Zhao‐Ying Liu
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View article: A two-dimensional liquid chromatography method with optimized pretreatment for detection of guanidine compounds in animal liver and kidney
A two-dimensional liquid chromatography method with optimized pretreatment for detection of guanidine compounds in animal liver and kidney Open
This study is centered on optimizing the derivatization reaction conditions and the protein precipitation reagent system for the detection of guanidine compounds (GCs) in animal liver and kidney. It introduces a two-dimensional liquid chro…
View article: The roles of GABA and NMDA receptors in viral infections: based on current literature
The roles of GABA and NMDA receptors in viral infections: based on current literature Open
Gamma-aminobutyric acid receptors (GABARs) primarily function by suppressing inflammatory responses, modulating neuronal excitability, and maintaining intracellular homeostasis, whereas N-methyl-D-aspartate receptors (NMDARs) play a key ro…
View article: Hypoxia tolerance determine differential gelsenicine-induced neurotoxicity between pig and mouse
Hypoxia tolerance determine differential gelsenicine-induced neurotoxicity between pig and mouse Open
View article: Experimental and Computational Investigation of the Target and Mechanisms of Gelsemium Alkaloids in the Central Nervous System
Experimental and Computational Investigation of the Target and Mechanisms of Gelsemium Alkaloids in the Central Nervous System Open
Gelsemium has a long history of medicinal use but is also a poisonous plant. Some low-toxicity alkaloids in Gelsemium exhibit anxiolytic, anti-inflammatory, analgesic, and other pharmacological effects; however, certain alkaloids in Gelsem…
View article: Two-Dimensional Liquid Chromatography for Determination of Guanidine Compounds in Animal Liver and Kidney: Pretreatment Optimization, Method Validation and Application
Two-Dimensional Liquid Chromatography for Determination of Guanidine Compounds in Animal Liver and Kidney: Pretreatment Optimization, Method Validation and Application Open
View article: Development of a Heart-Cut Two-Dimensional Liquid Chromatography Method for Guanidinosuccinic Acid, Guanidinoacetic Acid and Guanidinobutyric Acid in Biological Samples
Development of a Heart-Cut Two-Dimensional Liquid Chromatography Method for Guanidinosuccinic Acid, Guanidinoacetic Acid and Guanidinobutyric Acid in Biological Samples Open
View article: Cascade Amplifying Electrochemical Bioanalysis for Zearalenone Detection in Agricultural Products: Utilizing a Glucose–Fenton–HQ System on Bimetallic–ZIF@CNP Nanocomposites
Cascade Amplifying Electrochemical Bioanalysis for Zearalenone Detection in Agricultural Products: Utilizing a Glucose–Fenton–HQ System on Bimetallic–ZIF@CNP Nanocomposites Open
The integration of advanced materials and signaling cascade strategies is a promising and highly relevant topic for enhancing the performance of bioanalysis. In this study, a three-stage cascade amplification electrochemical bioanalysis (T…
View article: Effects of antibiotic and disinfectant exposure on the mouse gut microbiome and immune function
Effects of antibiotic and disinfectant exposure on the mouse gut microbiome and immune function Open
This study explores the effects of disinfectant and antibiotic exposure on gut health, focusing on gut microbiota balance and gut immune function. Our analysis indicates that disinfectants increase the proportion of Gram-positive bacteria,…
View article: The toxicology and detoxification of Gelsemium: Traditional and modern views
The toxicology and detoxification of Gelsemium: Traditional and modern views Open
Introduction: Gelsemium, a whole grass in the family Loganiaceae, is the world's poisonous plants. Due to its flower's resemblance to honeysuckle, there has been a rise in cases of accidental ingestion of Gelsemium, leading to poisoning an…
View article: An efficient method for the preparative isolation and purification of alkaloids from <i>Gelsemium</i> by using high speed counter-current chromatography and preparative HPLC
An efficient method for the preparative isolation and purification of alkaloids from <i>Gelsemium</i> by using high speed counter-current chromatography and preparative HPLC Open
We established an efficient method using high-speed countercurrent chromatography (HSCCC) combined with preparative high-performance liquid chromatography (prep-HPLC) for isolating and purifying Gelsemium elegans (G. elegans)…
View article: Insight into a Three-Stage Cascade Amplifying Electrochemical Bioanalysis: Based on Integrating the Glucose-Fenton-Hq System on Bimetallic-Zif@Cnp Nanocomposites
