Zhenning Wang
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View article: LLDT-8 attenuates brain metastasis in non-small cell lung cancer <i>via</i> selective p53 activation
LLDT-8 attenuates brain metastasis in non-small cell lung cancer <i>via</i> selective p53 activation Open
Dual-mode bioluminescence/fluorescence imaging visualizes NSCLC brain metastasis and its significant suppression by LLDT-8.
View article: A Wearable System Featuring Biomimetic Spatially Distributed Iontronic Sensing Array for Dynamic Monitoring of Deep Tissue Modulus
A Wearable System Featuring Biomimetic Spatially Distributed Iontronic Sensing Array for Dynamic Monitoring of Deep Tissue Modulus Open
Assessing soft tissue hardness is critical for disease diagnosis and motion monitoring. However, existing technologies are confined to skin‐level and quasi‐static measurements, leaving the dynamic behavior of deeper tissues, such as muscle…
View article: The Radio Flare and Multiwavelength Afterglow of the Short GRB 231117A: Energy Injection from a Violent Shell Collision
The Radio Flare and Multiwavelength Afterglow of the Short GRB 231117A: Energy Injection from a Violent Shell Collision Open
We present the early radio detection and multiwavelength modeling of the short gamma-ray burst (GRB) 231117A at redshift z = 0.257. The Australia Telescope Compact Array automatically triggered a 9 hr observation of GRB 231117A at 5.5 and …
View article: The YAP1/GPX4 axis alleviates osteoporosis by affecting ferroptosis in osteoblasts
The YAP1/GPX4 axis alleviates osteoporosis by affecting ferroptosis in osteoblasts Open
Background Osteoporosis (OP) is a disease in which weak bones increase the risk of fracture. It has been reported that the occurrence of ferroptosis accelerated the progression of OP. However, the underlying mechanism of ferroptosis in OP …
View article: The Effect of High-Speed Fragment Impact on the Overall Strength of Concrete Columns Under Pressure Load
The Effect of High-Speed Fragment Impact on the Overall Strength of Concrete Columns Under Pressure Load Open
As a common engineering building material, concrete material is widely used in buildings, bridges, and protective structures. Concrete load-bearing columns are one of the main load-bearing components in buildings. In order to analyze the c…
View article: Clinical Application Effect Analysis of the Improved Nasopharyngeal Swab Sampling Method for COVID-19 Nucleic Acid Testing
Clinical Application Effect Analysis of the Improved Nasopharyngeal Swab Sampling Method for COVID-19 Nucleic Acid Testing Open
This study aims to evaluate the clinical application effect of an improved nasopharyngeal swab sampling method for COVID-19 nucleic acid testing. A total of 100 nasopharyngeal swab samplers were randomly divided into two groups: a control …
View article: A hollow-tube-like hydrospongel for multimodal therapy of advanced colorectal cancer
A hollow-tube-like hydrospongel for multimodal therapy of advanced colorectal cancer Open
Preserving anal function in advanced-stage colorectal cancer (CRC) treatment remains a significant challenge. Here we introduce a hollow-tube-like hydrospongel (HTHSG) as an advanced neoadjuvant therapy. Constructed from cellulose nanofibe…
View article: A First-in-Human Study of Givastomig, a CLDN18.2 and 4-1BB Bispecific Antibody, as Monotherapy in Patients with CLDN18.2-Positive Advanced or Metastatic Solid Tumors
A First-in-Human Study of Givastomig, a CLDN18.2 and 4-1BB Bispecific Antibody, as Monotherapy in Patients with CLDN18.2-Positive Advanced or Metastatic Solid Tumors Open
Purpose: Givastomig is a bispecific antibody that targets CLDN18.2 and conditionally activates local 4-1BB–expressing T cells. This first-in-human study evaluated the safety, tolerability, pharmacokinetics, pharmacodynamics, and antitumor …
View article: LIMK1 as a Novel Kinase of β‐Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5
LIMK1 as a Novel Kinase of β‐Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5 Open
Metastasis is a major cause of cancer deaths, but the underlying molecular mechanisms remain largely unknown. Esophageal squamous cell carcinoma (ESCC) is a highly aggressive cancer with poor survival, yet the key kinases driving ESCC meta…
View article: Cleavage of CAD by caspase-3 determines the cancer cell fate during chemotherapy
Cleavage of CAD by caspase-3 determines the cancer cell fate during chemotherapy Open
Metabolic heterogeneity resulting from the intra-tumoral heterogeneity mediates massive adverse outcomes of tumor therapy, including chemotherapeutic resistance, but the mechanisms inside remain largely unknown. Here, we find that the de n…
View article: Dynamic Response and Anti-Collapse Analysis of Multi-Column Demolition Mode in Frame Structures
Dynamic Response and Anti-Collapse Analysis of Multi-Column Demolition Mode in Frame Structures Open
With the improvement of building safety requirements and the need for risk assessment under extreme conditions such as earthquakes, fires, and explosions, research related to the failure of some key components has received more attention i…
