Explanipedia

A novel gene signature for forecasting time to next relapse in multiple sclerosis using peripheral blood mononuclear cells Open

Huimin Zhang, Jiahui Yang, Xiaobo Zhang, Chao-Yi Wu, Zhen Zhao , et al. · 2025

BLK, P2RX5, GP1BA, and PF4 emerge as potential predictors of future disease activity in individuals with MS.

Key oncogenes and candidate drugs for hepatitis-B-driven hepatocellular carcinoma progression Open

Liqin Ruan, Ningbo Fang, Xinhua Zhao, Weili Chen, Zhaoping Wu , et al. · 2025

mRNA‐Lipid Nanoparticle‐Mediated Restoration of PTPN14 Exhibits Antitumor Effects by Overcoming Anoikis Resistance in Triple‐Negative Breast Cancer Open

Wei Li, Masha Huang, Zhaoping Wu, Yanwen Zhang, Ying Cai , et al. · 2024

Triple‐negative breast cancer (TNBC) poses a challenging prognosis due to early metastasis driven by anoikis resistance. Identifying crucial regulators to overcome this resistance is vital for improving patient outcomes. In this study, a g…

LOC646762 Is Involved in Adipogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells Open

Yifan Shao, Minqi Xiong, Jianyun Liu, Zhiping Gu, Zhaoping Wu , et al. · 2024

Long noncoding RNA (lncRNA) has been shown to participate in adipogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs). In this study, we aimed to investigate the role of lncRNA-LOC646762 in adipogenic differentiatio…

Construction of functional neural network tissue combining CBD-NT3-modified linear-ordered collagen scaffold and TrkC-modified iPSC-derived neural stem cells for spinal cord injury repair Open

Zhaoping Wu, Y Zhou, Xianglin Hou, Weidong Liu, Wen Yin , et al. · 2024

A prognostic signature based on snoRNA predicts the overall survival of lower-grade glioma patients Open

Yi Zhou, Wen Yin, Yirui Kuang, Zhaoping Wu, Haoxuan Huang , et al. · 2023

Introduction Small nucleolar RNAs (snoRNAs) are a group of non-coding RNAs enriched in the nucleus which direct post-transcriptional modifications of rRNAs, snRNAs and other molecules. Recent studies have suggested that snoRNAs have a sign…

Identification of cuproptosis-related subtypes and the development of a prognostic model in glioma Open

Zhaoping Wu, Wei Li, Hecheng Zhu, Xuewen Li, Zhou Yi , et al. · 2023

Introduction: A copper-dependent cell death, cuproptosis, involves copper binding with lipoylated tricarboxylic acid (TCA) cycle components. In cuproptosis, ferredoxin 1 (FDX1) and lipoylation act as key regulators. The mechanism of cuprop…

A cross-sectional study of smoking and depression among US adults: NHANES (2005–2018) Open

Zhaoping Wu, Qiang Yue, Zhen Zhao, Jun Wen, Lanying Tang , et al. · 2023

Background The relationship between smoking and depression remains controversial. This study aimed to investigate the association between smoking and depression from three aspects: smoking status, smoking volume, and smoking cessation. Met…

A computational approach based on weighted gene co-expression network analysis for biomarkers analysis of Parkinson’s disease and construction of diagnostic model Open

Zhaoping Wu, Zhiping Hu, Yunchun Gao, Yuechong Xia, Xiaobo Zhang , et al. · 2023

Background Parkinson’s disease (PD) is a common age-related chronic neurodegenerative disease. There is currently no affordable, effective, and less invasive test for PD diagnosis. Metabolite profiling in blood and blood-based gene transcr…

A practical and economical method for frontal sinus reconstruction after frontal craniotomy: A single-center experience with 140 patients Open

Youwei Guo, Xianyong Fu, Wen Yin, Zhipeng Jiang, Yirui Kuang , et al. · 2022

Background Frontal sinus exposure is a common consequence of frontal craniotomy. Cerebrospinal fluid leakage and infection are the major postoperative complications that may occur as a result of the open frontal sinus. The successful filli…

LncRNAs and their RBPs: How to influence the fate of stem cells? Open

Cong Zhao, Wen Xie, Hecheng Zhu, Ming Zhao, Weidong Liu , et al. · 2022

Stem cells are distinctive cells that have self-renewal potential and unique ability to differentiate into multiple functional cells. Stem cell is a frontier field of life science research and has always been a hot spot in biomedical resea…

APOBEC3C Served as a Novel Immune-Related Prognosis Biomarker in Glioma: A Pan-Cancer Analysis Open

Xingjun Jiang, Yirui Kuang, Zhaoqi Xin, Wen Yin, Quanwei Zhou , et al. · 2022

Background: Apolipoprotein B mRNA-editing enzyme catalytic subunit 3C (APOBEC3C) belongs to the cytidine deaminase family, and its function remains unknown in some cancers. The purpose of this study was to elucidate the role of APOBEC3C in…

Weighted Gene Coexpression Network Analysis of Specific Modules of Parkinson's Disease and Construction of Diagnostic Models Open

