Explanipedia

From Wild Vegetable to Renal Protector: The Therapeutic Potential of <i>Aralia elata</i> (Miq.) Seem Open

Zhiyong Xu, Huifeng Tan, Chunbo Jiang, Weiming He, Minggang Wei , et al. · 2025

Aralia elata (Miq.) Seem. ( A. elata ) is a medicinal and edible wild vegetable, which has potential applications in the pharmaceutical and health food industries. Araloside A (Ara A) is a natural triterpenoid saponin extracted from A. ela…

FCRLB-mediated dual control of tumor metabolism and macrophage polarization promotes lung cancer malignancy Open

Nueraili Maihemuti, Yueli Shi, Sujing Jiang, Pan Liu, Zhen Shi , et al. · 2025

Background Anti–PD-1 therapy has improved outcomes in non-small cell lung cancer (NSCLC), yet primary and acquired resistance remain common. Pinpointing regulators of tumor–immune crosstalk is therefore critical to enhance therapeutic effi…

Intratumoral heterogeneity and potential treatment strategies in small cell lung cancer Open

Yunke Yang, Na Liu, Jiaji Wu, Qingzhe Wu, Jiangnan Zhao , et al. · 2025

Small cell lung cancer (SCLC) is a highly aggressive malignancy characterized by early metastasis and poor prognosis due to the limited efficacy of current treatments. Although initially responsive to chemotherapy and radiotherapy, the maj…

Tracking myopia development through axial length progression: a retrospective longitudinal study Open

Zhengyang Tao, Jiao Wang, Zongyue Lv, Guangyi Hu, Zhiyong Xu , et al. · 2025

This study develops a personalized prediction model for progressive myopia, grounded on factors of the first visit AL progression and baseline AL/CR. The model offers a dynamic and reliable foundation for selecting effective myopia control…

Network pharmacology and experimental validation to elucidate the pharmacological mechanisms of Guben Xiezhuo decoction against renal fibrosis Open

Shutao Chen, Yue Liu, Zhu Liwei, Jingyi Wu, Zhiyong Xu , et al. · 2025

Guben Xiezhuo decoction (GBXZD), a traditional Chinese medicine (TCM), shows promise in treating chronic kidney disease (CKD) by reducing renal fibrosis (RF). This study seeks to uncover the exact mechanism behind GBXZD's therapeutic effec…

Efficacy, Quality of Life, and Cost‐Effectiveness of Superselective Adrenal Arterial Embolization in Idiopathic Hyperaldosteronism: A Comparative Study Open

Nouman Khan, Min Mao, Rui Feng, Zhong Zuo, Muhammad Arif Asghar , et al. · 2025

Idiopathic hyperaldosteronism (IHA) is the most common subtype of primary aldosteronism, typically managed with mineralocorticoid receptor antagonists (MRAs). However, long‐term MRA therapy is associated with suboptimal cardiovascular outc…

Toll‐Like Receptors in the Immunotherapy Era: Dual‐Edged Swords of Tumor Immunity and Clinical Translation Open

Nueraili Maihemuti, Yueli Shi, Zhang Kaiyue, Xinyuan Jiang, J. Chu , et al. · 2025

Toll‐like receptors (TLRs), which are critical components of innate immunity, play a significant role in immune responses and deepen our understanding of TLRs. TLRs are a group of transmembrane proteins with similar structures distributed …

Targeting Cystine Metabolism in the Lung Cancer Environment Enhances the Efficacy of Immune Checkpoint Inhibition Open

Yun Xu, Shumin Li, Jiaji Wu, Shumin Xu, Mo Shen , et al. · 2025

Immunotherapy with Immune Checkpoint Inhibitors (ICIs) has shown promising therapeutic effects in the treatment of lung cancer, the overall efficacy of PD‐1/PD‐L1 inhibitors is only 20%‐30%. Thus, more effective combination therapies are n…

Scaffolding Protein ENH Promotes Tumor Angiogenesis and Growth Through Macrophage Recruitment and Polarization Open

Yueli Shi, Zhiyong Xu, Huan Wang, Bufu Tang, Nueraili Maihemuti , et al. · 2025

Angiogenesis is vital for tumor growth and metastasis, with tumor‐associated macrophages (TAMs) being key pro‐angiogenic cells recruited by tumor‐secreted chemokines. High levels of TAMs contribute to tumor progression and antiangiogenic t…

HunyuanVideo-HOMA: Generic Human-Object Interaction in Multimodal Driven Human Animation Open

