Explanipedia

The hidden driver of osteoporosis: mitochondria-dominated inflammation Open

Binghan Yan, Wenhan Ju, Haipeng Xue, Zhanwang Xu, Daodi Qiu , et al. · 2025

Mitochondria are powerful multifunctional intracellular organelles involved in a wide array of cellular processes. Emerging evidence has highlighted mitochondria as pivotal activators of innate immunity and key participants in inflammatory…

Naringin inhibits the osteoblast-osteoclast pyroptosis cascade reaction mediated by accumulated bone marrow adipose tissue in the treatment of postmenopausal osteoporosis Open

Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li , et al. · 2025

This study highlights the pivotal role of BMAT-triggered pyroptosis cascades in PMOP pathogenesis and demonstrates NG's therapeutic potential. Our findings position bone marrow adiposity modulation as a promising anti-PMOP strategy, emphas…

Osteocytes: master orchestrators of skeletal homeostasis, remodeling, and osteoporosis pathogenesis Open

Yan Wu, Donghao Gan, Liu Hon, Daodi Qiu, Guoqing Tan , et al. · 2025

The skeleton functions as an endocrine organ. Osteocytes maintenance of skeletal strength and energy balance by sensing mechanical stress and communicating with surrounding cells. They are currently considered key regulators of bone remode…

The relationship between non-HDL-C/HDL-C ratio and bone mineral density: an NHANES study Open

Shuo Qi, Biao Peng, Zhanwang Xu, Daodi Qiu, Guoqing Tan · 2025

Background The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a newly developed lipid parameter. However, the current research has only explored the relationship with lumbar spine bone mine…

Accuracy of Percutaneous Pedicle Screw Placement Using Modified Single Anterior-Posterior Fluoroscopy with the C-Arm for the Treatment of Traumatic Thoracic and Lumbar Fractures Open

Kaiying Cui, Wen-Ming Chen, Mingliang Wang, Pengfei Hou, Zenghui Tian , et al. · 2024

The PPS placement method using modified single AP fluoroscopy for treating traumatic thoracic and lumbar spine fractures was fairly accurate and reduced the number of fluoroscopy shots and operation time. This technique requires only a C-a…

Discovery of potential ferroptosis and osteoporosis biomarkers through TMT proteomics and bioinformatics analysis Open

Hui Su, Guoqing Tan, Wenxuan Guo, Jin Yu, Zhanwang Xu , et al. · 2024

Gu Sui Bu (Drynaria fortunei J. Smith) prevents osteoporosis in ovariectomized rats by inhibiting pyroptosis through NLRP3/GSDMD/CASPASE-1 Open

Hui Su, Jun Dong, Luyao Liu, Zhihui Yan, Rujie Zhuang , et al. · 2024

Traditional Chinese medicine Gu Sui Bu (Drynaria fortunei J. Smith), has the effect of tonifying the kidneys and strengthening bone. There are many modern studies on the anti-osteoporosis pharmacological mechanism of Gu Sui Bu (Drynaria fo…

Natural Products in the Prevention of Degenerative Bone and Joint Diseases: Mechanisms Based on the Regulation of Ferroptosis Open

Kuanhui Gao, Lizhi Lv, Zhichao Li, Chenmoji Wang, Jiahao Zhang , et al. · 2024

Degenerative bone and joint diseases (DBJDs), characterized by osteoporosis, osteoarthritis, and chronic inflammation of surrounding soft tissues, are systemic conditions primarily affecting the skeletal system. Ferroptosis, a programmed c…

Magnetic resonance imaging classification in a percutaneous needle injury rat model of intervertebral disc degeneration Open

Songlin Liang, Nianhu Li, Jiawen Zhan, Zhichao Li, Changjun Tie , et al. · 2024

Cell life-or-death events in osteoporosis: All roads lead to mitochondrial dynamics Open

Zhichao Li, Songlin Liang, Liqing Ke, Mengjie Wang, Kuanhui Gao , et al. · 2024

Mitochondria exhibit heterogeneous shapes and networks within and among cell types and tissues, also in normal or osteoporotic bone tissues with complex cell types. This dynamic characteristic is determined by the high plasticity provided …

Pyroptosis: A spoiler of peaceful coexistence between cells in degenerative bone and joint diseases Open