Insight into a Three-Stage Cascade Amplifying Electrochemical Bioanalysis: Based on Integrating the Glucose-Fenton-Hq System on Bimetallic-Zif@Cnp Nanocomposites Open
View article: The antianxiety effects of koumine and gelsemine, two main active components in the traditional Chinese herbal medicine <i>Gelsemium</i>: A comprehensive review
The antianxiety effects of koumine and gelsemine, two main active components in the traditional Chinese herbal medicine <i>Gelsemium</i>: A comprehensive review Open
The genus Gelsemium belongs to the family Loganiaceae, one of the traditional Chinese herbs. Gelsemium is traditionally used to treat rheumatoid and neuropathic pain. Its root extracts were found to protect against anxiety, especially the …
View article: Reference Genes Screening and Gene Expression Patterns Analysis Involved in Gelsenicine Biosynthesis under Different Hormone Treatments in Gelsemium elegans
Reference Genes Screening and Gene Expression Patterns Analysis Involved in Gelsenicine Biosynthesis under Different Hormone Treatments in Gelsemium elegans Open
Reverse transcription quantitative polymerase chain reaction (RT-qPCR) is an accurate method for quantifying gene expression levels. Choosing appropriate reference genes to normalize the data is essential for reducing errors. Gelsemium ele…
View article: China Medicinal Plants of the Ampelopsis grossedentata—A Review of Their Botanical Characteristics, Use, Phytochemistry, Active Pharmacological Components, and Toxicology
China Medicinal Plants of the Ampelopsis grossedentata—A Review of Their Botanical Characteristics, Use, Phytochemistry, Active Pharmacological Components, and Toxicology Open
Ampelopsis grossedentata (AG) is mainly distributed in Chinese provinces and areas south of the Yangtze River Basin. It is mostly concentrated or scattered in mountainous bushes or woods with high humidity. Approximately 57 chemical compon…
View article: MC1R-targeted NIR-II aggregation-induced emission nanoparticles for melanoma imaging
MC1R-targeted NIR-II aggregation-induced emission nanoparticles for melanoma imaging Open
View article: Room Temperature Anhydrous Suzuki–Miyaura Polymerization Enabled by C−S Bond Activation
Room Temperature Anhydrous Suzuki–Miyaura Polymerization Enabled by C−S Bond Activation Open
The Suzuki–Miyaura cross‐coupling is one of the most important and powerful methods for constructing C−C bonds. However, the protodeboronation of arylboronic acids hinder the development of Suzuki–Miyaura coupling in the precise synthesis …
View article: Room Temperature Anhydrous Suzuki–Miyaura Polymerization Enabled by C−S Bond Activation
Room Temperature Anhydrous Suzuki–Miyaura Polymerization Enabled by C−S Bond Activation Open
The Suzuki–Miyaura cross‐coupling is one of the most important and powerful methods for constructing C−C bonds. However, the protodeboronation of arylboronic acids hinder the development of Suzuki–Miyaura coupling in the precise synthesis …
View article: Protocol to characterize target components of Gelsemium using an in-house herb database and high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry
Protocol to characterize target components of Gelsemium using an in-house herb database and high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry Open
View article: Determination of Brain Distribution of Amino Acid Neurotransmitters in Pigs and Rats by HPLC-UV
Determination of Brain Distribution of Amino Acid Neurotransmitters in Pigs and Rats by HPLC-UV Open
Background and objectivesAmino acid neurotransmitters are closely correlated to the neurological function of the brain, and the imbalance of amino acid neurotransmitters can lead to a variety of neurological diseases. Therefore, the develo…
View article: A Novel Two-Dimensional Liquid Chromatography Combined with Ultraviolet Detection Method for Quantitative Determination of Pyridoxal 5′-Phosphate, 4-Pyridoxine Acid and Pyridoxal in Animal Plasma
A Novel Two-Dimensional Liquid Chromatography Combined with Ultraviolet Detection Method for Quantitative Determination of Pyridoxal 5′-Phosphate, 4-Pyridoxine Acid and Pyridoxal in Animal Plasma Open
Vitamin B6 is an indispensable micronutrient in organisms and is widely distributed in blood, tissues, and organs. Changes in the content and ratio of vitamin B6 can affect the entire physiological condition of the body, so it becomes part…
View article: Network Pharmacology and Experimental Verification to Unveil the Mechanism of N-Methyl-D-Aspartic Acid Rescue Humantenirine-Induced Excitotoxicity
Network Pharmacology and Experimental Verification to Unveil the Mechanism of N-Methyl-D-Aspartic Acid Rescue Humantenirine-Induced Excitotoxicity Open