Ziyao Huang, Zongmin Zhou, Juan Cao, Yingjie Ma, Yi Chen , et al. · 2025

To address key limitations in human-object interaction (HOI) video generation -- specifically the reliance on curated motion data, limited generalization to novel objects/scenarios, and restricted accessibility -- we introduce HunyuanVideo…

Efficacy of naked-eye 3D technology in mitigating myopia progression among children Open

Zongyue Lv, Zhengyang Tao, Hang Chu, Guangyi Hu, Zhiyong Xu , et al. · 2025

Visual perceptual training employing naked-eye 3D technology is effective in decelerating myopia progression, improving binocular vision, and enhancing accommodation flexibility among children.

Autophagy in tumor immune escape and immunotherapy Open

Huan Wang, Peng Sun, Xijing Yuan, Zhiyong Xu, Xinyuan Jiang , et al. · 2025

The immunotherapy targeting tumor immune escape mechanisms has become a critical strategy in anticancer treatment; however, the challenge of immune resistance remains significant. Autophagy, a cellular response to various stressors, involv…

Phenotypic heterogeneity in mortality and prognosis of pulmonary alveolar proteinosis: a large-scale, global pooled analysis of individual-level data Open

Junfeng Huang, Shuojia Xie, Yuewen Gao, Zikai Lin, Zhe Xu , et al. · 2025

Correction: Chen et al. Transcriptome Analysis of Culex pipiens quinquefasciatus Larvae Exposed to a Semi-Lethal Dose of Vermistatin. Trop. Med. Infect. Dis. 2025, 10, 31 Open

Junhui Chen, Zhiyong Xu, Fei-Ying Yang, Jian Yang, Wendong Kuang , et al. · 2025

In the original publication [...]

Transcriptome Analysis of Culex pipiens quinquefasciatus Larvae Exposed to a Semi-Lethal Dose of Vermistatin Open

Junhui Chen, Zhiyong Xu, Fei-Ying Yang, Jian Yang, Wendong Kuang , et al. · 2025

Culex pipiens quinquefasciatus is a notorious vector transmitting severe diseases such as Zika virus and West Nile virus to humans worldwide. Vermistatin is a type of funicon-like compound and was first isolated from Penicillin vermiculatu…

Therapeutic Targeting of Nsclc with Cudc-907: Dual Hdac/Pi3k Inhibition Mediates Growth Arrest and Cisplatin Resistance Reversion Open

Yang Li, jiaji Wu, Mo Shen, Shumin Xu, Xinyuan Jiang , et al. · 2025

Targeting <i>SLC7A11</i> /xCT improves radiofrequency ablation efficacy of HCC by dendritic cells mediated anti‐tumor immune response Open

Yuzhao Jin, Songhua Cai, Yang Zhou, Dandan Guo, Yuzhen Zeng , et al. · 2024

After RFA treatment in patients with liver cancer, the expression of SLC7A11/xCT and the proportion of DCs in the TME were significantly increased. SLC7A11/xCT is a poor prognostic marker for liver cancer and is mainly expres…

CRISPR/Cas-based CAR-T cells: production and application Open

Ping Song, Qiqi Zhang, Zhiyong Xu, Yueli Shi, Ruirui Jing , et al. · 2024

Chimeric antigen receptor T cell (CAR-T) therapy has revolutionized the treatment approach for cancer, autoimmune disease, and heart disease. The integration of CAR into T cells is typically facilitated by retroviral or lentiviral vectors.…

New Naphthalene Derivatives from the Mangrove Endophytic Fungus Daldinia eschscholzii MCZ-18 Open

Zhiyong Xu, Ting Feng, Zhenchang Wen, Qing Li, Biting Chen , et al. · 2024

Five new naphthalene derivatives dalesconosides A–D, F (1–4, 6), a known synthetic analogue named dalesconoside E (5), and eighteen known compounds (7–24) were isolated from Daldinia eschscholzii MCZ-18, which is an endophytic fungus obtai…

Integrated analysis reveals critical cisplatin-resistance regulators E2F7 contributed to tumor progression and metastasis in lung adenocarcinoma Open

Xiaomin Mao, Shumin Xu, Huan Wang, Peng Xiao, Shumin Li , et al. · 2024

Background Drug resistance poses a significant challenge in cancer treatment, particularly as a leading cause of therapy failure. Cisplatin, the primary drug for lung adenocarcinoma (LUAD) chemotherapy, shows effective treatment outcomes. …

