Zhongping Zhan
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View article: Vericiguat as a novel PPARα ligand alleviates pressure-overload-induced heart failure
Vericiguat as a novel PPARα ligand alleviates pressure-overload-induced heart failure Open
Heart failure (HF) remains a critical global health challenge with limited therapeutic options. Vericiguat, a novel soluble guanylate cyclase (sGC) stimulator, has demonstrated clinical potential in HF management. This study aimed to inves…
View article: Targeted Oncolytic Therapy for Hepatocellular Carcinoma with High Specificity and Efficiency
Targeted Oncolytic Therapy for Hepatocellular Carcinoma with High Specificity and Efficiency Open
Introduction and hypothesis: Hepatocellular Carcinoma (HCC) represents a significant global health burden, characterized by high mortality rates and limited therapeutic options. Annually, over 500,000 new cases of HCC are diagnosed globall…
View article: The protective role of Agrin and CAF22 in hypertensive nephropathy
The protective role of Agrin and CAF22 in hypertensive nephropathy Open
Both rAgrin and rCAF22 exert protective effects against renal inflammation and fibrosis in HN. Moreover, CAF22 may serve as a promising biomarker for the diagnosis of HN.
View article: IL‐33‐Induced TREM2<sup>+</sup> Macrophages Promote Pathological New Bone Formation Through CREG1‐IGF2R Axis in Ankylosing Spondylitis
IL‐33‐Induced TREM2<sup>+</sup> Macrophages Promote Pathological New Bone Formation Through CREG1‐IGF2R Axis in Ankylosing Spondylitis Open
Pathological new bone formation is the main cause of disability in ankylosing spondylitis (AS), and so far, it lacks a targeted therapy. Macrophages are central orchestrators of inflammation progression and tissue remodeling, but their con…
View article: Serum triglyceride to high density lipoprotein cholesterol ratio in late pregnancy as a potential predictor of adverse birth outcomes: an analysis of real-world data
Serum triglyceride to high density lipoprotein cholesterol ratio in late pregnancy as a potential predictor of adverse birth outcomes: an analysis of real-world data Open
Real-world data showed an association between serum THR in late pregnancy and ABO risk, and this association may be partially mediated by prevalent pregnancy complications (PE/GDM/ICP), suggesting a potential role of THR in predicting ABO …
View article: Intermittent administration of PTH for the treatment of inflammatory bone loss does not enhance entheseal pathological new bone formation
Intermittent administration of PTH for the treatment of inflammatory bone loss does not enhance entheseal pathological new bone formation Open
Experimental animal models of AS treated with iPTH show improvement in trabecular bone density, but not entheseal pathological bone formation，indicating it may be a potential treatment for inflammatory bone loss does in AS.
View article: Pregnancy outcomes in patients receiving assisted reproductive therapy with systemic lupus erythematosus: a multi-center retrospective study
Pregnancy outcomes in patients receiving assisted reproductive therapy with systemic lupus erythematosus: a multi-center retrospective study Open
Objectives To evaluate the safety, efficacy, and maternal and fetal outcomes of assisted reproductive therapy (ART) in systemic lupus erythematosus (SLE). Methods Patients from three tertiary hospitals from Guangzhou, China followed-up fro…
View article: Clinical Characteristics and Associated Factors for Infection and in-Hospital Mortality in Inpatients with Polymyositis/Dermatomyositis in China: A Retrospective Study
Clinical Characteristics and Associated Factors for Infection and in-Hospital Mortality in Inpatients with Polymyositis/Dermatomyositis in China: A Retrospective Study Open
Infection is an early complication in PM/DM with a high proportion of lung involvement and predominance of gram-negative bacteria. It is a major contributor to in-hospital mortality. Older age, ILD, and number of episodes of infection are …
View article: CXCL12/CXCR4-Rac1–mediated migration of osteogenic precursor cells contributes to pathological new bone formation in ankylosing spondylitis
CXCL12/CXCR4-Rac1–mediated migration of osteogenic precursor cells contributes to pathological new bone formation in ankylosing spondylitis Open
Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by inflammatory back pain and spinal ankylosis due to pathological new bone formation. Here, we identified CXCL12 as a critical contributor to pathological new bon…
View article: RNA-seq of spinal ligament tissues from AS and control patients
RNA-seq of spinal ligament tissues from AS and control patients Open
Samples were collected.
