Zhengkun Tu
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View article: Tuning Electronic Structure of Mno2 Via Ammonium Intercalation for Aqueous Sodium-Ion Supercapacitors with Commercial-Level Mass-Loading
Tuning Electronic Structure of Mno2 Via Ammonium Intercalation for Aqueous Sodium-Ion Supercapacitors with Commercial-Level Mass-Loading Open
View article: Molybdate Pre-Intercalation-Assisted Electrochemical Reconstruction of Coni-Ldh for High-Mass-Loading Supercapacitors
Molybdate Pre-Intercalation-Assisted Electrochemical Reconstruction of Coni-Ldh for High-Mass-Loading Supercapacitors Open
View article: The novel mechanism facilitating chronic hepatitis B infection: immunometabolism and epigenetic modification reprogramming
The novel mechanism facilitating chronic hepatitis B infection: immunometabolism and epigenetic modification reprogramming Open
Hepatitis B Virus (HBV) infections pose a global public health challenge. Despite extensive research on this disease, the intricate mechanisms underlying persistent HBV infection require further in-depth elucidation. Recent studies have re…
View article: Activation of AIM2 by hepatitis B virus results in antiviral immunity that suppresses hepatitis C virus during coinfection
Activation of AIM2 by hepatitis B virus results in antiviral immunity that suppresses hepatitis C virus during coinfection Open
Hepatitis B virus (HBV) infection in immunocompetent adults is mostly self-limiting, whereas Hepatitis C virus (HCV) infection more often becomes chronic, suggesting that HBV is more susceptible to the host immune response. It is unclear h…
View article: Platelets mediate inflammatory monocyte activation by SARS-CoV-2 spike protein
Platelets mediate inflammatory monocyte activation by SARS-CoV-2 spike protein Open
Infection with SARS-CoV-2, the causative agent of COVID-19, causes mild to moderate disease in most patients but carries a risk of morbidity and mortality. Seriously affected individuals manifest disorders of hemostasis and a cytokine stor…
View article: TLR3 Mediates Senescence and Immunosurveillance of Hepatic Stellate Cells
TLR3 Mediates Senescence and Immunosurveillance of Hepatic Stellate Cells Open
Background: Activation of hepatic stellate cells (HSCs) is an important driver of liver fibrosis, which is a health problem of global concern, and there is no effective solution for it at the present. Senescent activated HSCs are preferent…
View article: Hepatitis B Virus Infection and Immunopathogenesis in a Humanized Mouse Model: Induction of Human-Specific Liver Fibrosis and M2-Like Macrophages
Hepatitis B Virus Infection and Immunopathogenesis in a Humanized Mouse Model: Induction of Human-Specific Liver Fibrosis and M2-Like Macrophages Open
The mechanisms of chronic HBV infection and immunopathogenesis are poorly understood due to a lack of a robust small animal model. Here we report the development of a humanized mouse model with both human immune system and human liver cell…
View article: Cross-linking of CD81 by HCV-E2 protein inhibits human intrahepatic plasmacytoid dendritic cells response to CpG-ODN
Cross-linking of CD81 by HCV-E2 protein inhibits human intrahepatic plasmacytoid dendritic cells response to CpG-ODN Open
Plasmacytoid dendritic cells (pDCs) are reported to be defective in HCV-infected patients, the mechanisms of which remain poorly understood. We isolated liver derived mononuclear cells (LMNCs) and pDCs from normal liver tissues of benign t…
View article: Hepatitis C virus core protein triggers expansion and activation of CD4+CD25+ regulatory T cells in chronic hepatitis C patients
Hepatitis C virus core protein triggers expansion and activation of CD4+CD25+ regulatory T cells in chronic hepatitis C patients Open
CD4+CD25+FoxP3+ regulatory T cells (Tregs) are increased in patients with chronic hepatitis C, which may contribute to the sustained suppression of hepatitis C virus (HCV)-specific T-cell responses and viral persistence in HCV-infected ind…
View article: The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway
The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway Open
View article: IL-10 plays a central regulatory role in the cytokines induced by hepatitis C virus core protein and polyinosinic acid:polycytodylic acid
IL-10 plays a central regulatory role in the cytokines induced by hepatitis C virus core protein and polyinosinic acid:polycytodylic acid Open
Hepatitis C virus (HCV) can cause persistent infection and chronic liver disease, and viral factors are involved in HCV persistence. HCV core protein, a highly conserved viral protein, not only elicits an immunoresponse, but it also regula…
View article: Regulatory NK cells mediated between immunosuppressive monocytes and dysfunctional T cells in chronic HBV infection
Regulatory NK cells mediated between immunosuppressive monocytes and dysfunctional T cells in chronic HBV infection Open