Integrated analysis reveals critical cisplatin-resistance regulators E2F7 contributed to tumor progression and metastasis in lung adenocarcinoma Open

Xiaomin Mao, Shumin Xu, Huan Wang, Peng Xiao, Shumin Li , et al. · 2024

Cisplatin resistance remains a significant barrier in treating lung adenocarcinoma (LUAD). While the search for predictive biomarkers in LUAD prognosis has seldom focused on cisplatin resistance genes. In this study, we analyzed 181 cispla…

PDZ and LIM Domain-Encoding Genes: Their Role in Cancer Development Open

Xinyuan Jiang, Zhiyong Xu, Sujing Jiang, Huan Wang, Mingshu Xiao , et al. · 2023

PDZ-LIM family proteins (PDLIMs) are a kind of scaffolding proteins that contain PDZ and LIM interaction domains. As protein–protein interacting molecules, PDZ and LIM domains function as scaffolds to bind to a variety of proteins. The PDL…

Talaromyces sp. Ethyl Acetate Crude Extract as Potential Mosquitocide to Control Culex pipiens quinquefasciatus Open

Junhui Chen, Zhiyong Xu, Yangqing Liu, Fei-Ying Yang, Limei Guan , et al. · 2023

Vector control is considered an effective approach to controlling diseases spread by mosquito bites. Entomopathogenic fungi are widely used in agriculture to control insect pests, and fungal metabolites can potentially be developed as effe…

Cinchonine exerts anti-tumor and immunotherapy sensitizing effects in lung cancer by impairing autophagic-lysosomal degradation Open

Huan Wang, Yuting Shi, Dannv Ma, Mengqing Cao, Yuchao Sun , et al. · 2023

Currently, there are several treatments approaches available for lung cancer; however, patients who develop drug resistance or have poor survival rates urgently require new therapeutic strategies for lung cancer. In autophagy, damaged prot…

Targeting immune checkpoints on tumor-associated macrophages in tumor immunotherapy Open

Shumin Xu, Chenyang Wang, Lingge Yang, Jiaji Wu, Mengshu Li , et al. · 2023

Unprecedented breakthroughs have been made in cancer immunotherapy in recent years. Particularly immune checkpoint inhibitors have fostered hope for patients with cancer. However, immunotherapy still exhibits certain limitations, such as a…

Identification of m7G-Related miRNA Signatures Associated with Prognosis, Oxidative Stress, and Immune Landscape in Lung Adenocarcinoma Open

Sujing Jiang, Mingshu Xiao, Yueli Shi, Yongfang Wang, Zhiyong Xu , et al. · 2023

The role of N7-methylguanosine(m7G)-related miRNAs in lung adenocarcinoma (LUAD) remains unclear. We used LUAD data from The Cancer Genome Atlas (TCGA) to establish a risk model based on the m7G-related miRNAs, and divided patients into hi…

The Mosquito Larvicidal Activity of Lignans from Branches of Cinnamomum camphora chvar. Borneol Open

Zhiyong Xu, Junhui Chen, Ruifeng Shang, Fan Yang, Chuanqi Xie , et al. · 2023

The chemical investigation of branches of Cinnamomum camphora chvar. Borneol guided by mosquito larvicidal activity led to the isolation of fourteen known lignans (1–14). Their structures were elucidated unambiguously based on comprehensiv…

A Dual-Crosslinked Hydrogel Based on Gelatin Methacryloyl and Sulfhydrylated Chitosan for Promoting Wound Healing Open

Shunxian Ji, Yushuang Zhao, Xinrang Zhai, Lu Wang, Huali Luo , et al. · 2023

The skin is the largest organ of the human body. Skin injuries, especially full-thickness injuries, are a major treatment challenge in clinical practice. Therefore, wound dressing materials with therapeutic effects have great practical sig…

Three New Sesquiterpene Lactones from Branches and Leaves of Cinnamomum Camphora Chvar. Borneol Open

Zhiyong Xu, Lihua Cao, Chuanqi Xie, Yunfei Liu, Xuefang Wen , et al. · 2023

Recent advances of nanomaterial-based anti-angiogenic therapy in tumor vascular normalization and immunotherapy Open

Mingshu Xiao, Yueli Shi, Sujing Jiang, Mengqing Cao, Weiyu Chen , et al. · 2022

Anti-angiogenesis therapy and immunotherapy are the first-line therapeutic strategies for various tumor treatments in the clinic, bringing significant advantages for tumor patients. Recent studies have shown that anti-angiogenic therapy ca…

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