Zhaorui Chang
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View article: The efficacy and effectiveness of enterovirus A71 vaccines against hand, foot, and mouth disease: A systematic review and meta-analysis
The efficacy and effectiveness of enterovirus A71 vaccines against hand, foot, and mouth disease: A systematic review and meta-analysis Open
Enterovirus A71 (EV-A71) is a major cause of severe hand, foot, and mouth disease (HFMD) among children in the Asia-Pacific region. Here we review randomised clinical trial data and post-licensure effectiveness studies of inactivated EV-A7…
View article: Disease burden of rotavirus related diarrhea in children under 5 years in China: a meta-analysis
Disease burden of rotavirus related diarrhea in children under 5 years in China: a meta-analysis Open
Rotavirus (RV) is a leading cause of severe diarrhea among children under five years of age in China. In this meta-analysis, we assessed the disease burden of RV-related diarrhea by analyzing 73 studies retrieved from the PubMed, Web of Sc…
View article: Epidemiological Characteristics and Influencing Factors of Bacillary Dysentery Outbreaks — China, 2008–2024
Epidemiological Characteristics and Influencing Factors of Bacillary Dysentery Outbreaks — China, 2008–2024 Open
In China, BD outbreak frequency has decreased substantially. September and October represent high-risk months, with schools serving as the primary outbreak setting during the back-to-school season. Strengthening BD prevention and control i…
View article: Spatiotemporal filtering modeling of hand, foot, and mouth disease: a case study from East China, 2009–2015
Spatiotemporal filtering modeling of hand, foot, and mouth disease: a case study from East China, 2009–2015 Open
Hand, foot, and mouth disease (HFMD) shows spatiotemporal heterogeneity in China. A spatiotemporal filtering model was constructed and applied to HFMD data to explore the underlying spatiotemporal structure of the disease and determine the…
View article: Effectiveness of Enterovirus 71 inactivated vaccines against hand, foot, and mouth disease: A test-negative case-control study
Effectiveness of Enterovirus 71 inactivated vaccines against hand, foot, and mouth disease: A test-negative case-control study Open
The Enterovirus A71 (EV-A71) vaccine was introduced in China in December 2015 as a preventive measure against hand, foot, and mouth disease (HFMD) caused by EV-A71. However, the effectiveness of the vaccine (VE) in real-world settings need…
View article: A preliminary exploration for co‐detecting RNA virus and STR type on capillary electrophoresis in forensic practice
A preliminary exploration for co‐detecting RNA virus and STR type on capillary electrophoresis in forensic practice Open
RNA virus infection such as the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection shows severe respiratory symptoms on human and could be an obvious individual characteristic for investigations in forensic science. As …
View article: Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 to Close Contacts, China, January–February 2020
Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 to Close Contacts, China, January–February 2020 Open
We estimated the symptomatic, PCR-confirmed secondary attack rate (SAR) for 2,382 close contacts of 476 symptomatic persons with coronavirus disease in Yichang, Hubei Province, China, identified during January 23-February 25, 2020. The SAR…
View article: Assessing Asymptomatic, Presymptomatic, and Symptomatic Transmission Risk of Severe Acute Respiratory Syndrome Coronavirus 2
Assessing Asymptomatic, Presymptomatic, and Symptomatic Transmission Risk of Severe Acute Respiratory Syndrome Coronavirus 2 Open
Background The relative contributions of asymptomatic, presymptomatic, and symptomatic transmission of severe acute respiratory syndrome coronavirus 2 have not been clearly measured, although control measures may differ in response to the …
View article: Regional-level risk factors for severe hand-foot-and-mouth disease: an ecological study from mainland China
Regional-level risk factors for severe hand-foot-and-mouth disease: an ecological study from mainland China Open
Background Severe hand-foot-and-mouth disease (HFMD) is a life-threatening contagious disease among young children and infants. Although enterovirus A71 has been well acknowledged to be the dominant cause of severe HFMD, there still remain…
View article: Basic Reproduction Number of Enterovirus 71 and Coxsackievirus A16 and A6: Evidence From Outbreaks of Hand, Foot, and Mouth Disease in China Between 2011 and 2018
