Ziang Lu
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View article: Cross-kingdom delivery and putative gene modulation of androgen pathways by plant-derived exosome-like nanoparticles from polygoni multiflori radix promotes hair growth via miRNA cargo
Cross-kingdom delivery and putative gene modulation of androgen pathways by plant-derived exosome-like nanoparticles from polygoni multiflori radix promotes hair growth via miRNA cargo Open
Plant-derived exosome-like nanoparticles (PENs) have emerged as promising nanocarriers for cross-kingdom delivery and putative gene modulation, yet their functional role in human physiology remains largely unexplored. Here, we isolate and …
View article: Single-cell imaging of <i>N</i>4-acetylcytidine-modified RNA using fluorine metabolic labeling mediated proximity ligation assay
Single-cell imaging of <i>N</i>4-acetylcytidine-modified RNA using fluorine metabolic labeling mediated proximity ligation assay Open
N 4-Acetylcytidine (ac4C) is an emerging epitranscriptomic mark involved in regulating RNA stability, translation, and gene expression. Despite its emerging role in gene regulation and disease, current methods for in situ detection of ac4C…
View article: Network Pharmacology and Molecular Docking Study on the Mechanism of the Therapeutic Effect of Strychni Semen in NSCLC
Network Pharmacology and Molecular Docking Study on the Mechanism of the Therapeutic Effect of Strychni Semen in NSCLC Open
Strychni Semen, characterized by its bitter taste and warm properties, has been confirmed to possess anti-tumor properties. However, the molecular mechanism of Strychni Semen in treating non-small cell lung cancer (NSCLC) needs further stu…
View article: Rapid degradation of DHX36 revealing its transcriptional role by interacting with G‐quadruplex
Rapid degradation of DHX36 revealing its transcriptional role by interacting with G‐quadruplex Open
Accumulating evidence indicates that G‐quadruplexes (G4s) are involved in transcriptional regulation. Previous studies have demonstrated that DHX36 preferentially resolves G4s, suggesting its potential impact on gene transcription mediated…
View article: Prompt-enhanced Federated Content Representation Learning for Cross-domain Recommendation
Prompt-enhanced Federated Content Representation Learning for Cross-domain Recommendation Open
Cross-domain Recommendation (CDR) as one of the effective techniques in\nalleviating the data sparsity issues has been widely studied in recent years.\nHowever, previous works may cause domain privacy leakage since they necessitate\nthe ag…
View article: A Malicious Program Behavior Detection Model Based on API Call Sequences
A Malicious Program Behavior Detection Model Based on API Call Sequences Open
To address the issue of low accuracy in detecting malicious program behaviors in new power system edge-side applications, we present a detection model based on API call sequences that combines rule matching and deep learning techniques in …
View article: Identification of G-quadruplex-interacting proteins in living cells using an artificial G4-targeting biotin ligase
Identification of G-quadruplex-interacting proteins in living cells using an artificial G4-targeting biotin ligase Open
G-quadruplexes (G4s) are noncanonical nucleic acid structures pivotal to cellular processes and disease pathways. Deciphering G4-interacting proteins is imperative for unraveling G4’s biological significance. In this study, we developed a …
View article: Exonuclease-assisted enrichment and base resolution analysis of pseudouridine in single-stranded RNA
Exonuclease-assisted enrichment and base resolution analysis of pseudouridine in single-stranded RNA Open
We developed RIPS for identification of Ψ sites with a higher signal-to-noise ratio by combining the CMC specific labeling and exonuclease digestion. What's more, we selectively identified Ψ sites in single-stranded RNA by applying RIPS.
View article: Investigating the Reconfiguration of Internationalization Strategies under Digitalization
Investigating the Reconfiguration of Internationalization Strategies under Digitalization Open
Digitalization can induce the structural changes of multinational enterprises (MNEs), therefore, it is important to reconsider their internal organization. In this paper, the changes in the roles of the subsidiaries of MNEs due to digitali…
View article: Inert Pepper aptamer-mediated endogenous mRNA recognition and imaging in living cells
Inert Pepper aptamer-mediated endogenous mRNA recognition and imaging in living cells Open
The development of RNA aptamers/fluorophores system is highly desirable for understanding the dynamic molecular biology of RNAs in vivo. Peppers-based imaging systems have been reported and applied for mRNA imaging in living cells. However…
View article: A Method of Fingerprint Legitimacy Discrimination Based on Fuzzy Matching Algorithms for Terminal
A Method of Fingerprint Legitimacy Discrimination Based on Fuzzy Matching Algorithms for Terminal Open
Nowadays, increasing number of network security events occur according to some illegal terminal counterfeiting intruding into the enterprise's internal network.The traditional terminal access system only uses some easy feature information …
View article: Unsupervised Typography Transfer
Unsupervised Typography Transfer Open
Traditional methods in Chinese typography synthesis view characters as an assembly of radicals and strokes, but they rely on manual definition of the key points, which is still time-costing. Some recent work on computer vision proposes a b…
View article: Development, characterization, and annotation of potential simple sequence repeats by transcriptome sequencing in pears (Pyrus pyrifolia Nakai)
Development, characterization, and annotation of potential simple sequence repeats by transcriptome sequencing in pears (Pyrus pyrifolia Nakai) Open
Simple sequence repeats (SSRs), one of the most powerful molecular markers, can be used for DNA fingerprinting, variety identification, genetic mapping, and marker-assisted selection. Using the pear's (Pyrus pyrifolia Nakai) 75,764 unigene…