Zhengbo Xue
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View article: Exome-wide genetic risk score (ExGRS) to predict high myopia across multi-ancestry populations
Exome-wide genetic risk score (ExGRS) to predict high myopia across multi-ancestry populations Open
View article: Exome-wide association study identifies KDELR3 mutations in extreme myopia
Exome-wide association study identifies KDELR3 mutations in extreme myopia Open
Extreme myopia (EM), defined as a spherical equivalent (SE) ≤ −10.00 diopters (D), is one of the leading causes of sight impairment. Known EM-associated variants only explain limited risk and are inadequate for clinical decision-making. To…
View article: Whole-Exome Sequencing Among School-Aged Children With High Myopia
Whole-Exome Sequencing Among School-Aged Children With High Myopia Open
Importance High myopia (HM) is one of the leading causes of visual impairment worldwide. Genetic factors are known to play an important role in the development of HM. Objective To identify risk variants in a large HM cohort and to examine …
View article: Whole-exome sequencing on 6215 school-aged children reveals the importance of genetic testing in high myopia
Whole-exome sequencing on 6215 school-aged children reveals the importance of genetic testing in high myopia Open
Importance High myopia (HM) is one of the leading causes of visual impairment and blindness worldwide. It is well-known that genetic factors play a significant role in the development of HM. Early school-aged population-based genetic scree…
View article: Sequencing of 19,219 exomes identifies a low-frequency variant in FKBP5 promoter predisposing to high myopia in a Han Chinese population
Sequencing of 19,219 exomes identifies a low-frequency variant in FKBP5 promoter predisposing to high myopia in a Han Chinese population Open
High myopia (HM) is one of the leading causes of visual impairment and blindness worldwide. Here, we report a whole-exome sequencing (WES) study in 9,613 HM cases and 9,606 controls of Han Chinese ancestry to pinpoint HM-associated risk va…
View article: Roles of non‐coding <scp>RNAs</scp> in eye development and diseases
Roles of non‐coding <span>RNAs</span> in eye development and diseases Open
The prevalence of ocular disorders is dramatically increasing worldwide, especially those that cause visual impairment and permanent loss of vision, including cataract, glaucoma, age‐related macular degeneration, and diabetic retinopathy. …
View article: Sequencing of 19,219 exomes identifies a low-frequency variant in<i>FKBP5</i>promoter predisposing to high myopia in a Han Chinese population
Sequencing of 19,219 exomes identifies a low-frequency variant in<i>FKBP5</i>promoter predisposing to high myopia in a Han Chinese population Open
SUMMARY High myopia (HM) is one of the leading causes of visual impairment and blindness worldwide. Here, we report a whole-exome sequencing (WES) study in 9,613 HM cases and 9,606 controls of Han Chinese ancestry to pinpoint HM-associated…
View article: Genome-wide association meta-analysis of 88,250 individuals highlights pleiotropic mechanisms of five ocular diseases in UK Biobank
Genome-wide association meta-analysis of 88,250 individuals highlights pleiotropic mechanisms of five ocular diseases in UK Biobank Open
The National Natural Science Foundation of China (61871294), Zhejiang Provincial Natural Science Foundation of China (LR19C060001), and the Scientific Research Foundation for Talents of Wenzhou Medical University (QTJ18023).
View article: Design, methodology, and baseline of whole city-million scale children and adolescents myopia survey (CAMS) in Wenzhou, China
Design, methodology, and baseline of whole city-million scale children and adolescents myopia survey (CAMS) in Wenzhou, China Open
View article: COVID-19 Quarantine Reveals That Behavioral Changes Have an Effect on Myopia Progression
COVID-19 Quarantine Reveals That Behavioral Changes Have an Effect on Myopia Progression Open
Myopia is the most common cause of visual impairment worldwide,1Holden B.A. Fricke T.R. Wilson D.A. et al.Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050.Ophthalmology. 2016; 123: 1036-1042Abstract Fu…
View article: EyeDiseases: an integrated resource for dedicating to genetic variants, gene expression and epigenetic factors of human eye diseases
EyeDiseases: an integrated resource for dedicating to genetic variants, gene expression and epigenetic factors of human eye diseases Open
Eye diseases are remarkably common and encompass a large and diverse range of morbidities that affect different components of the visual system and visual function. With advances in omics technology of eye disorders, genome-scale datasets …
View article: COVID-19 Quarantine Reveals Grade-specific Behavioral Modification of Myopia: One-Million Chinese Schoolchildren Study
COVID-19 Quarantine Reveals Grade-specific Behavioral Modification of Myopia: One-Million Chinese Schoolchildren Study Open
Summary Background High prevalence of myopia of adolescent has been a global public health concern. Their risk factors and effective prevention methods for myopia across schoolchildren developmental stages are critically needed but remain …
View article: Co-Expression of Mitochondrial Genes and ACE2 in Cornea Involved in COVID-19
Co-Expression of Mitochondrial Genes and ACE2 in Cornea Involved in COVID-19 Open
Our co-expression and protein interaction network analysis uncover that the mitochondrial function related genes in cornea contribute to the dissection of COVID-19 susceptibility and potential therapeutic interventions.
View article: Co-expression of Mitochondrial Genes and ACE2 in Cornea Involved in COVID-19 Infection
Co-expression of Mitochondrial Genes and ACE2 in Cornea Involved in COVID-19 Infection Open
The Coronavirus disease 2019 (COVID-19) pandemic severely challenges public health and necessitates the need for increasing our understanding of COVID-19 pathogenesis, especially host factors facilitating virus infection and propagation. H…
View article: Nc2Eye: A Curated ncRNAomics Knowledgebase for Bridging Basic and Clinical Research in Eye Diseases
Nc2Eye: A Curated ncRNAomics Knowledgebase for Bridging Basic and Clinical Research in Eye Diseases Open
Eye diseases (EDs) represent a group of disorders affecting the visual system, most of which can lead to visual impairment and blindness. Accumulating evidence reveals that non-coding RNAs (ncRNAs) are closely associated with a wide variet…
View article: Molecular Signatures Related to the Virulence of Bacillus cereus Sensu Lato, a Leading Cause of Devastating Endophthalmitis
Molecular Signatures Related to the Virulence of Bacillus cereus Sensu Lato, a Leading Cause of Devastating Endophthalmitis Open
In this study, we provided a detailed and comprehensive clinicopathological and pathogenic report of Bacillus endophthalmitis over the 8 years of the study period. We first reported the whole-genome sequence of Bacillus spp. causing devast…