Zhaoqiang Xu
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View article: GPR4 aggravates ferroptosis in nucleus pulposus cells by inhibiting mitophagy via MAPK pathway activation
GPR4 aggravates ferroptosis in nucleus pulposus cells by inhibiting mitophagy via MAPK pathway activation Open
Inflammatory diseases are known to lower the pH of the extracellular microenvironment. However, the role of proton-activated G protein-coupled receptors (GPRs) in the progression of intervertebral disc degeneration (IVDD) remains largely u…
View article: The immediate effect of anodal tDCS over the motor cortex on postural control and cortical activation in patients with chronic low back pain: A preliminary study
The immediate effect of anodal tDCS over the motor cortex on postural control and cortical activation in patients with chronic low back pain: A preliminary study Open
The improvement in postural control of patients with CLBP following anodal M1-tDCS, accompanied by reduced cortical activation and functional connectivity, suggests enhanced neural efficiency (more efficient neural processing) and reduced …
View article: A Novel 167‐Amino Acid Protein Encoded by CircPCSK6 Inhibits Intrahepatic Cholangiocarcinoma Progression via IKBα Ubiquitination
A Novel 167‐Amino Acid Protein Encoded by CircPCSK6 Inhibits Intrahepatic Cholangiocarcinoma Progression via IKBα Ubiquitination Open
Intrahepatic cholangiocarcinoma (ICC), a formidable challenge in oncology, demands innovative biomarkers and therapeutic targets. This research highlights the importance of the circular RNA (circRNA) circPCSK6 and its peptide derivative ci…
View article: Exosomal Non-Coding RNAs in Pancreatic Cancer: From Mechanisms to Clinical Applications
Exosomal Non-Coding RNAs in Pancreatic Cancer: From Mechanisms to Clinical Applications Open
Pancreatic cancer (PC) is an extremely aggressive cancer of the digestive system with insidious onset and the lack of effective biomarkers, resulting in late-stage diagnosis and poor prognosis. Exosomal non-coding RNAs (ncRNAs) are key med…
View article: Metallothionein 1B attenuates inflammation and hepatic steatosis in MASH by inhibiting the AKT/PI3K pathway
Metallothionein 1B attenuates inflammation and hepatic steatosis in MASH by inhibiting the AKT/PI3K pathway Open
Metabolic dysfunction-associated steatohepatitis (MASH) is a severe form of metabolic dysfunction-associated fatty liver disease metabolic dysfunction-associated steatohepatitis , characterized by hepatic steatosis, inflammation, and fibro…
View article: Polyribonucleotide nucleotidyltransferase 1 participates in metabolic-associated fatty liver disease pathogenesis by affecting lipid metabolism and mitochondrial homeostasis
Polyribonucleotide nucleotidyltransferase 1 participates in metabolic-associated fatty liver disease pathogenesis by affecting lipid metabolism and mitochondrial homeostasis Open
The study confirms the pivotal function of PNPT1 in the development of MAFLD through its interactions with Mcl-1 and its regulatory effects on lipid metabolism and mitochondrial stability. These insights highlight the intricate association…
View article: Research progress and applications of epigenetic biomarkers in cancer
Research progress and applications of epigenetic biomarkers in cancer Open
Epigenetic changes are heritable changes in gene expression without changes in the nucleotide sequence of genes. Epigenetic changes play an important role in the development of cancer and in the process of malignancy metastasis. Previous s…
View article: Ferroptosis: New Strategies and Ideas for the Treatment of Pancreatic Ductal Adenocarcinoma
Ferroptosis: New Strategies and Ideas for the Treatment of Pancreatic Ductal Adenocarcinoma Open
Pancreatic cancer is a malignancy that affects the digestive tract and has a low 5-year survival rate of lower than 15%. Owing to its genetic mutation and metabolic complexity, pancreatic cancer is difficult to treat with surgical resectio…
View article: Advances in Drug Therapy for Metastatic Pancreatic Ductal Adenocarcinoma
Advances in Drug Therapy for Metastatic Pancreatic Ductal Adenocarcinoma Open
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a notably poor prognosis. A large number of patients with PDAC develop metastases before they are diagnosed with metastatic pancreatic cancer (mPDAC). For mPDAC, FOLFIRI…
View article: Changes in cortical activation during upright stance in individuals with chronic low back pain: An fNIRS study
Changes in cortical activation during upright stance in individuals with chronic low back pain: An fNIRS study Open
Introduction Postural control deficits are a potential cause of persistent and recurrent pain in patients with chronic low back pain (CLBP). Although some studies have confirmed that the dorsolateral prefrontal cortex (DLPFC) contributes t…