Ning Zheng
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View article: Liouville Type Theorems for a Class of General Parabolic Hessian Quotient Type Equations
Liouville Type Theorems for a Class of General Parabolic Hessian Quotient Type Equations Open
We first consider the a priori estimates to a class of general parabolic $(k,l)-$ Hessian quotient type equations of the formwith $0{\le}1
View article: UBR-1 enzyme network regulates glutamate homeostasis to affect organismal behavior and developmental viability
UBR-1 enzyme network regulates glutamate homeostasis to affect organismal behavior and developmental viability Open
Johanson-Blizzard Syndrome (JBS) is an autosomal recessive spectrum disorder associated with the UBR-1 ubiquitin ligase that features developmental delay including motor abnormalities. Here, we demonstrate that C. elegans UBR-1 regulates h…
View article: Metagenomic next-generation sequencing-based characterization of the viral spectrum in clinical pulmonary and peripheral blood samples of patients
Metagenomic next-generation sequencing-based characterization of the viral spectrum in clinical pulmonary and peripheral blood samples of patients Open
Background Metagenomic next-generation sequencing (mNGS) enables comprehensive profiling of viral communities in clinical samples. However, comparative analyses of the virome across anatomical compartments and disease states remain limited…
View article: PCMT1 generates the C-terminal cyclic imide degron on CRBN substrates
PCMT1 generates the C-terminal cyclic imide degron on CRBN substrates Open
The E3 ligase substrate adapter cereblon (CRBN), the primary target of clinical agents thalidomide and lenalidomide, recognizes endogenous substrates bearing the C-terminal cyclic imide modification. Although C-terminal cyclic imides can f…
View article: Investigating the relationships of structural and functional neural networks of primary visual cortex with engineered AAVs and chemogenetic-fMRI techniques
Investigating the relationships of structural and functional neural networks of primary visual cortex with engineered AAVs and chemogenetic-fMRI techniques Open
Rationale: Neural networks are crucial for brain function, but the relationship between functional and structural networks remains unclear, hindering disease understanding and treatment. This study employs AAVs, MRI reporter gene (A…
View article: Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations
Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations Open
View article: UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors
UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors Open
View article: Recognition of BACH1 quaternary structure degrons by two F-box proteins under oxidative stress
Recognition of BACH1 quaternary structure degrons by two F-box proteins under oxidative stress Open
Ubiquitin-dependent proteolysis regulates diverse cellular functions with high substrate specificity, which hinges on the ability of ubiquitin E3 ligases to decode the targets' degradation signals, i.e., degrons. Here, we show that BACH1, …
View article: An artificial intelligence accelerated virtual screening platform for drug discovery
An artificial intelligence accelerated virtual screening platform for drug discovery Open
Structure-based virtual screening is a key tool in early drug discovery, with growing interest in the screening of multi-billion chemical compound libraries. However, the success of virtual screening crucially depends on the accuracy of th…
View article: Anchored PKA synchronizes adrenergic phosphoregulation of cardiac Cav1.2 channels
Anchored PKA synchronizes adrenergic phosphoregulation of cardiac Cav1.2 channels Open
Adrenergic modulation of voltage gated Ca2+ currents is a context specific process. In the heart Cav1.2 channels initiate excitation-contraction coupling. This requires PKA phosphorylation of the small GTPase Rad (Ras…
View article: DCAF15 control of cohesin dynamics sustains acute myeloid leukemia
DCAF15 control of cohesin dynamics sustains acute myeloid leukemia Open
View article: Distinct Perception Mechanisms of BACH1 Quaternary Structure Degrons by Two F-box Proteins under Oxidative Stress
Distinct Perception Mechanisms of BACH1 Quaternary Structure Degrons by Two F-box Proteins under Oxidative Stress Open
SUMMARY The transcription factor BACH1 regulates heme homeostasis and oxidative stress responses and promotes cancer metastasis upon aberrant accumulation. Its stability is controlled by two F-box protein ubiquitin ligases, FBXO22 and FBXL…
View article: William A. Catterall (1946–2024)
William A. Catterall (1946–2024) Open
View article: KBTBD4 Cancer Hotspot Mutations Drive Neomorphic Degradation of HDAC1/2 Corepressor Complexes
KBTBD4 Cancer Hotspot Mutations Drive Neomorphic Degradation of HDAC1/2 Corepressor Complexes Open
Cancer mutations can create neomorphic protein-protein interactions to drive aberrant function 1 . As a substrate receptor of the CULLIN3-RBX1 E3 ubiquitin ligase complex, KBTBD4 is recurrently mutated in medulloblastoma (MB) 2 , the most …
View article: Asymmetric Engagement of Dimeric CRL3<sup>KBTBD4</sup>by the Molecular Glue UM171 Licenses Degradation of HDAC1/2 Complexes
Asymmetric Engagement of Dimeric CRL3<sup>KBTBD4</sup>by the Molecular Glue UM171 Licenses Degradation of HDAC1/2 Complexes Open
UM171 is a potent small molecule agonist of ex vivo human hematopoietic stem cell (HSC) self-renewal, a process that is tightly controlled by epigenetic regulation. By co-opting KBTBD4, a substrate receptor of the CULLIN3-RING E3 ubiquitin…
