Zhanli Wang
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View article: Extracellular vesicular microRNAs and cardiac hypertrophy
Extracellular vesicular microRNAs and cardiac hypertrophy Open
Cardiac hypertrophy is an adaptive response to pressure or volume overload such as hypertension and ischemic heart diseases. Sustained cardiac hypertrophy eventually leads to heart failure. The pathophysiological alterations of hypertrophy…
View article: Therapeutic effects of Mongolian medical warm acupuncture on neuropathic pain via gut microbiota and inflammatory pathway regulation in a chronic constriction injury rat model
Therapeutic effects of Mongolian medical warm acupuncture on neuropathic pain via gut microbiota and inflammatory pathway regulation in a chronic constriction injury rat model Open
The study was designed to determine whether Mongolian medical warm acupuncture (MMWA) can alleviate neuropathic pain through regulating gut microbiota and inflammation-related pathways in the chronic constriction injury (CCI) rat model. Ra…
View article: Economic Assessment of Maritime Fuel Transformation for GHG Reduction in the International Shipping Sector
Economic Assessment of Maritime Fuel Transformation for GHG Reduction in the International Shipping Sector Open
This study aims to predict the economic transition pathway for alternative fuels in accordance with the 2023 IMO GHG Strategy goals. The assessment considers the impact of alternative fuel transition on fuel costs (∆COSTFuel,t), carbon emi…
View article: Multiplex PCR System for the Diagnosis of Plague
Multiplex PCR System for the Diagnosis of Plague Open
The plague caused by Yersinia pestis has a high case fatality rate. It is often transmitted from person to person through mosquito bites, causing serious disease transmission. Due to its clinical symptoms being very similar to influenza, i…
View article: <i>Dracocephalum moldavica</i> L. Extract Ameliorates Hypertension Through Modulating the Interaction Between miRNAs and Gut Microbiota in 2K1C Rats
<i>Dracocephalum moldavica</i> L. Extract Ameliorates Hypertension Through Modulating the Interaction Between miRNAs and Gut Microbiota in 2K1C Rats Open
Aim: To investigate the therapeutic effects of Dracocephalum moldavica L. extract (DME) against hypertension and elucidate the underlying molecular mechanism. Method: A two-kidney one-clip (2K1C) model was established in male Wistar rats, …
View article: Brucella infection and Toll-like receptors
Brucella infection and Toll-like receptors Open
Brucella consists of gram-negative bacteria that have the ability to invade and replicate in professional and non-professional phagocytes, and its prolonged persistence in the host leads to brucellosis, a serious zoonosis. Toll-like recept…
View article: Discovery of Natural Compounds as SARS-CoV-2’s Main Protease Inhibitors by Docking-based Virtual Screening
Discovery of Natural Compounds as SARS-CoV-2’s Main Protease Inhibitors by Docking-based Virtual Screening Open
Introduction: The novel coronavirus disease (COVID-19) is a viral disease caused by severe acute respiratory syndrome coronavirus 2 (SAR-CoV-2). The development of antiviral drugs has enhaced treatment of COVID-19. SARS-CoV-2 main protease…
View article: Toll-like receptors in cardiac hypertrophy
Toll-like receptors in cardiac hypertrophy Open
Toll-like receptors (TLRs) are a family of pattern recognition receptors (PRRs) that can identify pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). TLRs play an important role in the innate im…
View article: Research progress on complications of Brucellosis
Research progress on complications of Brucellosis Open
B rucellosis is a common zoonotic disease that is widely spread worldwide and poses a major threat to human health. Clinically, it often presents with non-specific symptoms such as fever, excessive sweating, malaise, myalgia, arthralgia, l…
View article: Dracocephalum moldavica L. Extract ameliorates intestinal inflammation by regulating gut microbiota and repairing the intestinal barrier in 2k1c rats
Dracocephalum moldavica L. Extract ameliorates intestinal inflammation by regulating gut microbiota and repairing the intestinal barrier in 2k1c rats Open
When used in ethnomedicine, Dracocephalum moldavica L. (DML) and its bioactive extract protect against several diseases caused by inflammation and oxidative stress. However, the effect of DML on intestinal inflammation in hypertension has …
