Zhengnian Ding
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View article: Effects of early diet resumption on the incidence of complications following polypectomy: A randomized controlled trial
Effects of early diet resumption on the incidence of complications following polypectomy: A randomized controlled trial Open
BACKGROUND Patients with early oral intake after intestinal surgery achieve better nutritional status and fewer postoperative complications. However, no guidelines or expert consensus have established the optimal timing for diet resumption…
View article: [Effects of retropubic and obturator urethral suspension on postoperative maximum flow rate and residual urine volume].
[Effects of retropubic and obturator urethral suspension on postoperative maximum flow rate and residual urine volume]. Open
Both TVT and TOT are effective in the treatment of stress incontinence, and have no effect on postoperative maximum flow rate and residual urine volume.
View article: KMV-mediated cardiomyocyte-to-endothelial cell signaling drives capillary rarefaction to promote heart failure following pressure overload
KMV-mediated cardiomyocyte-to-endothelial cell signaling drives capillary rarefaction to promote heart failure following pressure overload Open
Rationale: Pressure overload (PO)-induced heart failure (HF) is a global health burden with poor outcomes. Cardiomyocyte hypertrophy and capillary rarefaction are two features and drivers of PO-induced HF. Metabolism is altered in h…
View article: HSPA12A stimulates “Smurf1-Hif1α-aerobic glycolysis” axis to promote proliferation of renal tubular epithelial cells after hypoxia/reoxygenation injury
HSPA12A stimulates “Smurf1-Hif1α-aerobic glycolysis” axis to promote proliferation of renal tubular epithelial cells after hypoxia/reoxygenation injury Open
Proliferation of renal tubular epithelial cells (TECs) is critical for the recovery after kidney ischemia/reperfusion (KI/R). However, there is still a lack of ideal therapies for promoting TEC proliferation. Heat shock protein A12A (HSPA1…
View article: HSPA12A promotes c-Myc lactylation-mediated proliferation of tubular epithelial cells to facilitate renal functional recovery from kidney ischemia/reperfusion injury
HSPA12A promotes c-Myc lactylation-mediated proliferation of tubular epithelial cells to facilitate renal functional recovery from kidney ischemia/reperfusion injury Open
Proliferation of renal tubular epithelial cells (TEC) is essential for restoring tubular integrity and thereby to support renal functional recovery from kidney ischemia/reperfusion (KI/R) injury. Activation of transcriptional factor c-Myc …
View article: HSPA12A promotes c-Myc lactylation-mediated proliferation of tubular epithelial cell to facilitate renal functional recovery from kidney ischemia/reperfusion injury
HSPA12A promotes c-Myc lactylation-mediated proliferation of tubular epithelial cell to facilitate renal functional recovery from kidney ischemia/reperfusion injury Open
Proliferation of renal tubular epithelial cells (TEC) is essential to restore tubular integrity and thereby to support renal functional recovery from kidney ischemia/reperfusion (KI/R) injury. The transcriptional factor c-Myc is activated …
View article: HSPA12A maintains aerobic glycolytic homeostasis and Histone3 lactylation in cardiomyocytes to attenuate myocardial ischemia/reperfusion injury
HSPA12A maintains aerobic glycolytic homeostasis and Histone3 lactylation in cardiomyocytes to attenuate myocardial ischemia/reperfusion injury Open
Myocardial ischemia/reperfusion (MI/R) injury is a major cause of adverse outcomes of revascularization following myocardial infarction. Anaerobic glycolysis during myocardial ischemia is well studied, but the role of aerobic glycolysis du…
View article: Roles of heat shock protein A12A in the development of diabetic cardiomyopathy
Roles of heat shock protein A12A in the development of diabetic cardiomyopathy Open
Long-term hyperglycemia can lead to diabetic cardiomyopathy (DCM), a main lethal complication of diabetes. However, the mechanisms underlying DCM development have not been fully elucidated. Heat shock protein A12A (HSPA12A) is the atypic m…
View article: HSPA12A acts as a scaffolding protein to inhibit cardiac fibroblast activation and cardiac fibrosis
HSPA12A acts as a scaffolding protein to inhibit cardiac fibroblast activation and cardiac fibrosis Open
The present study provided clear evidence that HSPA12A is a novel endogenous inhibitor of CF activation and cardiac fibrosis. Targeting HSPA12A in CF could represent a promising strategy for the management of cardiac fibrosis in patients.
