Zhenghao Shen
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View article: Checkpoint kinases regulate the circadian clock after DNA damage by influencing chromatin dynamics
Checkpoint kinases regulate the circadian clock after DNA damage by influencing chromatin dynamics Open
The interplay between circadian clocks, the cell cycle, and DNA repair has been extensively documented, yet the epigenetic control of circadian clocks by DNA damage responses remains relatively unexplored. Here, we showed that checkpoint k…
View article: Pan-omics-based characterization and prediction of highly multidrug-adapted strains from an outbreak fungal species complex
Pan-omics-based characterization and prediction of highly multidrug-adapted strains from an outbreak fungal species complex Open
Strains from the Cryptococcus gattii species complex (CGSC) have caused the Pacific Northwest cryptococcosis outbreak, the largest cluster of life-threatening fungal infections in otherwise healthy human hosts known to date. In this…
View article: Fungicide-tolerant persister formation during cryptococcal pulmonary infection
Fungicide-tolerant persister formation during cryptococcal pulmonary infection Open
View article: Brain glucose induces fungicidal tolerance during fungal meningitis
Brain glucose induces fungicidal tolerance during fungal meningitis Open
In bacteria, antibiotic tolerance, the ability of a susceptible population to survive high doses of cidal drugs, has been shown to compromise therapeutic outcomes. In comparison, whether fungicide tolerance can be induced by host-derived f…
View article: Regulatory basis for reproductive flexibility in a meningitis-causing fungal pathogen
Regulatory basis for reproductive flexibility in a meningitis-causing fungal pathogen Open
Pathogenic fungi of the genus Cryptococcus can undergo two sexual cycles, involving either bisexual diploidization (after fusion of haploid cells of different mating type) or unisexual diploidization (by autodiploidization of a single cell…
View article: Efficient thermal dissipation in wafer-scale heterogeneous integration of single-crystalline β-Ga2O3 thin film on SiC
Efficient thermal dissipation in wafer-scale heterogeneous integration of single-crystalline β-Ga2O3 thin film on SiC Open
The semiconductor, β-Ga2O3 is attractive for applications in high power electronic devices with low conduction loss due to its ultra-wide bandgap (∼4.9 eV) and large Baliga's figure of merit. However, the thermal conductivity of β-Ga2O3 is…