Basic Reproduction Number of Enterovirus 71 and Coxsackievirus A16 and A6: Evidence From Outbreaks of Hand, Foot, and Mouth Disease in China Between 2011 and 2018 Open
Background Enterovirus 71 (EV-A71), coxsackievirus A16 (CV-A16), and coxsackievirus A6 (CV-A6) are common serotypes causing hand, foot, and mouth disease (HFMD). Analyses on the basic reproduction number (R0) of common pathogens causing HF…
View article: Migrant Representation in the U.K. Theatre Industry: How Covid-19 Catalysed a Movement
Migrant Representation in the U.K. Theatre Industry: How Covid-19 Catalysed a Movement Open
Migrants in Theatre is a movement made up of first-generation migrant theatre artists who joined efforts to campaign for more and better representation of UK based migrant theatre artists in British theatre. Due to the coronavirus pandemic…
View article: Short-term effects of rainfall on childhood hand, foot and mouth disease and related spatial heterogeneity: evidence from 143 cities in mainland China
Short-term effects of rainfall on childhood hand, foot and mouth disease and related spatial heterogeneity: evidence from 143 cities in mainland China Open
Background Numerous studies have demonstrated the potential association between rainfall and hand, foot and mouth disease (HFMD), but the results are inconsistent. This study aimed to quantify the relationship between rainfall and HFMD bas…
View article: Evidence for pre‐symptomatic transmission of coronavirus disease 2019 (COVID‐19) in China
Evidence for pre‐symptomatic transmission of coronavirus disease 2019 (COVID‐19) in China Open
Background Between mid‐January and early February, provinces of mainland China outside the epicentre in Hubei province were on high alert for importations and transmission of COVID‐19. Many properties of COVID‐19 infection and transmission…
View article: First Outbreak of Occupational Brucellosis Involving Multiple Clusters — Hubei Province, China, 2019
First Outbreak of Occupational Brucellosis Involving Multiple Clusters — Hubei Province, China, 2019 Open
In addition to measures aimed at this outbreak, the local agricultural department has issued special notices based on this investigation to adjust and strengthen local eradication program of brucellosis.
View article: Pathogen Spectrum of Hand, Foot, and Mouth Disease Based on Laboratory Surveillance — China, 2018
Pathogen Spectrum of Hand, Foot, and Mouth Disease Based on Laboratory Surveillance — China, 2018 Open
Further identification of other enterovirus serotypes is highly recommended for provincial CDCs, especially for severe HFMD. Studies contributing to a multivalent vaccine for HFMD should be prioritized.
View article: Emerging Enteroviruses Causing Hand, Foot and Mouth Disease, China, 2010–2016
Emerging Enteroviruses Causing Hand, Foot and Mouth Disease, China, 2010–2016 Open
Coxsackievirus A6 emerged as one of the predominant causative agents of hand, foot and mouth disease epidemics in many provinces of China in 2013 and 2015. This virus strain accounted for 25.9% of mild and 15.2% of severe cases in 2013 and…
View article: Epidemiology of Recurrent Hand, Foot and Mouth Disease, China, 2008–2015
Epidemiology of Recurrent Hand, Foot and Mouth Disease, China, 2008–2015 Open
Using China's national surveillance data on hand, foot and mouth disease (HFMD) for 2008-2015, we described the epidemiologic and virologic features of recurrent HFMD. A total of 398,010 patients had HFMD recurrence; 1,767 patients had 1,8…
View article: Epidemiology of hand, foot and mouth disease in China, 2008 to 2015 prior to the introduction of EV-A71 vaccine
Epidemiology of hand, foot and mouth disease in China, 2008 to 2015 prior to the introduction of EV-A71 vaccine Open
Introduction Hand, foot and mouth disease (HFMD) is usually caused by several serotypes from human enterovirus A species, including enterovirus 71 (EV-A71) and coxsackievirus A16 (CV-A16). Two inactivated monovalent EV-A71 vaccines have be…
View article: Hand, Foot, and Mouth Disease in China: Modeling Epidemic Dynamics of Enterovirus Serotypes and Implications for Vaccination
Hand, Foot, and Mouth Disease in China: Modeling Epidemic Dynamics of Enterovirus Serotypes and Implications for Vaccination Open
The ability of our models to capture the observed epidemic cycles suggests that herd immunity is driving the epidemic dynamics caused by the multiple serotypes of enterovirus. Our results predict that the EV-A71 and CV-A16 serotypes provid…