Zhichao Li, Wenxiang Cheng, Kuanhui Gao, Songlin Liang, Liqing Ke , et al. · 2024

In summary, an interesting identity for the unregulated pyroptosis pathway in the context of DBJDs was proposed in this review, which was undertaken as a spoiler of peaceful coexistence between cells in a degenerative environment. Over the…

Identifying potential biomarkers of Ferroptosis for Osteoporosis based on using TMT proteomics and bioinformatics analysis Open

Hui Su, Haipeng Xue, Wenxuan Guo, Jin‐Sheng Yu, Zhanwang Xu , et al. · 2024

Background: primary osteoporosis has increasingly become a major problem affecting human health, and its specific pathogenic mechanism is complex. Ferroptosis,as a research hotspot, has found play an important role in the pathogenesis of p…

Proteomic Analysis Based on TMT Regarding the Therapeutic Action of<i>Rhizoma Drynariae</i> on Rats in an Osteoporosis Model Open

Hui Su, Binghan Yan, Ruochong Wang, Zhichao Li, Zhanwang Xu , et al. · 2023

Background:: Primary osteoporosis has increasingly become one of the risk factors affecting human health, and the clinical effect and action mechanism of traditional Chinese medicine in the treatment of primary osteoporosis have been widel…

Regulatory mechanisms of autophagy-related ncRNAs in bone metabolic diseases Open

Binghan Yan, Zhichao Li, Hui Su, Haipeng Xue, Daodi Qiu , et al. · 2023

Bone metabolic diseases have been tormented and are plaguing people worldwide due to the lack of effective and thorough medical interventions and the poor understanding of their pathogenesis. Non-coding RNAs (ncRNAs) are heterogeneous tran…

Cell death regulation: A new way for natural products to treat osteoporosis Open

Zhichao Li, Dandan Li, Renchang Chen, Shang Gao, Zhanwang Xu , et al. · 2022

Osteoporosis is a common metabolic bone disease that results from the imbalance of homeostasis within the bone. Intra-bone homeostasis is dependent on a precise dynamic balance between bone resorption by osteoclasts and bone formation by m…

Autophagy: An important target for natural products in the treatment of bone metabolic diseases Open

Zhichao Li, Dandan Li, Hui Su, Haipeng Xue, Guoqing Tan , et al. · 2022

Bone homeostasis depends on a precise dynamic balance between bone resorption and bone formation, involving a series of complex and highly regulated steps. Any imbalance in this process can cause disturbances in bone metabolism and lead to…

Exosomes and exosomal miRNAs: A new therapy for intervertebral disc degeneration Open

Zhichao Li, Yan Wu, Guoqing Tan, Zhanwang Xu, Haipeng Xue · 2022

Low back pain has been found as a major cause of global disease burden and disability. Intervertebral disc degeneration is recognized as the vital factor causing low back pain. Intervertebral disc degeneration has a complex mechanism and c…

Effect of Rhizoma Drynariae on differential gene expression in ovariectomized rats with osteoporosis based on transcriptome sequencing Open

Hui Su, Haipeng Xue, Shang Gao, Binghan Yan, Ruochong Wang , et al. · 2022

Osteoporosis is increasingly becoming a serious problem affecting the quality of life of the older population. Several experimental studies have shown that Chinese medicine has a definite effect on improving osteoporosis. Based on transcri…

Research of a Safe and Simplified Intertransverse Process Approach for the Lower Thoracic Interbody Surgery Open

Nianhu Li, Rui‐qi Zou, Xue‐gang Zhao, Peng Kong, Yue Chen , et al. · 2022

Objective To assess a safe surgical approach for intertransverse process lower thoracic intervertebral body fusion (ITIF) based on measurements from enhanced three‐dimensional CT reconstruction, cadaver simulated operation, and patient ope…

The efficacy and safety of Tanghuang Jiangu capsule in the treatment osteoporosis: A meta-analysis of randomized controlled trials Open

hui su, haipeng xue, ruochong wang, Guoqing Tan, binghan yan , et al. · 2022

Review question / Objective: In order to more systematically and accurately evaluate the clinical efficacy and safety of Tenghuang Jiangu capsule in the treatment of osteoporosis, we used Meta-analysis to provide more reliable evidence-bas…

