Zhijian Xiao
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View article: Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development
Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development Open
Essential thrombocythemia (ET) includes the JAK2 ‐, CALR ‐, and MPL ‐mutated subtypes, and a triple‐negative (TN) ET subtype, which lacks these canonical drivers. How specific driver mutations affect hematopoietic stem cell (HSC) heterogen…
View article: Targeting cellular senescence in dystrophin-/-/utrophin-/-double knockout mice improves musculoskeletal health and increases lifespan
Targeting cellular senescence in dystrophin-/-/utrophin-/-double knockout mice improves musculoskeletal health and increases lifespan Open
Duchenne muscular dystrophy (DMD) is a severe genetic muscle disease caused by mutations of the dystrophin gene. Previous studies have detected senescent cells in the skeletal muscle of human DMD, dystrophin-deficient mice (Mdx), and rats.…
View article: Short-Term Cryopreservation Preserved the Function of MSCs from Bone Marrow Aspirate Concentrate
Short-Term Cryopreservation Preserved the Function of MSCs from Bone Marrow Aspirate Concentrate Open
Bone marrow aspirate concentrate (BMAC) is increasingly recognized as a valuable orthobiologic, offering promising outcomes in reducing inflammation, alleviating pain for patients with osteoarthritis (OA) and various musculoskeletal condit…
View article: Poster 171: Comparison of Fresh and Frozen Bone Marrow Aspirate Concentrate for Treatment of DMM Induced Osteoarthritis in Rats
Poster 171: Comparison of Fresh and Frozen Bone Marrow Aspirate Concentrate for Treatment of DMM Induced Osteoarthritis in Rats Open
Objectives: Bone marrow aspirate concentrate (BMAC) is a commonly clinically used cell source for muscular skeletal injury repair. However, it is often required multiple injections with multiple harvests which caused pain for patient. Ther…
View article: China Expert consensus on the application of metagenomic next-generation sequencing for the etiological diagnosis of infections in hematological disorders (2024)
China Expert consensus on the application of metagenomic next-generation sequencing for the etiological diagnosis of infections in hematological disorders (2024) Open
Infections are frequent complications in patients with hematological disorders, and pathogen diagnosis remains challenging. Metagenomic next-generation sequencing (mNGS) is an unbiased high-throughput technology that has been widely applie…
View article: Acute Leukemia of Mixed B/Myeloid Lineage with Dual BCR: : ABL1 and CBFβ: : MYH11 Fusion Genes
Acute Leukemia of Mixed B/Myeloid Lineage with Dual BCR: : ABL1 and CBFβ: : MYH11 Fusion Genes Open
View article: Exposure-response analyses of venetoclax combined with hypomethylating agents in myelodysplastic syndromes: a retrospective study
Exposure-response analyses of venetoclax combined with hypomethylating agents in myelodysplastic syndromes: a retrospective study Open
Background Venetoclax (VEN), an orally bioavailable B-cell lymphoma-2 inhibitor, shows promising activity in patients with myelodysplastic syndromes (MDS) when combined with hypomethylating agents (HMAs). However, research regarding the VE…
View article: Mutual stabilization of hybrid and inorganic perovskites for photovoltaics
Mutual stabilization of hybrid and inorganic perovskites for photovoltaics Open
View article: Comparative analysis of patients’ characteristics, treatment, and survival outcomes in CLL from China and the United States
Comparative analysis of patients’ characteristics, treatment, and survival outcomes in CLL from China and the United States Open
Background Chronic lymphocytic leukemia (CLL) is considerably more common in Americans compared with Asians. The basis for these differences and implications for therapy outcomes are controversial and mostly unknown. Methods We compared ba…
View article: A comparative analysis of clinical outcomes in hematological patients afflicted with bacteremia attributable to carbapenem-resistant Klebsiella pneumoniae versus Escherichia coli
A comparative analysis of clinical outcomes in hematological patients afflicted with bacteremia attributable to carbapenem-resistant Klebsiella pneumoniae versus Escherichia coli Open
Introduction Carbapenem-resistant Enterobacterales (CRE) bloodstream infections (BSI) represent a frequent and grave complication among hematological patients, whose prevailing culprits are Carbapenem-Resistant Klebsiella pneumoniae (CRKP)…
View article: Antibiotic stewardship in hematological patients with Escherichia coli and Klebsiella pneumoniae bloodstream infections: evaluating short-course and carbapenem-sparing strategies
Antibiotic stewardship in hematological patients with Escherichia coli and Klebsiella pneumoniae bloodstream infections: evaluating short-course and carbapenem-sparing strategies Open
View article: A correlation of ineffective erythropoiesis and dysregulated signaling pathways in myelodysplastic syndromes/neoplasms
A correlation of ineffective erythropoiesis and dysregulated signaling pathways in myelodysplastic syndromes/neoplasms Open
View article: [Avapritinib for systemic mastocytosis with an associated myelodysplastic/myeloproliferative neoplasm: a case report and literature review].
