Zhaobin Guo
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View article: Discovery of orally active and serine-targeting covalent inhibitors against hCES2A for ameliorating irinotecan-triggered gut toxicity
Discovery of orally active and serine-targeting covalent inhibitors against hCES2A for ameliorating irinotecan-triggered gut toxicity Open
View article: Stand structure and plant diversity characteristics of typical artificial forests after natural recovery in the hilly region of central Hainan
Stand structure and plant diversity characteristics of typical artificial forests after natural recovery in the hilly region of central Hainan Open
Introduction The global expansion of artificial forests has highlighted the necessity of restoring their ecological service functions and understanding natural succession mechanisms in forest restoration ecology. However, comprehensive ana…
View article: Prussian blue nanohybrid hydrogel combined with specific far-infrared based on graphene devices for promoting diabetic wound healing
Prussian blue nanohybrid hydrogel combined with specific far-infrared based on graphene devices for promoting diabetic wound healing Open
Diabetic wounds are difficult to treat in nature due to their distinct pathophysiological characteristics, such as inflammation and/or oxidative stress, which offers an opportunity to employ nanozymes. However, nanozymes may cause safety c…
View article: Editorial: Emerging bioanalytical techniques and therapies for human disease models
Editorial: Emerging bioanalytical techniques and therapies for human disease models Open
View article: Nanocomposite magnetic hydrogel with dual anisotropic properties induces osteogenesis through the NOTCH-dependent pathways
Nanocomposite magnetic hydrogel with dual anisotropic properties induces osteogenesis through the NOTCH-dependent pathways Open
Physical factors in the cellular microenvironment have critical effects on stem cell differentiation. The utilization of physical factors to promote the osteogenic differentiation of stem cells has been established as a new strategy for de…
View article: Corrigendum: The influence of physiological and pathological perturbations on blood-brain barrier function
Corrigendum: The influence of physiological and pathological perturbations on blood-brain barrier function Open
[This corrects the article DOI: 10.3389/fnins.2023.1289894.].
View article: A tissue-engineered model of the blood-tumor barrier during metastatic breast cancer
A tissue-engineered model of the blood-tumor barrier during metastatic breast cancer Open
View article: The influence of physiological and pathological perturbations on blood-brain barrier function
The influence of physiological and pathological perturbations on blood-brain barrier function Open
The blood-brain barrier (BBB) is located at the interface between the vascular system and the brain parenchyma, and is responsible for communication with systemic circulation and peripheral tissues. During life, the BBB can be subjected to…
View article: Mechano-biomimetic hydrogel 3D cell cultivation as a strategy to improve mammalian cell protein expression
Mechano-biomimetic hydrogel 3D cell cultivation as a strategy to improve mammalian cell protein expression Open
View article: Magnetic microspheres mimicking certain functions of macrophages: Towards precise antibacterial potency for bone defect healing
Magnetic microspheres mimicking certain functions of macrophages: Towards precise antibacterial potency for bone defect healing Open
A variety of novel biomaterials have recently been developed to promote bone regeneration. However, the current biomaterials cannot accurately and effectively resist bacterial invasion. In this study, we constructed microspheres that mimic…
View article: Modeling angiogenesis in the human brain in a tissue-engineered post-capillary venule
Modeling angiogenesis in the human brain in a tissue-engineered post-capillary venule Open
View article: Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood–brain barrier microvessels
Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood–brain barrier microvessels Open
View article: Visualization of the Dynamics of Invasion and Intravasation of the Bacterium That Causes Lyme Disease in a Tissue Engineered Dermal Microvessel Model
Visualization of the Dynamics of Invasion and Intravasation of the Bacterium That Causes Lyme Disease in a Tissue Engineered Dermal Microvessel Model Open
Lyme disease is a tick‐borne disease prevalent in North America, Europe, and Asia. Despite the accumulated knowledge from epidemiological, in vitro, and in animal studies, the understanding of dissemination of vector‐borne pathogens, such …
View article: Dynamics of <i>Borrelia Burgdorferi</i> Invasion and Intravasation in a Tissue Engineered Dermal Microvessel Model
Dynamics of <i>Borrelia Burgdorferi</i> Invasion and Intravasation in a Tissue Engineered Dermal Microvessel Model Open
Lyme disease is a tick-borne disease prevalent in North America, Europe, and Asia. Dissemination of vector-borne pathogens, such as Borrelia burgdorferi ( Bb ), results in infection of distant tissues and is the main contributor to poor ou…
View article: Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington’s disease
Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington’s disease Open
Huntington’s disease (HD) is an inherited neurodegenerative disease caused by expansion of cytosine–adenine–guanine (CAG) repeats in the huntingtin gene, which leads to neuronal loss and decline in cognitive and motor function. Increasing …
