Xiaocui Zhao
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View article: NF-κB in inflammation and cancer
NF-κB in inflammation and cancer Open
Nuclear factor-κB (NF-κB) is a family of transcription factors that transactivates genes associated with a wide range of biological processes, including immune responses, inflammation, cell growth and survival. Dysregulated NF-κB activatio…
View article: BCOR and ZC3H12A suppress a core stemness program in exhausted CD8+ T cells
BCOR and ZC3H12A suppress a core stemness program in exhausted CD8+ T cells Open
In chronic viral infections, sustained CD8+ T cell response relies on TCF1+ precursor-exhausted T cells (TPEX) exhibiting stem-like properties. TPEX self-renew and respond to PD-1 blockade, underscoring their paramount importance. However,…
View article: TMEM41B is an endoplasmic reticulum Ca2+ release channel maintaining naive T cell quiescence and responsiveness
TMEM41B is an endoplasmic reticulum Ca2+ release channel maintaining naive T cell quiescence and responsiveness Open
In mammalian cells, endoplasmic reticulum (ER) passively releases Ca 2+ under steady state, but channels involved remain elusive. Here, we report that TMEM41B, an ER-resident membrane protein critical for autophagy, lipid metabolism, and v…
View article: Induction of immortal-like and functional CAR T cells by defined factors
Induction of immortal-like and functional CAR T cells by defined factors Open
Long-term antitumor efficacy of chimeric antigen receptor (CAR) T cells depends on their functional persistence in vivo. T cells with stem-like properties show better persistence, but factors conferring bona fide stemness to T cells remain…
View article: TMEM41B is an endoplasmic reticulum Ca<sup>2+</sup>release channel maintaining T cell metabolic quiescence and responsiveness
TMEM41B is an endoplasmic reticulum Ca<sup>2+</sup>release channel maintaining T cell metabolic quiescence and responsiveness Open
SUMMARY Naive T cells are metabolically quiescent. Here, we report an unexpected role of endoplasmic reticulum (ER) Ca 2+ in preserving T cell metabolic quiescence. TMEM41B, an ER-resident membrane protein previously known for its crucial …
View article: Induction of immortal-like and functional CAR-T cells by defined factors
Induction of immortal-like and functional CAR-T cells by defined factors Open
Long-term antitumor efficacy of chimeric antigen receptor (CAR)-T cells depends on their functional persistence in vivo. T cells with stem-like property show better persistence, but factors conferring T cells bona fide stemness remain to b…
View article: One infusion of engineered long-lasting and multifunctional T cells cures asthma in mice
One infusion of engineered long-lasting and multifunctional T cells cures asthma in mice Open
Summary The majority of common chronic human diseases are incurable, which affect a large portion of population and require life-long treatments that impose huge disease, economic and social burden. For example, asthma is the most common r…
View article: VMP1 prevents Ca2+ overload in endoplasmic reticulum and maintains naive T cell survival
VMP1 prevents Ca2+ overload in endoplasmic reticulum and maintains naive T cell survival Open
Ca2+ in endoplasmic reticulum (ER) dictates T cell activation, proliferation, and function via store-operated Ca2+ entry. How naive T cells maintain an appropriate level of Ca2+ in ER remains poorly understood. Here, we show that the ER tr…
View article: Genome-wide fitness gene identification reveals Roquin as a potent suppressor of CD8 T cell expansion and anti-tumor immunity
Genome-wide fitness gene identification reveals Roquin as a potent suppressor of CD8 T cell expansion and anti-tumor immunity Open
Robust expansion of adoptively transferred T cells is a prerequisite for effective cancer immunotherapy, but how many genes in the genome modulate T cell expansion remains unknown. Here, we perform in vivo and in vitro CRISPR screens to sy…
View article: Pyrroline-5-carboxylate synthase senses cellular stress and modulates metabolism by regulating mitochondrial respiration
Pyrroline-5-carboxylate synthase senses cellular stress and modulates metabolism by regulating mitochondrial respiration Open
View article: Large-scale RNAi screen identified Dhpr as a regulator of mitochondrial morphology and tissue homeostasis
Large-scale RNAi screen identified Dhpr as a regulator of mitochondrial morphology and tissue homeostasis Open
Dhpr regulates mitochondrial morphology by modulating S-nitrosylation of Drp1.
View article: Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis
Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis Open
View article: Sec22 Regulates Endoplasmic Reticulum Morphology but Not Autophagy and Is Required for Eye Development in Drosophila
Sec22 Regulates Endoplasmic Reticulum Morphology but Not Autophagy and Is Required for Eye Development in Drosophila Open
The endoplasmic reticulum (ER) is a highly dynamic organelle that plays a critical role in many cellular processes. Abnormal ER morphology is associated with some human diseases, although little is known regarding how ER morphology is regu…