Zhengbing Zhuge
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View article: DNA methylation and immune regulation in osteoporosis: emerging epigenetic targets for drug discovery
DNA methylation and immune regulation in osteoporosis: emerging epigenetic targets for drug discovery Open
Osteoporosis (OP) is a complex skeletal disease characterized by the disruption of bone homeostasis, with immune dysregulation identified as a significant pathogenic cause. The interaction between immune cells and bone cells within the bon…
View article: Dietary Nitrate Prevents Cardiac Dysfunction in <scp>HFrEF</scp> by Improving Hemodynamics, Ameliorating Remodeling, and Resolving Inflammation
Dietary Nitrate Prevents Cardiac Dysfunction in <span>HFrEF</span> by Improving Hemodynamics, Ameliorating Remodeling, and Resolving Inflammation Open
Aims Impaired cardiac function, reduced nitric oxide (NO) bioavailability, and inflammation are key contributors to the pathogenesis and progression of heart failure with reduced ejection fraction (HFrEF). This study aimed to investigate w…
View article: Association between the oxidative balance score and testosterone deficiency in males: a cross-sectional study
Association between the oxidative balance score and testosterone deficiency in males: a cross-sectional study Open
Background Testosterone deficiency is a prevalent condition among males and warrants greater attention. The balance between oxidative and antioxidant capacity plays a critical role in testosterone deficiency. Methods This study conducted a…
View article: Divergent roles of red cell arginase in humans and mice: RBC Arg1 KO mice show preserved systemic l-arginine bioavailability and infarct size in vivo
Divergent roles of red cell arginase in humans and mice: RBC Arg1 KO mice show preserved systemic l-arginine bioavailability and infarct size in vivo Open
View article: Protective Effects of the Food Supplement Flexovital in a Model of Cardiovascular-Kidney-Metabolic Syndrome in Mice
Protective Effects of the Food Supplement Flexovital in a Model of Cardiovascular-Kidney-Metabolic Syndrome in Mice Open
Background/Objectives: The prevalence of cardiovascular-kidney-metabolic (CKM) syndrome is increasing rapidly, and cardiovascular complications pose significant risks in individuals with kidney disease and metabolic dysfunction. Understand…
View article: A novel model of cardiovascular–kidney–metabolic syndrome combining unilateral nephrectomy and high-salt–sugar–fat diet in mice
A novel model of cardiovascular–kidney–metabolic syndrome combining unilateral nephrectomy and high-salt–sugar–fat diet in mice Open
View article: Is NO-ferroheme a signaling entity?
Is NO-ferroheme a signaling entity? Open
Despite widespread recognition of nitric oxide (NO) synthase (NOS) signaling's biological significance, uncertainties persist regarding the chemical nature of NOS-derived bioactivity. Our research reveals that NO-like bioactivity can effic…
View article: NO-ferroheme is a signaling entity in the vasculature
NO-ferroheme is a signaling entity in the vasculature Open
View article: Cholinergic regulation of vascular endothelial function by human ChAT <sup>+</sup> T cells
Cholinergic regulation of vascular endothelial function by human ChAT <sup>+</sup> T cells Open
Endothelial dysfunction and impaired vasodilation are linked with adverse cardiovascular events. T lymphocytes expressing choline acetyltransferase (ChAT), the enzyme catalyzing biosynthesis of the vasorelaxant acetylcholine (ACh), regulat…
View article: NO-ferroheme is a signaling entity in the vasculature
NO-ferroheme is a signaling entity in the vasculature Open
Despite wide appreciation of the biological role of nitric oxide (NO) synthase (NOS) signaling, questions remain about the chemical nature of NOS-derived bioactivity. Here we show that NO-like bioactivity can be efficiently transduced by m…
View article: Red blood cells from endothelial nitric oxide synthase-deficient mice induce vascular dysfunction involving oxidative stress and endothelial arginase I
Red blood cells from endothelial nitric oxide synthase-deficient mice induce vascular dysfunction involving oxidative stress and endothelial arginase I Open
