Zhenyu Ju
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View article: Loss of Brd4 alleviates pathological bone loss via Slc9b2 suppression in osteoclastogenesis
Loss of Brd4 alleviates pathological bone loss via Slc9b2 suppression in osteoclastogenesis Open
Background Epigenetic regulation plays a crucial role in skeletal degenerative diseases, including osteoporosis. As an epigenetic reader, bromodomain protein 4 (Brd4) is known as a key driver of gene activation; however, its role in mainta…
View article: Computed tomography-guided ozone neurolysis lowers blood pressure
Computed tomography-guided ozone neurolysis lowers blood pressure Open
The regulation of blood pressure is closely linked to sympathetic activity. This retrospective study analyzed 142 hypertensive patients undergoing computed tomography (CT)-guided O 2 –O 3 neurolysis targeting intervertebral foramina or lum…
View article: Energy Deficiency‐Induced ATG4B Nuclear Translocation Inhibits PRMT1‐Mediated DNA Repair and Promotes Leukemia Progression
Energy Deficiency‐Induced ATG4B Nuclear Translocation Inhibits PRMT1‐Mediated DNA Repair and Promotes Leukemia Progression Open
Metabolic alterations and genomic instability are the hallmark features of many cancers. However, the precise mechanisms underlying the intricate links among these processes remain largely unknown. Here, a molecular mechanism is presented …
View article: The Tanyu Tongzhi Formula enhances IL-10 expression and macrophage efferocytosis to alleviate atherosclerosis in mice
The Tanyu Tongzhi Formula enhances IL-10 expression and macrophage efferocytosis to alleviate atherosclerosis in mice Open
IL-10-mediated efferocytosis potentiation is the critical pathway through which TTF stabilizes atherosclerotic plaques. The NF-κB/IL-10/efferocytosis axis provides a novel pharmacological target for macrophage-directed anti-atherosclerotic…
View article: Supplemental Review Material to Sleep Restriction Exacerbates Atherogenesis via Monocyte-Derived CCL15/CCR1 Signaling v1
Supplemental Review Material to Sleep Restriction Exacerbates Atherogenesis via Monocyte-Derived CCL15/CCR1 Signaling v1 Open
Sleep Restriction (SR) is a prevalent condition linked to heightened risk of atherosclerotic cardiovascular disease (ASCVD), yet the molecular mechanisms and biomarkers linking sleep deficiency to cardiovascular risk remain poorly defined.…
View article: SENP6 Maintains Mitochondrial Homeostasis by Regulating Mitochondrial Protein Import Through deSUMOylation of TOM40
SENP6 Maintains Mitochondrial Homeostasis by Regulating Mitochondrial Protein Import Through deSUMOylation of TOM40 Open
SUMOylation, a reversible post‐translational modification, regulates various mitochondrial processes, including biogenesis, dynamics, mitophagy, and the mitochondrial unfolded protein response. Although SUMOylation is shown to be triggered…
View article: RNA G-quadruplex (rG4) exacerbates cellular senescence by mediating ribosome pausing
RNA G-quadruplex (rG4) exacerbates cellular senescence by mediating ribosome pausing Open
Loss of protein homeostasis is a hallmark of cellular senescence, and ribosome pausing plays a crucial role in the collapse of proteostasis. However, our understanding of ribosome pausing in senescent cells remains limited. In this study, …
View article: Phase separation of MRG15 delays cellular senescence
Phase separation of MRG15 delays cellular senescence Open
Phase separation, a biophysical process that segregates subcellular environments into condensates, has been recognized for its role in transcriptional regulation. However, the extent of its influence on cellular senescence processes remain…
View article: Bimetallic NiCu‐MOF Protects DOX‐Induced Myocardial Injury and Cardiac Dysfunction by Suppressing Ferroptosis and Inflammation
Bimetallic NiCu‐MOF Protects DOX‐Induced Myocardial Injury and Cardiac Dysfunction by Suppressing Ferroptosis and Inflammation Open
Doxorubicin (DOX), a potent anthracycline chemotherapeutic agent, is widely used in cancer treatment but is associated with significant adverse effects, particularly DOX‐induced cardiomyopathy (DIC). DIC pathogenesis involves the generatio…
View article: FoxO3 controls cardiomyocyte proliferation and heart regeneration by regulating Sfrp2 expression in postnatal mice
FoxO3 controls cardiomyocyte proliferation and heart regeneration by regulating Sfrp2 expression in postnatal mice Open
The Forkhead box O3 (FoxO3) transcription factor is crucial to controlling heart growth in adulthood, but its exact role in cardiac repair and regeneration in postnatal mice remains unclear. Here, we show that FoxO3 deficiency promotes car…
View article: Nicotinamide mononucleotide supplementation ameliorates testicular damage induced by ischemia-reperfusion through reshaping macrophage and neutrophil inflammatory properties
Nicotinamide mononucleotide supplementation ameliorates testicular damage induced by ischemia-reperfusion through reshaping macrophage and neutrophil inflammatory properties Open
The beneficial effects of NMN supplementation indicated that boosting NAD+ may be a promising and safe strategy to improve clinical outcomes in I/R-induced testicular damage.
