Laurence Huang
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View article: Unanticipated Global Emergence of Multiple<i>Pneumocystis jirovecii</i>Mutants Selected by Mycophenolic Acid Driving Increasing Outbreaks in Solid Organ Transplant Recipients
Unanticipated Global Emergence of Multiple<i>Pneumocystis jirovecii</i>Mutants Selected by Mycophenolic Acid Driving Increasing Outbreaks in Solid Organ Transplant Recipients Open
Background Classified by the WHO as one of the 19 most dangerous fungal pathogens, Pneumocystis jirovecii has been associated with increasing outbreaks of Pneumocystis pneumonia (PCP) among solid organ transplant (SOT) recipients worldwide…
View article: Molecular diagnostics improve the yield of diagnosis of community-acquired pneumonia and multidrug-resistant pathogens in hospitalised patients with HIV in a low-income setting
Molecular diagnostics improve the yield of diagnosis of community-acquired pneumonia and multidrug-resistant pathogens in hospitalised patients with HIV in a low-income setting Open
Background. Community-acquired pneumonia (CAP) remains an important cause of morbidity and mortality in people with HIV (PWH), and antimicrobial resistance (AMR) leads to poor treatment outcomes. Better tests are required to overcome the l…
View article: Unanticipated Global Emergence of Multiple Pneumocystis Jirovecii Mutants Selected by Mycophenolic Acid Driving Increasing Outbreaks in Solid Organ Transplant Recipients
Unanticipated Global Emergence of Multiple Pneumocystis Jirovecii Mutants Selected by Mycophenolic Acid Driving Increasing Outbreaks in Solid Organ Transplant Recipients Open
View article: Intervention effect of regulating GABA-A receptor activity on the formation of experimental abdominal aortic aneurysm in rats
Intervention effect of regulating GABA-A receptor activity on the formation of experimental abdominal aortic aneurysm in rats Open
Abdominal aortic aneurysm is a potentially fatal vascular inflammatory disease characterized by infiltration of various inflammatory cells.The GABA-A receptor is expressed in many inflammatory cells such as macrophages and T cells and has …
View article: Strategies targeting tumor immune and stromal microenvironment and their clinical relevance
Strategies targeting tumor immune and stromal microenvironment and their clinical relevance Open
The critical role of tumor microenvironment (TME) in tumor initiation and development has been well-recognized after more than a century of studies. Numerous therapeutic approaches targeting TME are rapidly developed including those levera…
View article: Interferon-signaling pathways are upregulated in people with HIV with abnormal pulmonary diffusing capacity (DLCO)
Interferon-signaling pathways are upregulated in people with HIV with abnormal pulmonary diffusing capacity (DLCO) Open
Objective: People with HIV (PWH) are at greater risk of developing lung diseases even when they are antiretroviral therapy (ART)-adherent and virally suppressed. The most common pulmonary function abnormality in PWH is that of impaired dif…
View article: Hepatitis C Virus Clearance and Diffusing Capacity for Carbon Monoxide in Women With and Without Human Immunodeficiency Virus
Hepatitis C Virus Clearance and Diffusing Capacity for Carbon Monoxide in Women With and Without Human Immunodeficiency Virus Open
Hepatitis C virus (HCV) infection is associated with extrahepatic effects, including reduced diffusing capacity of the lungs. It is unknown whether clearance of HCV infection is associated with improved diffusing capacity. In this sample o…
View article: Accuracy of the tuberculosis molecular bacterial load assay to diagnose and monitor response to anti-tuberculosis therapy: a longitudinal comparative study with standard-of-care smear microscopy, Xpert MTB/RIF Ultra, and culture in Uganda
Accuracy of the tuberculosis molecular bacterial load assay to diagnose and monitor response to anti-tuberculosis therapy: a longitudinal comparative study with standard-of-care smear microscopy, Xpert MTB/RIF Ultra, and culture in Uganda Open
European and Developing Countries Clinical Trials Partnership, Makerere University Research and Innovation Fund, US National Institutes of Health.
