
View article: Human Gut-derived Bacterial Prophages
Human Gut-derived Bacterial Prophages Open
All documents in this project are process documents generated from the published article "A universe of human gut-derived bacterial prophages: Unveiling the hidden viral players in the intestinal microecology". Zhangming Pei, Yufei Liu, Yu…
View article: Human Gut-derived Bacterial Prophages
Human Gut-derived Bacterial Prophages Open
All documents in this project are process documents generated from the published article "A universe of human gut-derived bacterial prophages: Unveiling the hidden viral players in the intestinal microecology". Zhangming Pei, Yufei Liu, Yu…
View article: Chinese Human Gut Phageome
Chinese Human Gut Phageome Open
All documents in this project are process documents generated from the manuscript "Excavating the Chinese gut phageome: the overall landscape, predominant communities, bacteria-phage interactions, and geographical variations". For addition…
View article: <i>Bifidobacterium longum</i> subsp. <i>infantis</i> as widespread bacteriocin gene clusters carrier stands out among the <i>Bifidobacterium</i>
<i>Bifidobacterium longum</i> subsp. <i>infantis</i> as widespread bacteriocin gene clusters carrier stands out among the <i>Bifidobacterium</i> Open
Bifidobacterium is the dominant genus, particularly in the intestinal tract niche of healthy breast-fed infants, and many of these strains have been proven to elicit positive effects on infant development. In addition to its effective anti…
View article: Chinese Human Gut Phageome
Chinese Human Gut Phageome Open
All documents in this project are process documents generated from the manuscript "Excavating the gut phageome of Chinese population dominative communities, bacteria-phage trans-kingdom interactions, and variations across geography". Pleas…
View article: Clostridium butyricum Reduces Obesity in a Butyrate-Independent Way
Clostridium butyricum Reduces Obesity in a Butyrate-Independent Way Open
Accumulating evidence from recent studies links the gut microbiota to obesity, and microbiome therapy has been examined as a treatment. Clostridium butyricum (C. butyricum), an intestinal symbiont, protects the host from a range of disease…
View article: Uncovering the specificity and predictability of tryptophan metabolism in lactic acid bacteria with genomics and metabolomics
Uncovering the specificity and predictability of tryptophan metabolism in lactic acid bacteria with genomics and metabolomics Open
Tryptophan is metabolized by microorganisms into various indole derivatives that have been proven to alleviate diseases and promote human health. Lactic acid bacteria (LAB) are a broad microbial concept, some of which have been developed a…
View article: Characterization of CRISPR-Cas systems in Bifidobacterium breve
Characterization of CRISPR-Cas systems in Bifidobacterium breve Open
The clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated protein (Cas) system is an important adaptive immune system for bacteria to resist foreign DNA infection, which has been widely used in genotyping and …
View article: Evaluation of Tetracycline Resistance and Determination of the Tentative Microbiological Cutoff Values in Lactic Acid Bacterial Species
Evaluation of Tetracycline Resistance and Determination of the Tentative Microbiological Cutoff Values in Lactic Acid Bacterial Species Open
Lactic acid bacteria (LAB) are widely used as probiotics in the food industry owing to their beneficial effects on human health. However, numerous antibiotic resistance genes have been found in LAB strains, especially tetracycline resistan…
View article: Comparative Genomic Analysis of Bifidobacterium bifidum Strains Isolated from Different Niches
Comparative Genomic Analysis of Bifidobacterium bifidum Strains Isolated from Different Niches Open
The potential probiotic benefits of Bifidobacterium bifidum have received increasing attention recently. We used comparative genomic analysis to explore the differences in the genome and the physiological characteristics of B. bifidum isol…
View article: Comprehensive Scanning of Prophages in <i>Lactobacillus</i> : Distribution, Diversity, Antibiotic Resistance Genes, and Linkages with CRISPR-Cas Systems
Comprehensive Scanning of Prophages in <i>Lactobacillus</i> : Distribution, Diversity, Antibiotic Resistance Genes, and Linkages with CRISPR-Cas Systems Open
Lactobacilli are inherent microorganisms in the human gut and are widely used in the food processing industries due to their probiotic properties. Prophages were reportedly hidden in numerous Lactobacillus genomes and can potentially conta…
View article: The Diversity of the CRISPR-Cas System and Prophages Present in the Genome Reveals the Co-evolution of Bifidobacterium pseudocatenulatum and Phages
The Diversity of the CRISPR-Cas System and Prophages Present in the Genome Reveals the Co-evolution of Bifidobacterium pseudocatenulatum and Phages Open
Diverse CRISPR-Cas systems constitute an indispensable part of the bacterial adaptive immune system against viral infections. However, to escape from this immune system, bacteriophages have also evolved corresponding anti-defense measures.…
View article: Identification, characterization, and phylogenetic analysis of eight new inducible prophages in Lactobacillus
Identification, characterization, and phylogenetic analysis of eight new inducible prophages in Lactobacillus Open