Zheng Li
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View article: Machine learning-based time-to-event survival analysis in pediatric patients with severe sepsis
Machine learning-based time-to-event survival analysis in pediatric patients with severe sepsis Open
Background Pediatric sepsis remains a leading cause of mortality in critically ill children worldwide. Current approaches to sepsis prognosis rely on clinical criteria and biomarkers with variable performance. This study aimed to develop a…
View article: Research on the Mechanism of Action of Traditional Chinese and Western Medicine and the Course of Treatment for Shenrongbian Pills in the Treatment of Impotence and Premature Ejaculation
Research on the Mechanism of Action of Traditional Chinese and Western Medicine and the Course of Treatment for Shenrongbian Pills in the Treatment of Impotence and Premature Ejaculation Open
Objective: To investigate the clinical efficacy, mechanism of action of traditional Chinese and Western medicine, and reasonable treatment regimen of Shenrongbian pills in the treatment of impotence and premature ejaculation caused by…
View article: The Advantages of Shenrongbian Pills Combined with PDE5 Inhibitors in the Treatment of Impotence
The Advantages of Shenrongbian Pills Combined with PDE5 Inhibitors in the Treatment of Impotence Open
Objective: To investigate the clinical advantages of Shenrongbian Pills combined with PDE5 inhibitors in the treatment of impotence. Methods: A total of 160 patients with impotence were randomly divided into a combination therapy…
View article: Quantitative Structure–Activity Relationship Study of Cathepsin L Inhibitors as SARS-CoV-2 Therapeutics Using Enhanced SVR with Multiple Kernel Function and PSO
Quantitative Structure–Activity Relationship Study of Cathepsin L Inhibitors as SARS-CoV-2 Therapeutics Using Enhanced SVR with Multiple Kernel Function and PSO Open
Cathepsin L (CatL) is a critical protease involved in cleaving the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), facilitating viral entry into host cells. Inhibition of CatL is essential for preventing SARS…
View article: Awareness, knowledge and practices related to intra-abdominal hypertension and abdominal compartment syndrome among intensive care providers: a systematic scoping review
Awareness, knowledge and practices related to intra-abdominal hypertension and abdominal compartment syndrome among intensive care providers: a systematic scoping review Open
View article: Analysis of immune characteristics and inflammatory mechanisms in COPD patients: a multi-layered study combining bulk and single-cell transcriptome analysis and machine learning
Analysis of immune characteristics and inflammatory mechanisms in COPD patients: a multi-layered study combining bulk and single-cell transcriptome analysis and machine learning Open
Objective This study aims to investigate the potential roles and mechanisms of inflammatory genes in COPD. Methods Transcriptome data from the airway epithelial tissues of COPD patients and normal individuals were downloaded from the GEO d…
View article: A comprehensive review of Intelligent Question-Answering Systems in Traditional Chinese Medicine Based on LLMs
A comprehensive review of Intelligent Question-Answering Systems in Traditional Chinese Medicine Based on LLMs Open
View article: Effectiveness and safety of Shengxuening for treatment of renal anemia: a comprehensive systematic review and meta-analysis
Effectiveness and safety of Shengxuening for treatment of renal anemia: a comprehensive systematic review and meta-analysis Open
Aim We aimed to evaluate the efficacy and safety of Shengxuening (SXN) in treating renal anemia by systematic review and meta-analysis. Methods PubMed, Embase, the Cochrane Library, the ClinicalTrials.gov , SinoMed, the China Knowledge Net…
View article: Sequential Policy Gradient for Adaptive Hyperparameter Optimization
Sequential Policy Gradient for Adaptive Hyperparameter Optimization Open
Reinforcement learning is essential for neural architecture search and hyperparameter optimization, but the conventional approaches impede widespread use due to prohibitive time and computational costs. Inspired by DeepSeek-V3 multi-token …
View article: Dynamic Changes in the Gut Microbiota During Peripartum in Jennies
Dynamic Changes in the Gut Microbiota During Peripartum in Jennies Open
The peripartum period is critical for breeding female donkeys (i.e., jennies) and ensuring the delivery of healthy neonatal foals. The gut microbiota deeply influences the host metabolism. This study aimed to investigate the dynamic change…