View article: Sex and HIV Differences in Preserved Ratio Impaired Spirometry (PRISm) Among Ugandans Postpneumonia
Sex and HIV Differences in Preserved Ratio Impaired Spirometry (PRISm) Among Ugandans Postpneumonia Open
Background Preserved ratio impaired spirometry (PRISm), defined as a normal ratio of forced expiratory volume in 1 second (FEV1) to forced vital capacity (≥0.70) with low FEV1 (<80% predicted), has been associated with increased mortali…
View article: Diallyl disulfide attenuates hydrogen peroxide-induced oxidative damage of ovine rumen epithelial cells through the nuclear factor erythroid-2 related factor 2 signaling pathway
Diallyl disulfide attenuates hydrogen peroxide-induced oxidative damage of ovine rumen epithelial cells through the nuclear factor erythroid-2 related factor 2 signaling pathway Open
This study investigated the impact of diallyl disulfide (DADS) on oxidative stress induced by hydrogen peroxide (H 2 O 2 ) in ovine rumen epithelial cells (RECs). Initially, the effects of DADS were evaluated on cellular reactive oxygen sp…
View article: COPD in People with HIV: Epidemiology, Pathogenesis, Management, and Prevention Strategies
COPD in People with HIV: Epidemiology, Pathogenesis, Management, and Prevention Strategies Open
Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder characterized by airflow limitation and persistent respiratory symptoms. People with HIV (PWH) are particularly vulnerable to COPD development; PWH have dem…
View article: Response to: ‘No long-term effect of past Pneumocystis jirovecii pneumonia on pulmonary function in people with HIV’
Response to: ‘No long-term effect of past Pneumocystis jirovecii pneumonia on pulmonary function in people with HIV’ Open
aDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine bDivision of HIV, Infectious Diseases and Global Medicine, University of California San Francisco, San Francisco, California, USA. Correspondence to Katerina L. Byanova, MD,…
View article: COMPARING PULMONARY FUNCTION REFERENCE EQUATION PERFORMANCE IN EVALUATING ABNORMAL SPIROMETRY IN POST-PNEUMONIA UGANDAN ADULTS
COMPARING PULMONARY FUNCTION REFERENCE EQUATION PERFORMANCE IN EVALUATING ABNORMAL SPIROMETRY IN POST-PNEUMONIA UGANDAN ADULTS Open
View article: HIV-associated lung disease
HIV-associated lung disease Open
View article: Isolated abnormal diffusing capacity for carbon monoxide (iso↓DLco) is associated with increased respiratory symptom burden in people with HIV infection
Isolated abnormal diffusing capacity for carbon monoxide (iso↓DLco) is associated with increased respiratory symptom burden in people with HIV infection Open
Objectives An isolated reduction in the diffusing capacity for carbon monoxide (DLco; iso↓DLco) is one of the most common pulmonary function test (PFT) abnormalities in people living with HIV (PWH), but its clinical implications are incomp…
View article: Sex modifies the risk of HIV-associated obstructive lung disease in Ugandans postpneumonia
Sex modifies the risk of HIV-associated obstructive lung disease in Ugandans postpneumonia Open
Objectives: Spirometric abnormalities are frequent, and obstructive lung disease (OLD) is a common comorbidity among people with HIV (PWH). HIV increases the risk of many comorbidities to a greater degree in women than in men. Few studies …
View article: Magnetic-activated cell sorting identifies a unique lung microbiome community
Magnetic-activated cell sorting identifies a unique lung microbiome community Open
View article: Diagnostic accuracy of Xpert MTB/RIF Ultra and culture assays to detect Mycobacterium Tuberculosis using OMNIgene-sputum processed stool among adult TB presumptive patients in Uganda
Diagnostic accuracy of Xpert MTB/RIF Ultra and culture assays to detect Mycobacterium Tuberculosis using OMNIgene-sputum processed stool among adult TB presumptive patients in Uganda Open
Background Stool is a potential sample for diagnosing Mycobacterium tuberculosis ( Mtb ) in patients with difficulty in expectorating. However, high mycobacterial culture contamination rates and Xpert MTB/RIF Ultra test error rates on stoo…
View article: Feasibility and Sensitivity of Saliva GeneXpert MTB/RIF Ultra for Tuberculosis Diagnosis in Adults in Uganda
Feasibility and Sensitivity of Saliva GeneXpert MTB/RIF Ultra for Tuberculosis Diagnosis in Adults in Uganda Open
Tuberculosis is among the leading causes of morbidity and mortality worldwide, in large part because >3 million people go undiagnosed and untreated each year. Sputum has been the mainstay for TB diagnosis for over a century but can be diff…
View article: Association Between HIV and Prevalence and Manifestations of Asthma: Analysis of the Multicenter AIDS Cohort Study and Women's Interagency HIV Study
Association Between HIV and Prevalence and Manifestations of Asthma: Analysis of the Multicenter AIDS Cohort Study and Women's Interagency HIV Study Open