View article: Pharmacophore-Based Virtual Screening of Potential SARS-CoV-2 Main Protease Inhibitors from Library of Natural Products
Pharmacophore-Based Virtual Screening of Potential SARS-CoV-2 Main Protease Inhibitors from Library of Natural Products Open
Background: The SARS-CoV-2 main protease (M pro ) is an attractive target for drug discovery. Methods: A pharmacophore model was built using the three-dimensional (3D) pharmacophore generation algorithm HypoGen in Discovery Studio 2019. Th…
View article: Applications of polymerase chain reaction‑based methods for the diagnosis of plague (Review)
Applications of polymerase chain reaction‑based methods for the diagnosis of plague (Review) Open
Plague is an acute bacterial infection caused by Yersinia pestis. The three major clinical forms of plague are bubonic, pneumonic and septicemic, which have high case-mortality rates. Therefore, rapid and reliable diagnostic tools a…
View article: Influence of warm acupuncture on gut microbiota and metabolites in rats with insomnia induced by PCPA
Influence of warm acupuncture on gut microbiota and metabolites in rats with insomnia induced by PCPA Open
Background Insomnia is the most common of the sleep disorders. Current pharmacotherapy treatment options are usually associated with adverse effects and withdrawal phenomena. Therapeutic alternatives with a more favorable safety profile fo…
View article: Altered metabolic pathways in classic and hypervirulent Klebsiella pneumoniae isolates revealed by proteomics analysis
Altered metabolic pathways in classic and hypervirulent Klebsiella pneumoniae isolates revealed by proteomics analysis Open
Klebsiella pneumoniae is an opportunistic pathogen that causes a wide range of infections. The emergence and spread of hypervirulent K. pneumoniae (hvKp), which appears to be different from the classical K. pneumoniae (cKp) in several micr…
View article: Exosomes Derived From Hypertrophic Cardiomyocytes Induce Inflammation in Macrophages via miR-155 Mediated MAPK Pathway
Exosomes Derived From Hypertrophic Cardiomyocytes Induce Inflammation in Macrophages via miR-155 Mediated MAPK Pathway Open
The inflammatory immune microenvironment plays an important role in the development of cardiac hypertrophy. Exosomes have emerged as the potent modulators of inflammatory responses. This study aimed to determine how exosomes derived from a…
View article: Identification of two novel type II topoisomerase mutations in Enterococcus spp. isolated from a hospital in China
Identification of two novel type II topoisomerase mutations in Enterococcus spp. isolated from a hospital in China Open
Type II topoisomerases, including DNA gyrase (GyrA) and topoisomerase IV (ParC), contribute to fluoroquinolone resistance in Enterococcus spp. This study investigated the mutational status of the quinolone resistance-determining regions (Q…
View article: <i>Dracocephalum moldavica L</i>. Extracts Protect H9c2 Cardiomyocytes against H<sub>2</sub>O<sub>2</sub>‐Induced Apoptosis and Oxidative Stress
<i>Dracocephalum moldavica L</i>. Extracts Protect H9c2 Cardiomyocytes against H<sub>2</sub>O<sub>2</sub>‐Induced Apoptosis and Oxidative Stress Open
Background and Objectives . Dracocephalum moldavica L. is an herbal medicine used to treat cardiovascular diseases in China. The purpose of this study was to assess the cardioprotective effect of D. moldavica L . extracts against H 2 O 2 ‐…
View article: Comparative analysis of relative gene expression data reveals novel microRNAs in the artery of rats with renovascular hypertension
Comparative analysis of relative gene expression data reveals novel microRNAs in the artery of rats with renovascular hypertension Open
Hypertension is associated with impaired vascular endothelial function. However, the regulatory mechanisms of vascular dysfunction in rats with renovascular hypertension (RVH) remain poorly understood. In this study, the 2-kidney- 1-clip (…
View article: Cardiomyocyte-Derived Exosomes: Biological Functions and Potential Therapeutic Implications
Cardiomyocyte-Derived Exosomes: Biological Functions and Potential Therapeutic Implications Open
Exosomes, which are membrane-enclosed nanovesicles released by almost all cell types, have been recognized to play important roles in mediating cell-cell communication. In recent years, the physiological and pathological effects of exosome…
View article: Antimicrobial Activity and Mechanism of Action of Dracocephalum moldavica L. Extracts Against Clinical Isolates of Staphylococcus aureus