[Avapritinib for systemic mastocytosis with an associated myelodysplastic/myeloproliferative neoplasm: a case report and literature review]. Open
Systemic mastocytosis (SM) with an associated myelodysplastic/myeloproliferative neoplasm (MDS/MPN) is a rare subtype of myeloid neoplasms. Avapritinib, a potent and selective inhibitor of KIT D816V, is approved for treating advanced syste…
View article: [Analysis of the association between pre- and post-treatment genetic mutation status and treatment efficacy and survival in patients with newly diagnosed myelodysplastic syndromes with excess blasts receiving hypomethylating agent therapy].
[Analysis of the association between pre- and post-treatment genetic mutation status and treatment efficacy and survival in patients with newly diagnosed myelodysplastic syndromes with excess blasts receiving hypomethylating agent therapy]. Open
Objective: To investigate the association between pre- and post-treatment gene mutation profiles and clinical outcomes (treatment response and prognosis) in patients with myelodysplastic syndromes with excess blasts (MDS-EB) receivi…
View article: MORC2 facilitates cholangiocarcinoma progression through cell cycleacceleration and immune microenvironment modification
MORC2 facilitates cholangiocarcinoma progression through cell cycleacceleration and immune microenvironment modification Open
This study explored a novel therapeutic target, MORC2 (Microrchidia family CW-type zinc finger 2), for patients with unresectable advanced Cholangiocarcinoma (CCA), a lethal epithelial cell malignancy lacking effective treatments. Utilizin…
View article: XTSFormer: Cross-Temporal-Scale Transformer for Irregular-Time Event Prediction in Clinical Applications
XTSFormer: Cross-Temporal-Scale Transformer for Irregular-Time Event Prediction in Clinical Applications Open
Adverse clinical events related to unsafe care are among the top ten causes of death in the U.S. Accurate modeling and prediction of clinical events from electronic health records (EHRs) play a crucial role in patient safety enhancement. A…
View article: Molecular characteristics and clinical implications of TP53 mutations in therapy-related myelodysplastic syndromes
Molecular characteristics and clinical implications of TP53 mutations in therapy-related myelodysplastic syndromes Open
View article: Bone marrow mesenchymal stem cell exosomes improve fracture union via remodeling metabolism in nonunion rat model
Bone marrow mesenchymal stem cell exosomes improve fracture union via remodeling metabolism in nonunion rat model Open
View article: Continuous R-DA-EDOCH alternated with high-dose Ara-C induces deep remission and overcomes high-risk factors in young patients with newly diagnosed mantle cell lymphoma
Continuous R-DA-EDOCH alternated with high-dose Ara-C induces deep remission and overcomes high-risk factors in young patients with newly diagnosed mantle cell lymphoma Open
Objective: Our previous studies have indicated potentially higher proliferative activity of tumor cells in Chinese patients with mantle-cell lymphoma (MCL) than those in Western. Given the success and tolerability of R-DA-EDOCH immunochemo…
View article: Targeting CD38 effectively prevents myelofibrosis in myeloproliferative neoplasms
Targeting CD38 effectively prevents myelofibrosis in myeloproliferative neoplasms Open
Proinflammatory signaling is a hallmark of myeloproliferative neoplasms (MPNs). Several studies have shown that monocytes are a major source of proinflammatory cytokines and monocyte-derived fibrocytes play a pivotal role in the pathogenes…
View article: Patient and physician perceptions regarding treatment expectations and symptomatology in polycythemia vera: Insights from the Landmark 2.0 global health survey
Patient and physician perceptions regarding treatment expectations and symptomatology in polycythemia vera: Insights from the Landmark 2.0 global health survey Open