View article: Optical Cellular Micromotion: A New Paradigm to Measure Tumor Cells Invasion within Gels Mimicking the 3D Tumor Environments
Optical Cellular Micromotion: A New Paradigm to Measure Tumor Cells Invasion within Gels Mimicking the 3D Tumor Environments Open
Measuring tumor cell invasiveness through 3D tissues, particularly at the single‐cell level, can provide important mechanistic understanding and assist in identifying therapeutic targets of tumor invasion. However, current experimental app…
View article: Effects of acute and chronic oxidative stress on the blood–brain barrier in 2D and 3D in vitro models
Effects of acute and chronic oxidative stress on the blood–brain barrier in 2D and 3D in vitro models Open
Oxidative stress is a shared pathology of neurodegenerative disease and brain injuries, and is derived from perturbations to normal cell processes by aging or environmental factors such as UV exposure and air pollution. As oxidative cues a…
View article: Engineering the Human Blood–Brain Barrier at the Capillary Scale using a Double‐Templating Technique
Engineering the Human Blood–Brain Barrier at the Capillary Scale using a Double‐Templating Technique Open
In vitro blood–brain barrier (BBB) models have played an important role in studying processes such as immune cell trafficking and drug delivery, as well as contributing to the understanding of mechanisms of disease progression. Many biolog…
View article: IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function
IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function Open
BackgroundSome clinical features of severe COVID-19 represent blood vessel damage induced by activation of host immune responses initiated by the coronavirus SARS-CoV-2. We hypothesized autoantibodies against angiotensin-converting enzyme …
View article: Additional file 3 of Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood–brain barrier microvessels
Additional file 3 of Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood–brain barrier microvessels Open
Additional file 3. Summary of tight junction dynamics data.
View article: Additional file 2 of Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood–brain barrier microvessels
Additional file 2 of Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood–brain barrier microvessels Open
Additional file 2. Summary of bulk RNA-sequencing data.
View article: Additional file 1 of Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington’s disease
Additional file 1 of Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington’s disease Open
Additional file 1. Summary of RNA sequencing data.
View article: Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington’s disease
Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington’s disease Open
Huntington’s disease (HD) is an inherited neurodegenerative disease caused by expansion of cytosine–adenine–guanine (CAG) repeats in the huntingtin gene, which leads to neuronal loss and decline in cognitive and motor function. Increasing …
View article: Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood-brain barrier microvessels
Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood-brain barrier microvessels Open
The blood-brain barrier (BBB) plays a pivotal role in brain health and disease. In the BBB, brain microvascular endothelial cells (BMECs) are connected by tight junctions which regulate paracellular transport, and express specialized trans…
View article: Optical Cellular Micromotion: A New Paradigm to Measure Tumour Cells Invasion in 3D Tumour Environments
Optical Cellular Micromotion: A New Paradigm to Measure Tumour Cells Invasion in 3D Tumour Environments Open
Measuring tumour cell invasiveness through three-dimensional (3D) tissues, particularly at the single cell level, can provide important mechanistic understanding and assist in identifying therapeutic targets of tumour invasion. However, cu…
View article: Multicellular Spheroids Formation on Hydrogel Enhances Osteogenic/Odontogenic Differentiation of Dental Pulp Stem Cells Under Magnetic Nanoparticles Induction
Multicellular Spheroids Formation on Hydrogel Enhances Osteogenic/Odontogenic Differentiation of Dental Pulp Stem Cells Under Magnetic Nanoparticles Induction Open
Three-dimensional spheroids culture of DPSCs based on composite viscoelastic materials combined with mechanical/magnetic stimulation may provide a theoretical basis for the subsequent development of dentin or bone regeneration technology.
View article: Dual anisotropicity comprising 3D printed structures and magnetic nanoparticle assemblies: towards the promotion of mesenchymal stem cell osteogenic differentiation
Dual anisotropicity comprising 3D printed structures and magnetic nanoparticle assemblies: towards the promotion of mesenchymal stem cell osteogenic differentiation Open
Leveraging physical factors in cellular microenvironments to promote adipose tissue-derived stem cell (ADSC) osteogenic differentiation has emerged as a new strategy in the development of scaffolds for bone tissue engineering. Anisotropici…
View article: Assembly-induced microwave band resonance in gold nanoparticles-based ultrathin and flexible spoof localized surface plasmon
Assembly-induced microwave band resonance in gold nanoparticles-based ultrathin and flexible spoof localized surface plasmon Open
View article: Hele Shaw microfluidic device: A new tool for systematic investigation into the effect of the fluid shear stress for organs-on-chips
Hele Shaw microfluidic device: A new tool for systematic investigation into the effect of the fluid shear stress for organs-on-chips Open