Zhengjun Lin
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View article: Lactylation‑mediated ferroptosis: A novel mechanism and therapeutic prospects in human diseases (Review)
Lactylation‑mediated ferroptosis: A novel mechanism and therapeutic prospects in human diseases (Review) Open
View article: Association of sugar-sweetened, artificially sweetened, and unsweetened tea with all-cause and cause-specific mortality: a prospective cohort study in UK biobank
Association of sugar-sweetened, artificially sweetened, and unsweetened tea with all-cause and cause-specific mortality: a prospective cohort study in UK biobank Open
View article: Supplementary Data from Leveraging Artificial Intelligence for Neoantigen Prediction
Supplementary Data from Leveraging Artificial Intelligence for Neoantigen Prediction Open
(For publication) Supplementary Table S1-S5 and Supplementary Fig. S1-S3
View article: Data from Leveraging Artificial Intelligence for Neoantigen Prediction
Data from Leveraging Artificial Intelligence for Neoantigen Prediction Open
Neoantigens represent a class of antigens within tumor microenvironments that arise from diverse somatic mutations and aberrations specific to tumorigenesis, holding substantial promise for advancing tumor immunotherapy. However, only a su…
View article: Associations of breakfast cereal consumption with all-cause and cause-specific mortality: a large-scale prospective analysis
Associations of breakfast cereal consumption with all-cause and cause-specific mortality: a large-scale prospective analysis Open
View article: Correction: Cold exposure-induced plasma exosomes impair bone mass by inhibiting autophagy
Correction: Cold exposure-induced plasma exosomes impair bone mass by inhibiting autophagy Open
View article: Correction: Cold exposure-induced plasma exosomes impair bone mass by inhibiting autophagy
Correction: Cold exposure-induced plasma exosomes impair bone mass by inhibiting autophagy Open
View article: Cancer therapy resistance mediated by cancer-associated fibroblast-derived extracellular vesicles: biological mechanisms to clinical significance and implications
Cancer therapy resistance mediated by cancer-associated fibroblast-derived extracellular vesicles: biological mechanisms to clinical significance and implications Open
Cancer-associated fibroblasts (CAFs) are a diverse stromal cell population within the tumour microenvironment, where they play fundamental roles in cancer progression and patient prognosis. Multiple lines of evidence have identified that C…
View article: <scp>SPP1</scp> could be an immunological and prognostic biomarker: From pan‐cancer comprehensive analysis to osteosarcoma validation
<span>SPP1</span> could be an immunological and prognostic biomarker: From pan‐cancer comprehensive analysis to osteosarcoma validation Open
Secreted phosphoprotein 1 (SPP1), also known as osteopontin, is a phosphorylated protein. High SPP1 expression levels have been detected in multiple cancers and are associated with poor prognosis and reduced survival rates. However, only a…
View article: Cold exposure-induced plasma exosomes impair bone mass by inhibiting autophagy
Cold exposure-induced plasma exosomes impair bone mass by inhibiting autophagy Open
Recently, environmental temperature has been shown to regulate bone homeostasis. However, the mechanisms by which cold exposure affects bone mass remain unclear. In our present study, we observed that exposure to cold temperature (CT) decr…
View article: Risk/benefit trade-off of habitual physical activity and air pollution on mortality: A large-scale prospective analysis in the UK Biobank
Risk/benefit trade-off of habitual physical activity and air pollution on mortality: A large-scale prospective analysis in the UK Biobank Open
Our study provides additional evidence that higher PA and lower air pollutant levels are independently connected with reduced mortality risk. The benefits of PA are not significantly affected by long-term air pollution exposure, indicating…
View article: Adipose exosomal noncoding RNAs: Roles and mechanisms in metabolic diseases
Adipose exosomal noncoding RNAs: Roles and mechanisms in metabolic diseases Open
Summary Exosomes are extracellular vesicles, measuring 40–160 nm in diameter, that are released by many cell types and tissues, including adipose tissue. Exosomes are critical mediators of intercellular communication and their contents are…
View article: Harnessing ferroptosis for enhanced sarcoma treatment: mechanisms, progress and prospects
Harnessing ferroptosis for enhanced sarcoma treatment: mechanisms, progress and prospects Open
Sarcoma is a malignant tumor that originates from mesenchymal tissue. The common treatment for sarcoma is surgery supplemented with radiotherapy and chemotherapy. However, patients have a 5-year survival rate of only approximately 60%, and…
View article: The crosstalk of CD8+ T cells and ferroptosis in cancer
The crosstalk of CD8+ T cells and ferroptosis in cancer Open
Ferroptosis is an iron-dependent, novel form of programmed cell death characterized by lipid peroxidation and glutathione depletion and is widespread in a variety of diseases. CD8+ T cells are the most important effector cells of cytotoxic…
View article: Identification and verification of PTPN3 as a novel biomarker in predicting cancer prognosis, immunity, and immunotherapeutic efficacy
Identification and verification of PTPN3 as a novel biomarker in predicting cancer prognosis, immunity, and immunotherapeutic efficacy Open
