Zheng Quan Toh
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View article: IgG Antibodies to Pneumococcal Serotypes 1 and 5 in Relation to PCV13 Vaccination Status in Children Aged Under 5 Years in Lao PDR: A Cross-Sectional Survey
IgG Antibodies to Pneumococcal Serotypes 1 and 5 in Relation to PCV13 Vaccination Status in Children Aged Under 5 Years in Lao PDR: A Cross-Sectional Survey Open
Background/Objectives: Pneumococcal serotypes 1 and 5 are associated with invasive pneumococcal disease (IPD). However, data on the circulation of these serotypes in Asia following the introduction of the pneumococcal conjugate vaccine (PC…
View article: Differentiating Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Responses Between Infection and Vaccination: Challenges for Epidemiological Research
Differentiating Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Responses Between Infection and Vaccination: Challenges for Epidemiological Research Open
Some common coronavirus disease 2019 (COVID-19) vaccines elicit antibody responses that most serological tests are unable to differentiate from an infection response. This presents a challenge for COVID-19 epidemiology and serosurveys. In …
View article: Agreement between self-reported COVID-19 and dried blood spot serology
Agreement between self-reported COVID-19 and dried blood spot serology Open
Introduction Identifying likely COVID-19 cases with good accuracy is essential for epidemiological research on the pandemic’s health effects. Therefore, evaluating case detection methods for cost-effectiveness and reliability is important.…
View article: Systems serology analysis shows IgG1 and IgG3 memory responses six years after one dose of quadrivalent HPV vaccine
Systems serology analysis shows IgG1 and IgG3 memory responses six years after one dose of quadrivalent HPV vaccine Open
View article: The immunogenicity, reactogenicity, and safety of a bivalent mRNA or protein COVID-19 vaccine given as a fourth dose
The immunogenicity, reactogenicity, and safety of a bivalent mRNA or protein COVID-19 vaccine given as a fourth dose Open
At day 28 post-vaccination, higher immunogenicity was observed following Moderna vaccination compared to Novavax vaccination when given as a fourth dose in healthy adults for Ancestral and Omicron subvariants, including JN.1. However, loca…
View article: Evaluation of SARS-CoV-2 Antibody Response Between Paired Fingerprick (HemaPEN®) and Venepuncture Collected Samples in Children and Adults
Evaluation of SARS-CoV-2 Antibody Response Between Paired Fingerprick (HemaPEN®) and Venepuncture Collected Samples in Children and Adults Open
Serological surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies is important to monitor population COVID-19 immunity. Dried blood spots (DBS) are a valuable method for serosurveys, particularly in remote…
View article: Memory B cell responses induced by pneumococcal conjugate vaccine schedules with fewer doses: analysis of a randomised-controlled trial in Viet Nam
Memory B cell responses induced by pneumococcal conjugate vaccine schedules with fewer doses: analysis of a randomised-controlled trial in Viet Nam Open
View article: Evaluation of SARS-CoV-2 antibody response between paired fingerprick (hemaPEN®) and venepuncture collected samples in children and adults
Evaluation of SARS-CoV-2 antibody response between paired fingerprick (hemaPEN®) and venepuncture collected samples in children and adults Open
Serological surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies is important to monitor population COVID-19 immunity. Dried blood spots (DBS) are a valuable method for serosurveys, particularly in remote…
View article: Immunogenicity of BNT162b2 as a first booster after a ChAdOx1 primary series in a Thai geriatric population living with frailty
Immunogenicity of BNT162b2 as a first booster after a ChAdOx1 primary series in a Thai geriatric population living with frailty Open
The parent study was registered under the Thai Clinical Trials Registry (TCTR20220112002).