View article: Comprehensive analysis of multi‐omics single‐cell data using the single‐cell analyst
Comprehensive analysis of multi‐omics single‐cell data using the single‐cell analyst Open
The rapid advancement of multi‐omics single‐cell technologies has significantly enhanced our ability to investigate complex biological systems at unprecedented resolution. However, many existing analysis tools are complex, requiring substa…
View article: Atezolizumab and Trastuzumab Plus Chemotherapy for <i>ERBB2</i>-Positive Locally Advanced Resectable Gastric Cancer
Atezolizumab and Trastuzumab Plus Chemotherapy for <i>ERBB2</i>-Positive Locally Advanced Resectable Gastric Cancer Open
Importance Effective treatment of locally advanced gastric cancer (GC) or gastroesophageal junction (GEJ) cancer remains a challenge. Objective To compare the efficacy and safety of atezolizumab plus trastuzumab plus capecitabine and oxali…
View article: Exhumation Degree of Intrusions in the Kangguer–Huangshan Area and Its Constraint on Ore‐Preservation in the Jueluotage Tectonic Belt, Eastern Tianshan
Exhumation Degree of Intrusions in the Kangguer–Huangshan Area and Its Constraint on Ore‐Preservation in the Jueluotage Tectonic Belt, Eastern Tianshan Open
The Kangguer–Huangshan ductile shear zone lies in the Eastern Tianshan area, southeast of the Central Asian Orogenic Belt (CAOB), it is a complex and strong tectonic deformation zone that is oriented from east to west. The area in Northwes…
View article: Research on Psychological Treatment of Depression Based on Virtual Reality Technology
Research on Psychological Treatment of Depression Based on Virtual Reality Technology Open
Depression is one of the most diagnosed mental illnesses in modern society, with leading causes such as psycho-trauma concerning interpersonal relationships, primarily relationships and familial dynamics, and both physical and psychologica…
View article: A Synthetic Data-Driven Radiology Foundation Model for Pan-tumor Clinical Diagnosis
A Synthetic Data-Driven Radiology Foundation Model for Pan-tumor Clinical Diagnosis Open
AI-assisted imaging made substantial advances in tumor diagnosis and management. However, a major barrier to developing robust oncology foundation models is the scarcity of large-scale, high-quality annotated datasets, which are limited by…
View article: Study on the Impact Resistance of the Honeycomb Composite Sandwich Structure by a Fragment Flight Angle
Study on the Impact Resistance of the Honeycomb Composite Sandwich Structure by a Fragment Flight Angle Open
At present, the typical targets in the air are mainly high-speed impact bodies such as fragments, which pose a great threat to aviation equipment such as drones. It is urgent to study the impact resistance of different initial conditions o…
View article: Reduced intestinal‐to‐diffuse conversion and immunosuppressive responses underlie superiority of neoadjuvant immunochemotherapy in gastric adenocarcinoma
Reduced intestinal‐to‐diffuse conversion and immunosuppressive responses underlie superiority of neoadjuvant immunochemotherapy in gastric adenocarcinoma Open
Neoadjuvant immunochemotherapy (NAIC) achieves superior clinical benefits over neoadjuvant chemotherapy (NAC) in multiple types of human cancers, including gastric adenocarcinoma (GAC). However, it is poorly understood how the malignant ep…
View article: A Comprehensive Survey of Direct Preference Optimization: Datasets, Theories, Variants, and Applications
A Comprehensive Survey of Direct Preference Optimization: Datasets, Theories, Variants, and Applications Open
With the rapid advancement of large language models (LLMs), aligning policy models with human preferences has become increasingly critical. Direct Preference Optimization (DPO) has emerged as a promising approach for alignment, acting as a…
View article: Energy Absorption and Damage Analysis of Fragments in High-Speed Impact on Composite Honeycomb Sandwich Structures
Energy Absorption and Damage Analysis of Fragments in High-Speed Impact on Composite Honeycomb Sandwich Structures Open
With the continuous innovation of UAV technology, composite honeycomb sandwich structures are used more and more in the fuselage structure of UAVs, and their anti-high-speed fragment impact performance has become a concern. In order to stu…
View article: Cleavage of CAD by caspase-3 determines the cancer cell fate during chemotherapy
Cleavage of CAD by caspase-3 determines the cancer cell fate during chemotherapy Open
Metabolic heterogeneity resulting from the intrinsic heterogeneity of human tumors has been shown to cause a myriad of adverse outcomes of tumor therapy, including resistance to chemotherapy, but the mechanisms inside remain largely unknow…
View article: Advances and Prospects in Liquid Biopsy Techniques for Malignant Tumor Diagnosis and Surveillance
Advances and Prospects in Liquid Biopsy Techniques for Malignant Tumor Diagnosis and Surveillance Open
Liquid biopsy technology provides invaluable support for the early diagnosis of tumors and surveillance of disease course by detecting tumor‐related biomarkers in bodily fluids. Currently, liquid biopsy techniques are mainly divided into t…