View article: Enhancing the immunomodulatory osteogenic properties of Ti-Mg alloy by Mg2+-containing nanostructures
Enhancing the immunomodulatory osteogenic properties of Ti-Mg alloy by Mg2+-containing nanostructures Open
Facilitating an appropriate immune response is crucial for promoting bone tissue regeneration upon biomaterial implantation. In this study, the Mg2+-containing nanostructures on the surface of Ti-1.25Mg alloy were prepared by a one-step hy…
View article: An integrative evaluation of circadian gene TIMELESS as a pan-cancer immunological and predictive biomarker
An integrative evaluation of circadian gene TIMELESS as a pan-cancer immunological and predictive biomarker Open
View article: Identification and validation of novel biomarkers associated with immune infiltration for the diagnosis of osteosarcoma based on machine learning
Identification and validation of novel biomarkers associated with immune infiltration for the diagnosis of osteosarcoma based on machine learning Open
Objectives: Osteosarcoma is the most common primary malignant tumor in children and adolescents, and the 5-year survival of osteosarcoma patients gained no substantial improvement over the past decades. Effective biomarkers in diagnosing o…
View article: Ferroptosis-related gene HIC1 in the prediction of the prognosis and immunotherapeutic efficacy with immunological activity
Ferroptosis-related gene HIC1 in the prediction of the prognosis and immunotherapeutic efficacy with immunological activity Open
Background Hypermethylated in Cancer 1 (HIC1) was originally confirmed as a tumor suppressor and has been found to be hypermethylated in human cancers. Although growing evidence has supported the critical roles of HIC1 in cancer initiation…
View article: Association of oily fish and nonoily fish intakes with all-cause mortality and cause-specific mortality: a large population-based prospective study
Association of oily fish and nonoily fish intakes with all-cause mortality and cause-specific mortality: a large population-based prospective study Open
View article: Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study
Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study Open
View article: Association of milk consumption with all-cause mortality and cardiovascular outcomes: a UK Biobank based large population cohort study
Association of milk consumption with all-cause mortality and cardiovascular outcomes: a UK Biobank based large population cohort study Open
View article: Association between glucosamine use and cancer mortality: A large prospective cohort study
Association between glucosamine use and cancer mortality: A large prospective cohort study Open
Objective Previous studies have shown anti-cancer and anti-inflammatory benefits of glucosamine. This study was performed to prospectively evaluate the association between glucosamine supplementation and the mortality of multiple cancers b…
View article: Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential
Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential Open
View article: Pan-cancer analysis of CREB3L1 as biomarker in the prediction of prognosis and immunotherapeutic efficacy
Pan-cancer analysis of CREB3L1 as biomarker in the prediction of prognosis and immunotherapeutic efficacy Open
Background: CAMP response element binding protein 3-like 1 (CREB3L1) has been indicated as a critical biomarker and can modulate multifaced behaviors of tumor cells in diverse cancers. However, a systematic assessment of CREB3L1 in pan-can…
View article: Association of Milk Consumption With All-Cause Mortality And Cardiovascular Outcomes: A Large Population-Based Cohort Study
Association of Milk Consumption With All-Cause Mortality And Cardiovascular Outcomes: A Large Population-Based Cohort Study Open
View article: Transcriptome Sequencing Analysis of lncRNA and mRNA Expression Profiles in Bone Nonunion
Transcriptome Sequencing Analysis of lncRNA and mRNA Expression Profiles in Bone Nonunion Open
Background . Bone nonunion is a serious complication of fracture. This study explored the differentially expressed lncRNAs (DELs) and mRNAs (DEGs) and identified potential lncRNA‐mRNA interactions in bone nonunion. Methods . We extracted t…
View article: Association of Oily and Nonoily Fish Intake with All Cause and Cause Specific Mortality: A Large Population-Based Prospective Study
Association of Oily and Nonoily Fish Intake with All Cause and Cause Specific Mortality: A Large Population-Based Prospective Study Open
View article: Association of Never Eating Sugar or Foods/Drinks Containing Sugar with Risks of All-Cause Mortality and Cardiovascular Disease Outcomes: A Prospective Cohort Study
Association of Never Eating Sugar or Foods/Drinks Containing Sugar with Risks of All-Cause Mortality and Cardiovascular Disease Outcomes: A Prospective Cohort Study Open
View article: Identification and Validation of Pyroptosis-Related lncRNA Signature and Its Correlation with Immune Landscape in Soft Tissue Sarcomas
Identification and Validation of Pyroptosis-Related lncRNA Signature and Its Correlation with Immune Landscape in Soft Tissue Sarcomas Open
In conclusion, our study revealed the clinical significance and critical roles of pyroptosis-related lncRNAs in STS, and constructed novel risk signatures based on pyroptosis-related lncRNAs that could effectively predict clinical outcomes…