View article: Response of the gut microbiota to changes in the nutritional status of red deer during winter
Response of the gut microbiota to changes in the nutritional status of red deer during winter Open
Unravelling abrupt alterations in the gut microbiota of wild species associated with nutritional stress is imperative but challenging for wildlife conservation. This study assessed the nutritional status of wild red deer during winter on t…
View article: WITHDRAWN: Characterization of Ag2O nanorods/TiO2 nanotubes hybrid coating for potential orthopedic implant applications
WITHDRAWN: Characterization of Ag2O nanorods/TiO2 nanotubes hybrid coating for potential orthopedic implant applications Open
View article: Prevalence and risk of nonalcoholic fatty liver disease among adult psoriatic patients: A systematic review, meta-analysis, and trial sequential analysis
Prevalence and risk of nonalcoholic fatty liver disease among adult psoriatic patients: A systematic review, meta-analysis, and trial sequential analysis Open
Background: This systematic review and meta-analysis aimed to report the evaluation of the prevalence and risk of nonalcoholic fatty liver disease (NAFLD) among adult psoriatic patients in a systematic review and meta-analysis. Methods: A …
View article: Damage Mechanism Investigation on Fiber Reinforced Recycled Cement Aggregate Concrete in a Cold Region
Damage Mechanism Investigation on Fiber Reinforced Recycled Cement Aggregate Concrete in a Cold Region Open
In order to investigate the internal damage mechanism of carbon fiber-reinforced recycled concrete, microscopic, mechanical, and freeze-thaw cycle experimental programs were conducted. Three categories of recycled concrete specimens with d…
View article: Integrating Transcriptome and Chemical Analyses to Provide Insights into Biosynthesis of Terpenoids and Flavonoids in the Medicinal Industrial Crop Andrographis paniculate and Its Antiviral Medicinal Parts
Integrating Transcriptome and Chemical Analyses to Provide Insights into Biosynthesis of Terpenoids and Flavonoids in the Medicinal Industrial Crop Andrographis paniculate and Its Antiviral Medicinal Parts Open
Andrographis paniculata is a medicinal plant traditionally used to produce diterpene lactones and flavonoids, which possess various biological activities. Widely distributed in China, India, and other Southeast Asia countries, A. paniculat…
View article: Comparative Analysis of Volatile Compounds in the Flower Buds of Three Panax Species Using Fast Gas Chromatography Electronic Nose, Headspace-Gas Chromatography-Ion Mobility Spectrometry, and Headspace Solid Phase Microextraction-Gas Chromatography-Mass Spectrometry Coupled with Multivariate Statistical Analysis
Comparative Analysis of Volatile Compounds in the Flower Buds of Three Panax Species Using Fast Gas Chromatography Electronic Nose, Headspace-Gas Chromatography-Ion Mobility Spectrometry, and Headspace Solid Phase Microextraction-Gas Chromatography-Mass Spectrometry Coupled with Multivariate Statistical Analysis Open
The flower buds of three Panax species (PGF: P. ginseng; PQF: P. quinquefolius; PNF: P. notoginseng) widely consumed as health tea are easily confused in market circulation. We aimed to develop a green, fast, and easy analysis strategy to …
View article: A New Strategy to Control Low Temperature Stress of Maize in North China: Phosphorus Fertilization Compensating Growing Degree Days
A New Strategy to Control Low Temperature Stress of Maize in North China: Phosphorus Fertilization Compensating Growing Degree Days Open
View article: Toxic Effects of Chlorantraniliprole on Zebrafish (Danio Rerio) at Different Developmental Stages Under Antibiotic Pressure
Toxic Effects of Chlorantraniliprole on Zebrafish (Danio Rerio) at Different Developmental Stages Under Antibiotic Pressure Open
View article: An Exploration of Dynamic Changes in the Mulberry Growth Process Based on UPLC-Q-Orbitrap-MS, HS-SPME-GC-MS, and HS-GC-IMS
An Exploration of Dynamic Changes in the Mulberry Growth Process Based on UPLC-Q-Orbitrap-MS, HS-SPME-GC-MS, and HS-GC-IMS Open
This work was designed to investigate the dynamic changes process of non-volatile organic compounds (n-VOCs) and volatile organic compounds (VOCs) in mulberries during different growth periods using UPLC-Q-Orbitrap-MS, HS-SPME-GC-MS, and H…
View article: Chemical constituents, pharmacological activities and quality evaluation methods of genus Hippocampus: A comprehensive review