View article: Memory B cell responses induced by pneumococcal conjugate vaccine schedules with fewer doses: analysis of a randomised-controlled trial in Viet Nam
Memory B cell responses induced by pneumococcal conjugate vaccine schedules with fewer doses: analysis of a randomised-controlled trial in Viet Nam Open
The use of pneumococcal conjugate vaccine (PCV) schedules with fewer doses are being considered to reduce costs and improve access, particularly in low- and middle-income countries. While several studies have assessed their immunogenicity,…
View article: Development of a human papillomavirus (HPV) multiplex immunoassay to profile HPV antibodies
Development of a human papillomavirus (HPV) multiplex immunoassay to profile HPV antibodies Open
Neutralizing antibodies (NAbs) are considered the primary mechanism of vaccine‐mediated protection against human papillomaviruses (HPV), the causative agent of cervical cancer. However, the minimum level of NAb needed for protection is cur…
View article: Immunogenicity and reactogenicity of repeated intradermal mRNA COVID-19 vaccines administered as a second booster dose in a Thai geriatric population
Immunogenicity and reactogenicity of repeated intradermal mRNA COVID-19 vaccines administered as a second booster dose in a Thai geriatric population Open
Background Geriatric populations are at an increased risk of severe presentations, hospitalization, and loss of life from COVID-19. Few studies have explored vaccination regimens in adults >65 years old. Repeated booster vaccination is …
View article: Editorial: HPV natural history, immunological responses and vaccination strategies: challenges and opportunities
Editorial: HPV natural history, immunological responses and vaccination strategies: challenges and opportunities Open
EDITORIAL article Front. Immunol., 08 January 2024Sec. Viral Immunology Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1349664
View article: The Immunogenicity, Reactogenicity, and Safety of a Bivalent mRNA or Protein-Based COVID-19 Vaccine Given as a Fourth Dose in Healthy Adults in Australia: a Randomised Controlled Trial
The Immunogenicity, Reactogenicity, and Safety of a Bivalent mRNA or Protein-Based COVID-19 Vaccine Given as a Fourth Dose in Healthy Adults in Australia: a Randomised Controlled Trial Open
View article: Humoral and cellular immune responses in vaccinated and unvaccinated children following SARS‐CoV‐2 Omicron infection
Humoral and cellular immune responses in vaccinated and unvaccinated children following SARS‐CoV‐2 Omicron infection Open
Objectives The immune response in children elicited by SARS‐CoV‐2 Omicron infection alone or in combination with COVID‐19 vaccination (hybrid immunity) is poorly understood. We examined the humoral and cellular immune response following SA…
View article: Immunogenicity and reactogenicity of fractional, heterologous primary COVID-19 vaccination schedules with BNT162b2 boosters in 5–11-year-old Thai children: A multicenter, prospective, double-blind, randomized control trial
Immunogenicity and reactogenicity of fractional, heterologous primary COVID-19 vaccination schedules with BNT162b2 boosters in 5–11-year-old Thai children: A multicenter, prospective, double-blind, randomized control trial Open
Standard and fractional heterologous regimens of CoronaVac-BNT162b2 induced similar or higher humoral immunity than homologous BNT162b2 and represent alternative vaccine regimens for children. These findings are highly relevant in settings…
View article: The immunogenicity and reactogenicity of four COVID-19 booster vaccinations against SARS-CoV-2 variants following CoronaVac or ChAdOx1 nCoV-19 primary series
The immunogenicity and reactogenicity of four COVID-19 booster vaccinations against SARS-CoV-2 variants following CoronaVac or ChAdOx1 nCoV-19 primary series Open
Heterologous boosting with BNT162b2 following CoronaVac or ChAdOx1 primary series is most immunogenic. Additional studies are needed to verify the clinical efficacy and persistence of immunity following half-dose BNT162b2.
