Explanipedia

Estradiol levels in women with hormone receptor-positive advanced breast cancer on fulvestrant therapy Open

Xi Wang, Zhongyu Yuan, Fei Xu, Xiaoming Xie, Jiajia Huang , et al. · 2025

Limited data are available on estradiol (E2) levels during fulvestrant treatment in women with hormone receptor-positive breast cancer. We measured plasma E2 levels in women receiving fulvestrant using liquid chromatography-tandem mass spe…

Real-world outcomes of trastuzumab deruxtecan in HR-negative HER2-low metastatic breast cancer Open

Mengqian Ni, Daining Wang, S.L. Dun, Qifeng Zhou, Wen Xia , et al. · 2025

This real-world, multicenter study evaluated trastuzumab deruxtecan (T-DXd) in 64 patients with HR-negative, HER2-low metastatic breast cancer between May 2022 and May 2025. The median lines of therapy were 3 (range 1-7). The objective res…

Development of a risk prediction model for gastrointestinal adverse events associated with semaglutide administration in patients with type 2 diabetes mellitus Open

Deyong Yue, Xuesheng Hua, Ling Zhu, Cheng Wang, Lihua Gu , et al. · 2025

Objective This study aims to identify the risk factors associated with gastrointestinal adverse events induced by semaglutide in patients with type 2 diabetes mellitus (T2DM) and to develop a predictive risk model. Methods A total of 215 p…

Type-I IFNs induce GBPs and lysosomal defense in hepatocytes to control malaria 2178 Open

Clyde Schmidt-Silva, Carson Bowers, Justine C. Shiau, Eui‐Soon Park, Zhongyu Yuan , et al. · 2025

Description Plasmodium parasites develop and replicate within the hepatocytes before infecting the erythrocytes and initiating clinical malaria. Although type-I interferons (IFNs) can hinder Plasmodium infection within the liver, the under…

Efficacy and Safety of T‐ DXd in HER2 + and Low/Zero Metastatic BCBM : A Retrospective Multicenter Real‐World Study Open

Qifeng Zhou, Yuanyuan Li, Ni He, Guorong Zou, Mengqian Ni , et al. · 2025

Accumulating data demonstrate the robust overall and intracranial activity of trastuzumab deruxtecan (T‐DXd) in HER2‐positive breast cancer brain metastasis (BCBM). Limited data are available on HER2‐low/zero BCBM, as well as patients with…

Metallogenic environment incentral southern TanluFault revealedby P-wave tomography Open

Ya Sun, Zhongyu Yuan, Jinqiang Huang, Jian-tai ZHANG, Fuquan Li , et al. · 2025

Establishment of a CRISPR/dCas9 Activation Library for Screening Transcription Factors Co-Regulating OCT4 with GATA4 in Pig Cells Open

Xiaoxia Yao, Mingfang Feng, Chengbo Sun, Sijia Yang, Zhongyu Yuan , et al. · 2025

OCT4 is a critical transcription factor for early embryonic development and pluripotency. Previous studies have shown that the regulation of OCT4 by the transcription factor GATA4 is species-specific in pigs. This study aimed to further in…

Improving the Efficiency of CRISPR/Cas9-Mediated Non-Homologous End Joining Gene Knockout Using Small Molecules in Porcine Cells Open

Shihao Lv, Xiaokang Xu, Sijia Yang, Mingfang Feng, Zhongyu Yuan , et al. · 2025

The CRISPR/Cas9 genome editing system has emerged as an effective platform to generate loss-of-function gene edits through non-homologous end joining (NHEJ) without a repair template. To verify whether small molecules can enhance the effic…

HER2-positive breast cancer with invasive micropapillary carcinoma component shows immunosuppressive microenvironment and resistance to neoadjuvant therapy Open

Lulu Zhang, Lijia Zhou, Anli Yang, Shaoquan Zheng, Keming Chen , et al. · 2025

Background Invasive micropapillary carcinoma (IMPC) is a rare histopathological subtype of breast cancer (BC) that shows a high incidence of human epidermal growth factor receptor 2 (HER2)-positive expression. However, the therapeutic effi…

Incidence of Metastasis in the Central Nervous System in Advanced Breast Cancer Treated With CDK 4/6 Inhibitors: A Multicenter, Retrospective Study Open

Yanling Wen, Xiwen Bi, Xuewen Zhang, Si‐Fen Wang, Chang Jiang , et al. · 2025

Central nervous system (CNS) metastasis remains a major cause of mortality in advanced breast cancer (ABC). While cyclin‐dependent kinase 4/6 inhibitors (CDKIs) combined with endocrine therapy (ET) delay resistance in hormone receptor (HR)…

Role of mitochondrial quality control in neurodegenerative disease progression Open

Tingting Liu, Weibo Sun, Shao-mei Guo, Zhongyu Yuan, Minghang Zhu , et al. · 2025

Neurodegenerative diseases are a diverse group of neurological disorders, in which abnormal mitochondrial function is closely associated with their development and progression. This has generated significant research interest in the field.…

Metronomic Capecitabine Plus Aromatase Inhibitor as Initial Therapy in Patients With Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer: The Phase III MECCA Trial Open

Ruoxi Hong, Fei Xu, Jiajia Huang, Yue-E Teng, Quchang Ouyang , et al. · 2025

PURPOSE The effects of metronomic chemotherapy plus endocrine therapy have yet to be elucidated through a randomized phase III clinical trial. METHODS Randomized clinical trials were conducted at 12 centers in China from August 22, 2017, t…