Background: The association between HIV and asthma prevalence and manifestations remains unclear, with few studies including women. Setting: A retrospective observational cohort study from the Multicenter AIDS Cohort Study and Women's Inte…
View article: Pulmonary Function Trajectories in People with HIV: Analysis of the Pittsburgh HIV Lung Cohort
Pulmonary Function Trajectories in People with HIV: Analysis of the Pittsburgh HIV Lung Cohort Open
Rationale: Human immunodeficiency virus (HIV) infection is associated with chronic lung disease and impaired pulmonary function; however, longitudinal pulmonary function phenotypes in HIV are undefined. Objectives: To identif…
View article: Associations of HIV persistence, cigarette smoking, inflammation, and pulmonary dysfunction in people with HIV on antiretroviral therapy
Associations of HIV persistence, cigarette smoking, inflammation, and pulmonary dysfunction in people with HIV on antiretroviral therapy Open
We aimed to investigate the relationship between measures of HIV persistence with antiretroviral therapy (ART) and cigarette smoking, systemic markers of inflammation, and pulmonary function. Retrospective study of 82 people with HIV (PWH)…
View article: Lung Function in Women With and Without Human Immunodeficiency Virus
Lung Function in Women With and Without Human Immunodeficiency Virus Open
Background Prior studies have found that human immunodeficiency virus (HIV) infection is associated with impaired lung function and increased risk of chronic lung disease, but few have included large numbers of women. In this study, we inv…
View article: Pneumonia surveillance with culture-independent metatranscriptomics in HIV-positive adults in Uganda: a cross-sectional study
Pneumonia surveillance with culture-independent metatranscriptomics in HIV-positive adults in Uganda: a cross-sectional study Open
US National Institutes of Health, Chan Zuckerberg Biohub.
View article: Feasibility and Sensitivity of Saliva GeneXpert MTB/RIF Ultra for Tuberculosis Diagnosis in Adults in Uganda
Feasibility and Sensitivity of Saliva GeneXpert MTB/RIF Ultra for Tuberculosis Diagnosis in Adults in Uganda Open
The objective of this prospective, observational study carried out at China-Uganda Friendship Hospital-Naguru in Kampala, Uganda, was to determine the performance of GeneXpert MTB/RIF Ultra (Xpert) testing on saliva for active tuberculosis…
View article: Soluble Immune Checkpoints Are Dysregulated in COVID-19 and Heavy Alcohol Users With HIV Infection
Soluble Immune Checkpoints Are Dysregulated in COVID-19 and Heavy Alcohol Users With HIV Infection Open
Immune checkpoints (ICPs) consist of paired receptor-ligand molecules that exert inhibitory or stimulatory effects on immune defense, surveillance, regulation, and self-tolerance. ICPs exist in both membrane and soluble forms in vivo and i…
View article: High Mycobacterium tuberculosis Bacillary Loads Detected by Tuberculosis Molecular Bacterial Load Assay in Patient Stool: a Potential Alternative for Nonsputum Diagnosis and Treatment Response Monitoring of Tuberculosis
High Mycobacterium tuberculosis Bacillary Loads Detected by Tuberculosis Molecular Bacterial Load Assay in Patient Stool: a Potential Alternative for Nonsputum Diagnosis and Treatment Response Monitoring of Tuberculosis Open
This paper highlights the value of stool as a sample type for diagnosis of tuberculosis. While other studies have used DNA-based assays like the Xpert MTB/RIF and culture to detect Mycobacterium tuberculosis in stool, this is the first stu…
View article: Accuracy of GenoQuick MTB test in detection of <i>Mycobacterium tuberculosis</i> in sputum from TB presumptive patients in Uganda
Accuracy of GenoQuick MTB test in detection of <i>Mycobacterium tuberculosis</i> in sputum from TB presumptive patients in Uganda Open
Objective: The objective of the study was to determine the diagnostic performance of the GenoQuick MTB test on heated sputum against the conventional Lowenstein–Jensen Mycobacterium tuberculosis culture as the reference method for tubercul…
View article: Association Between HIV and Prevalence and Manifestations of Asthma: Analysis of the Multicenter AIDS Cohort Study and Women's Interagency HIV Study
Association Between HIV and Prevalence and Manifestations of Asthma: Analysis of the Multicenter AIDS Cohort Study and Women's Interagency HIV Study Open
Background:The association between HIV and asthma prevalence and manifestations remains unclear, with few studies including women.Setting:A retrospective observational cohort study from the Multicenter AIDS Cohort Study and Women's Interag…
View article: Association between Short-Term Exposure to Fine Particulate Matter and Hospitalization in Women with or at Risk for HIV
Association between Short-Term Exposure to Fine Particulate Matter and Hospitalization in Women with or at Risk for HIV Open