Zhishen Jiang
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View article: Global and regional burden and inequalities of oral conditions in children, adolescents, and young adults (0–39 years), 1990 to 2021
Global and regional burden and inequalities of oral conditions in children, adolescents, and young adults (0–39 years), 1990 to 2021 Open
Previous Global Burden of Disease studies often encompassed the entire age spectrum or treated adolescents and young adults as a single cohort. This methodology has limited the opportunity for a detailed analysis and modelling of oral heal…
View article: SOAT1 Activates NLRP3 Inflammasome to Promote Cancer‐Related Lymphangiogenesis and Metastasis via IL‐1β/IL‐1R‐1 Axis in Oral Squamous Cell Carcinoma
SOAT1 Activates NLRP3 Inflammasome to Promote Cancer‐Related Lymphangiogenesis and Metastasis via IL‐1β/IL‐1R‐1 Axis in Oral Squamous Cell Carcinoma Open
Oral squamous cell carcinoma (OSCC) is a prevalent type of cancer in the head and neck region, significantly impacting patient survival rates and quality of life. Lymph node (LN) metastasis is a lead contributor to the poor prognosis assoc…
View article: MoBA: Mixture of Block Attention for Long-Context LLMs
MoBA: Mixture of Block Attention for Long-Context LLMs Open
Scaling the effective context length is essential for advancing large language models (LLMs) toward artificial general intelligence (AGI). However, the quadratic increase in computational complexity inherent in traditional attention mechan…
View article: Efficacy of root canal treatment for autotransplanted third molars: a 6-Year cohort study of 167 teeth in southern China
Efficacy of root canal treatment for autotransplanted third molars: a 6-Year cohort study of 167 teeth in southern China Open
Background Autogenous tooth transplantation offers significant advantages and promising success rates for replacing non-retainable teeth. This study aimed to investigate the prognostic factors, especially the impact of root canal treatment…
View article: <scp>SCG2</scp> Mediates <scp>HNSCC</scp> Progression With <scp>CCL2</scp> / <scp> TGFβ1 <sup>high</sup> M2 </scp> Macrophage Infiltration
<span>SCG2</span> Mediates <span>HNSCC</span> Progression With <span>CCL2</span> / <span> TGFβ1 <sup>high</sup> M2 </span> Macrophage Infiltration Open
Objectives This study aims to unravel the mechanisms underlying M2 macrophage polarization in head and neck squamous cell carcinoma (HNSCC), and identify potential therapeutic targets. Materials and Methods We conducted an integrated bioin…
View article: Sema3A secreted by sensory nerve induces bone formation under mechanical loads
Sema3A secreted by sensory nerve induces bone formation under mechanical loads Open
Bone formation and deposition are initiated by sensory nerve infiltration in adaptive bone remodeling. Here, we focused on the role of Semaphorin 3A (Sema3A), expressed by sensory nerves, in mechanical loads-induced bone formation and nerv…
View article: Crosstalk among T cells, epithelial cells, and fibroblasts identifies a prognostic signature in oral squamous cell carcinoma
Crosstalk among T cells, epithelial cells, and fibroblasts identifies a prognostic signature in oral squamous cell carcinoma Open
Objectives This study aimed to analyze the crosstalk network among T cells, epithelial cells, and fibroblasts in the tumor microenvironment of oral squamous cell carcinoma (OSCC) and to determine their prognostic values. Materials and Meth…