Zhenfang Wu
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View article: Rewiring of 3D chromatin topology orchestrates transcriptional reprogramming in muscle fiber-type specification and transformation
Rewiring of 3D chromatin topology orchestrates transcriptional reprogramming in muscle fiber-type specification and transformation Open
The composition of muscle fibers, characterized by distinct contractile and metabolic properties, significantly influences meat quality and glucose homeostasis. However, the mechanisms by which three-dimensional (3D) genome topology integr…
View article: Genome Selection and Genome-Wide Association Analyses for Litter Size Traits in Large White Pigs
Genome Selection and Genome-Wide Association Analyses for Litter Size Traits in Large White Pigs Open
(1) Background: Litter size traits are critical for pig breeding efficiency but pose challenges due to low heritability and sex-limited influences. This study aimed to elucidate the genetic architecture and identify candidate genes for the…
View article: Cell-cell communication-mediated cell-type-specific parent-of-origin effects in mammals
Cell-cell communication-mediated cell-type-specific parent-of-origin effects in mammals Open
View article: Origins, Dispersal, and Impact: Bidirectional Introgression Between Chinese and European Pig Populations (Adv. Sci. 22/2025)
Origins, Dispersal, and Impact: Bidirectional Introgression Between Chinese and European Pig Populations (Adv. Sci. 22/2025) Open
View article: Origins, Dispersal, and Impact: Bidirectional Introgression Between Chinese and European Pig Populations
Origins, Dispersal, and Impact: Bidirectional Introgression Between Chinese and European Pig Populations Open
Human mediated intra‐continental exchange of genetic material among domesticated organisms has never been restricted to a single direction. The introduction of pig breeds between China and Europe aims to enhance economically important trai…
View article: Rewiring of 3D chromatin topology orchestrates transcriptional reprogramming in muscle fiber-type specification and transformation
Rewiring of 3D chromatin topology orchestrates transcriptional reprogramming in muscle fiber-type specification and transformation Open
The composition of muscle fibers, characterized by distinct contractile and metabolic properties, significantly influences meat quality and glucose homeostasis. However, the mechanisms by which three-dimensional (3D) genome topology integr…
View article: Genome-wide detection of multiple variants associated with teat number in French Yorkshire pigs
Genome-wide detection of multiple variants associated with teat number in French Yorkshire pigs Open
Our research provides an in-depth analysis of the complex genetic structure underlying teat number, contributing to the genetic enhancement of sows with improved reproductive performance and, ultimately, bolstering the economic benefits of…
View article: Comprehensive Analysis of Placental DNA Methylation Changes and Fetal Birth Weight in Pigs
Comprehensive Analysis of Placental DNA Methylation Changes and Fetal Birth Weight in Pigs Open
Birth weight is a complex multifactorial trait relevant to health states and disease risks in later life. The placenta is essential for proper fetal growth and facilitates gas, nutrient, and waste exchange between the mother and developing…
View article: Wdr17 Regulates Cell Proliferation, Cell Cycle Progression and Apoptosis in Mouse Spermatocyte Cell Line
Wdr17 Regulates Cell Proliferation, Cell Cycle Progression and Apoptosis in Mouse Spermatocyte Cell Line Open
We identified Wdr17 as a highly expressed gene in pachytene spermatocytes by transcriptomic analysis of mouse testis. Germ cell-deficient infertile mouse models had significantly reduced Wdr17 expression. We performed gene interference and…
View article: Treatment of Donor Cells with Oxidative Phosphorylation Inhibitor CPI Enhances Porcine Cloned Embryo Development
Treatment of Donor Cells with Oxidative Phosphorylation Inhibitor CPI Enhances Porcine Cloned Embryo Development Open
Somatic cell nuclear transfer (SCNT) technology holds great promise for livestock industry, life science and human biomedicine. However, the development and application of this technology is limited by the low developmental potential of SC…
