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View article: HERVH-derived eRNA activates a super-enhancer–driven ALDH1A3/SAT1 axis to promote ferroptosis escape and pancreatic cancer development
HERVH-derived eRNA activates a super-enhancer–driven ALDH1A3/SAT1 axis to promote ferroptosis escape and pancreatic cancer development Open
Endogenous retroviruses (ERVs), widely distributed in the human genome, are usually epigenetically silenced but can be reactivated in cancer. Activated ERVs may act as regulatory elements or produce noncoding RNAs that modulate gene expres…
View article: Emerging role of long non‑coding RNAs in the Rho/ROCK signaling pathway in tumor metastasis (Review)
Emerging role of long non‑coding RNAs in the Rho/ROCK signaling pathway in tumor metastasis (Review) Open
Metastasis is a critical feature of malignant tumors and a major cause of treatment failure and poor prognosis. This complex process primarily involves the rearrangement of the cytoskeleton. Among several cytoskeleton‑associated signaling …
View article: Synergistic Effects of Biochar and Bacillus thuringiensis NL-11 on Ophiopogon japonicus Growth and Soil Microbial Diversity in Trampled Urban Forest Soils
Synergistic Effects of Biochar and Bacillus thuringiensis NL-11 on Ophiopogon japonicus Growth and Soil Microbial Diversity in Trampled Urban Forest Soils Open
Bare soil expansion in urban forests, driven by persistent high-intensity trampling, degrades both macro-scale natural resources and micro ecological conditions. Targeted interventions are therefore essential. In this study, trampled bare …
View article: An urban environmental noise source identification model based on parallel deep learning network with convolutional block attention
An urban environmental noise source identification model based on parallel deep learning network with convolutional block attention Open
With the rapid development of urbanization, noise pollution has become a serious environmental issue affecting human health and quality of life. Timely acquisition of accurate information about noise sources is crucial for efficient and pr…
View article: Construction of green technology model based on enterprise digital economy of environmental protection
Construction of green technology model based on enterprise digital economy of environmental protection Open
The deteriorating environmental problems worldwide pose a serious challenge to human society and ecosystems, especially for enterprises that rely on natural resources. This article studies the construction of a green technology model for e…
View article: Graphic Design with Large Multimodal Model
Graphic Design with Large Multimodal Model Open
In the field of graphic design, automating the integration of design elements into a cohesive multi-layered artwork not only boosts productivity but also paves the way for the democratization of graphic design. One existing practice is Gra…
View article: <sup>68</sup>Ga-Labeled Peptide for Noninvasive Quantifying Tumor Exposure of PD-L1 Therapeutics
<sup>68</sup>Ga-Labeled Peptide for Noninvasive Quantifying Tumor Exposure of PD-L1 Therapeutics Open
[68Ga]HF12 was successfully synthesized as a radiotracer for noninvasive quantitative PET imaging of PD-L1 expression levels. This radiotracer exhibited the potential to quantify PD-L1 expression across various tumors, thereby facilitating…
View article: A novel telomere-associated genes signature for the prediction of prognosis and treatment responsiveness of hepatocellular carcinoma
A novel telomere-associated genes signature for the prediction of prognosis and treatment responsiveness of hepatocellular carcinoma Open
In this study, we developed a novel prognostic model comprising 18 TRGs for HCC, which exhibited remarkable accuracy in predicting HCC patients' prognosis. Additionally, through MR analysis, we have successfully established a causal relati…
View article: Construction and Validation of a Novel Butyrylation-Related Gene Signature Related to Prognosis, Clinical Implications, and Immune Microenvironment Characterization of Hepatocellular Carcinoma
Construction and Validation of a Novel Butyrylation-Related Gene Signature Related to Prognosis, Clinical Implications, and Immune Microenvironment Characterization of Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) is a common and highly lethal malignant tumor that poses a serious threat to human health. The post-transcriptional modification of proteins known as butyrylation has emerged as a critical factor in tumorigen…
View article: Study on the expression of S100A4 and HMGA1 in endometrial carcinoma and their correlation with metastasis
Study on the expression of S100A4 and HMGA1 in endometrial carcinoma and their correlation with metastasis Open
The increased positive expression of HMGA1 and S100A4 in the endometrial cancer tissues is closely related to the clinicopathological features and postoperative recurrence and metastasis. HMGA1 and S100A4 have significant predictive value …
View article: The deubiquitinating enzyme ATXN3 promotes hepatocellular carcinoma progression by stabilizing TAZ
The deubiquitinating enzyme ATXN3 promotes hepatocellular carcinoma progression by stabilizing TAZ Open
Hepatocellular carcinoma (HCC) was a primary cause of cancer-related morbidity and mortality in China. ATXN3 was a deubiquitinase (DUB) associated with spinocerebellar ataxia, widely expressed in the cytoplasm and nucleus of cells in the c…
View article: Reciprocal tumor‐platelet interaction through the EPHB1‐EFNB1 axis in the liver metastatic niche promotes metastatic tumor outgrowth in pancreatic ductal adenocarcinoma