Sodium Ion Pre-Intercalation Synergistically Enhances the Lithium Storage Performance of Ti3c2tx Mxene Open

Sizhuo Li, Zhongyu Yuan, Lamin Wang, Wen‐Sheng Zhao, Hui Zheng , et al. · 2025

Overexpression of SFPQ Improves Cognition and Memory in AD Mice Open

Jin-Shan Tie, Hongxiang Wu, Wei Liu, Yuying Li, Lu Li , et al. · 2025

Alzheimer’s disease (AD) is a complex neurodegenerative disorder with multifaceted pathogenesis, which has been extensively investigated, yet effective treatments remain lacking. Splicing factor proline and glutamine rich (SFPQ) is known t…

Differences in HER2-0 and HER2-low Breast Cancer: Androgen Receptor and Programmed Death Ligand 1 as Predictive Factors Open

Xiaoqi Zhang, Ciqiu Yang, Yitian Chen, Junsheng Zhang, Peiyong Li , et al. · 2025

There is currently insufficient evidence to classify HER2-low breast cancer as a distinct subtype. Our study revealed that AR expression, along with negative PD-L1 expression, contributes to lower pCR rates.

Combined pyrotinib and fulvestrant for hormone receptor‐positive and HER2‐positive metastatic breast cancer: A multicenter, single‐arm, phase II trial Open

Jianli Zhao, Yunfang Yu, Wei Ren, Linxiaoxiao Ding, Yongjian Chen , et al. · 2024

This multicenter, single‐arm, phase II clinical trial (NCT04034589) evaluated the efficacy and safety of pyrotinib combined with fulvestrant in patients with HR‐positive/HER2‐positive metastatic breast cancer who had experienced trastuzuma…

Low 25-Hydroxyvitamin D Post-Kidney Transplant Is Associated with Increased Risk of BK Polyomavirus-Associated Nephropathy Open

Sumesh Raj, Angela L. Zhou, Ekaterina Fedorova, Zhongyu Yuan, Didier A. Mandelbrot , et al. · 2024

BK viremia (BKPyV-DNAemia) and nephropathy (BKPyVAN) are significant causes of morbidity and mortality in kidney transplant recipients (KTRs). Vitamin D supports immune function, yet low 25-hydroxyvitamin D [25(OH)D] is common among KTRs. …

Type-I IFNs induce GBPs and lysosomal defense in hepatocytes to control malaria Open

Camila Marques-da-Silva, Clyde Schmidt-Silva, Carson Bowers, Essel Charles-Chess, Justine C. Shiau , et al. · 2024

Plasmodium parasites undergo development and replication within the hepatocytes before infecting the erythrocytes and initiating clinical malaria. Although type-I interferons (IFNs) are known to hinder Plasmodium infection within the liver…

High Post-Kidney Transplant Serum Uric Acid Levels Are Associated with Detrimental Outcomes Open

Kian Djamali, Zhongyu Yuan, Brad C. Astor, Kurtis J. Swanson, Didier A. Mandelbrot , et al. · 2024

Key Points Post-transplant increased serum uric acid levels are associated with congestive heart failure and graft failure for kidney transplant recipients. kidney transplant recipients age 60 years and older with high serum uric acid are …

Eribulin plus carboplatin combination for HER2-negative metastatic breast cancer: a multicenter, real-world cohort study Open

Mengqian Ni, Lijia Zhou, Yongkui Lu, Dachuan Guo, Xiuyue Li , et al. · 2024

ErCb demonstrated favorable efficacy and tolerability in patients with heavily pre-treated mBC, especially TNBC. The findings of the current study warrant further investigation of the application of this combination in earlier lines of mBC…

Clinical significance of serum estradiol monitoring in women receiving adjuvant aromatase inhibitor for hormone receptor-positive early breast cancer Open

Shuqin Dai, Xingping Wu, Xuefang Huang, Jibin Li, Xi Wang , et al. · 2024

Interpretable multitemporal liver function indicator model for prediction and risk factor analysis of drug induced liver injury Open

Zhongyu Yuan, Jiaxuan Peng, Zhenyu Shu, Xuejun Qin, JianGuo Zhong · 2024

The occurrence of liver injury during cancer treatment is extremely harmful. The risk factors for drug.induced liver injury (DILI) in the pancreatic cancer population have not been investigated. This study aims to develop and validate an i…

Clinical utility of the 4S-AF scheme in predicting recurrence of atrial fibrillation after radiofrequency catheter ablation Open

Naiyuan Cui, Haiwei Li, Weiping Sun, Zefeng Wang, Zhongyu Yuan , et al. · 2024

Background The 4S-AF scheme, consisting of four domains related to atrial fibrillation (AF) [stroke risk (St), symptoms (Sy), severity of AF burden (Sb), and substrate (Su)], represents a novel approach for the structural characterization …

The abnormalities of free fatty acid metabolism in patients with hypertrophic cardiomyopathy, a single-center retrospective observational study Open

Ke Zhang, Zhongyu Yuan, Shuiyun Wang, Shifeng Zhao, Hao Cui , et al. · 2024

Pyrotinib and trastuzumab plus palbociclib and fulvestrant in HR+/HER2+ breast cancer patients with brain metastasis Open

Dongshao Chen, Fei Xu, Yongkui Lu, Wen Xia, Caiwen Du , et al. · 2024

Supplementary Tables from A Subpopulation of Luminal Progenitors Secretes Pleiotrophin to Promote Angiogenesis and Metastasis in Inflammatory Breast Cancer Open