View article: Paraventricular Mast Cell-Derived Histamine Activates CRH Neurons to Mediate Adult Visceral Hypersensitivity Induced by Neonatal Maternal Separation
Paraventricular Mast Cell-Derived Histamine Activates CRH Neurons to Mediate Adult Visceral Hypersensitivity Induced by Neonatal Maternal Separation Open
Neonatal maternal separation (NMS) is an early-life stress (ELS) that can result in adult visceral hypersensitivity, which is usually manifested as chronic visceral pain. Although mast cells and corticotropin-releasing hormone (CRH) neuron…
View article: Effect of ultrasound‐guided thoracic paravertebral block on perioperative analgesia in elderly patients undergoing video‐assisted thoracic lobectomy in China: An interventional clinical randomized controlled trial
Effect of ultrasound‐guided thoracic paravertebral block on perioperative analgesia in elderly patients undergoing video‐assisted thoracic lobectomy in China: An interventional clinical randomized controlled trial Open
Background The aim of this study was to investigate the analgesic effect and safety of ultrasound‐guided thoracic paravertebral block (UG‐TPVB) in Chinese elderly patients undergoing video‐assisted thoracic lobectomy (VATL) and to study th…
View article: HSPA12A controls cerebral lactate homeostasis to maintain hippocampal neurogenesis and mood stabilization
HSPA12A controls cerebral lactate homeostasis to maintain hippocampal neurogenesis and mood stabilization Open
View article: Transcutaneous carbon dioxide measurements in patients undergoing retroperitoneoscopic urologic surgery: A prospective observational study
Transcutaneous carbon dioxide measurements in patients undergoing retroperitoneoscopic urologic surgery: A prospective observational study Open
Purpose: The aim of the current study was to investigate the accuracy of transcutaneous CO 2 pressure (P TC CO 2 ) monitoring and the correlation between it and arterial CO 2 pressure (P a CO 2 ), so as to determine P a CO 2 in patients un…
View article: Hepatocyte HSPA12A inhibits macrophage chemotaxis and activation to attenuate liver ischemia/reperfusion injury via suppressing glycolysis-mediated HMGB1 lactylation and secretion of hepatocytes
Hepatocyte HSPA12A inhibits macrophage chemotaxis and activation to attenuate liver ischemia/reperfusion injury via suppressing glycolysis-mediated HMGB1 lactylation and secretion of hepatocytes Open
Rationale: Liver ischemia-reperfusion (LI/R) injury is characterized by two interconnected phases: local ischemia that causes hepatic cell damage to release damage-associated molecular pattern (DAMPs), and DAMPs that recruit immune …
View article: Heat shock protein A12A activates migration of hepatocellular carcinoma cells in a monocarboxylate transporter 4–dependent manner
Heat shock protein A12A activates migration of hepatocellular carcinoma cells in a monocarboxylate transporter 4–dependent manner Open
View article: HSPA12A Stimulates p38/ERK‐AP‐1 Signaling to Promote Angiogenesis and Is Required for Functional Recovery Postmyocardial Infarction
HSPA12A Stimulates p38/ERK‐AP‐1 Signaling to Promote Angiogenesis and Is Required for Functional Recovery Postmyocardial Infarction Open
Angiogenesis plays a critical role in wound healing postmyocardial infarction (MI). However, there is still a lack of ideal angiogenic therapeutics for rescuing ischemic hearts clinically, suggesting that a more understanding regarding ang…
View article: Comment on: Randomized clinical trial on closure versus non-closure of mesenteric defects during laparoscopic gastric bypass surgery
Comment on: Randomized clinical trial on closure versus non-closure of mesenteric defects during laparoscopic gastric bypass surgery Open
View article: Safety application of muscle relaxants and the traditional low-frequency ventilation during the flexible or rigid bronchoscopy in patients with central airway obstruction: a retrospective observational study
Safety application of muscle relaxants and the traditional low-frequency ventilation during the flexible or rigid bronchoscopy in patients with central airway obstruction: a retrospective observational study Open
Background Bronchoscopy treatments of central airway obstruction (CAO) under general anesthesia are high-risky procedures, and posing a giant challenge to the anesthesiologists. We summarized and analyzed our clinical experience in patient…
View article: Perioperative pulmonary aspiration and regurgitation without aspiration in adults: a retrospective observational study of 166,491 anesthesia records
Perioperative pulmonary aspiration and regurgitation without aspiration in adults: a retrospective observational study of 166,491 anesthesia records Open
The incidence of pulmonary aspiration and regurgitation without aspiration was low, especially in elective cases. Regurgitation during anesthesia induction had mostly developed aspiration. Further evaluation of the effect of modified RSI p…
View article: Penehyclidine mitigates postoperative nausea and vomiting and intraoperative oculocardiac reflex in patients undergoing strabismus surgery: a prospective, randomized, double-blind comparison
Penehyclidine mitigates postoperative nausea and vomiting and intraoperative oculocardiac reflex in patients undergoing strabismus surgery: a prospective, randomized, double-blind comparison Open