Efficacy of acupuncture in promoting postoperative recovery from rotator cuff injuries: systemic Evaluation and meta-analysis Open

Hui Su, shang gao, ruochong wang, binghan yan, Guoqing Tan , et al. · 2022

Review question / Objective: In previous systematic reviews of studies, there were limited studies on the clinical efficacy of acupuncture after rotator cuff injury and lacked strong convincing.Therefore, we decided to conduct a systematic…

Biphasic Effect of Pirfenidone on Angiogenesis Open

Donghao Gan, Wenxiang Cheng, Liqing Ke, Antonia RuJia Sun, Qingyun Jia , et al. · 2022

Pirfenidone (PFD), a synthetic arsenic compound, has been found to inhibit angiogenesis at high concentrations. However, the biphasic effects of different PFD concentrations on angiogenesis have not yet been elucidated, and the present stu…

Effects of miRNAs, lncRNAs and circRNAs on osteoporosis as regulatory factors of bone homeostasis (Review) Open

Zhichao Li, Haipeng Xue, Guoqing Tan, Zhanwang Xu · 2021

Osteoporosis is a common metabolic bone disorder typically characterized by decreased bone mass and an increased risk of fracture. At present, the detailed molecular mechanism underlying the development of osteoporosis remains to be elucid…

Clinical Observations of <span>Kümmell</span> Disease Treatment Through Percutaneous Fixation Combined with Vertebroplasty Open

Donghao Gan, Meng‐Ze Fang, Haipeng Xue, Guoqing Tan, Nianhu Li , et al. · 2021

Objective To explore the safety and efficacy of percutaneous pedicle screw fixation combined with vertebroplasty for the treatment of stage III Kümmell disease. Methods The clinical data and follow‐up results of 22 patients with Kümmell di…

Repurposing of Pirfenidone (Anti-Pulmonary Fibrosis Drug) for Treatment of Rheumatoid Arthritis Open

Donghao Gan, Wenxiang Cheng, Liqing Ke, Antonia RuJia Sun, Qingyun Jia , et al. · 2021

Clinical studies have shown that pirfenidone (PFD) effectively relieves joint pain in rheumatoid arthritis (RA) patients. However, the detailed mechanisms underlying the anti-RA effects of PFD have not been investigated. This study was und…

The effect and mechanism of QufengZhitong capsule for the treatment of osteoarthritis in a rat model Open

Wenxiang Cheng, Donghao Gan, Yiping Hu, Zheng‐Tan Zheng, Qingqiang Zeng , et al. · 2021

Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway Open

Wenxiang Cheng, Huan Huang, Jianhai Chen, Tiantian Zhang, Guo‐Yuan Zhu , et al. · 2019

Network Pharmacology-Based Pharmacological Mechanism of the Chinese Medicine Rhizoma drynariae Against Osteoporosis Open

Donghao Gan, Xiaowei Xu, Deqiang Chen, Feng Peng, Zhanwang Xu · 2019

d_abstr_R Rhizoma drynariae is the main traditional Chinese medicine used for the treatment of osteoporosis, but its anti-osteoporotic targeting mechanism has not been fully elucidated due to the complexity of its active ingredients. In th…

Locomotor activity of rats with SCI is improved by dexmedetomidine by targeting the expression of inflammatory factors Open

Weiguo Wang, Lin Wang, Zhen‐Hua Jiao, Bin Xue, Zhanwang Xu · 2018

Dexmedetomidine, a well‑known selective α‑2 adrenoceptor agonist, inhibits the apoptosis of neurons and protects other organs from oxidative damage. In the present study, the effect of dexmedetomidine on spinal cord injury (SCI) in a rat m…

[A comparative study of titanium elastic intramedullary nail internal fixation and bone plate internal fixation in the treatment of adult Galeazzi fracture]. Open

Junwei Zhang, Lingling Chen, Zhaohui Li, Wei-Zhi Nie, Zhanwang Xu · 2018

Minimally invasive fixation with titanium elastic nail has such advantages as small damage, quick recovery, no skin scarring, etc. As long as the correct indication is selected, minimally invasive titanium intramedullary nail intern…

Zhanwang Xu YOU? Author Swipe