Jing Gao
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View article: <scp>EMB</scp> ‐01, a Tetravalent Bispecific Antibody, Inducing Co‐Degradation of <scp>EGFR</scp> and c‐Met for Enhanced Anti‐Tumor Efficacy
<span>EMB</span> ‐01, a Tetravalent Bispecific Antibody, Inducing Co‐Degradation of <span>EGFR</span> and c‐Met for Enhanced Anti‐Tumor Efficacy Open
The bispecific antibody EMB‐01 (bafisontamab), constructed using EpimAb's proprietary FIT‐Ig platform, is designed to simultaneously target epidermal growth factor receptor (EGFR) and receptor tyrosine kinase Met (c‐Met). Here, we characte…
View article: Impact of SARS-CoV-2 variants and vaccination on pediatric febrile seizures: a retrospective cohort study
Impact of SARS-CoV-2 variants and vaccination on pediatric febrile seizures: a retrospective cohort study Open
Objective This study aimed to investigate the associations between SARS-CoV-2 variants, inflammatory markers, vaccination history, and demographic characteristics in relation to the occurrence of febrile seizures (FS) in pediatric patients…
View article: Erythematous, pruritic and indurated plaques following treatment for melanoma
Erythematous, pruritic and indurated plaques following treatment for melanoma Open
A 35-year-old man presented with two itchy, nontender, indurated erythematous plaques on his forehead and upper back. Three months prior, he had completed a 12-month course of adjuvant pembrolizumab for stage IIIC melanoma. Clinical and im…
View article: Characteristics and outcomes of patients with pregnancy-associated colorectal cancer
Characteristics and outcomes of patients with pregnancy-associated colorectal cancer Open
Introduction Pregnancy-associated colorectal cancer (PACRC) is a rare condition with limited existing research. Its occurrence during pregnancy introduces unique physiological complexities, making diagnosis and treatment particularly chall…
View article: Accelerated biological aging as potential mediator in the relationship between central obesity and lung cancer risk
Accelerated biological aging as potential mediator in the relationship between central obesity and lung cancer risk Open
Background The increased prevalence of obesity and incidence of lung cancer have raised significant concerns worldwide. However, the relationship between obesity and lung cancer risk, and the potential mediating effect of biological aging …
View article: Carbon ion combined photon radiotherapy induces ferroptosis via NCOA4-mediated ferritinophagy in glioblastoma
Carbon ion combined photon radiotherapy induces ferroptosis via NCOA4-mediated ferritinophagy in glioblastoma Open
Glioblastoma (GBM), the most prevalent and lethal primary malignancy of the central nervous system, remains refractory to conventional photon radiotherapy due to inherent limitations in dose distribution. Although carbon ion radiotherapy o…
View article: Fatal Pulmonary Artery Dissection in the Setting of Aneurysm and Pulmonary Hypertension: A Case Report and Literature Review
Fatal Pulmonary Artery Dissection in the Setting of Aneurysm and Pulmonary Hypertension: A Case Report and Literature Review Open
Pulmonary artery aneurysm (PAA) with dissection is an extremely rare and highly fatal cardiovascular emergency. We present the case of a 56-year-old woman with a history of poorly controlled hypertension who developed sudden-onset chest pa…
View article: A multicentre, randomised controlled clinical trial evaluating the effect of the adsorptive filter oXiris on haemodynamics in abdominal septic shock patients requiring continuous renal replacement therapy (Oxiris for Abdominal SEptic Shock study)
A multicentre, randomised controlled clinical trial evaluating the effect of the adsorptive filter oXiris on haemodynamics in abdominal septic shock patients requiring continuous renal replacement therapy (Oxiris for Abdominal SEptic Shock study) Open
Introduction Septic shock-associated acute kidney injury (AKI) is known to carry a poor prognosis. The present study aims to evaluate the effect of absorptive blood purification on haemodynamic status and clinical outcomes in patients with…
View article: Association between examined lymph node count and survival in resectable cervical cancer: a retrospective analysis using SEER data
Association between examined lymph node count and survival in resectable cervical cancer: a retrospective analysis using SEER data Open
Background The optimal examined lymph node (ELN) in resectable nonmetastatic cervical cancer patients remains controversial. Methods A total of 7435 N0 patients and 1385 N1 patients were enrolled from the Surveillance, Epidemiology, and En…
View article: Long-term outcomes and prognostic factors of eye-preserving treatment with particle beam radiotherapy for orbital malignancies
Long-term outcomes and prognostic factors of eye-preserving treatment with particle beam radiotherapy for orbital malignancies Open
Particle radiotherapy following eye-preserving treatment provided a favorable local control and survivals with moderate acute and late toxicities, even in patients with unresectable disease. Particle radiotherapy was a promising strategy f…
View article: Impact of SARS-CoV-2 Variants and Vaccination on Pediatric Febrile Seizures: A Retrospective Cohort Study
Impact of SARS-CoV-2 Variants and Vaccination on Pediatric Febrile Seizures: A Retrospective Cohort Study Open