Background and aims HBV infection represents a major health problem worldwide, but the immunological mechanisms by which HBV causes chronic persistent infection remain only partly understood. Recently, cell subsets with suppressive feature…
View article: Hepatitis B virus–induced imbalance of inflammatory and antiviral signaling by differential phosphorylation of STAT1 in human monocytes
Hepatitis B virus–induced imbalance of inflammatory and antiviral signaling by differential phosphorylation of STAT1 in human monocytes Open
It is not clear how hepatitis B virus (HBV) modulates host immunity during chronic infection. In addition to the key mediators of inflammatory response in viral infection, monocytes also express a high-level IFN-stimulated gene, CH25H, upo…
View article: Activated NK cells kill hepatic stellate cells via p38/PI3K signaling in a TRAIL-involved degranulation manner
Activated NK cells kill hepatic stellate cells via p38/PI3K signaling in a TRAIL-involved degranulation manner Open
NK cells are important in regulating hepatic fibrosis via their cytotoxic killing of hepatic stellate cells (HSCs). NK cells are activated by both cytokines such as IL-12 and IL-18, and innate immune stimuli such as ligation of TLRs. The s…
View article: HCV core protein inhibits polarization and activity of both M1 and M2 macrophages through the TLR2 signaling pathway
HCV core protein inhibits polarization and activity of both M1 and M2 macrophages through the TLR2 signaling pathway Open
Hepatitis C virus (HCV) establishes persistent infection in most infected patients, and eventually causes chronic hepatitis, cirrhosis, and hepatocellular carcinoma in some patients. Monocytes and macrophages provide the first line of defe…
View article: Hepatitis C Virus Induces MDSCs-Like Monocytes through TLR2/PI3K/AKT/STAT3 Signaling
Hepatitis C Virus Induces MDSCs-Like Monocytes through TLR2/PI3K/AKT/STAT3 Signaling Open
Recent studies reveal the accumulation of myeloid derived suppressor cells (MDSCs) in human peripheral blood mononuclear cells (PBMCs) following HCV infection, which may facilitate and maintain HCV persistent infection. The mechanisms by w…
View article: Brucella Dysregulates Monocytes and Inhibits Macrophage Polarization through LC3-Dependent Autophagy
Brucella Dysregulates Monocytes and Inhibits Macrophage Polarization through LC3-Dependent Autophagy Open
Brucellosis is caused by infection with Brucella species and exhibits diverse clinical manifestations in infected humans. Monocytes and macrophages are not only the first line of defense against Brucella infection but also a main reservoir…
View article: Immune suppression in chronic hepatitis B infection associated liver disease: A review
Immune suppression in chronic hepatitis B infection associated liver disease: A review Open
Hepatitis B virus (HBV) infection is one the leading risk factors for chronic hepatitis, liver fibrosis, cirrhosis and hepatocellular cancer (HCC), which are a major global health problem. A large number of clinical studies have shown that…
View article: Hepatitis B Virus–Induced Imbalance of Inflammatory and Antiviral Signaling by Differential Phosphorylation of STAT1 in Human Monocytes
Hepatitis B Virus–Induced Imbalance of Inflammatory and Antiviral Signaling by Differential Phosphorylation of STAT1 in Human Monocytes Open
It is not clear how hepatitis B virus (HBV) modulates host immunity during chronic infection. In addition to the key mediators of inflammatory response in viral infection, monocytes also express a high-level IFN-stimulated gene, CH25H, upo…
View article: Activated NK cells kill hepatic stellate cells via p38/PI3K signaling in a TRAIL-involved degranulation manner
Activated NK cells kill hepatic stellate cells via p38/PI3K signaling in a TRAIL-involved degranulation manner Open
NK cells are important in regulating hepatic fibrosis via their cytotoxic killing of hepatic stellate cells (HSCs). NK cells are activated by both cytokines such as IL-12 and IL-18, and innate immune stimuli such as ligation of TLRs. The s…
View article: Mononuclear phagocyte system in hepatitis C virus infection
Mononuclear phagocyte system in hepatitis C virus infection Open
The mononuclear phagocyte system (MPS), which consists of monocytes, dendritic cells (DCs), and macrophages, plays a vital role in the innate immune defense against pathogens. Hepatitis C virus (HCV) is efficient in evading the host immuni…
View article: Iron metabolism disorders in patients with hepatitis B-related liver diseases
Iron metabolism disorders in patients with hepatitis B-related liver diseases Open
Iron metabolism disorders occur in patients with HBV-related liver diseases. The serum markers of iron metabolism disorders vary in different stages of HBV-related liver diseases.
