Z. J. Shang
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View article: LncRNA AC116914.2 promotes the progression of oral cancer by targeting METTL3 via miR-1245a/ZNF250
LncRNA AC116914.2 promotes the progression of oral cancer by targeting METTL3 via miR-1245a/ZNF250 Open
This study shows that lncRNA AC116914.2, as a competing endogenous RNA (ceRNA), regulates the expression of METTL3 by competitively binding to miR-1245a with ZNF250, thus promoting OSCC progression. The discovery of this regulatory axis pr…
View article: Spatial metabolomics atlas in the progression of oral squamous cell carcinoma
Spatial metabolomics atlas in the progression of oral squamous cell carcinoma Open
View article: Colony stimulation factor-2 triggers NNMT-dependent myofibroblasts activation in head and neck cancer
Colony stimulation factor-2 triggers NNMT-dependent myofibroblasts activation in head and neck cancer Open
Myofibroblastic cancer-associated fibroblasts (myoCAFs) represent a crucial stromal cell subpopulation associated with tumor growth, relapse, and metastasis. In this study, we identify a noncanonical mechanism through which head and neck c…
View article: Bifunctional Nanoplatform Against Bone Invasion In Oral Squamous Cell Carcinoma
Bifunctional Nanoplatform Against Bone Invasion In Oral Squamous Cell Carcinoma Open
Aim or purpose: This study developed a bifunctional nanoplatform for tumor suppression and osteogenic promotion, aiming to provide a novel therapeutic strategy integrating tumor therapy and bone repair for oral squamous cell carcinoma (OSC…
View article: Engineered Cell Nanovesicles Overcome Immunotherapy Resistance In HNSCC
Engineered Cell Nanovesicles Overcome Immunotherapy Resistance In HNSCC Open
Aim or purpose: In recent years, immune checkpoint inhibitors struggle to overcome the immune evasion mechanisms of tumor cells in some subtypes of head and neck squamous cell carcinoma (HNSCC), so we designed engineered nanovesicles deriv…
View article: Efficient Multi-turn RL for GUI Agents via Decoupled Training and Adaptive Data Curation
Efficient Multi-turn RL for GUI Agents via Decoupled Training and Adaptive Data Curation Open
Vision-language model (VLM) based GUI agents show promise for automating complex desktop and mobile tasks, but face significant challenges in applying reinforcement learning (RL): (1) slow multi-turn interactions with GUI environments for …
View article: Congenital Anomaly–Related Mortality in Children Aged 0 to 14 Years in the US
Congenital Anomaly–Related Mortality in Children Aged 0 to 14 Years in the US Open
This cross-sectional study examines the mortality trends and sociodemographic disparities in congenital malformations among US children aged 0 to 14 years from 1999 to 2023.
View article: Research on Shape–Performance Integrated Monitoring Technology for Planetary Gearboxes Based on the Integration of Artificial Intelligence, Finite Element Analysis, and Multibody Dynamics Simulation
Research on Shape–Performance Integrated Monitoring Technology for Planetary Gearboxes Based on the Integration of Artificial Intelligence, Finite Element Analysis, and Multibody Dynamics Simulation Open
To address gear tooth damage and the difficulty of acquiring performance data under high-speed and high-load operating conditions of planetary gearboxes, a digital twin-based system for operational state recognition and performance predict…
View article: Color-and-Polarization Encoded Annular LED Array for Real-Time Active Polarization Imaging
Color-and-Polarization Encoded Annular LED Array for Real-Time Active Polarization Imaging Open
This paper proposes a real-time active polarization imaging technology based on a color-and-polarization-encoded annular LED array. By replacing conventional monochromatic light sources with red, green, and blue (RGB) linearly polarized an…
View article: Author Correction: Organoids in the oral and maxillofacial region: present and future
Author Correction: Organoids in the oral and maxillofacial region: present and future Open
View article: Optimization of Actuator Arrangement of Cable–Strut Tension Structures Based on Multi-Population Genetic Algorithm
Optimization of Actuator Arrangement of Cable–Strut Tension Structures Based on Multi-Population Genetic Algorithm Open
This study addresses the optimization of actuator arrangements in adaptive cable–strut tension structures to enhance structural controllability and performance. Two novel optimization criteria are proposed: (1) a weighted sensitivity crite…
View article: TongUI: Internet-Scale Trajectories from Multimodal Web Tutorials for Generalized GUI Agents
TongUI: Internet-Scale Trajectories from Multimodal Web Tutorials for Generalized GUI Agents Open
Building Graphical User Interface (GUI) agents is a promising research direction, which simulates human interaction with computers or mobile phones to perform diverse GUI tasks. However, a major challenge in developing generalized GUI agen…
View article: Know2Vec: A Black-Box Proxy for Neural Network Retrieval
Know2Vec: A Black-Box Proxy for Neural Network Retrieval Open
For general users, training a neural network from scratch is usually challenging and labor-intensive. Fortunately, neural network zoos enable them to find a well-performing model for directly use or fine-tuning it in their local environmen…
View article: Research on Leak Detection and Localization Algorithm for Oil and Gas Pipelines Using Wavelet Denoising Integrated with Long Short-Term Memory (LSTM)–Transformer Models
Research on Leak Detection and Localization Algorithm for Oil and Gas Pipelines Using Wavelet Denoising Integrated with Long Short-Term Memory (LSTM)–Transformer Models Open
Traditional leakage prediction models for long-distance pipelines have limitations in effectively synchronizing spatial and temporal features of leakage signals, leading to data processing that heavily relies on manual experience and exhib…
View article: High-speed image reconstruction in dual-channel super resolution FRET microscopy
