Zhicai Zuo
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View article: Altitude-Linked Distribution Patterns of Serum and Hair Mineral Elements in Healthy Yak Calves from Ganzi Prefecture
Altitude-Linked Distribution Patterns of Serum and Hair Mineral Elements in Healthy Yak Calves from Ganzi Prefecture Open
Mineral imbalances in livestock can critically impair growth, immunity, and productivity. Yaks inhabiting the Qinghai–Tibetan Plateau face unique environmental challenges, including high-altitude-induced nutrient variability. This study in…
View article: Recombinant serralysin metalloproteases D enhances the intracellular replication of infectious bovine rhinotracheitis virus
Recombinant serralysin metalloproteases D enhances the intracellular replication of infectious bovine rhinotracheitis virus Open
Infectious bovine rhinotracheitis virus (IBRV) and Serratia marcescens co-infection are commonly observed in the respiratory tract of cattle subjected to respiratory diseases. However, the potential effects of proteases from Serratia marce…
View article: Effects of Copper on Steroid Hormone Secretion, Steroidogenic Enzyme Expression, and Transcriptomic Profiles in Yak Ovarian Granulosa Cells
Effects of Copper on Steroid Hormone Secretion, Steroidogenic Enzyme Expression, and Transcriptomic Profiles in Yak Ovarian Granulosa Cells Open
Yak (Bos grunniens) is the main economic animal growing in the Qinghai–Tibet Plateau. Because of its poor growing environment, copper deficiency is common. Studies have shown that appropriate copper supplementation can improve the reproduc…
View article: Establishment and application of multiplex PCR method for detection of Trichophyton verrucosum, Microsporum canis, and Trichophyton mentagrophytes from cattle
Establishment and application of multiplex PCR method for detection of Trichophyton verrucosum, Microsporum canis, and Trichophyton mentagrophytes from cattle Open
Introduction Dermatophytosis, which is a contagious fungal skin infection common in animals and humans, is the most common skin disease in cattle. It has a serious negative impact on the livestock industry. In order to circumvent the short…
View article: Proteomics analysis reveals the mechanism of anemoside B4 in treating clinical mastitis in dairy cows
Proteomics analysis reveals the mechanism of anemoside B4 in treating clinical mastitis in dairy cows Open
(1) Background: The therapeutic efficacy of AB4 in cows with CM is well-established, but the specific mechanism remains to be explored. This study was based on Label free relative quantitative proteomics technology to reveal the internal m…
View article: Effects of Trace Elements and Vitamins on the Synthesis of Steroid Hormones in Follicular Granulosa Cells of Yak
Effects of Trace Elements and Vitamins on the Synthesis of Steroid Hormones in Follicular Granulosa Cells of Yak Open
Yak (Bos grunniens), a special breed of cattle on the Qinghai–Tibet Plateau, has low fertility due to nutritional deficiency, especially the trace elements. The steroid hormones estradiol (E2) and progesterone (P4) synthesized by yak folli…
View article: Multi-omics investigation into long-distance road transportation effects on respiratory health and immunometabolic responses in calves
Multi-omics investigation into long-distance road transportation effects on respiratory health and immunometabolic responses in calves Open
View article: Resistin alleviates lipopolysaccharide-induced inflammation in bovine alveolar macrophages by activating the AMPK/mTOR signaling pathway and autophagy
Resistin alleviates lipopolysaccharide-induced inflammation in bovine alveolar macrophages by activating the AMPK/mTOR signaling pathway and autophagy Open
RETN can promote autophagy in BAMs by activating the AMPK/mTOR signaling pathway, it may help prevent LPS-induced inflammation.