View article: Description of organ-specific phenotype, and functional characteristics of tissue resident lymphocytes from liver transplantation donor and research on immune tolerance mechanism of liver
Description of organ-specific phenotype, and functional characteristics of tissue resident lymphocytes from liver transplantation donor and research on immune tolerance mechanism of liver Open
Prior to transplantation, Donation after Cardiac Death (DCD) liver transplantation livers are perfused with preservation solution. Therefore, this provides an abundant source of human liver lymphocytes, as well as mesenteric lymph node and…
View article: An Autoimmune Disease-Associated Risk Variant in the <i>TNFAIP3</i> Gene Plays a Protective Role in Brucellosis That Is Mediated by the NF-κB Signaling Pathway
An Autoimmune Disease-Associated Risk Variant in the <i>TNFAIP3</i> Gene Plays a Protective Role in Brucellosis That Is Mediated by the NF-κB Signaling Pathway Open
Naturally occurring functional variants (rs148314165 and rs200820567, collectively referred to as TT>A) reduce the expression of the tumor necrosis factor alpha-induced protein 3 ( TNFAIP3 ) gene, a negative regulator of NF-κB signaling, a…
View article: Antitumor potential of a novel camptothecin derivative, ZBH-ZM-06
Antitumor potential of a novel camptothecin derivative, ZBH-ZM-06 Open
Camptothecin (CPT) is a cytotoxic quinoline alkaloid that is used clinically as an anticancer drug. However, the clinical application of CPT is limited due to its low solubility as well as serious and unfathomable side-effects. In the pres…
View article: HCV immune evasion and regulatory T cell activation: cause or consequence?
HCV immune evasion and regulatory T cell activation: cause or consequence? Open
View article: Regulatory NK cells mediated between immunosuppressive monocytes and dysfunctional T cells in chronic HBV infection
Regulatory NK cells mediated between immunosuppressive monocytes and dysfunctional T cells in chronic HBV infection Open
Background and aims HBV infection represents a major health problem worldwide, but the immunological mechanisms by which HBV causes chronic persistent infection remain only partly understood. Recently, cell subsets with suppressive feature…
View article: Brucella Dysregulates Monocytes and Inhibits Macrophage Polarization through LC3-Dependent Autophagy
Brucella Dysregulates Monocytes and Inhibits Macrophage Polarization through LC3-Dependent Autophagy Open
Brucellosis is caused by infection with Brucella species and exhibits diverse clinical manifestations in infected humans. Monocytes and macrophages are not only the first line of defense against Brucella infection but also a …
View article: The Role of Monocytes/Macrophages in HBV and HCV Infection
The Role of Monocytes/Macrophages in HBV and HCV Infection Open
Monocytes/macrophages constitute the first line of defence for external intrusion or infection. Circulatory monocytes represent about 10% of leukocytes in human blood and resident macrophages are distributed in a variety of tissues and org…
View article: Comprehensive mapping of antigen specific T cell responses in hepatitis C virus infected patients with or without spontaneous viral clearance
Comprehensive mapping of antigen specific T cell responses in hepatitis C virus infected patients with or without spontaneous viral clearance Open
Elucidating protective immunity against HCV is important for the development of a preventative vaccine. We hypothesize that spontaneous resolution of acute HCV infection offers clue to protective immune responses, and that DAA therapy affe…