Zhengming Chen
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View article: MRD-driven Initial Therapy of Acalabrutinib and Lenalidomide plus Rituximab (ALR) or Obinutuzumab (ALO) for Mantle Cell Lymphoma
MRD-driven Initial Therapy of Acalabrutinib and Lenalidomide plus Rituximab (ALR) or Obinutuzumab (ALO) for Mantle Cell Lymphoma Open
This phase 2 study evaluated the efficacy and safety of combining acalabrutinib (A) and lenalidomide (L) with either rituximab (ALR) or obinutuzumab (ALO), with longitudinal minimal residual disease (MRD) monitoring in frontline MCL treatm…
View article: Figure 3 from Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival
Figure 3 from Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival Open
ATF4 is required in DLBCL cells and is partially responsible for SIRT3′s functions to promote DLBCL cell proliferation and survival. A, Effect of ATF4 knockdown on the proliferation of DLBCL cell lines. Each cell line was infected w…
View article: Figure 6 from Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival
Figure 6 from Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival Open
ATF4 translation and protein level respond to nutrient level and are regulated by autophagy. A, FCs of mean fluorescence intensity (MFI) of the GFP reporter expressed from the ATF4-5′UTR-GFP translation reporter in Karpas 422 cells …
View article: Figure 7 from Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival
Figure 7 from Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival Open
Graphical summary of SIRT3–ATF4 regulation in DLBCLs. Left, DLBCL cells depend on glutamine anaplerosis driven by SIRT3 and GDH to produce metabolic precursors from the TCA cycle for cell survival and proliferation, which also suppress aut…
View article: Figure 4 from Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival
Figure 4 from Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival Open
ATF4 protein level is decreased in vavP-Bcl2;Sirt3−/− mice and associated with lymphoma progression. A, Western blot results show the protein levels of ATF4, LC3, EIF2A, ACTB, and SIRT3 in splenocytes from vavP-…
View article: Figure 2 from Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival
Figure 2 from Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival Open
Knockdown SIRT3 caused ATF4 protein decrease via translation regulation. A, Western blots show ATF4 protein levels in different DLBCL cells with control or SIRT3 shRNAs. SIRT3 was blotted showing knockdown efficiency, and ACTB was u…
View article: Figure 1 from Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival
Figure 1 from Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival Open
Knocking down SIRT3 caused ATF4 signaling inhibition but not HIF1a. A, Dendrograms from hierarchical clustering of RNA-seq data from three DLBCL cells lines transduced with lentiviruses containing control (scramble) or two SIRT3 shR…
View article: Expanded mosaic chromosomal alterations, frailty, and risks of all-cause and cause-specific mortality among Chinese and the UK adults: evidence from two prospective cohorts
Expanded mosaic chromosomal alterations, frailty, and risks of all-cause and cause-specific mortality among Chinese and the UK adults: evidence from two prospective cohorts Open
Our findings suggested that expanded mCAs were significantly associated with all-cause and cause-specific deaths and could serve as a complement to the FI in providing a more comprehensive perspective on mortality risk, especially for canc…
View article: International collaboration in cohort studies in China: opportunities and challenges
International collaboration in cohort studies in China: opportunities and challenges Open
Zhengming Chen and colleagues outline the key value, opportunities, and challenges of international collaboration in cohort studies in China
View article: CDK4/6 Inhibition Reverses MEIS2 Suppression of CRL4<sup>CRBN</sup> to Enhance Immunomodulatory Drug Therapy in Multiple Myeloma
CDK4/6 Inhibition Reverses MEIS2 Suppression of CRL4<sup>CRBN</sup> to Enhance Immunomodulatory Drug Therapy in Multiple Myeloma Open
MEIS2 was identified biochemically as a substrate of cereblon (CRBN), a receptor of the CRL4 CRBN E3 ubiquitin ligase required for the anti-myeloma activity of immunomodulatory drugs (IMiD)s and CELMoDs. However, its function in myeloma is…
