Zhengjun Guo
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View article: <scp>NFATc4</scp> Promotes Lung Adenocarcinoma Progression via the <scp>CCNB1</scp>/<scp>CDK1</scp> Pathway and Is a Potential Prognostic Biomarker
<span>NFATc4</span> Promotes Lung Adenocarcinoma Progression via the <span>CCNB1</span>/<span>CDK1</span> Pathway and Is a Potential Prognostic Biomarker Open
Nuclear factor of activated T‐cells, cytoplasmic 4 (NFATc4), a transcription factor of the NFAT family, has been reported to participate in the tumorigenesis and progression of several cancers. However, the function and regulation of NFATc…
View article: Integration of intratumoral and peritumoral CT radiomic features with machine learning algorithms for predicting induction therapy response in locally advanced non-small cell lung cancer
Integration of intratumoral and peritumoral CT radiomic features with machine learning algorithms for predicting induction therapy response in locally advanced non-small cell lung cancer Open
The INTRAPERI_GradientBoosting model, which integrates intra-tumoral and peritumoral features, performs better than the INTRA intra-tumoral and PERI peritumoral radiomics models in predicting the efficacy of IT therapy in LA-NSCLC. Additio…
View article: A Novel Scoring System to Predict Acute Radiation Enteritis Recovery in Cervical Cancer Patients Undergoing Concurrent Chemoradiotherapy: A Southwest China Cohort Study
A Novel Scoring System to Predict Acute Radiation Enteritis Recovery in Cervical Cancer Patients Undergoing Concurrent Chemoradiotherapy: A Southwest China Cohort Study Open
The ITS system provides a robust and reliable tool for predicting RE recovery in cervical cancer patients undergoing CCRT, surpassing traditional models in accuracy and reliability. This tool enables better patient management by allowing f…
View article: Predicting radiation pneumonitis in lung cancer using machine learning and multimodal features: a systematic review and meta-analysis of diagnostic accuracy
Predicting radiation pneumonitis in lung cancer using machine learning and multimodal features: a systematic review and meta-analysis of diagnostic accuracy Open
PROSPERO (CRD42024497599).
View article: Distinguishing High-Metastasis-Potential Circulating Tumor Cells through Fluidic Shear Stress in a Bloodstream-Like Microfluidic Circulatory System
Distinguishing High-Metastasis-Potential Circulating Tumor Cells through Fluidic Shear Stress in a Bloodstream-Like Microfluidic Circulatory System Open
Circulating tumor cells (CTCs) play a critical role as initiators in tumor metastasis, which unlocks an irreversible process of cancer progression. Regarding the fluid environment of intravascular CTCs, a comprehensive understanding of the…
View article: Ionic Conjugated Microporous Polymers for Cycloaddition of Carbon Dioxide to Epoxides
Ionic Conjugated Microporous Polymers for Cycloaddition of Carbon Dioxide to Epoxides Open
Along the development of ionic porous organic polymers, simple and efficient synthetic methods are actively pursued. Herein, the Debus–Radziszewski reaction is applied to synthesize ionic conjugated microporous polymers (iCMPs) in one step…
View article: Pregnancy Zone Protein Serves as a Prognostic Marker and Favors Immune Infiltration in Lung Adenocarcinoma
Pregnancy Zone Protein Serves as a Prognostic Marker and Favors Immune Infiltration in Lung Adenocarcinoma Open
Lung adenocarcinoma (LUAD) is a public enemy with a very high incidence and mortality rate, for which there is no specific detectable biomarker. Pregnancy zone protein (PZP) is an immune-related protein; however, the functions of PZP in LU…
View article: Macroscale Conjugated Microporous Polymers: Controlling Versatile Functionalities Over Several Dimensions
Macroscale Conjugated Microporous Polymers: Controlling Versatile Functionalities Over Several Dimensions Open
Since discovered in 2007, conjugated microporous polymers (CMPs) have been developed for numerous applications including gas adsorption, sensing, organic and photoredox catalysis, energy storage, etc. While featuring abundant micropores, t…
View article: Expression and clinical significance of adenosine deaminase acting on RNA-1 in lung adenocarcinoma
Expression and clinical significance of adenosine deaminase acting on RNA-1 in lung adenocarcinoma Open
Objective To investigate the expression of adenosine deaminase acting on RNA-1 (ADAR1) in lung adenocarcinoma and its association with clinicopathological characteristics and prognosis. Methods Immunohistochemical staining was applied to d…
View article: The potential prognostic values of the ADAMTS-like protein family: an integrative pan-cancer analysis
The potential prognostic values of the ADAMTS-like protein family: an integrative pan-cancer analysis Open
Our findings extend understandings of the role of the ADAMTSL family in cancers and are a valuable resource on their clinical utility. This article provides insight into the clinical importance of next-generation sequencing technology to i…
View article: The transcription factor RUNX2 fuels YAP1 signaling and gastric cancer tumorigenesis
The transcription factor RUNX2 fuels YAP1 signaling and gastric cancer tumorigenesis Open
Despite considerable efforts in the detection and treatment of gastric cancer (GC), the underlying mechanism of the progression of GC remains unknown. Our previous work has demonstrated the remarkable role of Runt‐related transcription fac…
View article: Migration and Transformation of Heavy Metals in the Soil of the Water-Level Fluctuation Zone in the Three Gorges Reservoir under Simulated Nitrogen Deposition
Migration and Transformation of Heavy Metals in the Soil of the Water-Level Fluctuation Zone in the Three Gorges Reservoir under Simulated Nitrogen Deposition Open
The accumulation of heavy metals (HMs) in the water-level fluctuation zone (WLFZ) of the Three Gorges Reservoir (TGR) area is potentially harmful to the water environment. In order to reveal whether nitrogen (N) deposition is a potential d…
View article: Oncogenic miR-132 sustains proliferation and self-renewal potential by inhibition of polypyrimidine tract-binding protein 2 in glioblastoma cells
Oncogenic miR-132 sustains proliferation and self-renewal potential by inhibition of polypyrimidine tract-binding protein 2 in glioblastoma cells Open
Glioblastoma multiforme (GBM) is the leading type of brain tumor, exhibiting unlimited proliferation and invasion potential. The present study indicated that a high expression level of miR‑132 was detected in the neural subtype of GBM and …
View article: Transcription factor RUNX2 up-regulates chemokine receptor CXCR4 to promote invasive and metastatic potentials of human gastric cancer
Transcription factor RUNX2 up-regulates chemokine receptor CXCR4 to promote invasive and metastatic potentials of human gastric cancer Open
Runt-related transcription factor 2 (RUNX2) is a regulator of embryogenesis and development, but has also been implicated in the progression of certain human cancer. This study aimed to elucidate the role of RUNX2 in the invasive and metas…
View article: High ERα36 Expression Level and Membrane Location Predict Poor Prognosis in Renal Cell Carcinoma
High ERα36 Expression Level and Membrane Location Predict Poor Prognosis in Renal Cell Carcinoma Open
Estrogen receptor alpha 36 (ERα36), a truncated variant of ERα, is located in cytoplasm and membrane that is different from other nuclear receptors of ERα family. ERα36 is involved in progression and treatment resistance of a variety of ca…