Ye Xu
YOU?
Author Swipe
View article: Systemic immune inflammation index guides machine learning for rapid TTP diagnosis: a retrospective cohort study
Systemic immune inflammation index guides machine learning for rapid TTP diagnosis: a retrospective cohort study Open
Thrombotic thrombocytopenic purpura (TTP) is a rare, life threatening thrombotic microangiopathy that requires prompt diagnosis to reduce mortality. However, its early identification is often hindered by delayed ADAMTS13 testing, particula…
View article: The hidden burden of infertility: multimorbidity patterns and longitudinal disease trajectories in a population-based cohort of 2 million women
The hidden burden of infertility: multimorbidity patterns and longitudinal disease trajectories in a population-based cohort of 2 million women Open
Infertility is increasingly recognized not only as a reproductive concern but also as a potential sentinel of systemic health vulnerability in women. Yet, the broader multimorbidity patterns and temporal progression of diseases surrounding…
View article: Urban Forest Health Under Rapid Urbanization: Spatiotemporal Patterns and Driving Mechanisms from the Chang–Zhu–Tan Green Heart Area
Urban Forest Health Under Rapid Urbanization: Spatiotemporal Patterns and Driving Mechanisms from the Chang–Zhu–Tan Green Heart Area Open
The Ecological Green Heart Area of the Chang–Zhu–Tan Urban Agglomeration in Central China faces increasing forest health threats due to rapid urbanization and land use change. This study assessed the spatiotemporal dynamics and drivers of …
View article: Long‐Term Survival Analysis of Neoadjuvant Chemoradiotherapy Versus Adjuvant Chemoradiotherapy for Locally Advanced Low Rectal Cancer
Long‐Term Survival Analysis of Neoadjuvant Chemoradiotherapy Versus Adjuvant Chemoradiotherapy for Locally Advanced Low Rectal Cancer Open
Purpose To compare the long‐term survival of patients with locally advanced low rectal cancer (LALRC), receiving neoadjuvant chemoradiotherapy (NCRT) versus adjuvant chemoradiotherapy (ACRT). Methods and Materials This retrospective observ…
View article: Large Language Model in Materials Science: Roles, Challenges, and Strategic Outlook
Large Language Model in Materials Science: Roles, Challenges, and Strategic Outlook Open
Large language models (LLMs) are creating a new paradigm for materials science by transforming textual insights into experimental findings. Leveraging their strengths in natural language understanding, multimodal alignment, and few‐shot re…
View article: Prediction of long-term major adverse cardiac events after myocardial infarction: value of combination of inflammatory biomarkers and GRACE score
Prediction of long-term major adverse cardiac events after myocardial infarction: value of combination of inflammatory biomarkers and GRACE score Open
Objective This study aims to investigate the prognostic value of integrating inflammatory biomarkers with the established Global Registry of Acute Coronary Events (GRACE) risk score for predicting clinical outcomes in patients with myocard…
View article: Comparative analysis of Chinese large language model performance on atrial fibrillation questions
Comparative analysis of Chinese large language model performance on atrial fibrillation questions Open
Background The first seven Chinese Large language models （LLMs）were launched to the public on August 31st, 2023.However, the extent to which Chinese LLMs can assist atrial fibrillation（AF）patients remains unknown. We sought to assess the C…
View article: Garsorasib, a KRAS G12C inhibitor, with or without cetuximab, an EGFR antibody, in colorectal cancer cohorts of a phase II trial in advanced solid tumors with KRAS G12C mutation
Garsorasib, a KRAS G12C inhibitor, with or without cetuximab, an EGFR antibody, in colorectal cancer cohorts of a phase II trial in advanced solid tumors with KRAS G12C mutation Open
Mutations in the KRAS gene have long been implicated in the pathogenesis of colorectal cancer (CRC). KRAS G12C inhibitors overcome the “undruggable” challenge, enabling precision therapy. Garsorasib (D-1553), a highly potent and selective …
View article: Alisertib impairs the stemness of hepatocellular carcinoma by inhibiting purine synthesis
Alisertib impairs the stemness of hepatocellular carcinoma by inhibiting purine synthesis Open
View article: A Large‐Scale Retrospective Study of Serum Des‐Gamma‐Carboxy Prothrombin as a Diagnostic Marker of <scp>HCC</scp>: Effect of Liver Function on Specificity
A Large‐Scale Retrospective Study of Serum Des‐Gamma‐Carboxy Prothrombin as a Diagnostic Marker of <span>HCC</span>: Effect of Liver Function on Specificity Open
