Zhaokai Yao
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View article: Atorvastatin improves spermatogenesis in murine and in vitro human chronic orchitis models through restoring blood-testis barriers
Atorvastatin improves spermatogenesis in murine and in vitro human chronic orchitis models through restoring blood-testis barriers Open
View article: Deciphering the regulatory networks of human male germline development from embryo to adulthood
Deciphering the regulatory networks of human male germline development from embryo to adulthood Open
Male germline development is crucial for the proper establishment of spermatogonial stem cell pool and life-long production of spermatozoa, but the full-term developmental profiling of human male germline is not fully understood. Here, by …
View article: Lovastatin promotes the self-renewal of murine and primate spermatogonial stem cells
Lovastatin promotes the self-renewal of murine and primate spermatogonial stem cells Open
The spermatogonial stem cell (SSC) niche is critical for SSC maintenance and subsequent spermatogenesis. Numerous reproductive hazards impair the SSC niche, thereby resulting in aberrant SSC self-renewal and male infertility. However, prom…
View article: BMP4 drives primed to naïve transition through PGC-like state
BMP4 drives primed to naïve transition through PGC-like state Open
View article: Cell-fate transition and determination analysis of mouse male germ cells throughout development
Cell-fate transition and determination analysis of mouse male germ cells throughout development Open
View article: The chromatin accessibility landscape reveals distinct transcriptional regulation in the induction of human primordial germ cell-like cells from pluripotent stem cells
The chromatin accessibility landscape reveals distinct transcriptional regulation in the induction of human primordial germ cell-like cells from pluripotent stem cells Open
In vitro induction of human primordial germ cell-like cells (hPGCLCs) provides an ideal platform to recapitulate hPGC development. However, the detailed molecular mechanisms regulating the induction of hPGCLCs remain largely uncharacterize…
View article: Single Cell Sequencing Reveals Early PGC-like Intermediates During Mouse Primed to Naïve Transition
Single Cell Sequencing Reveals Early PGC-like Intermediates During Mouse Primed to Naïve Transition Open
Single cell analysis provides clarity unattainable with bulk approaches. Here we apply single cell RNA-seq to a newly established BMP4 induced mouse primed to naive transition (Bi-PNT) system and show that the reset is not a direct reversa…
View article: The histone demethylase KDM2B regulates human primordial germ cell-like cells specification
The histone demethylase KDM2B regulates human primordial germ cell-like cells specification Open
Germline specification is a fundamental step for human reproduction and this biological phenomenon possesses technical challenges to study in vivo as it occurs immediately after blastocyst implantation. The establishment of in vi…
View article: Efficient generation of human primordial germ cell-like cells from pluripotent stem cells in a methylcellulose-based 3D system at large scale
Efficient generation of human primordial germ cell-like cells from pluripotent stem cells in a methylcellulose-based 3D system at large scale Open
Background The mechanisms underlying human germ cell development and infertility remain largely unknown due to bioethical issues and the shortage of experimental materials. Therefore, an effective in vitro induction system of human primord…
View article: Single-Cell RNA Sequencing Analysis Reveals Sequential Cell Fate Transition during Human Spermatogenesis
Single-Cell RNA Sequencing Analysis Reveals Sequential Cell Fate Transition during Human Spermatogenesis Open