View article: A Feedback Loop Driven by H4K12 Lactylation and HDAC3 in Macrophages Regulates Lactate‐Induced Collagen Synthesis in Fibroblasts Via the TGF‐β Signaling
A Feedback Loop Driven by H4K12 Lactylation and HDAC3 in Macrophages Regulates Lactate‐Induced Collagen Synthesis in Fibroblasts Via the TGF‐β Signaling Open
The decrease in fibroblast collagen is a primary contributor to skin aging. Lactate can participate in collagen synthesis through lysine lactylation by regulating gene transcription. However, the precise mechanism by which lactate influenc…
View article: A Baicalin‐Based Functional Polymer in Dynamic Reversible Networks Alleviates Osteoarthritis by Cellular Interactions
A Baicalin‐Based Functional Polymer in Dynamic Reversible Networks Alleviates Osteoarthritis by Cellular Interactions Open
Osteoarthritis (OA) is increasingly recognized as a whole‐organ disease predominantly affecting the elderly, characterized by typical alterations in subchondral bone and cartilage, along with recurrent synovial inflammation. Despite the av…
View article: Exosomes containing circSCP2 in colorectal cancer promote metastasis via sponging miR-92a-1-5p and interacting with PTBP1 to stabilize IGF2BP1
Exosomes containing circSCP2 in colorectal cancer promote metastasis via sponging miR-92a-1-5p and interacting with PTBP1 to stabilize IGF2BP1 Open
Exosomes have emerged as significant biomarkers for multiple diseases, including cancers. Circular RNAs (circRNAs), abundant in exosomes, are involved in regulating cancer development. However, the regulatory function and the underlying mo…
View article: The emerging role and therapeutical implications of ferroptosis in wound healing
The emerging role and therapeutical implications of ferroptosis in wound healing Open
Wound healing is a complex biological process involving multiple steps, including hemostasis, inflammation, proliferation, and remodeling. A novel form of regulated cell death, ferroptosis, has garnered attention because of its involvement…
View article: DDO1002, an NRF2–KEAP1 inhibitor, improves hematopoietic stem cell aging and stress response
DDO1002, an NRF2–KEAP1 inhibitor, improves hematopoietic stem cell aging and stress response Open
Oxidative stress diminishes the functionality of hematopoietic stem cells (HSCs) as age advances, with heightened reactive oxygen species (ROS) levels exacerbating DNA damage, cellular senescence, and hematopoietic impairment. DDO1002, a p…
View article: CK-666 protects against ferroptosis and renal ischemia-reperfusion injury through a microfilament-independent mechanism
CK-666 protects against ferroptosis and renal ischemia-reperfusion injury through a microfilament-independent mechanism Open
Ferroptosis is a type of regulated cell death driven by iron-dependent accumulation of lipid peroxidation, exhibiting unique morphological changes. While actin microfilaments are crucial for various cellular processes, including morphogene…
View article: Both 20S and 19S proteasome components are essential for meiosis in male mice
Both 20S and 19S proteasome components are essential for meiosis in male mice Open
The proteasome, an evolutionarily conserved proteolytic complex comprising the 20S core particle and 19S regulatory particles, performs both shared and distinct functions across various tissues and organs. Spermatogenesis, a highly complex…
View article: MOGAT3-mediated DAG accumulation drives acquired resistance to anti-BRAF/anti-EGFR therapy in BRAFV600E-mutant metastatic colorectal cancer
MOGAT3-mediated DAG accumulation drives acquired resistance to anti-BRAF/anti-EGFR therapy in BRAFV600E-mutant metastatic colorectal cancer Open
BRAFV600E-mutant metastatic colorectal cancer (mCRC) is associated with poor prognosis. The combination of anti-BRAF/anti-EGFR (encorafenib/cetuximab) treatment for patients with BRAFV600E-mutant mCRC improves clinical benefits; unfortunat…
View article: YTHDC1-mediated microRNA maturation is essential for hematopoietic stem cells maintenance
YTHDC1-mediated microRNA maturation is essential for hematopoietic stem cells maintenance Open
YTHDC1, a reader of N6-methyladenosine (m 6 A) modifications on RNA, is posited to exert significant influence over RNA metabolism. Despite its recognized importance, the precise function and underlying mechanisms of YTHDC1 in the preserva…
View article: Figure S8 from Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer
Figure S8 from Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer Open
Figure S8.
View article: Supplementary Data, Table S1-3 from Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer
Supplementary Data, Table S1-3 from Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer Open
Supplementary Data.
View article: Figure S9 from Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer
Figure S9 from Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer Open
Figure S9.
View article: Supplementary Data from Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer
Supplementary Data from Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer Open
supplementary materials 2.
View article: Figure S7 from Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer
Figure S7 from Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer Open
Figure S7.
View article: Figure S2 from Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer
Figure S2 from Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer Open
Figure S2.
View article: Data from Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer
Data from Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer Open
Tumor stroma plays a critical role in fostering tumor progression and metastasis. Cancer-associated fibroblasts (CAF) are a major component of the tumor stroma. Identifying the key molecular determinants for the protumor properties of CAFs…