View article: Calculating Volume of Pig Point Cloud Based on Improved Poisson Reconstruction
Calculating Volume of Pig Point Cloud Based on Improved Poisson Reconstruction Open
Pig point cloud data can be used to digitally reconstruct surface features, calculate pig body volume and estimate pig body weight. Volume, as a pig novel phenotype feature, has the following functions: (a) It can be used to estimate lives…
View article: Supplementation of SkQ1 Increases Mouse In Vitro Oocyte Maturation and Subsequent Embryonic Development by Reducing Oxidative Stress
Supplementation of SkQ1 Increases Mouse In Vitro Oocyte Maturation and Subsequent Embryonic Development by Reducing Oxidative Stress Open
In vitro oocyte maturation (IVM) technology is important for assisted animal and human reproduction. However, the maturation rates and developmental potential of in vitro-matured oocytes are usually lower than those of in vivo-matured oocy…
View article: Porcine Granulosa-Cell-Derived Exosomes Enhance Oocyte Development: An In Vitro Study
Porcine Granulosa-Cell-Derived Exosomes Enhance Oocyte Development: An In Vitro Study Open
Recent studies have established that exosomes (EXs) derived from follicular fluid (FF) can promote oocyte development. However, the specific sources of these EXs and their regulatory mechanisms remain elusive. It is universally acknowledge…
View article: Genomic prediction based on preselected single‐nucleotide polymorphisms from genome‐wide association study and imputed whole‐genome sequence data annotation for growth traits in Duroc pigs
Genomic prediction based on preselected single‐nucleotide polymorphisms from genome‐wide association study and imputed whole‐genome sequence data annotation for growth traits in Duroc pigs Open
The use of whole‐genome sequence (WGS) data is expected to improve genomic prediction (GP) power of complex traits because it may contain mutations that in strong linkage disequilibrium pattern with causal mutations. However, a few previou…
View article: Gender Control of Mouse Embryos by Activation of TLR7/8 on X Sperm via Ligands dsRNA-40 and dsRNA-DR
Gender Control of Mouse Embryos by Activation of TLR7/8 on X Sperm via Ligands dsRNA-40 and dsRNA-DR Open
Gender control technologies are promising for enhancing the production efficiency of the farm animal industry, and preventing sex-linked hereditary diseases in humans. It has been shown that the X sperm of mammalian animals specifically ex…
View article: Multi-omic characterization of allele-specific regulatory variation in hybrid pigs
Multi-omic characterization of allele-specific regulatory variation in hybrid pigs Open
Genetic variation in the regulation of gene expression contributes substantially to phenotypic variation. Understanding how variation in DNA sequences and epigentic modifications leads to gene expression variation remains a challenging tas…
View article: WITHDRAWN: Genomic and Phenotypic Consequences of Bi-Directional Introgression Between Chinese and European Pig Breeds
WITHDRAWN: Genomic and Phenotypic Consequences of Bi-Directional Introgression Between Chinese and European Pig Breeds Open
Withdrawal Statement The authors have withdrawn this manuscript because [the results have been updated with new data and revised analyses]. Therefore, the authors do not wish this work to be cited as reference for the project. If you have …
View article: Genome-Wide Association Study for Somatic Skeletal Traits in Duroc × (Landrace × Yorkshire) Pigs
Genome-Wide Association Study for Somatic Skeletal Traits in Duroc × (Landrace × Yorkshire) Pigs Open
The pig bone weight trait holds significant economic importance in southern China. To expedite the selection of the pig bone weight trait in pig breeding, we conducted molecular genetic research on these specific traits. These traits encom…
View article: Genetic evaluation for production and body size traits using different animal models in purebred-Duroc pigs
Genetic evaluation for production and body size traits using different animal models in purebred-Duroc pigs Open
Duroc pigs are popular crossbred terminal sires, and accurate assessment of genetic parameters in the population can help to rationalize breeding programmes. The principle aim of this study were to evaluate the genetic parameters of produc…