High-speed image reconstruction in dual-channel super resolution FRET microscopy Open
Structured illumination-based super-resolution Förster resonance energy transfer microscopy (SIM-FRET) enables the investigation of molecular structure and function in sub-diffraction regions of live cells. However, limitations in acquisit…
View article: Global burden and trends of norovirus-associated diseases from 1990 to 2021 an observational trend study
Global burden and trends of norovirus-associated diseases from 1990 to 2021 an observational trend study Open
Background Norovirus remains a significant viral cause of waterborne and foodborne gastroenteritis outbreaks and epidemics worldwide. The burden of norovirus extends across different income settings. Methods Leveraging secondary data from …
View article: Hybrid Physics-Data-Driven Model for Temperature Field Prediction of Asphalt Pavement Based on Physics-Informed Neural Network
Hybrid Physics-Data-Driven Model for Temperature Field Prediction of Asphalt Pavement Based on Physics-Informed Neural Network Open
View article: FAT1 knockdown enhances the CSC properties of HNSCC through p-CaMKII-mediated inactivation of the IFN pathway
FAT1 knockdown enhances the CSC properties of HNSCC through p-CaMKII-mediated inactivation of the IFN pathway Open
FAT atypical cadherin 1 (FAT1), which encodes an atypical cadherin-coding protein, has a high mutation rate and is commonly regarded as a tumor suppressor gene in head and neck squamous cell carcinoma (HNSCC). Nonetheless, the poten…
View article: Know2Vec: A Black-Box Proxy for Neural Network Retrieval
Know2Vec: A Black-Box Proxy for Neural Network Retrieval Open
For general users, training a neural network from scratch is usually challenging and labor-intensive. Fortunately, neural network zoos enable them to find a well-performing model for directly use or fine-tuning it in their local environmen…
View article: Tumor-derived Extracellular Vesicles-mediated Oxidative Stress Transfer Activates Glycometabolic Reprogramming of CAFs
Tumor-derived Extracellular Vesicles-mediated Oxidative Stress Transfer Activates Glycometabolic Reprogramming of CAFs Open
Background Stressed by the adverse conditions of the tumor microenvironment (TME), hyperproliferation of tumor cells is accompanied by high production of reactive oxygen species (ROS). Tumor-derived extracellular vesicles (TEVs) exert a va…
View article: Tea leaf-derived nanovesicles for ferric-supply-amplified ICD and macrophage reprogramming to boost immunotherapy against head and neck squamous carcinoma
Tea leaf-derived nanovesicles for ferric-supply-amplified ICD and macrophage reprogramming to boost immunotherapy against head and neck squamous carcinoma Open
View article: CAFs-derived lactate enhances the cancer stemness through inhibiting the MST1 ubiquitination degradation in OSCC
CAFs-derived lactate enhances the cancer stemness through inhibiting the MST1 ubiquitination degradation in OSCC Open
View article: Organoids in the oral and maxillofacial region: present and future
Organoids in the oral and maxillofacial region: present and future Open
The oral and maxillofacial region comprises a variety of organs made up of multiple soft and hard tissue, which are anatomically vulnerable to the pathogenic factors of trauma, inflammation, and cancer. The studies of this intricate entity…
View article: Drainage estimation across mountainous regions from large-scale soil moisture observations
Drainage estimation across mountainous regions from large-scale soil moisture observations Open
Drainage is a crucial soil hydrological process that governs the partitioning of rainfall into runoff, groundwater recharge, soil water storage and evapotranspiration. Despite its significance, the drainage process is poorly understood due…
View article: Comparison of Reconstruction Plates and Miniplates in Mandibular Defect Reconstruction with Free Iliac Flap
Comparison of Reconstruction Plates and Miniplates in Mandibular Defect Reconstruction with Free Iliac Flap Open
Objective Given the increasing demand for precise and reliable reconstructive techniques in maxillofacial surgery, we try to offer valuable insights for clinicians in selecting optimal fixation methods. Materials and Methods Patients were …
View article: EphA2 promotes the transcription of KLF4 to facilitate stemness in oral squamous cell carcinoma
EphA2 promotes the transcription of KLF4 to facilitate stemness in oral squamous cell carcinoma Open
Ephrin receptor A2 (EphA2), a member of the Ephrin receptor family, is closely related to the progression of oral squamous cell carcinoma (OSCC). Cancer stem cells (CSCs) play essential roles in OSCC development and occurrence. The underly…
View article: L-cysteine contributes to destructive activities of odontogenic cysts/tumor
L-cysteine contributes to destructive activities of odontogenic cysts/tumor Open
View article: Enhanced lipid biosynthesis in oral squamous cell carcinoma cancer‐associated fibroblasts contributes to tumor progression: Role of <scp>IL8</scp>/<scp>AKT</scp>/<scp>p‐ACLY</scp> axis
Enhanced lipid biosynthesis in oral squamous cell carcinoma cancer‐associated fibroblasts contributes to tumor progression: Role of <span>IL8</span>/<span>AKT</span>/<span>p‐ACLY</span> axis Open
Lipid metabolic reprogramming of tumor cells has been proven to play a critical role in tumor initiation and development. However, lipid metabolism in cancer‐associated fibroblasts (CAFs) has rarely been studied, particularly in CAFs of or…
View article: Lactate-driven type I collagen deposition facilitates cancer stem cell-like phenotype of head and neck squamous cell carcinoma
Lactate-driven type I collagen deposition facilitates cancer stem cell-like phenotype of head and neck squamous cell carcinoma Open
View article: Stromal thrombospondin 1 suppresses angiogenesis in oral submucous fibrosis
Stromal thrombospondin 1 suppresses angiogenesis in oral submucous fibrosis Open