View article: P11.12.A A PAN-CANCER ATLAS OF LEPTOMENINGEAL DISEASE REVEALS BRANCHED CHAIN KETO ACIDS DRIVE IMMUNOSUPPRESSION AND NEURODEGENERATION
P11.12.A A PAN-CANCER ATLAS OF LEPTOMENINGEAL DISEASE REVEALS BRANCHED CHAIN KETO ACIDS DRIVE IMMUNOSUPPRESSION AND NEURODEGENERATION Open
BACKGROUND Leptomeningeal disease (LMD) is one of the most devastating complications of advanced cancer, resulting in severe neurological deterioration and poor survival outcomes. MATERIAL AND METHODS Using single-cell transcriptomics and …
View article: Safety and efficacy of bridging radiation therapy prior to CD19 CAR T for non-Hodgkin lymphoma: a systematic review and meta-analysis
Safety and efficacy of bridging radiation therapy prior to CD19 CAR T for non-Hodgkin lymphoma: a systematic review and meta-analysis Open
Bridging radiation therapy (BRT) is increasingly utilized prior to CART19 in NHL patients. However, its impact on CART19 outcomes is not established. We conducted a systematic review and meta-analysis to estimate the safety and efficacy of…
View article: Hyperuricemia, gout and the associated comorbidities in China: findings from a prospective study of 0.5 million adults
Hyperuricemia, gout and the associated comorbidities in China: findings from a prospective study of 0.5 million adults Open
Kadoorie Charitable Foundation, National Natural Science Foundation of China, Noncommunicable Chronic Diseases-National Science and Technology Major Project, British Heart Foundation, Cancer Research UK, Wellcome Trust, UK Medical Research…
View article: Formation Mechanism of Granitic Basement Reservoir Linked to Felsic Minerals and Tectonic Stress in the Qiongdongnan Basin, South China Sea
Formation Mechanism of Granitic Basement Reservoir Linked to Felsic Minerals and Tectonic Stress in the Qiongdongnan Basin, South China Sea Open
Recent exploration efforts in the Qiongdongnan Basin have revealed hydrocarbon resources within granitic basement rocks in buried hill traps. However, the formation mechanisms and primary controlling factors of these reservoirs remain poor…
View article: Long-term exposure to fine particulate matter interacting with individual conditions increase breast cancer incidence: a large-scale Chinese cohort
Long-term exposure to fine particulate matter interacting with individual conditions increase breast cancer incidence: a large-scale Chinese cohort Open
Background Breast cancer is the most frequently diagnosed malignancy among women worldwide. This study aimed to investigate the impact of long-term fine particulate matter (PM2.5) exposure on breast cancer incidence in a cohort of 281,152 …
View article: Acute Impact of Nonoptimal Ambient Temperatures on Plasma Levels of 3000 Proteins in Chinese Adults
Acute Impact of Nonoptimal Ambient Temperatures on Plasma Levels of 3000 Proteins in Chinese Adults Open
Nonoptimal ambient temperatures (i.e., cold and heat) are leading environmental determinants of major diseases worldwide, but the underlying pathological mechanisms are still poorly understood. We used distributed-lag nonlinear models to e…
View article: Effect of Long-Term Fine Particulate Matter Exposure on Lung Cancer Incidence and Mortality in Chinese Nonsmokers
Effect of Long-Term Fine Particulate Matter Exposure on Lung Cancer Incidence and Mortality in Chinese Nonsmokers Open
Rationale: The association between fine particulate matter (particulate matter ⩽2.5 μm in aerodynamic diameter, PM2.5) and lung cancer incidence in nonsmokers (LCINS) remains inconsistent. Objectives: To investigat…
View article: Associations Between Snoring, Body Mass Index and Coronary Artery Diseases: Observational and Mendelian Randomization Study in Asia
Associations Between Snoring, Body Mass Index and Coronary Artery Diseases: Observational and Mendelian Randomization Study in Asia Open
Background and Objective Previous observational studies reported a complex relationship between snoring and coronary artery disease (CAD). We aimed to estimate the causal associations between snoring and CAD among East Asian people, and th…
View article: Geological Conditions and Sedimentary Models of Oligocene and Eocene Effective Source Rocks in the Northern Yinggehai Basin