Reciprocal tumor‐platelet interaction through the EPHB1‐EFNB1 axis in the liver metastatic niche promotes metastatic tumor outgrowth in pancreatic ductal adenocarcinoma Open
Background The interaction between the metastatic microenvironment and tumor cells plays an important role in metastatic tumor formation. Platelets play pivotal roles in hematogenous cancer metastasis through tumor cell‐platelet interactio…
View article: DDO1002, an NRF2–KEAP1 inhibitor, improves hematopoietic stem cell aging and stress response
DDO1002, an NRF2–KEAP1 inhibitor, improves hematopoietic stem cell aging and stress response Open
Oxidative stress diminishes the functionality of hematopoietic stem cells (HSCs) as age advances, with heightened reactive oxygen species (ROS) levels exacerbating DNA damage, cellular senescence, and hematopoietic impairment. DDO1002, a p…
View article: Aberrant Energy Metabolism in Tumors and Potential Therapeutic Targets
Aberrant Energy Metabolism in Tumors and Potential Therapeutic Targets Open
Energy metabolic reprogramming is frequently observed during tumor progression as tumor cells necessitate adequate energy production for rapid proliferation. Although current medical research shows promising prospects in studying the chara…
View article: Graphic Design with Large Multimodal Model
Graphic Design with Large Multimodal Model Open
In the field of graphic design, automating the integration of design elements into a cohesive multi-layered artwork not only boosts productivity but also paves the way for the democratization of graphic design. One existing practice is Gra…
View article: Prognostic value and therapeutic potential of NEK family in stomach adenocarcinoma
Prognostic value and therapeutic potential of NEK family in stomach adenocarcinoma Open
Never in mitosis gene A-related kinase (NEK) is an 11-membered family of serine/threonine kinases (NEK1-NEK11), which are known to play important roles in the formation and development of cancer. However, few studies have examined the role…
View article: A Nutrient-Deficient Microenvironment Facilitates Ferroptosis Resistance via the FAM60A–PPAR Axis in Pancreatic Ductal Adenocarcinoma
A Nutrient-Deficient Microenvironment Facilitates Ferroptosis Resistance via the FAM60A–PPAR Axis in Pancreatic Ductal Adenocarcinoma Open
Ferroptosis, a nonapoptotic form of cell death, is an emerging potential therapeutic target for various diseases, including cancer. However, the role of ferroptosis in pancreatic cancer remains poorly understood. Pancreatic ductal adenocar…
View article: Immunological role and prognostic value of somatostatin receptor family members in colon adenocarcinoma
Immunological role and prognostic value of somatostatin receptor family members in colon adenocarcinoma Open
Colon adenocarcinoma (COAD) is among the most prevalent cancers worldwide, ranking as the third most prevalent malignancy in incidence and mortality. The somatostatin receptor (SSTR) family comprises G-protein-coupled receptors (GPCRs), wh…
View article: Lysine Methyltransferase SMYD1 Regulates Myogenesis via skNAC Methylation
Lysine Methyltransferase SMYD1 Regulates Myogenesis via skNAC Methylation Open
The SMYD family is a unique class of lysine methyltransferases (KMTases) whose catalytic SET domain is split by a MYND domain. Among these, Smyd1 was identified as a heart- and skeletal muscle-specific KMTase and is essential for cardiogen…
View article: Mineral-Solubilizing Microbial Inoculums Promote <em>Robinia pseudoacacia</em> L. Growth by Optimizing the Rhizosphere Soil Microbial Community Structure
Mineral-Solubilizing Microbial Inoculums Promote <em>Robinia pseudoacacia</em> L. Growth by Optimizing the Rhizosphere Soil Microbial Community Structure Open
The addition of mineral-solubilizing microbial inoculums is a kind of biological measure for vegetation restoration of rock mining areas. Its function is to accelerate soil weathering, improve soil fertility, improve the ability of plants …
View article: Data from SPON2 Promotes M1-like Macrophage Recruitment and Inhibits Hepatocellular Carcinoma Metastasis by Distinct Integrin–Rho GTPase–Hippo Pathways
Data from SPON2 Promotes M1-like Macrophage Recruitment and Inhibits Hepatocellular Carcinoma Metastasis by Distinct Integrin–Rho GTPase–Hippo Pathways Open
Tumor-associated macrophages (TAM) represent key regulators of the complex interplay between cancer and the immune microenvironment. Matricellular protein SPON2 is essential for recruiting lymphocytes and initiating immune responses. Recen…
View article: Supplementary Tables S1-3 from SPON2 Promotes M1-like Macrophage Recruitment and Inhibits Hepatocellular Carcinoma Metastasis by Distinct Integrin–Rho GTPase–Hippo Pathways
Supplementary Tables S1-3 from SPON2 Promotes M1-like Macrophage Recruitment and Inhibits Hepatocellular Carcinoma Metastasis by Distinct Integrin–Rho GTPase–Hippo Pathways Open
Supplementary tables of correlation of clinicopathological features with SPON2 expression, primers for PCR, and sequence of shRNA and siRNA
View article: Supplementary materials and methods from SPON2 Promotes M1-like Macrophage Recruitment and Inhibits Hepatocellular Carcinoma Metastasis by Distinct Integrin–Rho GTPase–Hippo Pathways
Supplementary materials and methods from SPON2 Promotes M1-like Macrophage Recruitment and Inhibits Hepatocellular Carcinoma Metastasis by Distinct Integrin–Rho GTPase–Hippo Pathways Open
Supplementary materials and methods of isolation of hMC, immunohistochemical and H&E staining, 3D spheroid analysis, PLA, q-PCR, lentivirus production and cell transduction, siRNA, production of rSPON2, ELISA assay and chemokine assay