Polycythemia vera (PV) is a myeloproliferative neoplasm associated with a high symptom and psychological burden, resulting in decreased quality of life (QoL). Patients with PV have an increased risk of cardiovascular (CV) complications, ma…
View article: Giving fish or teaching fishing? the impact of China’s foreign aid on digital service trade in belt and road initiative countries
Giving fish or teaching fishing? the impact of China’s foreign aid on digital service trade in belt and road initiative countries Open
This paper empirically analyzes the relationship between China’s foreign aid and the digital service trade of Belt and Road Initiative (BRI) countries, using panel data from 2005 to 2017. We find that under the framework of the BRI, China’…
View article: A Machine Learning–Guided Clinical Decision Support System for Early Antibiotic Selection in Pseudomonas Aeruginosa Bloodstream Infections Among Onco-Hematology Patients: A Multicenter Study
A Machine Learning–Guided Clinical Decision Support System for Early Antibiotic Selection in Pseudomonas Aeruginosa Bloodstream Infections Among Onco-Hematology Patients: A Multicenter Study Open
View article: Dtymk is a Prognostic Biomarker and Potential Target in Intrahepatic Cholangiocarcinoma
Dtymk is a Prognostic Biomarker and Potential Target in Intrahepatic Cholangiocarcinoma Open
View article: Evaluation of gecacitinib vs hydroxyurea in patients with intermediate-2 or high-risk myelofibrosis: final analysis results from a randomized phase 3 study
Evaluation of gecacitinib vs hydroxyurea in patients with intermediate-2 or high-risk myelofibrosis: final analysis results from a randomized phase 3 study Open
To compare the efficacy and safety of gecacitinib (also known as jaktinib) with hydroxyurea (HU) in treating myelofibrosis (MF) patients. In this multicenter, randomized phase 3 trial (ZGJAK016), intermediate- or high-risk primarily JAK in…
View article: Poorly controlled type II diabetes mellitus significantly enhances postoperative chemoresistance in patients with stage III colon cancer
Poorly controlled type II diabetes mellitus significantly enhances postoperative chemoresistance in patients with stage III colon cancer Open
BACKGROUND Type II diabetes mellitus (T2DM) has been associated with increased risk of colon cancer (CC) and worse prognosis in patients with metastases. The effects of T2DM on postoperative chemoresistance rate (CRR) and long-term disease…
View article: [Next-generation sequencing-based minimal residual disease detection reveals clonal evolution in pediatric acute B-lymphoblastic leukemia: a case report and literature review].
[Next-generation sequencing-based minimal residual disease detection reveals clonal evolution in pediatric acute B-lymphoblastic leukemia: a case report and literature review]. Open
Minimal residual disease (MRD), a crucial biomarker for assessing efficacy and predicting recurrence, refers to residual tumor cells remaining in the body of patients with hematological malignancies who achieved complete remission after tr…
View article: Evolution of surgical treatment for hepatolithiasis
Evolution of surgical treatment for hepatolithiasis Open
Hepatolithiasis is a common disease where stones are located in the intrahepatic bile duct. Hepatolithiasis is a disease with regional characteristics. The complication and postoperative recurrence rates of the disease are high. The intrah…
View article: Molecular remission uncoupled with complete haematological response in polycythaemia vera treatment with ropeginterferon alfa‐2b
Molecular remission uncoupled with complete haematological response in polycythaemia vera treatment with ropeginterferon alfa‐2b Open
View article: [The value of WT1 mRNA expression level in the diagnosis and prognosis evaluation of myelodysplastic syndromes].
[The value of WT1 mRNA expression level in the diagnosis and prognosis evaluation of myelodysplastic syndromes]. Open
Objectives: To analyze the value of the WT1 mRNA expression level in the diagnosis and prognostic evaluation of myelodysplastic syndrome (MDS) . Methods: A total of 403 patients with MDS, suspected MDS, and acute myeloid leuk…