RBCs from mice lacking eNOS, and patients with preeclampsia, induce endothelial dysfunction in adjacent blood vessels. Thus, RBC-derived NO bioactivity acts to prevent induction of vascular oxidative stress occurring via RBC NOX4-derived R…
View article: Downregulation of eNOS and preserved endothelial function in endothelial-specific arginase 1-deficient mice
Downregulation of eNOS and preserved endothelial function in endothelial-specific arginase 1-deficient mice Open
Arginase 1 (Arg1) is a ubiquitous enzyme belonging to the urea cycle that catalyzes the conversion of l-arginine into l-ornithine and urea. In endothelial cells (ECs), Arg1 was proposed to limit the availability of l-arginine for the endot…
View article: Inorganic nitrate and nitrite ameliorate kidney fibrosis by restoring lipid metabolism via dual regulation of AMP-activated protein kinase and the AKT-PGC1α pathway
Inorganic nitrate and nitrite ameliorate kidney fibrosis by restoring lipid metabolism via dual regulation of AMP-activated protein kinase and the AKT-PGC1α pathway Open
View article: Identification and Characterization of Human Activation-Induced ChAT<sup>+</sup>CD4<sup>+</sup>T Cells
Identification and Characterization of Human Activation-Induced ChAT<sup>+</sup>CD4<sup>+</sup>T Cells Open
Vasodilation is a cornerstone of inflammation physiology. By regulating vasodilation and tissue entry of T cells, CD4 + T lymphocytes expressing choline acetyltransferase (ChAT), a key enzyme for biosynthesis of the vasorelaxant acetylchol…
View article: Renovascular effects of inorganic nitrate following ischemia-reperfusion of the kidney
Renovascular effects of inorganic nitrate following ischemia-reperfusion of the kidney Open
Acute treatment with inorganic nitrate prior to renal ischemia may serve as a novel therapeutic approach to prevent AKI and CKD and associated risk of developing cardiovascular dysfunction.
View article: Head-to-head comparison of inorganic nitrate and metformin in a mouse model of cardiometabolic disease
Head-to-head comparison of inorganic nitrate and metformin in a mouse model of cardiometabolic disease Open
Nitrate and metformin had equipotent metabolic effects, while nitrate was superior regarding protection against cardiovascular dysfunction and liver steatosis. If reproduced in future clinical trials, these findings may have implications f…
View article: Dietary nitrate attenuates high-fat diet-induced obesity via mechanisms involving higher adipocyte respiration and alterations in inflammatory status
Dietary nitrate attenuates high-fat diet-induced obesity via mechanisms involving higher adipocyte respiration and alterations in inflammatory status Open
Emerging evidence indicates that dietary nitrate can reverse several features of the metabolic syndrome, but the underlying molecular mechanisms still remain elusive. The aim of the present study was to explore mechanisms involved in the e…
View article: Maternal androgen excess induces cardiac hypertrophy and left ventricular dysfunction in female mice offspring
Maternal androgen excess induces cardiac hypertrophy and left ventricular dysfunction in female mice offspring Open
Aims Polycystic ovary syndrome (PCOS) is a common endocrinopathy that is suggested to increase the risk for cardiovascular disease. How PCOS may lead to adverse cardiac outcomes is unclear and here we hypothesized that prenatal exposure to…
View article: MON-217 Maternal Androgen Excess and Obesity Induce Cardiac Hypertrophy and Left Ventricular Dysfunction in Female Offspring
MON-217 Maternal Androgen Excess and Obesity Induce Cardiac Hypertrophy and Left Ventricular Dysfunction in Female Offspring Open
Polycystic ovary syndrome (PCOS) is suggested to increase the risk for cardiovascular disease and type 2 diabetes. We hypothesized here that prenatal exposure to dihydrotestosterone (DHT) and/or maternal obesity lead to adverse metabolic a…
View article: Hemoglobin β93 Cysteine Is Not Required for Export of Nitric Oxide Bioactivity From the Red Blood Cell
Hemoglobin β93 Cysteine Is Not Required for Export of Nitric Oxide Bioactivity From the Red Blood Cell Open
Background: Nitrosation of a conserved cysteine residue at position 93 in the hemoglobin β chain (β93C) to form S-nitroso (SNO) hemoglobin (Hb) is claimed to be essential for export of nitric oxide (NO) bioactivity by the red blood cell (R…
