Zhaoxia Tan
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View article: Short-term pegylated interferon alpha in chronic HBV patients with ultra-low HBsAg: a retrospective study
Short-term pegylated interferon alpha in chronic HBV patients with ultra-low HBsAg: a retrospective study Open
Background and aims Hepatitis B surface antigen (HBsAg) clearance—defined as an HBsAg level below the lower limit of detection—is critical for the functional cure of chronic hepatitis B (CHB). This study evaluated the efficacy of short-ter…
View article: Dexamethasone treatment is associated with a higher HBsAg sero-clearance rate in HBeAg-positive patients with hepatitis B flares
Dexamethasone treatment is associated with a higher HBsAg sero-clearance rate in HBeAg-positive patients with hepatitis B flares Open
Our study confirmed the beneficial role of low-dose and short-term dexamethasone treatment in flare patients, particularly in patients with ALT ≥ 30 × ULN and platelet counts ≥ 110 × 109/L.
View article: Anti-HBc IgM associates with acute flare and HBeAg/HBsAg loss in chronic hepatitis B patients with acute exacerbation
Anti-HBc IgM associates with acute flare and HBeAg/HBsAg loss in chronic hepatitis B patients with acute exacerbation Open
Acute exacerbation (AE) is common for patients with chronic hepatitis B (CHB). The aim of the study is to investigate the values of hepatitis B core antibody (anti-HBc) IgM in CHB-AE. Patients were screened from a prospective sub-cohort, 4…
View article: Retrograde inferior vena cava perfusion reduces the risk of acute kidney injury depending on the oxygen extraction ratio. A retrospective cohort study
Retrograde inferior vena cava perfusion reduces the risk of acute kidney injury depending on the oxygen extraction ratio. A retrospective cohort study Open
Background Total aortic arch replacement surgery (TARS) for Acute type A aortic dissection is associated with high incidence of postoperative acute kidney injury (AKI), at least partly due to the lower body ischemia during circulatory arre…
View article: Predictors of Clinical Cure and off-treatment HBsAg Reversion in Patients with Chronic Hepatitis B receiving Peg-interferon-α-based Therapy
Predictors of Clinical Cure and off-treatment HBsAg Reversion in Patients with Chronic Hepatitis B receiving Peg-interferon-α-based Therapy Open
Background Currently, pegylated interferon-α (Peg-IFN-α)-based antiviral therapy brings dawn to the clinical cure of chronic hepatitis B(CHB). Our aim was to investigate markers associated with clinical cure and off-treatment hepatitis B s…
View article: Cardiopulmonary bypass for total aortic arch replacement surgery: A review of three techniques
Cardiopulmonary bypass for total aortic arch replacement surgery: A review of three techniques Open
One treatment for acute type A aortic dissection is to replace the ascending aorta and aortic arch with a graft during circulatory arrest of the lower body, but this is associated with high mortality and morbidity. Maintaining the balance …
View article: Dexamethasone Treatment is Associated with Increased HBsAg Sero-Clearance Rate in Patients with Chronic Hepatitis B Flares
Dexamethasone Treatment is Associated with Increased HBsAg Sero-Clearance Rate in Patients with Chronic Hepatitis B Flares Open
View article: An inhibitor of leukotriene-A <sub>4</sub> hydrolase from bat salivary glands facilitates virus infection
An inhibitor of leukotriene-A <sub>4</sub> hydrolase from bat salivary glands facilitates virus infection Open
Significance An immunosuppressant protein (MTX), which facilitates virus infection by inhibiting leukotriene A 4 hydrolase (LTA 4 H) to produce the lipid chemoattractant leukotriene B 4 (LTB 4 ), was identified and characterized from the s…
View article: Testosterone and Estradiol as Novel Prognostic Indicators for HBV-Related Acute-on-Chronic Liver Failure
Testosterone and Estradiol as Novel Prognostic Indicators for HBV-Related Acute-on-Chronic Liver Failure Open
Background: HBV-related acute-on-chronic liver failure (HBV-ACLF) has a high short-term mortality and urgently needs an early warning system with simplicity and high accuracy. Previous studies show that sex hormones play potential roles in…
View article: SARS-CoV-2 Quasispecies Provides an Advantage Mutation Pool for the Epidemic Variants
SARS-CoV-2 Quasispecies Provides an Advantage Mutation Pool for the Epidemic Variants Open
RNA virus population in a host does not consist of a consensus single haplotype but rather an ensemble of related sequences termed quasispecies. The dynamics of quasispecies afford SARS-CoV-2 a great ability on genetic fitness during intra…
View article: SIX1/EYA1 are novel liver damage biomarkers in chronic hepatitis B and other liver diseases
SIX1/EYA1 are novel liver damage biomarkers in chronic hepatitis B and other liver diseases Open
SIX1 and EYA1 are novel biomarkers of liver damage in patients of CHB and other liver diseases, with potential clinical utility.