Background This retrospective multicenter study is aimed at evaluating the diagnostic accuracy and influence factors of serum des‐gamma‐carboxy prothrombin (DCP) as a diagnostic biomarker of hepatocellular carcinoma (HCC). Methods Clinical…
View article: Recognizing significance of propensity score matching and clinical practice in evaluating oncological survivals of pancreatic cancer
Recognizing significance of propensity score matching and clinical practice in evaluating oncological survivals of pancreatic cancer Open
View article: A new insight into the anatomical ablation approach at R-L ILT for VAs with a left ventricular summit origination: electrophysiological characteristics and catheter ablation
A new insight into the anatomical ablation approach at R-L ILT for VAs with a left ventricular summit origination: electrophysiological characteristics and catheter ablation Open
An anatomical ablation approach at R-L ILT was effective for most VAs with an LVS origin. Different ECG and electrophysiological characteristics could be observed in VAs with different EAS. Poor pace mapping results in all regions with an …
View article: CapeOX as neoadjuvant chemotherapy for locally advanced rectal cancer: might less be more?
CapeOX as neoadjuvant chemotherapy for locally advanced rectal cancer: might less be more? Open
View article: Effect of Pulmonary Vein Isolation with Left Atrial Wall Isolation Plus Selective CFAE Ablation in Patients with Persistent Atrial Fibrillation
Effect of Pulmonary Vein Isolation with Left Atrial Wall Isolation Plus Selective CFAE Ablation in Patients with Persistent Atrial Fibrillation Open
Background: Pulmonary vein isolation (PVI) is a foundational treatment for persistent atrial fibrillation (PeAF), but the effectiveness of adding posterior wall isolation (PWI) and selective complex fractionated atrial electrogram (CFAE) a…
View article: Immunogenicity and safety of Vero cell culture-derived Japanese encephalitis vaccine: a phase 3 study in Chinese infants
Immunogenicity and safety of Vero cell culture-derived Japanese encephalitis vaccine: a phase 3 study in Chinese infants Open
The trial was registered in the Chinese Clinical Trial Registry (https://www.chictr.org.cn/showproj.html?proj = 203130; registration number: ChiCTR2300074692; registration date: 14/08/2023).
View article: Approaches for Lynch syndrome screening and characteristics of subtypes with mismatch repair deficiency in patients with colorectal carcinoma
Approaches for Lynch syndrome screening and characteristics of subtypes with mismatch repair deficiency in patients with colorectal carcinoma Open
To evaluate different Lynch syndrome (LS) screening approaches and establish an efficient and sensitive strategy are critical for clinical practice. In total, 583 patients with colorectal carcinoma (CRC) at Fudan University Shanghai Cancer…
View article: Simultaneous ST-elevation in lead augmented vector right (aVR) and III in non-ST-elevation acute coronary syndromes
Simultaneous ST-elevation in lead augmented vector right (aVR) and III in non-ST-elevation acute coronary syndromes Open
The NSTEACS cases with simultaneous ST-elevation in lead III and aVR tended to present with more multiple leads with ST-depression, higher degree of ST-depression, and more LM or multi-vessel lesions, suggesting a broader range of severe m…
View article: Manipulating Liver Bile Acid Signaling by Nanodelivery of Bile Acid Receptor Modulators for Liver Cancer Immunotherapy
Manipulating Liver Bile Acid Signaling by Nanodelivery of Bile Acid Receptor Modulators for Liver Cancer Immunotherapy Open
Gut bacteria and their metabolites influence the immune microenvironment of liver through the gut-liver axis, thus representing emerging therapeutic targets for liver cancer therapy. However, directly manipulating gut microbiota or their m…
View article: Role of triggering receptor expressed on myeloid cells-1 in kidney diseases: A biomarker and potential therapeutic target
Role of triggering receptor expressed on myeloid cells-1 in kidney diseases: A biomarker and potential therapeutic target Open
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily. As an amplifier of the inflammatory response, TREM-1 is mainly involved in the production of inflammatory mediators and the regulation…
View article: Microsatellite instability in mismatch repair proficient colorectal cancer: clinical features and underlying molecular mechanisms
Microsatellite instability in mismatch repair proficient colorectal cancer: clinical features and underlying molecular mechanisms Open
This work was supported by the Science and Technology Commission of Shanghai Municipality (20DZ1100101).