Geological Conditions and Sedimentary Models of Oligocene and Eocene Effective Source Rocks in the Northern Yinggehai Basin Open
The development of the effective source rocks of the Eocene and Oligocene directly determines the oil and gas exploration potential in the northern Yinggehai Basin in China. Based on the analogy with the Hanoi Depression in Vietnam and the…
View article: Comparison of models to predict incident chronic liver disease: a systematic review and external validation in Chinese adults
Comparison of models to predict incident chronic liver disease: a systematic review and external validation in Chinese adults Open
View article: Deep Convolutional Transformer Network for Stock Movement Prediction
Deep Convolutional Transformer Network for Stock Movement Prediction Open
The prediction and modeling of stock price movements have been shown to possess considerable economic significance within the finance sector. Recently, a range of artificial intelligence methodologies, encompassing both traditional machine…
View article: Mosaic loss of chromosome Y, tobacco smoking and risk of age-related lung diseases: insights from two prospective cohorts
Mosaic loss of chromosome Y, tobacco smoking and risk of age-related lung diseases: insights from two prospective cohorts Open
Background Little is known about the underlying relationship between mosaic loss of chromosome Y (mLOY), the most common chromosomal alterations in older men, and the risk of age-related lung diseases. Methods We included 217 780 participa…
View article: Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis
Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis Open
View article: The impact of trade reforms on industry wage premia in Pakistan: A sectoral perspective
The impact of trade reforms on industry wage premia in Pakistan: A sectoral perspective Open
Pakistan witnessed significant trade liberalization reforms between 1988 and 2005. This study investigates the impact of Pakistan's significant trade liberalization policies in 1988 on industry wage premia. We use an estimation strategy th…
View article: Reproductive factors and risk of lung cancer among 300,000 Chinese female never-smokers: evidence from the China Kadoorie Biobank study
Reproductive factors and risk of lung cancer among 300,000 Chinese female never-smokers: evidence from the China Kadoorie Biobank study Open
View article: Correlates and consequences of atrial fibrillation in a prospective study of 25 000 participants in the China Kadoorie Biobank
Correlates and consequences of atrial fibrillation in a prospective study of 25 000 participants in the China Kadoorie Biobank Open
Aims The prevalence of atrial fibrillation (AF) is positively correlated with prior cardiovascular diseases (CVD) and CVD risk factors but is lower in Chinese than Europeans despite their higher burden of CVD. We examined the prevalence an…
View article: Analysis of the Evolution Pattern and Regional Conservation of Cultural Heritage from the Perspective of Urban Sustainable Transformation: The Case of Xiamen, China
Analysis of the Evolution Pattern and Regional Conservation of Cultural Heritage from the Perspective of Urban Sustainable Transformation: The Case of Xiamen, China Open
This study focuses on the cultural heritage of Xiamen and uses the spatial analysis method of ArcGIS to analyze the spatiotemporal evolution and distribution characteristics of cultural heritage. Through analysis, we aim to optimize the st…
View article: Predicting risk of chronic liver disease in Chinese adults: External validation of the CLivD score
Predicting risk of chronic liver disease in Chinese adults: External validation of the CLivD score Open
View article: Supplementary Table 1 from XPO1 Enables Adaptive Regulation of mRNA Export Required for Genotoxic Stress Tolerance in Cancer Cells
Supplementary Table 1 from XPO1 Enables Adaptive Regulation of mRNA Export Required for Genotoxic Stress Tolerance in Cancer Cells Open
Supplementary Table 1
View article: Supplementary Data from XPO1 Enables Adaptive Regulation of mRNA Export Required for Genotoxic Stress Tolerance in Cancer Cells
Supplementary Data from XPO1 Enables Adaptive Regulation of mRNA Export Required for Genotoxic Stress Tolerance in Cancer Cells Open
Supplementary Figures and Tables