View article: Dietary Nitrate Reduces Blood Pressure in Rats With Angiotensin II–Induced Hypertension via Mechanisms That Involve Reduction of Sympathetic Hyperactivity
Dietary Nitrate Reduces Blood Pressure in Rats With Angiotensin II–Induced Hypertension via Mechanisms That Involve Reduction of Sympathetic Hyperactivity Open
Several experimental and clinical studies have shown that dietary nitrate supplementation can increase nitric oxide bioavailability. In the oral cavity, commensal bacteria reduce nitrate to nitrite, which is subsequently absorbed into the …
View article: AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis
AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis Open
Significance Liver steatosis, or fatty liver, is the most common liver disease in the world, affecting up to 25% of all Americans. There is currently no approved drug available for this condition, which may progress to serious disease, inc…
View article: Enhanced Renal Afferent Arteriolar Reactive Oxygen Species and Contractility to Endothelin-1 Are Associated with Canonical Wnt Signaling in Diabetic Mice
Enhanced Renal Afferent Arteriolar Reactive Oxygen Species and Contractility to Endothelin-1 Are Associated with Canonical Wnt Signaling in Diabetic Mice Open
Background/Aims: Canonical Wnt signaling is involved in oxidative stress, vasculopathy and diabetes mellitus but its role in diabetic renal microvascular dysfunction is unclear. We tested the hypothesis that enhanced canonica…
View article: The novel organic mononitrate NDHP attenuates hypertension and endothelial dysfunction in hypertensive rats
The novel organic mononitrate NDHP attenuates hypertension and endothelial dysfunction in hypertensive rats Open
Acute treatment with the novel organic nitrate NDHP increases NO formation, which is associated with vasorelaxation and a significant reduction of blood pressure in hypertensive animals. Chronic NDHP treatment attenuates the progression of…
View article: Renal denervation attenuates hypertension and renal dysfunction in a model of cardiovascular and renal disease, which is associated with reduced NADPH and xanthine oxidase activity
Renal denervation attenuates hypertension and renal dysfunction in a model of cardiovascular and renal disease, which is associated with reduced NADPH and xanthine oxidase activity Open
View article: Dietary nitrate attenuates renal ischemia-reperfusion injuries by modulation of immune responses and reduction of oxidative stress
Dietary nitrate attenuates renal ischemia-reperfusion injuries by modulation of immune responses and reduction of oxidative stress Open
View article: Synthesis and characterization of a novel organic nitrate NDHP: Role of xanthine oxidoreductase-mediated nitric oxide formation
Synthesis and characterization of a novel organic nitrate NDHP: Role of xanthine oxidoreductase-mediated nitric oxide formation Open
In this report, we describe the synthesis and characterization of 1,3-bis(hexyloxy)propan-2-yl nitrate (NDHP), a novel organic mono nitrate. Using purified xanthine oxidoreductase (XOR), chemiluminescence and electron paramagnetic resonanc…
View article: Genetic Abrogation of Adenosine A <sub>3</sub> Receptor Prevents Uninephrectomy and High Salt–Induced Hypertension
Genetic Abrogation of Adenosine A <sub>3</sub> Receptor Prevents Uninephrectomy and High Salt–Induced Hypertension Open
Background Early‐life reduction in nephron number (uninephrectomy [ UNX] ) and chronic high salt ( HS ) intake increase the risk of hypertension and chronic kidney disease. Adenosine signaling via its different receptors has been implicate…
View article: Ophiopogon japonicus strains from different cultivation regions exhibit markedly different properties on cytotoxicity, pregnane X receptor activation and cytochrome P450 3A4 induction
Ophiopogon japonicus strains from different cultivation regions exhibit markedly different properties on cytotoxicity, pregnane X receptor activation and cytochrome P450 3A4 induction Open
Maidong, known as Ophiopogon japonicus, is one of the two basic ingredients of Shenmai injection, which is a widely used herbal preparation in traditional Chinese medicine (TCM) for the treatment of atherosclerotic coronary heart di…