Objective This study aimed to investigate the associations between SARS-CoV-2 variants, neuroinflammatory markers, vaccination history, and demographic characteristics in relation to the occurrence of febrile seizures (FS) in pediatric pat…
View article: Clinical outcomes of particle beam radiation therapy for patients with newly-diagnosed major salivary gland tumors
Clinical outcomes of particle beam radiation therapy for patients with newly-diagnosed major salivary gland tumors Open
As a potentially safe and efficient treatment option for newly-diagnosed MSGTs, proton and carbon ion radiation offers an excellent alternative for traditional methods. More investigation is required to determine the long-term results and …
View article: Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer
Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer Open
Proteasome is an essential organelle responsible for maintaining cellular protein homeostasis, but its relationship with DNA methylation remains unknown. In this study, we assessed DNA methylation of colorectal cancer (CRC) cells following…
View article: Gender disparities in the association between atherogenic index of plasma and chronic kidney disease
Gender disparities in the association between atherogenic index of plasma and chronic kidney disease Open
Objective This study investigates the relationship between the atherogenic index of plasma (AIP) and chronic kidney disease (CKD) occurrence in the general population, with a focus on potential gender disparities. Methods The study include…
View article: Comprehensive transcriptome and proteome analysis revealed the molecular mechanisms of melatonin priming and waterlogging response in peach
Comprehensive transcriptome and proteome analysis revealed the molecular mechanisms of melatonin priming and waterlogging response in peach Open
Waterlogging substantially hampers the growth and development of plants. The escalating trajectory of global climate change is heightening both the frequency and intensity of waterlogging events. Peach trees are particularly vulnerable to …
View article: Antiviral effects and mechanism of Qi pi pill against influenza viruses
Antiviral effects and mechanism of Qi pi pill against influenza viruses Open
Background Qi pi pill (QPP), which contains Renshen, Baizhu, Fuling, Gancao, Chenpi, Shanyao, Lianzi, Shanzha, Liushenqu, Maiya, and Zexie, was recommended for preventing and treating COVID‐19 in Shandong Province (China). However, the mec…
View article: Efficacy of honey suppositories in treating paediatric functional constipation: A comparative study
Efficacy of honey suppositories in treating paediatric functional constipation: A comparative study Open
Aim This study sought to assess the clinical efficacy of honey suppositories in managing functional constipation in pre‐school children, with a focus on those exhibiting Yin deficiency and intestinal dryness according to traditional Chines…
View article: Long-term Outcomes and Prognostic Factors of Eye-preserving Treatment with Particle Beam Radiotherapy for Orbital Malignancies
Long-term Outcomes and Prognostic Factors of Eye-preserving Treatment with Particle Beam Radiotherapy for Orbital Malignancies Open
Background This retrospective study report the clinical experience of eye-preserving treatment follow by particle beam radiotherapy (IMPT or CIRT) for orbital malignancies. And to evaluate prognostic factors for orbital and lacrimal gland …
View article: Screening, genotyping and haematological analysis of glucose‐6‐phosphate dehydrogenase deficiency in the blood donors of Wuxi City, China
Screening, genotyping and haematological analysis of glucose‐6‐phosphate dehydrogenase deficiency in the blood donors of Wuxi City, China Open
Background and Objectives To investigate the prevalence, genotype and haematological characteristics of glucose‐6‐phosphate dehydrogenase ( G6PD ) deficiency in the blood donor population of Wuxi area (Jiangsu Province, China) and to asses…
View article: Long-term outcomes after particle radiation therapy in patients with nasopharyngeal adenoid cystic carcinoma
Long-term outcomes after particle radiation therapy in patients with nasopharyngeal adenoid cystic carcinoma Open
Background Nasopharyngeal adenoid cystic carcinoma (NACC) is a relatively rare salivary gland tumor that is generally associated with poor outcomes. High-dose radiotherapy is a key treatment for patients with NACC. This study reported the …
View article: Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer
Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer Open
Proteasome is an essential organelle in guarding cellular protein homeostasis. Here, we report that inhibition of proteasome leads to alterations in DNA methylation patterns in colorectal cancer (CRC) by surpressing the synthesis of DNA me…
View article: Tumor-derived extracellular vesicle proteins as new biomarkers and targets in precision oncology
Tumor-derived extracellular vesicle proteins as new biomarkers and targets in precision oncology Open
Extracellular vesicles (EVs) are important carriers of signaling molecules, such as nucleic acids, proteins, and lipids, and have become a focus of increasing interest due to their numerous physiological and pathological functions. For a l…