Antimicrobial Activity and Mechanism of Action of Dracocephalum moldavica L. Extracts Against Clinical Isolates of Staphylococcus aureus Open
Background: Dracocephalum moldavica L. is a popular traditional medicine used by many countries, which has a wide range of pharmacological effects. The aim of this work was to investigate the antimicrobial effects of D. mo…
View article: Alteration of the Gut Microbiota and Its Effect on AMPK/NADPH Oxidase Signaling Pathway in 2K1C Rats
Alteration of the Gut Microbiota and Its Effect on AMPK/NADPH Oxidase Signaling Pathway in 2K1C Rats Open
Background . The purpose of this study was to evaluate the alteration of the gut microbiota and its effect on adenosine monophosphate-activated protein kinase (AMPK)/nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) signa…
View article: Distribution of acquired antibiotic resistance genes among Enterococcus spp. isolated from a hospital in Baotou, China
Distribution of acquired antibiotic resistance genes among Enterococcus spp. isolated from a hospital in Baotou, China Open
A total of 73 enterococca lisolates from clinical samples were collected from December 2016 to September 2017. Of the 73 enterococcal isolates, 36 (49.3%), 35 (47.9%), 1 (1.4%), and 1 (1.4%) were identified as E. faecium, E. faecalis, E. g…
View article: MiR-382 targets GOLM1 to inhibit metastasis of hepatocellular carcinoma and its down-regulation predicts a poor survival.
MiR-382 targets GOLM1 to inhibit metastasis of hepatocellular carcinoma and its down-regulation predicts a poor survival. Open
Accumulating evidences have illuminated that an amount of microRNAs are involved in human diseases including hepatocellular carcinoma (HCC). In this study, we found that the expression of miR-382 in HCC tissues was down-regulated compared …
View article: Repetitive extragenic palindromic DNA sequences from Brucella melitensis stimulate Toll-like receptor 9 signaling in macrophages
Repetitive extragenic palindromic DNA sequences from Brucella melitensis stimulate Toll-like receptor 9 signaling in macrophages Open
Brucella DNA activates the host innate immune system via the intracellular Toll-like receptor 9 (TLR9). However, the Brucella DNA sequences which are responsible for these immunostimulatory effects remain to be elucidated. The present stud…
View article: The prevalence of aminoglycoside-modifying enzyme and virulence genes among enterococci with high-level aminoglycoside resistance in Inner Mongolia, China
The prevalence of aminoglycoside-modifying enzyme and virulence genes among enterococci with high-level aminoglycoside resistance in Inner Mongolia, China Open
View article: Intestinal Microbiota Distinguish Gout Patients from Healthy Humans
Intestinal Microbiota Distinguish Gout Patients from Healthy Humans Open
View article: The effects of evodiamine on serum total cholesterol and triglyceride levels are associated with the activation of the AMPK signaling pathway in rats with hyperlipemia
The effects of evodiamine on serum total cholesterol and triglyceride levels are associated with the activation of the AMPK signaling pathway in rats with hyperlipemia Open
Evodiamine, a naturally occurring indole alkaloid, has been reported to have numerous biological activities, including antitumor, antimicrobial and anti-inflammatory effects. Previous studies also suggest that evodiamine prevents obesity. …
View article: Effects of two novel amino acid substitutions on the penicillin binding properties of the PBP5 C-terminal from Enterococcus faecium
Effects of two novel amino acid substitutions on the penicillin binding properties of the PBP5 C-terminal from Enterococcus faecium Open
The low‑affinity penicillin‑binding protein (PBP)5 is responsible for resistance to β‑lactam antibiotics in Enterococcus faecium. (E. faecium). In order to evaluate more fully the potential of this species for the development of resistance…
View article: MiR-139-3p is related to left ventricular hypertrophy and cardiomyocyte apoptosis in two-kidney one-clip hypertensive rats
MiR-139-3p is related to left ventricular hypertrophy and cardiomyocyte apoptosis in two-kidney one-clip hypertensive rats Open
MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression in many physiological and pathological processes. Previous studies have reported the role of miR-139-3p in cancer. However, its specific roles and function…