Zhenghan Luo
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Author Swipe
View article: An ERA-CRISPR/Cas12a Method for Highly Sensitive Detection of Human Adenovirus Type 55
An ERA-CRISPR/Cas12a Method for Highly Sensitive Detection of Human Adenovirus Type 55 Open
Background/Objectives: Human adenovirus 55 (HAdV55) is a notable pathogen causing community-acquired pneumonia; outbreaks occur frequently in military camps, hospitals, and schools, thereby posing a threat to public health security. This s…
View article: Respiratory transmission potential of severe fever with thrombocytopenia syndrome bunyavirus: evidence from intranasal exposure in a humanized mouse model
Respiratory transmission potential of severe fever with thrombocytopenia syndrome bunyavirus: evidence from intranasal exposure in a humanized mouse model Open
Severe Fever with Thrombocytopenia Syndrome Bunyavirus (SFTSV) is a highly lethal pathogen with expanding endemic regions in Asia. While primarily transmitted by ticks, recent evidence suggests potential airborne transmission, raising sign…
View article: Development and Validation of an Explainable Machine Learning Model for Warning of Hepatitis E Virus‐Related Acute Liver Failure
Development and Validation of an Explainable Machine Learning Model for Warning of Hepatitis E Virus‐Related Acute Liver Failure Open
Background and Aims Early identification of patients with acute hepatitis E (AHE) who are at high risk of progressing to hepatitis E virus‐related acute liver failure (HEV‐ALF) is crucial for enabling timely monitoring and intervention. Th…
View article: The predictive value of fibrosis profiles for hepatitis E virus-related liver failure among hospitalized patients with acute hepatitis E: a retrospective cohort study
The predictive value of fibrosis profiles for hepatitis E virus-related liver failure among hospitalized patients with acute hepatitis E: a retrospective cohort study Open
View article: Multifaceted environmental factors linked to metabolic dysfunction-associated fatty liver disease: an environment-wide association study
Multifaceted environmental factors linked to metabolic dysfunction-associated fatty liver disease: an environment-wide association study Open
View article: The association between weekly mean temperature and the epidemic of influenza across 122 countries/regions, 2014–2019
The association between weekly mean temperature and the epidemic of influenza across 122 countries/regions, 2014–2019 Open
The study examined the association between weekly mean temperature and influenza cases across 122 countries/regions (2014-2019) using a distributed lag non-linear model (DLNM). We analyzed 3145206 cases of overall influenza (Flu-All), with…
View article: The Underlying Mechanism of Cardiac Injury in Exertional Heat Stroke Rats Based on the Scrna-Seq Analysis
The Underlying Mechanism of Cardiac Injury in Exertional Heat Stroke Rats Based on the Scrna-Seq Analysis Open
View article: The underlying mechanism of cardiac injury in exertional heat stroke rats based on the scRNA-seq analysis
The underlying mechanism of cardiac injury in exertional heat stroke rats based on the scRNA-seq analysis Open
Background Heat dissipation relies on an intact cardiovascular system to dilate cutaneous blood vessels and increase cardiac output. However, the heart becomes a vulnerable organ and is susceptible to cardiac arrhythmias, functional failur…
View article: The association between Ambient Temperature and Influenza Activity across 124 countries globally during 2014–2019
The association between Ambient Temperature and Influenza Activity across 124 countries globally during 2014–2019 Open
Background: The results of the association between ambient temperature and influenza in previous studies have been inconsistent in different regions. And global, multi-regional studies are lacking. Methods: Our study used two stages of ana…
View article: Evaluation of the efficacy, safety and influencing factors of concomitant and sequential administration of viral respiratory infectious disease vaccines: a systematic review and meta-analysis
Evaluation of the efficacy, safety and influencing factors of concomitant and sequential administration of viral respiratory infectious disease vaccines: a systematic review and meta-analysis Open
Background There is no clear conclusion on the immunogenicity and adverse events of concomitant administration the viral respiratory infectious disease vaccines. We aimed to evaluate the impact of concomitant administering viral respirator…
View article: The burden of HEV-related acute liver failure in Bangladesh, China and India: a systematic review and meta-analysis
The burden of HEV-related acute liver failure in Bangladesh, China and India: a systematic review and meta-analysis Open
Background Hepatitis E can potentially progress to HEV-related acute liver failure (HEV-ALF). East and South Asia bear a substantial burden of HEV infection, with Bangladesh, China, and India facing the most severe threat in this region. T…
View article: Tiratricol inhibits yellow fever virus replication through targeting viral RNA-dependent RNA polymerase of NS5
Tiratricol inhibits yellow fever virus replication through targeting viral RNA-dependent RNA polymerase of NS5 Open
Yellow fever virus (YFV) infection is a major public concern that threatens a large population in South America and Africa. No specific antiviral drugs are available for treating yellow fever. Here, we report that tiratricol (triiodothyroa…
View article: The burden of HEV related acute liver failure in the developing world: a systematic review and meta-analysis
The burden of HEV related acute liver failure in the developing world: a systematic review and meta-analysis Open
Background Hepatitis E has the potential to progress into HEV related acute liver failure (HEV-ALF), but its burden in the developing world remains unclear. We systematically evaluated the burden of HEV-ALF in these regions regarding the f…
View article: Evaluation of the Therapeutic Effect of Antibiotics on Scrub Typhus: A Systematic Review and Network Meta-Analysis
Evaluation of the Therapeutic Effect of Antibiotics on Scrub Typhus: A Systematic Review and Network Meta-Analysis Open
Background To explore the efficacy and safety of drugs in patients with scrub typhus. Methods For this systematic review and network meta-analysis, we searched PubMed, Embase, Web of Science, Cochrane Central Register of Clinical Trials, C…
View article: Meta-analysis of the effects of ambient temperature and relative humidity on the risk of mumps
Meta-analysis of the effects of ambient temperature and relative humidity on the risk of mumps Open
Many studies have shown that the relationship between ambient temperature, relative humidity and mumps has been highlighted. However, these studies showed inconsistent results. Therefore, the goal of our study is to conduct a meta-analysis…
View article: Rifapentine is an entry and replication inhibitor against yellow fever virus both in vitro and in vivo
Rifapentine is an entry and replication inhibitor against yellow fever virus both in vitro and in vivo Open
Yellow fever virus (YFV) infection is a major public concern that threatens a large population in South America and Africa. No specific anti-YFV drugs are available till now. Here, we report that rifapentine is a potent YFV inhibitor in va…
View article: Rifapentine is an entry and replication inhibitor against yellow fever virus both in vitro and in vivo
Rifapentine is an entry and replication inhibitor against yellow fever virus both in vitro and in vivo Open
Yellow fever virus (YFV) infection is a major public concern that threatens a large population in South America and Africa. No specific anti-YFV drugs are available till now. Here, we report that rifapentine is a potent YFV inhibitor in va…