View article: Effect of SARS-CoV-2 coinfection was not apparent on the dynamics of chronic hepatitis B infection
Effect of SARS-CoV-2 coinfection was not apparent on the dynamics of chronic hepatitis B infection Open
View article: SARS-CoV-2 Quasispecies provides insight into its genetic dynamics during infection
SARS-CoV-2 Quasispecies provides insight into its genetic dynamics during infection Open
A novel coronavirus disease (COVID-19) caused by SARS-CoV-2 has been pandemic worldwide. The genetic dynamics of quasispecies afford RNA viruses a great fitness on cell tropism and host range. However, no quasispecies data of SARS-CoV-2 ha…
View article: Viral Kinetics and Antibody Responses in Patients with COVID-19
Viral Kinetics and Antibody Responses in Patients with COVID-19 Open
Background A pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been spreading over the world. However, the viral dynamics, host serologic responses, and their associa…
View article: Retrograde Inferior Vena caval Perfusion for Total Aortic arch Replacement Surgery (RIVP-TARS): study protocol for a multicenter, randomized controlled trial
Retrograde Inferior Vena caval Perfusion for Total Aortic arch Replacement Surgery (RIVP-TARS): study protocol for a multicenter, randomized controlled trial Open
Clinicaltrials.gov, ID: NCT03607786 . Registered on 30 July 2018.
View article: Retrograde inferior vena caval perfusion for total aortic arch replacement surgery (RIVP-TARS): study protocol for a multicenter, randomized, controlled trial
Retrograde inferior vena caval perfusion for total aortic arch replacement surgery (RIVP-TARS): study protocol for a multicenter, randomized, controlled trial Open
Background: During total aortic arch replacement surgery (TARS) for patients with acute type A aortic dissection, organs in the lower body such as the viscera and spinal cord are at risk of ischemia even when antegrade cerebral perfusion (…
View article: Corrigendum to “High-Dose Polymerized Hemoglobin Fails to Alleviate Cardiac Ischemia/Reperfusion Injury due to Induction of Oxidative Damage in Coronary Artery”
Corrigendum to “High-Dose Polymerized Hemoglobin Fails to Alleviate Cardiac Ischemia/Reperfusion Injury due to Induction of Oxidative Damage in Coronary Artery” Open
[This corrects the article DOI: 10.1155/2015/125106.].
View article: Retrograde Inferior Vena Caval Perfusion for Total Aortic Arch Replacement Surgery (RIVP-TARS): A Multicenter, Randomized, Controlled, Double-Blind Trial
Retrograde Inferior Vena Caval Perfusion for Total Aortic Arch Replacement Surgery (RIVP-TARS): A Multicenter, Randomized, Controlled, Double-Blind Trial Open
Background: During total aortic arch replacement surgery (TARS) for patients with acute type A aortic dissection, organs in the lower body such as the viscera and spinal cord are at risk of ischemia even when antegrade cerebral perfusion (…
View article: Combining Cerebral Perfusion With Retrograde Inferior Vena Caval Perfusion for Aortic Arch Surgery
Combining Cerebral Perfusion With Retrograde Inferior Vena Caval Perfusion for Aortic Arch Surgery Open
View article: Effect of intralipid on myocardial injury during valve replacement surgery with concomitant radiofrequency ablation
Effect of intralipid on myocardial injury during valve replacement surgery with concomitant radiofrequency ablation Open
There was no observed beneficial effect of ILPC on myocardial injury documented by the cardiac biomarkers in patients undergoing valve replacement surgery with concomitant RFA, and the effect of intralipid against myocardial I/R injury is …
View article: Effectiveness of PIVKA-II in the detection of hepatocellular carcinoma based on real-world clinical data
Effectiveness of PIVKA-II in the detection of hepatocellular carcinoma based on real-world clinical data Open
Our data showed that PIVKA-II effectively increases the detection rate of HCC was a valid complement to AFP and image examination in HCC surveillance.
View article: Correction: Corrigendum: Efficacy of PIVKA-II in prediction and early detection of hepatocellular carcinoma: a nested case-control study in Chinese patients
Correction: Corrigendum: Efficacy of PIVKA-II in prediction and early detection of hepatocellular carcinoma: a nested case-control study in Chinese patients Open
Scientific Reports 6: Article number: 35050; published online: 12 October 2016; updated: 19 December 2016
View article: Efficacy of PIVKA-II in prediction and early detection of hepatocellular carcinoma: a nested case-control study in Chinese patients
Efficacy of PIVKA-II in prediction and early detection of hepatocellular carcinoma: a nested case-control study in Chinese patients Open
Prognosis of hepatocellular carcinoma (HCC) remains unsatisfying due to a lack of early detecting methods. Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II) has been proved to be an efficient biomarker for HCC. However, the …
View article: Low-Dose Sevoflurane May Reduce Blood Loss and Need for Blood Products After Cardiac Surgery
Low-Dose Sevoflurane May Reduce Blood Loss and Need for Blood Products After Cardiac Surgery Open
Patients undergoing cardiac surgery often experience abnormal bleeding, due primarily to cardiopulmonary bypass (CPB)-induced activation of platelets. Sevoflurane may inhibit platelet activation, raising the possibility that administering …
View article: Performance of Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II) for Hepatocellular Carcinoma Screening in Chinese Population
Performance of Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II) for Hepatocellular Carcinoma Screening in Chinese Population Open
PIVKA-II was as efficient as AFP when used as a single marker for HCC screening and the combination of two biomarkers gave a better performance.
View article: High-Dose Polymerized Hemoglobin Fails to Alleviate Cardiac Ischemia/Reperfusion Injury due to Induction of Oxidative Damage in Coronary Artery
High-Dose Polymerized Hemoglobin Fails to Alleviate Cardiac Ischemia/Reperfusion Injury due to Induction of Oxidative Damage in Coronary Artery Open
Objective . Ischemia/reperfusion (I/R) injury is an unavoidable event for patients in cardiac surgery under cardiopulmonary bypass (CPB). This study was designed to investigate whether glutaraldehyde-polymerized human placenta hemoglobin (…