Zhiyuan Xu
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View article: A phase II randomized trial of individualized neoantigen peptide vaccine combined with unusual radiotherapy (iNATURE) in advanced solid tumors-GCOG0028
A phase II randomized trial of individualized neoantigen peptide vaccine combined with unusual radiotherapy (iNATURE) in advanced solid tumors-GCOG0028 Open
Background Neoantigen-based vaccines show promising therapeutic potential in solid tumors such as melanoma, GBM, NSCLC, and CRC. However, clinical responses remain suboptimal in stage IV patients, due to ineffective T-cell function and hig…
View article: Associations of acute stress disorder and depression with coping self-efficacy and perceived social support in healthcare workers during COVID-19
Associations of acute stress disorder and depression with coping self-efficacy and perceived social support in healthcare workers during COVID-19 Open
View article: A comprehensive proteomic analysis uncovers novel molecular subtypes of gastric signet ring cell carcinoma: Identification of potential prognostic biomarkers and therapeutic targets
A comprehensive proteomic analysis uncovers novel molecular subtypes of gastric signet ring cell carcinoma: Identification of potential prognostic biomarkers and therapeutic targets Open
Gastric signet ring cell carcinoma (GSRCC) is a distinct subtype of gastric cancer with unique epidemiological and pathogenic characteristics. However, its prognostic features and molecular landscape remain poorly understood, limiting the …
View article: Adjuvant chemotherapy may have no significant survival benefit in older patients with stage II/III gastric cancer: a multicenter retrospective study
Adjuvant chemotherapy may have no significant survival benefit in older patients with stage II/III gastric cancer: a multicenter retrospective study Open
View article: International Consensus Guideline on Delineation of the Clinical Target Volumes at Different Dose Levels for Nasopharyngeal Carcinoma (2024 Version)
International Consensus Guideline on Delineation of the Clinical Target Volumes at Different Dose Levels for Nasopharyngeal Carcinoma (2024 Version) Open
Amidst the challenges of diverging practices, a comprehensive consensus guideline has been devised based on updated evidence and collective agreement among international experts. This serves as a practical reference for optimal target cove…
View article: Supplementary Tables from Denosumab Enhances Antitumor Immunity by Suppressing SPP1 and Boosting Cytotoxic T Cells
Supplementary Tables from Denosumab Enhances Antitumor Immunity by Suppressing SPP1 and Boosting Cytotoxic T Cells Open
Supplementary Table 1. Clinical information of giant cell of bone tumour samples for single-cell RAN sequencing. Supplementary Table 2. Clinical information of giant cell of bone tumour patients treated with denosumab.
View article: Supplementary Figure 6 from Denosumab Enhances Antitumor Immunity by Suppressing SPP1 and Boosting Cytotoxic T Cells
Supplementary Figure 6 from Denosumab Enhances Antitumor Immunity by Suppressing SPP1 and Boosting Cytotoxic T Cells Open
Supplementary Figure 6. Pan-cancer analysis of overall survival rates of patients with different levels of CD8A, SPP1, and CD8A:SPP1 a. Overall survival rate of patients stratified by the ration of CD8A:SPP1 est…
View article: Supplementary Figure 7 from Denosumab Enhances Antitumor Immunity by Suppressing SPP1 and Boosting Cytotoxic T Cells
Supplementary Figure 7 from Denosumab Enhances Antitumor Immunity by Suppressing SPP1 and Boosting Cytotoxic T Cells Open
Supplementary Figure 7. Pan-cancer analysis of SPP1 expression in normal and tumour tissues The y-axis represents the log2 transformed value of the transcripts per million (TPM) incremented by 1. Cancer types with a sample size of f…
View article: Supplementary Figure 3 from Denosumab Enhances Antitumor Immunity by Suppressing SPP1 and Boosting Cytotoxic T Cells
Supplementary Figure 3 from Denosumab Enhances Antitumor Immunity by Suppressing SPP1 and Boosting Cytotoxic T Cells Open
Supplementary Figure 3. Copy number variation heterogeneity of neoplastic cells from individual patients The heatmap displays copy number variation (CNV) of individual neoplastic cells, separated by patients. Significant CNV gain was obser…
View article: Supplementary Figure 1 from Denosumab Enhances Antitumor Immunity by Suppressing SPP1 and Boosting Cytotoxic T Cells
Supplementary Figure 1 from Denosumab Enhances Antitumor Immunity by Suppressing SPP1 and Boosting Cytotoxic T Cells Open
Supplementary Figure 1. Characterization of subclusters of mesenchymal cells, leukocytes, and endothelial cells a. Dot plots illustrate the top three gene markers of individual mesenchymal cell clusters. The dot size indicates the percenta…