View article: RNA-seq of spinal ligament tissues from AS and control patients
RNA-seq of spinal ligament tissues from AS and control patients Open
Samples were collected.
View article: Single cell seq of entheseal tissues in CAIA and control mice
Single cell seq of entheseal tissues in CAIA and control mice Open
Tissue sample were collected and scRNA analysis was conducted.
View article: Single cell seq of entheseal tissues in CAIA and control mice
Single cell seq of entheseal tissues in CAIA and control mice Open
Tissue sample were collected and scRNA analysis was conducted.
View article: Infective patterns of cryptococcosis in patients with connective tissue disease: a retrospective study
Infective patterns of cryptococcosis in patients with connective tissue disease: a retrospective study Open
Background: Cryptococcal infection is a life-threatening complication in patients with connective tissue disease (CTD). This retrospective study was performed to explore the clinical features and associated factors of cryptococcosis in pat…
View article: Infective patterns of cryptococcosis in patients with connective tissue disease:a retrospective study
Infective patterns of cryptococcosis in patients with connective tissue disease:a retrospective study Open
Background: Cryptococcal infection is a life-threatening complication in patients with connective tissue disease (CTD). This retrospective study was performed to explore the clinical features and associated factors of cryptococcosis in pat…
View article: Invasive fungal disease in patients with systemic lupus erythematosus from Southern China: a retrospective study
Invasive fungal disease in patients with systemic lupus erythematosus from Southern China: a retrospective study Open
Objective To investigate the characteristics and associated factors of invasive fungal disease in patients with systemic lupus erythematosus from Southern China. Methods A retrospective study was performed. Demographic and clinical charact…
View article: Long noncoding RNA LERFS negatively regulates rheumatoid synovial aggression and proliferation
Long noncoding RNA LERFS negatively regulates rheumatoid synovial aggression and proliferation Open
Fibroblast-like synoviocytes (FLSs) are critical to synovial aggression and joint destruction in rheumatoid arthritis (RA). The role of long noncoding RNAs (lncRNAs) in RA is largely unknown. Here, we identified a lncRNA, LERFS (lowly expr…
View article: Fetal and Maternal Outcomes of Planned Pregnancy in Patients with Systemic Lupus Erythematosus: A Retrospective Multicenter Study
Fetal and Maternal Outcomes of Planned Pregnancy in Patients with Systemic Lupus Erythematosus: A Retrospective Multicenter Study Open
Objective . To investigate the fetal and maternal outcomes as well as predictors of APOs in women with SLE who conceived when the disease was stable, the so-called “planned pregnancy.” Methods . A retrospective multicenter study of 243 pat…
View article: Herpes zoster in patients with systemic lupus erythematosus: Clinical features, complications and risk factors
Herpes zoster in patients with systemic lupus erythematosus: Clinical features, complications and risk factors Open
Herpes Zoster (HZ) is reported as the most prevalent viral infection in patients with systemic lupus erythematosus (SLE). The aim of the present study was to investigate the clinical features, complications, and potential risk factors of H…
View article: Rare Cyclophosphamide-Induced Hemorrhagic Cystitis in a Chinese Population with Rheumatic Diseases
Rare Cyclophosphamide-Induced Hemorrhagic Cystitis in a Chinese Population with Rheumatic Diseases Open
CYC-induced HC was rare and highly variable in Chinese patients with rheumatic diseases. Individualized treatment should be performed according to the severity of HC for each patient. More aggressive treatment strategies might improve the …