View article: Increased Accuracy of Genomic Prediction Using Preselected SNPs from GWAS with Imputed Whole-Genome Sequence Data in Pigs
Increased Accuracy of Genomic Prediction Using Preselected SNPs from GWAS with Imputed Whole-Genome Sequence Data in Pigs Open
Enhancing the accuracy of genomic prediction is a key goal in genomic selection (GS) research. Integrating prior biological information into GS methods using appropriate models can improve prediction accuracy for complex traits. Genome-wid…
View article: Modulation of cell cycle increases CRISPR-mediated homology-directed DNA repair
Modulation of cell cycle increases CRISPR-mediated homology-directed DNA repair Open
Background Gene knock‐in (KI) in animal cells via homology‐directed repair (HDR) is an inefficient process, requiring a laborious work for screening from few modified cells. HDR tends to occur in the S and G2/M phases of cell cycle; theref…
View article: Genome-wide association analysis unveils candidate genes and loci associated with aplasia cutis congenita in pigs
Genome-wide association analysis unveils candidate genes and loci associated with aplasia cutis congenita in pigs Open
View article: Composition, function, and timing: exploring the early-life gut microbiota in piglets for probiotic interventions
Composition, function, and timing: exploring the early-life gut microbiota in piglets for probiotic interventions Open
View article: Identification of Candidate Genes for Economically Important Carcass Cutting in Commercial Pigs through GWAS
Identification of Candidate Genes for Economically Important Carcass Cutting in Commercial Pigs through GWAS Open
During the process of pork production, the carcasses of pigs are divided and sold, which provides better economic benefits and market competitiveness for pork production than selling the carcass as a whole. Due to the significant cost of p…
View article: Genomic prediction based on selective linkage disequilibrium pruning of low-coverage whole-genome sequence variants in a pure Duroc population
Genomic prediction based on selective linkage disequilibrium pruning of low-coverage whole-genome sequence variants in a pure Duroc population Open
View article: Luteolin regulates the distribution and function of organelles by controlling SIRT1 activity during postovulatory oocyte aging
Luteolin regulates the distribution and function of organelles by controlling SIRT1 activity during postovulatory oocyte aging Open
The quality of oocytes determines their development competence, which will be rapidly lost if the oocytes are not fertilized at the proper time after ovulation. SIRT1, one of the sirtuin family members, has been proven to protect the quali…
View article: Genome-Wide Association Study of Body Conformation Traits in a Three-Way Crossbred Commercial Pig Population
Genome-Wide Association Study of Body Conformation Traits in a Three-Way Crossbred Commercial Pig Population Open
Body conformation is the most direct production index, which can fully reflect pig growth status and is closely related to critical economic traits. In this study, we conducted a genome-wide association study (GWAS) on body conformation tr…
View article: Identification and characterization of circRNAs in peri-implantation endometrium between Yorkshire and Erhualian pigs
Identification and characterization of circRNAs in peri-implantation endometrium between Yorkshire and Erhualian pigs Open
View article: Fisetin Delays Postovulatory Oocyte Aging by Regulating Oxidative Stress and Mitochondrial Function through Sirt1 Pathway
Fisetin Delays Postovulatory Oocyte Aging by Regulating Oxidative Stress and Mitochondrial Function through Sirt1 Pathway Open
The quality of oocytes determines the development potential of an embryo and is dependent on their timely fertilization after ovulation. Postovulatory oocyte aging is an inevitable factor during some assisted reproduction technology proced…
View article: Genome-Wide Association Study Identifies the Crucial Candidate Genes for Teat Number in Crossbred Commercial Pigs
Genome-Wide Association Study Identifies the Crucial Candidate Genes for Teat Number in Crossbred Commercial Pigs Open
The number of teats is a crucial reproductive trait with significant economic implications on maternal capacity and litter size. Consequently, improving this trait is essential to facilitate genetic selection for increased litter size. In …