View article: Data from Denosumab Enhances Antitumor Immunity by Suppressing SPP1 and Boosting Cytotoxic T Cells
Data from Denosumab Enhances Antitumor Immunity by Suppressing SPP1 and Boosting Cytotoxic T Cells Open
Denosumab, a RANK ligand inhibitor, is primarily used to prevent osteoclastogenesis in the treatment of conditions such as osteoporosis, bone metastasis, and giant cell tumor of bone (GCTB). RANK ligand also plays an important role in immu…
View article: Supplementary Figure 2 from Denosumab Enhances Antitumor Immunity by Suppressing SPP1 and Boosting Cytotoxic T Cells
Supplementary Figure 2 from Denosumab Enhances Antitumor Immunity by Suppressing SPP1 and Boosting Cytotoxic T Cells Open
Supplementary Figure 2. Comparison of cell-to-cell interaction between neoplastic cells and inflammatory cells in benign GCTB a. Bar charts display the outgoing (top) and incoming (bottom) information flow of neoplastic cells. The "B+" sym…
View article: Supplementary Figure 4 from Denosumab Enhances Antitumor Immunity by Suppressing SPP1 and Boosting Cytotoxic T Cells
Supplementary Figure 4 from Denosumab Enhances Antitumor Immunity by Suppressing SPP1 and Boosting Cytotoxic T Cells Open
Supplementary Figure 4. Cell-to-cell communication heatmap of neoplastic cells in benign and malignant GCTB without denosumab treatment a. Heatmap illustrating cell-to-cell communication from neoplastic cells (sender) to inflammatory cells…
View article: Supplementary Figure 5 from Denosumab Enhances Antitumor Immunity by Suppressing SPP1 and Boosting Cytotoxic T Cells
Supplementary Figure 5 from Denosumab Enhances Antitumor Immunity by Suppressing SPP1 and Boosting Cytotoxic T Cells Open
Supplementary Figure 5. Comparison of cell-to-cell interaction between benign and malignant GCTB naïve to denosumab treatment a. Bar charts display the outgoing (top) and incoming (bottom) information flow of neoplastic cells. The "M-" sym…
View article: The Impact of Rural Population Aging on the Development of Green Agricultural Technology: A Spatial Perspective Study
The Impact of Rural Population Aging on the Development of Green Agricultural Technology: A Spatial Perspective Study Open
Promoting the green development of agriculture is an essential path toward modernizing agriculture in China, while the regional aging of the rural population structure poses new challenges to green agricultural development. Based on the sp…
View article: Clinical-Radiomic Prognostic Model Integrating Staging Before and after Neoadjuvant Chemotherapy in Gastric Cancer: A Multicenter Retrospective Study
Clinical-Radiomic Prognostic Model Integrating Staging Before and after Neoadjuvant Chemotherapy in Gastric Cancer: A Multicenter Retrospective Study Open
View article: Applications and Prospects of Single‐Cell RNA Sequencing and Spatial Transcriptomics in Cervical Cancer
Applications and Prospects of Single‐Cell RNA Sequencing and Spatial Transcriptomics in Cervical Cancer Open
Cervical cancer (CC) is the fourth commonest malignant tumor among women worldwide and is characterized by high heterogeneity and a complex ecosystem. A comprehensive understanding of the heterogeneity of tumors and the tumor microenvironm…
View article: The mitigating effect of green Space's spatial and temporal patterns on the urban heat island in the context of urban densification: A case study of Xi'an
The mitigating effect of green Space's spatial and temporal patterns on the urban heat island in the context of urban densification: A case study of Xi'an Open
View article: Advances and challenges in immunotherapy for locally advanced nasopharyngeal carcinoma
Advances and challenges in immunotherapy for locally advanced nasopharyngeal carcinoma Open
Nasopharyngeal carcinoma (NPC) is a prevalent malignant tumor of the head and neck, with approximately 70 % of patients being diagnosed at a locally advanced stage. Despite the responsiveness to radiotherapy and chemotherapy, the 5-year su…
View article: Ninth Version of the AJCC and UICC Nasopharyngeal Cancer TNM Staging Classification
Ninth Version of the AJCC and UICC Nasopharyngeal Cancer TNM Staging Classification Open
Importance Accurate staging is a fundamental step in treating patients with nasopharyngeal carcinoma (NPC) worldwide; this is crucial not only for prognostication, but also for guiding treatment decisions. The American Joint Committee on C…
View article: First experience: low junction-dose-gradient VMAT based on standard linac with true attachment free for total body irradiation