Zhaoping Wu, Xiaobo Zhang, Yuechong Xia, Zhiping Hu · 2022

Contralateral Axon Sprouting but Not Ipsilateral Regeneration Is Responsible for Spontaneous Locomotor Recovery Post Spinal Cord Hemisection Open

Yudong Cao, Ya Shi, Zhifeng Xiao, Xi Chen, Bing Chen , et al. · 2021

Spinal cord injury (SCI) usually results in permanent functional impairment and is considered a worldwide medical problem. However, both motor and sensory functions can spontaneously recover to varying extents in humans and animals with in…

METTL7B is a novel prognostic biomarker of lower-grade glioma based on pan-cancer analysis Open

Zhipeng Jiang, Wen Yin, Hecheng Zhu, Jun Tan, Youwei Guo , et al. · 2021

Development of an Immune-Related LncRNA Prognostic Signature for Glioma Open

Yudong Cao, Hecheng Zhu, Jun Tan, Wen Yin, Quanwei Zhou , et al. · 2021

Introduction Glioma is the most common primary cancer of the central nervous system with dismal prognosis. Long noncoding RNAs (lncRNAs) have been discovered to play key roles in tumorigenesis in various cancers, including glioma. Because …

Identification of collagen genes related to immune infiltration and epithelial-mesenchymal transition in glioma Open

Wen Yin, Hecheng Zhu, Jun Tan, Zhaoqi Xin, Quanwei Zhou , et al. · 2021

Background Gliomas account for the majority of fatal primary brain tumors, and there is much room for research in the underlying pathogenesis, the multistep progression of glioma, and how to improve survival. In our study, we aimed to iden…

Hepatectomy is associated with survival in intrahepatic cholangiocarcinoma Open

Wei‐Li Chen, Zhaoping Wu, Lingling Cao · 2021

Liver resection (LR) is a major treatment modality in select patients with stage I-III Intrahepatic cholangiocarcinoma (ICC), yet many studies demonstrated low rates of resection. The aim of the present study is to evaluate whether increas…

Molecular Subtypes Based on the Stemness Index Predict Prognosis in Glioma Patients Open

Jun Tan, Hecheng Zhu, Guihua Tang, Hongwei Liu, Siyi Wanggou , et al. · 2021

Glioma is the common histological subtype of malignancy in the central nervous system, with high morbidity and mortality. Glioma cancer stem cells (CSCs) play essential roles in tumor recurrence and treatment resistance. Thus, exploring th…

Diagnosis of Streptococcus suis Meningoencephalitis with metagenomic next-generation sequencing of the cerebrospinal fluid: a case report with literature review Open

Xiaobo Zhang, Zhaoping Wu, Kai Wang · 2020

Management and survival for patients with stage-I hepatocellular carcinoma Open

Zhaoping Wu, Wei‐Li Chen, Ting Ouyang, Hechun Liu, Lingling Cao · 2020

It is controversial regarding the treatment allocation for patients with stage I hepatocellular carcinoma (SI-HCC). The aim of the present study was to compare the long-term survival in SI-HCC patients undergoing liver transplantation (LT)…

Identification of collagen genes related to immune infiltration and epithelial-mesenchymal transition in glioma Open

Wen Yin, Jun Jie Tan, Zhaoqi Xin, Quanwei Zhou, Yudong Cao , et al. · 2020

Background: Gliomas account for the majority of fatal primary brain tumors, and there is much room for research in the underlying pathogenesis, the multistep progression of glioma, and how to improve survival. In our study, we aimed to ide…

Identification of collagen genes related to immune infiltration and epithelial-mesenchymal transition in glioma Open

Wen Yin, Jun Tan, Zhaoqi Xin, Quanwei Zhou, Yudong Cao , et al. · 2020

Background: Gliomas account for the majority of fatal primary brain tumors, and there is much room for research in the underlying pathogenesis, the multistep progression of glioma, and how to improve survival. In our study, we aimed to ide…

Development and Validation of a Tumor Mutation Burden–Related Immune Prognostic Model for Lower-Grade Glioma Open

Wen Yin, Xingjun Jiang, Jun Tan, Zhaoqi Xin, Quanwei Zhou , et al. · 2020

Tumor mutation burden (TMB) is a useful biomarker to predict prognosis and the efficacy of immune checkpoint inhibitors (ICIs). In this study, we aimed to explore the prognostic value of TMB and the potential association between TMB and im…

Identification of collagen genes related to immune infiltration and epithelial-mesenchymal transition in glioma Open

Wen Yin, Jun Tan, Zhaoqi Xin, Quanwei Zhou, Yudong Cao , et al. · 2020

Background Gliomas account for the majority of fatal primary brain tumors, and there is much room for development in the underlying pathogenesis, the multistep progression of glioma, and how to improve survival. In our study, we aimed to i…

Expression Profile Analysis Identifies a Novel Five-Gene Signature to Improve Prognosis Prediction of Glioblastoma Open

Wen Yin, Guihua Tang, Quanwei Zhou, Yudong Cao, Haixia Li , et al. · 2019

Glioblastoma multiforme (GBM) is the most aggressive primary central nervous system malignant tumor. The median survival of GBM patients is 12-15 months, and the 5 years survival rate is less than 5%. More novel molecular biomarkers are st…

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