View article: Immunogenicity and reactogenicity of heterologous COVID-19 vaccination in pregnant women
Immunogenicity and reactogenicity of heterologous COVID-19 vaccination in pregnant women Open
This open-labeled non-inferiority trial evaluated immunogenicity and reactogenicity of heterologous and homologous COVID-19 vaccination schedules in pregnant Thai women. 18–45-year-old pregnant women with no history of COVID-19 infection o…
View article: Immunogenicity and Reactogenicity of Messenger RNA Coronavirus Disease 2019 Vaccine Booster Administered by Intradermal or Intramuscular Route in Thai Older Adults
Immunogenicity and Reactogenicity of Messenger RNA Coronavirus Disease 2019 Vaccine Booster Administered by Intradermal or Intramuscular Route in Thai Older Adults Open
Background Intradermal (ID) vaccination may alleviate COVID-19 vaccine shortages and vaccine hesitancy. Methods Persons aged ≥65 years who were vaccinated with 2-dose ChAdOx1 12–24 weeks earlier were randomized to receive a booster vaccina…
View article: Immunogenicity and reactogenicity of accelerated regimens of fractional intradermal COVID-19 vaccinations
Immunogenicity and reactogenicity of accelerated regimens of fractional intradermal COVID-19 vaccinations Open
Introduction This phase I study explored the immunogenicity and reactogenicity of accelerated, Q7 fractional, intradermal vaccination regimens for COVID-19. Methods Participants (n = 60) aged 18-60 years, naïve to SARS-CoV-2 infection or v…
View article: Immunogenicity and reactogenicity of mRNA COVID-19 vaccine booster administered by intradermal or intramuscular route in Thai Older adults
Immunogenicity and reactogenicity of mRNA COVID-19 vaccine booster administered by intradermal or intramuscular route in Thai Older adults Open
Introduction Intradermal (ID) vaccination may alleviate COVID-19 vaccine shortages and vaccine hesitancy due to systemic reactogenicity among older adults. Objectives To compare the immunogenicity and reactogenicity of fractional ID and st…
View article: Comparison of antibody responses to SARS-CoV-2 variants in Australian children
Comparison of antibody responses to SARS-CoV-2 variants in Australian children Open
View article: Prevalence and risk factors for human papillomavirus infection among female sex workers in Hanoi and Ho Chi Minh City, Viet Nam: a cross-sectional study
Prevalence and risk factors for human papillomavirus infection among female sex workers in Hanoi and Ho Chi Minh City, Viet Nam: a cross-sectional study Open
Background: Female sex workers (FSWs) are at high risk of human papillomavirus (HPV) infections and cervical cancer due to their high number of sexual partners. The objectives of this study were to determine the prevalence of HPV and ident…
View article: Safety and immunogenicity of intradermal administration of fractional dose CoronaVac®, ChAdOx1 nCoV-19 and BNT162b2 as primary series vaccination
Safety and immunogenicity of intradermal administration of fractional dose CoronaVac®, ChAdOx1 nCoV-19 and BNT162b2 as primary series vaccination Open
There is a limited supply of COVID-19 vaccines, with less than 20% of eligible populations in low-income countries having received one dose. Intradermal delivery of fractional dose vaccines is one way to improve global vaccine access, but …
View article: Evaluation of the Safety and Immunogenicity of Fractional Intradermal COVID-19 Vaccines as a Booster: A Pilot Study
Evaluation of the Safety and Immunogenicity of Fractional Intradermal COVID-19 Vaccines as a Booster: A Pilot Study Open
Intradermal vaccination using fractional dosages of the standard vaccine dose is one strategy to improve access to COVID-19 immunization. We conducted a pilot study in healthy adults in Thailand to evaluate the safety and immunogenicity of…
View article: SARS-CoV-2 infection in children and implications for vaccination
SARS-CoV-2 infection in children and implications for vaccination Open
View article: Comparison of antibody responses to SARS-CoV-2 variants in Australian children
Comparison of antibody responses to SARS-CoV-2 variants in Australian children Open
There is limited understanding of antibody responses in children across different SARS-CoV-2 variants. As part of an ongoing household cohort study, we assessed the antibody response among unvaccinated children infected with Wuhan, Delta o…
View article: Safety and Immunogenicity of Intradermal Administration of Fractional Dose CoronaVac<sup>®</sup>, ChAdOx1 nCoV-19 and BNT162b2 as Primary Series Vaccination
Safety and Immunogenicity of Intradermal Administration of Fractional Dose CoronaVac<sup>®</sup>, ChAdOx1 nCoV-19 and BNT162b2 as Primary Series Vaccination Open
There is a limited supply of COVID-19 vaccines, with less than 20% of eligible populations in low-income countries having received one dose. Intradermal delivery of fractional dose vaccines is one way to improve global vaccine access, but …
View article: Evaluation of the safety and immunogenicity of fractional intradermal COVID-19 vaccines as a booster: A pilot study
Evaluation of the safety and immunogenicity of fractional intradermal COVID-19 vaccines as a booster: A pilot study Open
Intradermal vaccination using fractional dosage of the standard vaccine dose is one strategy to improve access to COVID-19 immunization. We conducted a pilot study in healthy adults in Thailand to evaluate the safety and immunogenicity of …
View article: Review 2: "Safety, Immunogenicity and Antibody Persistence of a Bivalent Beta-Containing Booster Vaccine"
Review 2: "Safety, Immunogenicity and Antibody Persistence of a Bivalent Beta-Containing Booster Vaccine" Open
While this study presents important data for new-generation COVID-19 vaccines, uncertainty about the study design and reporting of outcomes suggests that the findings should be interpreted with caution.