View article: Development and characterization of an immortalized nasopharyngeal epithelial cell line to explore airway physiology and pathology in yak (Bos grunniens)
Development and characterization of an immortalized nasopharyngeal epithelial cell line to explore airway physiology and pathology in yak (Bos grunniens) Open
Airway epithelial cells play a crucial role in investigating the physiological and pathological mechanisms of the respiratory tract in yaks, a species whose unique respiratory system has garnered extensive interest. Despite this growing in…
View article: Effects of meloxicam on the welfare of Holstein calves from 6 weeks to 6 months old undergoing amputation dehorning
Effects of meloxicam on the welfare of Holstein calves from 6 weeks to 6 months old undergoing amputation dehorning Open
Amputation dehorning (AD) is a common practice performed on calves, causing harmful effects such as pain, distress, anxiety, and fear. These effects extend to behavioral, physiological, and hematological responses, prompting serious ethica…
View article: Multi-omics reveals that alkaline mineral water improves the respiratory health and growth performance of transported calves
Multi-omics reveals that alkaline mineral water improves the respiratory health and growth performance of transported calves Open
View article: Matrine and icariin can inhibit bovine viral diarrhoea virus replication by promoting type I interferon response <i>in vitro</i>
Matrine and icariin can inhibit bovine viral diarrhoea virus replication by promoting type I interferon response <i>in vitro</i> Open
Introduction Bovine viral diarrhoea virus (BVDV) can cause diarrhoea (BVD) in an animal herd, leading to heavy economic losses. There are limited drugs available for treating and controlling BVD. This research aims to investigate the antiv…
View article: Retraction Note: Effect of intranasal instillation of Escherichia coli on apoptosis of spleen cells in diet-induced-obese mice
Retraction Note: Effect of intranasal instillation of Escherichia coli on apoptosis of spleen cells in diet-induced-obese mice Open
View article: Metabolome and Transcriptome Combinatory Profiling Reveals Fluconazole Resistance Mechanisms of Trichosporon asahii and the Role of Farnesol in Fluconazole Tolerance
Metabolome and Transcriptome Combinatory Profiling Reveals Fluconazole Resistance Mechanisms of Trichosporon asahii and the Role of Farnesol in Fluconazole Tolerance Open
Trichosporon asahii is a basidiomycete yeast that is pathogenic to humans and animals, and fluconazole-resistant strains have recently increased. Farnesol secreted by fungi is a factor that causes variations in fluconazole resistance; howe…
View article: Apoptosis and DNA damage mediated by ROS involved in male reproductive toxicity in mice induced by Nickel
Apoptosis and DNA damage mediated by ROS involved in male reproductive toxicity in mice induced by Nickel Open
Nickel (Ni) is the most important environmental pollution in the world. Ni has been confirmed to have multi-organ toxicology and carcinogenicity. Recently, Ni also can impair the male reproductive system, however, its precious mechanism st…
View article: Nickel induces blood-testis barrier damage through ROS-mediated p38 MAPK pathways in mice
Nickel induces blood-testis barrier damage through ROS-mediated p38 MAPK pathways in mice Open
Nickel (Ni) is an essential common environmental contaminant, it is hazardous to male reproduction, but the precise mechanisms are still unknown. Blood-testis barrier (BTB), an important testicular structure consisting of connections betwe…
View article: Metabolic Nutrient Preferences of<i>Vibrio mimicus</i>: Leveraging Nucleotides and Oligopeptides from Yellow Catfish for Enhanced Infectivity
Metabolic Nutrient Preferences of<i>Vibrio mimicus</i>: Leveraging Nucleotides and Oligopeptides from Yellow Catfish for Enhanced Infectivity Open
In the context of host-microbe interactions, the microenvironment plays a critical role in facilitating microbial survival, and variations in these microenvironments may influence the pathogenicity of microorganisms. Vibrio mimicus , a maj…
View article: Low Glucose plus β-Hydroxybutyrate Induces an Enhanced Inflammatory Response in Yak Alveolar Macrophages via Activating the GPR109A/NF-κB Signaling Pathway
Low Glucose plus β-Hydroxybutyrate Induces an Enhanced Inflammatory Response in Yak Alveolar Macrophages via Activating the GPR109A/NF-κB Signaling Pathway Open
Yaks are often subject to long-term starvation and a high prevalence of respiratory diseases and mortality in the withered season, yet the mechanisms that cause this remain unclear. Research has demonstrated that β-hydroxybutyrate (BHB) pl…
View article: Autophagy-mediated ferroptosis involved in nickel-induced nephrotoxicity in the mice
Autophagy-mediated ferroptosis involved in nickel-induced nephrotoxicity in the mice Open
Nickel, as a widely polluted metal, has been shown nephrotoxicity. Ferroptosis is a new type of cell death driven by iron-dependent lipid peroxidation. Our study found that nickel chloride (NiCl2) induced ferroptosis in mouse ki…
View article: Integrated bioinformatics identifies key mediators in cytokine storm and tissue remodeling during Vibrio mimicus infection in yellow catfish (Pelteobagrus fulvidraco)
