Shuang Zhao
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View article: Vine Tea Combined with a Lidocaine Microneedle Patch for Enhanced Treatment of Psoriasis
Vine Tea Combined with a Lidocaine Microneedle Patch for Enhanced Treatment of Psoriasis Open
Vine tea, a traditional Chinese herbal tea with well-known medicinal properties, contains various bioactive compounds, with dihydromyricetin (DMY) standing out as particularly notable. However, the therapeutic potential of DMY is hindered …
View article: Comprehensive analysis of CDC20 as a prognostic biomarker in lung adenocarcinoma
Comprehensive analysis of CDC20 as a prognostic biomarker in lung adenocarcinoma Open
Background Lung adenocarcinoma, the most prevalent lung cancer subtype, is increasingly diagnosed in non-smokers and females. The cell cycle regulator CDC20 (Cell Division Cycle 20), a crucial activator of the Anaphase-Promoting Complex/Cy…
View article: Effects of permissive hypercapnia on intraoperative cerebral oxygenation and early postoperative cognitive function in elderly patients undergoing laparoscopic surgery
Effects of permissive hypercapnia on intraoperative cerebral oxygenation and early postoperative cognitive function in elderly patients undergoing laparoscopic surgery Open
Background This study examines the effect of permissive hypercapnia (PH) on cerebral oxygenation (rSO 2 ) and early postoperative cognitive function in elderly patients (EP) undergoing laparoscopic surgery (LS). Methods This retrospective …
View article: Integrative multi-omics approach for drug repositioning in Alzheimer's disease
Integrative multi-omics approach for drug repositioning in Alzheimer's disease Open
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder with an insidious onset, and effective therapeutic agents are urgently needed. Objective: This study employed a multi-omics integration strategy for drug repu…
View article: Genetic imputation of transcriptome and proteome illuminates novel therapeutic targets of cutaneous melanoma
Genetic imputation of transcriptome and proteome illuminates novel therapeutic targets of cutaneous melanoma Open
Genomic heterogeneity in melanoma tumors remains a major obstacle to achieving durable responses with conventional and targeted therapies. In this study, we performed a genome-wide association study meta-analysis, integrated with proteome-…
View article: An axiomatic system engineering design method based on NSGA-II algorithm applied to complex systems
An axiomatic system engineering design method based on NSGA-II algorithm applied to complex systems Open
This study proposes an integrated framework that combines Axiomatic Design with Model-Based Systems Engineering, incorporating NSGA-II as an intelligent optimization engine. The framework constructs a multi-level traceability matrix linkin…
View article: Combined surgical excision with open wound healing and photodynamic therapy for periocular basal cell carcinoma: A case report
Combined surgical excision with open wound healing and photodynamic therapy for periocular basal cell carcinoma: A case report Open
This study evaluated a combined approach of surgical excision with open wound healing and photodynamic therapy (PDT) for periocular basal cell carcinoma (BCC) in a 72-year-old male patient, whose lesion involved a high-risk anatomical loca…
View article: Feasibility of Using Biomarkers for Assessing Heavy-Metal Contamination in Soil: A Meta-Analysis
Feasibility of Using Biomarkers for Assessing Heavy-Metal Contamination in Soil: A Meta-Analysis Open
Soil contamination by heavy metals represents a critical environmental challenge, demanding reliable assessment methods. While biotoxicity assays are widely employed, the selection of sensitive biomarkers for heavy-metal contamination rema…
View article: Evaluating the effects of liraglutide, empagliflozin and linagliptin on mild cognitive impairment remission in patients with type 2 diabetes (LIGHT-MCI): study protocol for a multicentre, randomised controlled trial with an extension phase
Evaluating the effects of liraglutide, empagliflozin and linagliptin on mild cognitive impairment remission in patients with type 2 diabetes (LIGHT-MCI): study protocol for a multicentre, randomised controlled trial with an extension phase Open
Introduction Diabetes is a significant modifiable risk factor for cognitive dysfunction. There are currently no effective treatments that delay or reverse the progression of cognitive dysfunction. Accumulating evidence demonstrates that sp…
View article: Antitumor Activity of Ruditapes philippinarum Polysaccharides Through Mitochondrial Apoptosis in Cellular and Zebrafish Models
Antitumor Activity of Ruditapes philippinarum Polysaccharides Through Mitochondrial Apoptosis in Cellular and Zebrafish Models Open
Colorectal cancer (CRC) remains a predominant cause of global cancer-related mortality, highlighting the pressing demand for innovative therapeutic strategies. Natural polysaccharides have emerged as promising candidates in cancer research…
View article: Supplementary Table 3 from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma
Supplementary Table 3 from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma Open
Supplementary Table 3. Interfering sequence of siRNAs.
View article: Supplementary Table 4 from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma
Supplementary Table 4 from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma Open
Supplementary Table 4. Sequence (5’ to 3’) of primers used for RT-qPCR.
View article: Supplementary Figure 1 from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma
Supplementary Figure 1 from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma Open
Supplementary Figure 1. Subclustering and characterization of melanocytes.
View article: Supplementary Table 5 from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma
Supplementary Table 5 from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma Open
Supplementary Table 5. Gene list associated with functional pathways used to define the fibroblast subgroups.
View article: Supplementary Figure 4 from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma
Supplementary Figure 4 from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma Open
Supplementary Figure 4. Cell clustering and cellular interaction analysis of immune cells.
View article: Supplementary Figure 5 from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma
Supplementary Figure 5 from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma Open
Supplementary Figure 5. Cell clustering and cellular interaction analysis of ECs.
View article: Supplementary Table 2 from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma
Supplementary Table 2 from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma Open
Supplementary Table 2. Gene list of high-expression markers associated with clusters 1-4.
View article: Data from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma
Data from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma Open
Purpose:Approximately 30% of nonchronically sun-damaged melanomas originate from nevi, yet the dynamic changes and crucial mechanisms driving the transition from benign nevi to melanoma remain elusive.Experimental Design:In this study, we …
View article: Supplementary Figure 3 from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma
Supplementary Figure 3 from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma Open
Supplementary Figure 3. Distinct characters among melanocyte clusters.
View article: Supplementary Figure 2 from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma
Supplementary Figure 2 from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma Open
Supplementary Figure 2. Functional changes of melanocytes during melanoma progression.
View article: Supplementary Table 6 from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma
Supplementary Table 6 from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma Open
Supplementary Table 6. Hazard Ratio (HR) and 95% Confidence Interval (CI) of univariate Cox regression between different variables and overall survival, related to Supplementary Fig. 6G.
View article: Supplementary Figure 6 from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma
Supplementary Figure 6 from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma Open
Supplementary Figure 6. Characterization of fibroblasts, tumor purity analysis, and prognostic evaluation based on progression index.
View article: Supplementary Table 1 from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma
Supplementary Table 1 from The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma Open
Supplementary Table 1. Sample information.