Gelsemium is a medicinal plant that has been used to treat various diseases, but it is also well-known for its high toxicity. Complex alkaloids are considered the main poisonous components in Gelsemium. However, the toxic mechanism of Gels…
View article: Effect of Macleaya cordata extract on the growth performance and growth-related expression gene pathways in rats was investigated by liver transcriptome technology
Effect of Macleaya cordata extract on the growth performance and growth-related expression gene pathways in rats was investigated by liver transcriptome technology Open
Macleaya cordata is a perennial upright herb belonging to the family Papaveraceae that represents a natural and low-residue product that has good effects in the prevention and treatment of livestock and poultry diseases and improves produc…
View article: The multicomponent residue depletion of Gelsemium elegans in pig tissues, urine, and plasma
The multicomponent residue depletion of Gelsemium elegans in pig tissues, urine, and plasma Open
Introduction Gelsemium elegans ( G. elegans ) as a traditional medicinal plant used in livestock production. The use of G. elegans in veterinary clinics may pose safety risks to human health. Objectives The aim of this study was to investi…
View article: Effect of Dietary <i>Gelsemium elegans</i> Benth. Extract on the Growth, Slaughter Performance, Meat Quality, Intestinal Morphology, and Microflora of Yellow-Feathered Chickens
Effect of Dietary <i>Gelsemium elegans</i> Benth. Extract on the Growth, Slaughter Performance, Meat Quality, Intestinal Morphology, and Microflora of Yellow-Feathered Chickens Open
The plant species Gelsemium elegans Benth. (GEB) promotes pig and sheep growth; however, little is known about its effects in chickens. In this study, a GEB extract (GEBE) was prepared, and its effects on the growth, slaughter, anti…
View article: Sex Differences in the In Vivo Exposure Process of Multiple Components of Gelsemium elegans in Rats
Sex Differences in the In Vivo Exposure Process of Multiple Components of Gelsemium elegans in Rats Open
Asian Gelsemium elegans (G. elegans) has a wide range of pharmacological activities. However, its strong toxicity limits its potential development and application. Interestingly, there are significant gender differences in G. elegans toxic…
View article: Two-Dimensional Liquid Chromatography Method for the Determination of Gelsemium Alkaloids in Honey
Two-Dimensional Liquid Chromatography Method for the Determination of Gelsemium Alkaloids in Honey Open
Toxic Chinese medicine residues in honey pose a serious threat to consumer health. Gelsemium is one of the nine ancient poisons, making the whole plant virulent. The residue of Gelsemium alkaloid in honey causes poisoning from time to time…
View article: Excretion, Metabolism, and Tissue Distribution of Gelsemium elegans (Gardn. & Champ.) Benth in Pigs
Excretion, Metabolism, and Tissue Distribution of Gelsemium elegans (Gardn. & Champ.) Benth in Pigs Open
Gelsemium elegans (Gardn. & Champ.) Benth is a toxic flowering plant in the family Loganiaceae used to treat skin diseases, neuralgia and acute pain. The high toxicity of G. elegans restricts its development and clinical applications, but …
View article: Suppressive Effects of Gelsemine on Anxiety-like Behaviors Induced by Chronic Unpredictable Mild Stress in Mice
Suppressive Effects of Gelsemine on Anxiety-like Behaviors Induced by Chronic Unpredictable Mild Stress in Mice Open
Gelsemine is an active principle and a major alkaloid found in Gelsemium genus of plants belonging to the Loganiaceae family. The aim of the present study was to explore whether gelsemine exerts anxiolytic effects on a mouse model of chron…
View article: Toxicity assessment of gelsenicine and the search for effective antidotes
Toxicity assessment of gelsenicine and the search for effective antidotes Open
Background Gelsenicine, one of the most toxic alkaloids of Gelsemium elegans Benth ( G. elegans), causes severe respiratory depression. However, its toxicity mechanisms are yet to be elucidated and no effective antidotes are available. Obj…
View article: Fatty Acid-Inducible Part/ANGPTL4 Regulates Lipid Oxidation Response to Gelsemium Elegans Alkaloids
Fatty Acid-Inducible Part/ANGPTL4 Regulates Lipid Oxidation Response to Gelsemium Elegans Alkaloids Open
Background：The Gelsemium elegans alkaloids have been used in animal feed additives and already achieved terrific results in the pig’s gut health and weight gain. A series of studies have been conducted to explore the mechanisms by which it…