View article: A retrospective observational study of anesthesia management during the flexible or rigid bronchoscopy in patients with central airway obstruction: Safety application of muscle relaxants and the traditional Low-frequency ventilation
A retrospective observational study of anesthesia management during the flexible or rigid bronchoscopy in patients with central airway obstruction: Safety application of muscle relaxants and the traditional Low-frequency ventilation Open
Background: Bronchoscopy treatments of central airway obstruction (CAO) under general anesthesia are high-risky procedures, and posing a giant challenge to the anesthesiologists. We summarized and analyzed our clinical experience in anesth…
View article: Glycogen Synthase Kinase 3β Promotes Postoperative Cognitive Dysfunction by Inducing the M1 Polarization and Migration of Microglia
Glycogen Synthase Kinase 3β Promotes Postoperative Cognitive Dysfunction by Inducing the M1 Polarization and Migration of Microglia Open
Postoperative cognitive dysfunction (POCD) is a common postoperative central nervous system complication, especially in the elderly. It has been consistently reported that the pathological process of this clinical syndrome is related to ne…
View article: Penehyclidine mitigates intraoperative oculocardiac reflex and postoperative nausea and vomiting in the patients with strabismus surgery: a prospective, randomized, double-blinded comparison
Penehyclidine mitigates intraoperative oculocardiac reflex and postoperative nausea and vomiting in the patients with strabismus surgery: a prospective, randomized, double-blinded comparison Open
BackgroundPONV is one of the most frequent complications following anesthesia and strabismus surgery. Penehyclidine, an anticholinergic, is widely and preoperatively used for reducing glandular secretion in patients. This study investigate…
View article: Anesthesia Management in Patients With Central Airway Stenosis Undergoing Bronchoscopy Treatments - Safety Application of Muscle Relaxants and the Traditional Low-frequency Ventilation : A Retrospective Observational Study
Anesthesia Management in Patients With Central Airway Stenosis Undergoing Bronchoscopy Treatments - Safety Application of Muscle Relaxants and the Traditional Low-frequency Ventilation : A Retrospective Observational Study Open
Background: Bronchoscopy treatments of central airway stenosis (CAO) under general anesthesia are high-risky procedures, and posing a giant challenge to the anesthesiologists. The aim of this research was to estimate the safety application…
View article: A new self-designed “tongue root holder” device to aid fiberoptic intubation
A new self-designed “tongue root holder” device to aid fiberoptic intubation Open
Objective In this study, we aimed to assess the feasibility of fiberoptic intubation (FOI), using a new, self-designed, “tongue root holder” device, in combination with the jaw thrust maneuver. Methods Three hundred patients undergoing ele…
View article: HSPA12A attenuates lipopolysaccharide-induced liver injury through inhibiting caspase-11-mediated hepatocyte pyroptosis via PGC-1α-dependent acyloxyacyl hydrolase expression
HSPA12A attenuates lipopolysaccharide-induced liver injury through inhibiting caspase-11-mediated hepatocyte pyroptosis via PGC-1α-dependent acyloxyacyl hydrolase expression Open
Liver dysfunction is strongly associated with poor survival of sepsis patients. Cytosolic lipopolysaccharide (LPS) sensing by Caspase-4/5/11 for pyroptosis activation is a major driver of the development of sepsis. Studies in macrophages a…
View article: Alpha-lipoic acid inhibits proliferation and migration of human vascular endothelial cells through downregulating HSPA12B/VEGF signaling axis
Alpha-lipoic acid inhibits proliferation and migration of human vascular endothelial cells through downregulating HSPA12B/VEGF signaling axis Open
View article: Heat‐Shock protein A12A is a novel PCNA‐binding protein and promotes hepatocellular carcinoma growth
Heat‐Shock protein A12A is a novel PCNA‐binding protein and promotes hepatocellular carcinoma growth Open
Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. Proliferating cell nuclear antigen (PCNA) plays a pivotal role in cancer development and progression. However, the long‐term dismal prognosis of HCC mandates more i…
View article: Alpha‐lipoic acid inhibits lung cancer growth via mTOR‐mediated autophagy inhibition
Alpha‐lipoic acid inhibits lung cancer growth via mTOR‐mediated autophagy inhibition Open
Lung cancer is the leading cause of cancer‐related death, and there remains a need for novel therapies for this malignancy. Here, we examined the effects of alpha‐lipoic acid (LA), a drug used for treating human diabetic complications, on …
View article: HSPA12A unstabilizes CD147 to inhibit lactate export and migration in human renal cell carcinoma
HSPA12A unstabilizes CD147 to inhibit lactate export and migration in human renal cell carcinoma Open
Background: Metastasis accounts for 90% of cancer-associated mortality in patients with renal cell carcinoma (RCC). However, the clinical management of RCC metastasis is challenging. Lactate export is known to play an important role…