First experience: low junction-dose-gradient VMAT based on standard linac with true attachment free for total body irradiation Open
Purpose: We develop a new low junction-dose-gradient VMAT planning technique to mitigate the position-induced dose error based on standard linac with true attachment free. Methods: An eight years old girl diagnosed with acute lymphocytic l…
View article: In-depth metaproteomics analysis of tongue coating for gastric cancer: a multicenter diagnostic research study
In-depth metaproteomics analysis of tongue coating for gastric cancer: a multicenter diagnostic research study Open
View article: Concurrent chemoradiotherapy followed by adjuvant chemotherapy versus concurrent chemoradiotherapy alone in locally advanced cervical cancer: A systematic review and meta-analysis
Concurrent chemoradiotherapy followed by adjuvant chemotherapy versus concurrent chemoradiotherapy alone in locally advanced cervical cancer: A systematic review and meta-analysis Open
Objective This study aimed to assess the efficacy and safety of adjuvant chemotherapy (ACT) after concurrent chemoradiation (CCRT) in patients with locally advanced cervical cancer (LACC) via meta-analysis. Methods A systematic literature …
View article: Establishment of a prognostic nomogram for patients with locoregionally advanced nasopharyngeal carcinoma incorporating clinical characteristics and dynamic changes in hematological and inflammatory markers
Establishment of a prognostic nomogram for patients with locoregionally advanced nasopharyngeal carcinoma incorporating clinical characteristics and dynamic changes in hematological and inflammatory markers Open
Background This study aims to investigate the prognostic value of changes in hematological and inflammatory markers during induction chemotherapy (IC) and concurrent chemo-radiation (CCRT), thus construct nomograms to predict progression f…
View article: A machine learning model for grade 4 lymphopenia prediction during pelvic radiotherapy in patients with cervical cancer
A machine learning model for grade 4 lymphopenia prediction during pelvic radiotherapy in patients with cervical cancer Open
Background/purpose Severe lymphopenia during pelvic radiotherapy (RT) predicts poor survival in patients with cervical cancer. However, the risk of severe lymphopenia has not been well predicted. We developed a machine learning model using…
View article: Palliative radiotherapy combined with stent insertion to relieve dysphagia in advanced esophageal carcinoma patients: A systematic review and meta−analysis
Palliative radiotherapy combined with stent insertion to relieve dysphagia in advanced esophageal carcinoma patients: A systematic review and meta−analysis Open
Introduction Esophageal cancer is one of the most aggressive malignancies with limited treatment options, thus resulting in high morbidity and mortality. For patients with advanced esophageal cancer, the median survival is 3–6 months, with…
View article: Comparison of effectiveness and safety of camrelizumab between HBV-related and non-B, non-C hepatocellular carcinoma: A retrospective study in China
Comparison of effectiveness and safety of camrelizumab between HBV-related and non-B, non-C hepatocellular carcinoma: A retrospective study in China Open
Purpose: This study aimed to compare the clinical outcomes of camrelizumab in hepatitis B virus-related hepatocellular carcinoma (HBV–HCC) patients and non-HBV, non-HCV hepatocellular carcinoma (NBNC–HCC) patients in China. Materials and m…
View article: Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors
Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors Open
View article: A Radiomics Nomogram Integrated With Clinic-Radiological Features for Preoperative Prediction of DNA Mismatch Repair Deficiency in Gastric Adenocarcinoma
A Radiomics Nomogram Integrated With Clinic-Radiological Features for Preoperative Prediction of DNA Mismatch Repair Deficiency in Gastric Adenocarcinoma Open
Purpose To develop and validate a radiomics nomogram integrated with clinic-radiological features for preoperative prediction of DNA mismatch repair deficiency (dMMR) in gastric adenocarcinoma. Materials and Methods From March 2014 to Augu…
View article: Machine Learning of Dose-Volume Histogram Parameters Predicting Overall Survival in Patients with Cervical Cancer Treated with Definitive Radiotherapy
Machine Learning of Dose-Volume Histogram Parameters Predicting Overall Survival in Patients with Cervical Cancer Treated with Definitive Radiotherapy Open
Purpose. To analyze the effects of dosimetric parameters and clinical characteristics on overall survival (OS) by machine learning algorithms. Methods and Materials. 128 patients with cervical cancer were treated with definitive pelvic rad…