View article: The Shigella kinase effector OspG modulates host ubiquitin signaling to escape septin-cage entrapment
The Shigella kinase effector OspG modulates host ubiquitin signaling to escape septin-cage entrapment Open
Shigella flexneri is a Gram-negative bacterium causing severe bloody dysentery. Its pathogenesis is largely dictated by a plasmid-encoded type III secretion system (T3SS) and its associated effectors. Among these, the effector OspG has bee…
View article: An artificial intelligence accelerated virtual screening platform for drug discovery
An artificial intelligence accelerated virtual screening platform for drug discovery Open
Structure-based virtual screening is a key tool in early drug discovery, with growing interest in the screening of multi-billion chemical compound libraries. However, the success of virtual screening crucially depends on the accuracy of th…
View article: Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin
Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin Open
View article: Altered interaction network in the gut microbiota of current cigarette smokers
Altered interaction network in the gut microbiota of current cigarette smokers Open
The association between cigarette smoking and the gut microbiota remains unclear, and there is no agreement on how smoking affects the composition of gut microorganisms. In this study, the relationship between smoking status and gut microb…
View article: Enrichment Pretreatment Expands the Microbial Diversity Cultivated from Marine Sediments
Enrichment Pretreatment Expands the Microbial Diversity Cultivated from Marine Sediments Open
The majority of the microbial diversity in nature has not been recovered through cultivation. Enrichment is a classical technique widely used in the selective cultivation of specific taxa. Whether enrichment is suitable for cultivation stu…
View article: Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7
Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7 Open
Voltage-gated sodium channels in peripheral nerves conduct nociceptive signals from nerve endings to the spinal cord. Mutations in voltage-gated sodium channel NaV1.7 are responsible for a number of severe inherited pain syndromes, includi…
View article: Structural basis for inhibition of the cardiac sodium channel by the atypical antiarrhythmic drug ranolazine
Structural basis for inhibition of the cardiac sodium channel by the atypical antiarrhythmic drug ranolazine Open
View article: Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na <sub>V</sub> 1.7
Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na <sub>V</sub> 1.7 Open
Gain-of-function mutations in voltage-gated sodium channel Na V 1.7 cause severe inherited pain syndromes, including inherited erythromelalgia (IEM). The structural basis of these disease mutations, however, remains elusive. Here, we focus…
View article: Total chemical synthesis of sumoylated histone H4 reveals negative biochemical crosstalk with histone ubiquitylation
Total chemical synthesis of sumoylated histone H4 reveals negative biochemical crosstalk with histone ubiquitylation Open
An efficient total chemical synthesis of site-specifically sumoylated histone H4 revealed its negative biochemical crosstalk with histone H2B ubiquitylation in vitro and in human cells.
View article: Analyses of Cullin1 homologs reveal functional redundancy in S-RNase-based self-incompatibility and evolutionary relationships in eudicots
Analyses of Cullin1 homologs reveal functional redundancy in S-RNase-based self-incompatibility and evolutionary relationships in eudicots Open
In Petunia (Solanaceae family), self-incompatibility (SI) is regulated by the polymorphic S-locus, which contains the pistil-specific S-RNase and multiple pollen-specific S-Locus F-box (SLF) genes. SLFs assemble into E3 ubiquitin ligase co…
View article: Loss-of-function variants in<i>MYCBP2</i>cause neurobehavioural phenotypes and corpus callosum defects
Loss-of-function variants in<i>MYCBP2</i>cause neurobehavioural phenotypes and corpus callosum defects Open
The corpus callosum is a bundle of axon fibres that connects the two hemispheres of the brain. Neurodevelopmental disorders that feature dysgenesis of the corpus callosum as a core phenotype offer a valuable window into pathology derived f…
View article: INOSITOL (1,3,4) TRIPHOSPHATE 5/6 KINASE1-dependent inositol polyphosphates regulate auxin responses in Arabidopsis
INOSITOL (1,3,4) TRIPHOSPHATE 5/6 KINASE1-dependent inositol polyphosphates regulate auxin responses in Arabidopsis Open
The combinatorial phosphorylation of myo-inositol results in the generation of different inositol phosphates (InsPs), of which phytic acid (InsP6) is the most abundant species in eukaryotes. InsP6 is also an important precursor of the high…
View article: Defining molecular glues with a dual-nanobody cannabidiol sensor
Defining molecular glues with a dual-nanobody cannabidiol sensor Open
“Molecular glue” (MG) is a term coined to describe the mechanism of action of the plant hormone auxin and subsequently used to characterize synthetic small molecule protein degraders exemplified by immune-modulatory imide drugs (IMiDs). Pr…
View article: Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor
Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor Open
c-Myc (hereafter, Myc) is a cancer driver whose abundance is regulated by the SCF Fbw7 ubiquitin ligase and proteasomal degradation. Fbw7 binds to a phosphorylated Myc degron centered at threonine 58 (T58), and mutations of Fbw7 or T58 imp…
View article: The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic target
The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic target Open