Chemical constituents, pharmacological activities and quality evaluation methods of genus Hippocampus: A comprehensive review Open
The genus Hippocampus is a multi-origin animal species with high medicinal and healthcare values. About 57 species of Hippocampus spread worldwide, of which about 14 species can be used as medicine, showing anti-oxidation, an…
View article: Study of Archaeal Diversity in the Arctic Meltwater Lake Region
Study of Archaeal Diversity in the Arctic Meltwater Lake Region Open
Two typical lakes formed from meltwater in the Ny-Ålesund area were taken as the study subjects in 2018. To investigate the archaeal community compositions of the two lakes, 16S rRNA genes from soil samples from the intertidal and subtidal…
View article: Deep Learning Network of Amomum villosum Quality Classification and Origin Identification Based on X-ray Technology
Deep Learning Network of Amomum villosum Quality Classification and Origin Identification Based on X-ray Technology Open
A machine vision system based on a convolutional neural network (CNN) was proposed to sort Amomum villosum using X-ray non-destructive testing technology in this study. The Amomum villosum fruit network (AFNet) algorithm was developed to i…
View article: Characterization of the key volatile organic components of different parts of fresh and dried perilla frutescens based on headspace-gas chromatography-ion mobility spectrometry and headspace solid phase microextraction-gas chromatography-mass spectrometry
Characterization of the key volatile organic components of different parts of fresh and dried perilla frutescens based on headspace-gas chromatography-ion mobility spectrometry and headspace solid phase microextraction-gas chromatography-mass spectrometry Open
Perilla frutescens was an annual herb considered as one of the “One Root of Medicine and Food”, and it was used widely for food and medical treatment. Its main active ingredients were volatile organic compounds (VOCs), but it was easily af…
View article: An online automatic sorting system for defective Ginseng Radix et Rhizoma Rubra using deep learning
An online automatic sorting system for defective Ginseng Radix et Rhizoma Rubra using deep learning Open
The overall results indicated that the proposed Faster R-CNN based classification model has great potential for non-destructive detection of red ginseng with internal defects.
View article: Immunoregulatory effects of Tetrastigma hemsleyanum polysaccharide via TLR4-mediated NF-κB and MAPK signaling pathways in Raw264.7 macrophages
Immunoregulatory effects of Tetrastigma hemsleyanum polysaccharide via TLR4-mediated NF-κB and MAPK signaling pathways in Raw264.7 macrophages Open
Polysaccharide of Tetrastigma hemsleyanum (THP) exert antioxidant, antibacterial, lipid-lowering, and anti-inflammatory properties, especially some evidences have highlighted the efficiency of it as an anti-tumor agent. However, as a biolo…
View article: Quantification and Holistic Quality Evaluation of Wulingzhi Extract by HPLC-QE- Orbitrap-HRMS Coupled with Chemometric Approaches
Quantification and Holistic Quality Evaluation of Wulingzhi Extract by HPLC-QE- Orbitrap-HRMS Coupled with Chemometric Approaches Open
View article: Integration of Non-Targeted Multicomponent Profiling, Targeted Characteristic Chromatograms and Quantitative to Accomplish Systematic Quality Evaluation Strategy of Huo-Xiang-Zheng-Qi Oral Liquid
Integration of Non-Targeted Multicomponent Profiling, Targeted Characteristic Chromatograms and Quantitative to Accomplish Systematic Quality Evaluation Strategy of Huo-Xiang-Zheng-Qi Oral Liquid Open
View article: Investigation on Psychological Status of Patients with Cervical Precancerous Lesions and Cancer Among Han and Ethnic Minority in Yunnan Province of China
Investigation on Psychological Status of Patients with Cervical Precancerous Lesions and Cancer Among Han and Ethnic Minority in Yunnan Province of China Open
View article: Extensive Evaluation of Plasma Metabolic Sample Preparation Process Based on Liquid Chromatography-Mass Spectrometry and its Application in the in Vivo Metabolism of Shuang-Huang-Lian Powder Injection
Extensive Evaluation of Plasma Metabolic Sample Preparation Process Based on Liquid Chromatography-Mass Spectrometry and its Application in the in Vivo Metabolism of Shuang-Huang-Lian Powder Injection Open
View article: Effects of T-2 toxin on growth performance, feather quality, tibia development and blood parameters in Yangzhou goslings
Effects of T-2 toxin on growth performance, feather quality, tibia development and blood parameters in Yangzhou goslings Open