Integrated bioinformatics identifies key mediators in cytokine storm and tissue remodeling during Vibrio mimicus infection in yellow catfish (Pelteobagrus fulvidraco) Open
Introduction The pathogenesis of Vibrio mimicus infection in yellow catfish ( Pelteobagrus fulvidraco ) remains poorly understood, particularly regarding the impact of infection with the pathogen on primary target organs such as the skin a…
View article: RAGE–TLR4 Crosstalk Is the Key Mechanism by Which High Glucose Enhances the Lipopolysaccharide-Induced Inflammatory Response in Primary Bovine Alveolar Macrophages
RAGE–TLR4 Crosstalk Is the Key Mechanism by Which High Glucose Enhances the Lipopolysaccharide-Induced Inflammatory Response in Primary Bovine Alveolar Macrophages Open
The receptor of advanced glycation end products (RAGE) and Toll-like receptor 4 (TLR4) are important receptors for inflammatory responses induced by high glucose (HG) and lipopolysaccharide (LPS) and show crosstalk phenomena in inflammator…
View article: A Clinical Trial on the Welfare Effects of Administering Meloxicam to 10 to 21 Day Dairy Calves Following Caustic Paste Disbudding
A Clinical Trial on the Welfare Effects of Administering Meloxicam to 10 to 21 Day Dairy Calves Following Caustic Paste Disbudding Open
Caustic paste disbudding (CPD) is widely utilized for calves, which has been known to result in adverse effects on the calves and ethical concerns related to animal welfare, despite the use of local anesthetics. The administration of melox…
View article: Process of Glucose Increases Rather Than Constant High Glucose Was the Main Cause of Abnormal Glucose Induced Glomerulus Epithelial Cells Inflammatory Response
Process of Glucose Increases Rather Than Constant High Glucose Was the Main Cause of Abnormal Glucose Induced Glomerulus Epithelial Cells Inflammatory Response Open
Abnormal glycemia is frequently along with nephritis, whose pathogenesis is unexplicit. Here, we investigated the effects of abnormal glucose on the renal glomerulus epithelial cells by stimulating immortalized bovine renal glomerulus epit…
View article: Isolation, characterization and complete genome sequencing of a Streptococcus dysgalactiae associated with cultured channel catfish mortalities in China
Isolation, characterization and complete genome sequencing of a Streptococcus dysgalactiae associated with cultured channel catfish mortalities in China Open
Streptococcus dysgalactiae has emerged as an important pathogen that affects fish and mammals. Recently, channel catfish cultured in Sichuan, suffered an infectious disease characterized by neurological symptoms and many partial ulcers thr…
View article: Altered Fecal Microbiome and Correlations of the Metabolome with Plasma Metabolites in Dairy Cows with Left Displaced Abomasum
Altered Fecal Microbiome and Correlations of the Metabolome with Plasma Metabolites in Dairy Cows with Left Displaced Abomasum Open
LDA is a major contributor to economic losses in the dairy industry worldwide; however, the mechanisms associated with the metabolic changes in LDA remain unclear. Most previous studies have focused on the rumen microbiota in terms of unde…
View article: Microsporum gypseum Isolated from Ailuropoda melanoleuca Provokes Inflammation and Triggers Th17 Adaptive Immunity Response
Microsporum gypseum Isolated from Ailuropoda melanoleuca Provokes Inflammation and Triggers Th17 Adaptive Immunity Response Open
Microsporum gypseum causes dermatomycoses in giant pandas (Ailuropoda melanoleuca). This study aimed to investigate the immune response of M. gypseum following deep infection. The degree of damage to the heart, liver, spleen, lungs, and ki…
View article: The combination of high glucose and LPS induces autophagy in bovine kidney epithelial cells via the Notch3/mTOR signaling pathway
The combination of high glucose and LPS induces autophagy in bovine kidney epithelial cells via the Notch3/mTOR signaling pathway Open
Background Aside respiratory diseases, beef cattle may also suffer from serious kidney diseases after transportation. Hyperglycemia and gram-negative bacterial infection may be the main reasons why bovine is prone to severe kidney disease …
View article: Corrigendum: The Microbiota and It’s Correlation With Metabolites in the Gut of Mice With Nonalcoholic Fatty Liver Disease
Corrigendum: The Microbiota and It’s Correlation With Metabolites in the Gut of Mice With Nonalcoholic Fatty Liver Disease Open
[This corrects the article DOI: 10.3389/fcimb.2022.870785.].
View article: Beta-Hydroxybutyrate: A Dual Function Molecular and Immunological Barrier Function Regulator
Beta-Hydroxybutyrate: A Dual Function Molecular and Immunological Barrier Function Regulator Open
Ketone bodies are crucial intermediate metabolites widely associated with treating metabolic diseases. Accumulating evidence suggests that ketone bodies may act as immunoregulators in humans and animals to attenuate pathological inflammati…
View article: More Active Intestinal Immunity Developed by Obese Mice Than Non-Obese Mice After Challenged by Escherichia coli
More Active Intestinal Immunity Developed by Obese Mice Than Non-Obese Mice After Challenged by Escherichia coli Open
Obese mice presented lower mortality to non-fatal pneumonia induced by Escherichia coli ( E. coli ) than the non-obese mice. However, it remained obscure whether the intestine contributed to the protective effect of obese mice with infecti…