View article: LncRNA GAS6-AS1 contributes to 5-fluorouracil resistance in colorectal cancer by facilitating the binding of PCBP1 with MCM3
LncRNA GAS6-AS1 contributes to 5-fluorouracil resistance in colorectal cancer by facilitating the binding of PCBP1 with MCM3 Open
5-Fluorouracil (5-FU) resistance has always been a formidable obstacle in the adjuvant treatment of advanced colorectal cancer (CRC), significantly compromising the patients’ prognosis. In recent years, long non-coding RNAs (lncRNAs) have …
View article: <scp>FLRT3</scp> and <scp>TGF</scp>‐β/<scp>SMAD4</scp> signalling: Impacts on apoptosis, autophagy and ion channels in supraventricular tachycardia
<span>FLRT3</span> and <span>TGF</span>‐β/<span>SMAD4</span> signalling: Impacts on apoptosis, autophagy and ion channels in supraventricular tachycardia Open
To explore the underlying molecular mechanisms of supraventricular tachycardia (SVT), this study aimed to analyse the complex relationship between FLRT3 and TGF‐β/SMAD4 signalling pathway, which affects Na + and K + channels in cardiomyocy…
View article: Tomographic characteristics of thick corneas
Tomographic characteristics of thick corneas Open
Purpose: To investigate the tomographic characteristics of corneas with excessive thickness and to explore their potential impact on the assessment of candidates for refractive surgery. Methods: One hundred and two eyes from 102 patients w…
View article: Long-read transcriptome landscapes of primary and metastatic liver cancers at transcript resolution
Long-read transcriptome landscapes of primary and metastatic liver cancers at transcript resolution Open
Background The liver ranks as the sixth most prevalent site of primary cancer in humans, and it frequently experiences metastases from cancers originating in other organs. To facilitate the development of effective treatments and improve s…
View article: Mitochondrial Quality Control Orchestrates the Symphony of B Cells and Plays Critical Roles in B Cell‐Related Diseases
Mitochondrial Quality Control Orchestrates the Symphony of B Cells and Plays Critical Roles in B Cell‐Related Diseases Open
B cells are essential for humoral immune response due to their ability to secrete antibodies. The development of B cells from the bone marrow to the periphery is tightly regulated by a complex set of immune signals, and each subset of B ce…
View article: Additional file 1 of Long-read transcriptome landscapes of primary and metastatic liver cancers at transcript resolution
Additional file 1 of Long-read transcriptome landscapes of primary and metastatic liver cancers at transcript resolution Open
Supplementary Material 1
View article: Virus-derived small interfering RNAs serve as new intercellular immune modulators against viral infection in mammals
Virus-derived small interfering RNAs serve as new intercellular immune modulators against viral infection in mammals Open
View article: Advancing diabetes treatment: novel formulation of polydatin long-circulating liposomes and their glucose-regulating impact on hyperlipidemia-induced type 2 diabetic mice
Advancing diabetes treatment: novel formulation of polydatin long-circulating liposomes and their glucose-regulating impact on hyperlipidemia-induced type 2 diabetic mice Open
Polydatin, a monomer derived from the dried roots and stems of traditional Chinese medicinal herb, Polygonum cuspidatum , boasts extensive pharmacological activities.
View article: LncRNA GAS6-AS1 Contributes to 5-Fluorouracil Resistance in Colorectal Cancer by Facilitating the Binding of PCBP1 with MCM3
LncRNA GAS6-AS1 Contributes to 5-Fluorouracil Resistance in Colorectal Cancer by Facilitating the Binding of PCBP1 with MCM3 Open
View article: FCTformer: Fusing Convolutional Operations and Transformer for 3D Rectal Tumor Segmentation in MR Images
FCTformer: Fusing Convolutional Operations and Transformer for 3D Rectal Tumor Segmentation in MR Images Open
Accurate and reliable segmentation of rectal cancer in Magnetic Resonance Imaging holds crucial significance in preoperative prediction, tumor staging, and neoadjuvant therapy. Currently, the automated segmentation methods for rectal tumor…