Zhengran Li
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View article: Complete Mitochondrial Genome of <i>Acheilognathus mengyangensis</i> (Cypriniformes, Cyprinidae, and Acheilognathinae): Characterization and Phylogenetic Analysis
Complete Mitochondrial Genome of <i>Acheilognathus mengyangensis</i> (Cypriniformes, Cyprinidae, and Acheilognathinae): Characterization and Phylogenetic Analysis Open
In this study, the mitochondrial genome data of Acheilognathus mengyangensis were subjected to a multigene tandem method to elucidate its taxonomic status. The total length of the mitochondrial genome was determined to be 16,779 bp, includ…
View article: Family History of Hypertension Predicts Thyroid Cancer Risk in Women: A Population‐Based Cross‐Sectional Study With Integrative Machine Learning and Genomic Analyses
Family History of Hypertension Predicts Thyroid Cancer Risk in Women: A Population‐Based Cross‐Sectional Study With Integrative Machine Learning and Genomic Analyses Open
Introduction Thyroid cancer is one of the most common endocrine malignancies globally, with a markedly higher incidence in women. Although pregnancy‐induced hypertension is recognized as a risk factor, the underlying mechanisms linking hyp…
View article: Novel High‐Resolution Lipidomes Could Serve as New Biomarkers for Diabetic Retinopathy: A Bidirectional and Mediated Mendelian Randomization Study
Novel High‐Resolution Lipidomes Could Serve as New Biomarkers for Diabetic Retinopathy: A Bidirectional and Mediated Mendelian Randomization Study Open
Although lipid metabolism is a critical factor in the pathogenesis of diabetic retinopathy (DR), the connection between lipidome and DR is still a subject of debate. We aimed to demonstrate that lipidome could serve as novel biomarkers for…
View article: Integration of multi-omics transcriptome-wide analysis for the identification of novel therapeutic drug targets in diabetic retinopathy
Integration of multi-omics transcriptome-wide analysis for the identification of novel therapeutic drug targets in diabetic retinopathy Open
View article: Hepatic Arterial Infusion Chemotherapy Combined with Lenvatinib and PD-1 Inhibitors for Managing Arterioportal Shunt in Hepatocellular Carcinoma with Portal Vein Tumor Thrombus: A Retrospective Cohort Study
Hepatic Arterial Infusion Chemotherapy Combined with Lenvatinib and PD-1 Inhibitors for Managing Arterioportal Shunt in Hepatocellular Carcinoma with Portal Vein Tumor Thrombus: A Retrospective Cohort Study Open
Combining HAIC with LEN and PD-1 inhibitors proves to be both effective and safe in managing APS in HCC with PVTT, potentially improving patient survival.
View article: Transarterial Chemoembolization (TACE) Combined with Lenvatinib versus TACE Alone in Intermediate-Stage Hepatocellular Carcinoma Patients Beyond Up-To-Seven Criteria: A Retrospective, Propensity Score-Matched Analysis
Transarterial Chemoembolization (TACE) Combined with Lenvatinib versus TACE Alone in Intermediate-Stage Hepatocellular Carcinoma Patients Beyond Up-To-Seven Criteria: A Retrospective, Propensity Score-Matched Analysis Open
Background: To compare the treatment efficacy and safety of transarterial chemoembolization (TACE) combined with lenvatinib versus TACE alone in patients with intermediate-stage hepatocellular carcinoma (HCC) beyond up-to-seven criteria. M…
View article: Causal Effects of COVID-19 on the Risk of Thrombosis: A Two-Sample Mendel Randomization Study
Causal Effects of COVID-19 on the Risk of Thrombosis: A Two-Sample Mendel Randomization Study Open
Background Coronavirus disease 2019 (COVID-19) and thrombosis are linked, but the biomolecular mechanism is unclear. We aimed to investigate the causal relationship between COVID-19 and thrombotic biomarkers. Methods We used two-sample Men…
View article: Unravelling the Link Between Primary Sclerosing Cholangitis and Sepsis: A Mendelian Randomization Study
Unravelling the Link Between Primary Sclerosing Cholangitis and Sepsis: A Mendelian Randomization Study Open
Background: autoimmune diseases (ADS) are associated with sepsis. This study aims to investigate the causalities between ADs and sepsis using Mendelian randomization (MR). Methods: we extracted single-nucleotide polymorphisms (SNPs) closel…
View article: Deep Learning Radiomics Based on DCE-MRI Predicts Response of Conversion Therapy for Unresectable Hepatocellular Carcinoma
Deep Learning Radiomics Based on DCE-MRI Predicts Response of Conversion Therapy for Unresectable Hepatocellular Carcinoma Open
View article: Causal association between oral disease and chronic obstructive pulmonary disease: A Mendelian Randomization study
Causal association between oral disease and chronic obstructive pulmonary disease: A Mendelian Randomization study Open
Background The association between oral diseases and chronic obstructive pulmonary disease (COPD) has been revealed by many epidemiological studies in clinical aspects. Therefore, we elucidate genetic relationships using Mendelian randomiz…
View article: A cross-sectional study of optimal exercise combinations for type 2 diabetes
A cross-sectional study of optimal exercise combinations for type 2 diabetes Open
Aim The currently recommended exercise methods for patients with diabetes require strict physical fitness and are not suitable for all diabetic patients. This study aims to explore the best exercise combination for diabetic patients and to…
View article: Liver failure resolved via corticosteroids plus plasma exchange in a patient with hepatocellular carcinoma receiving nivolumab immunotherapy: case report
Liver failure resolved via corticosteroids plus plasma exchange in a patient with hepatocellular carcinoma receiving nivolumab immunotherapy: case report Open
Background: Therapy with immune checkpoint inhibitors (ICIs) is an option for advanced hepatocellular carcinoma (HCC). Prednisone is recommended for immune-mediated hepatotoxicity (IMH) induced by ICIs in guidelines. However, liver failure…
View article: DNA N6-methyladenine involvement and regulation of hepatocellular carcinoma development
DNA N6-methyladenine involvement and regulation of hepatocellular carcinoma development Open
DNA N6-methyladenine (6 mA) is a new type of DNA methylation identified in various eukaryotic cells. However, its alteration and genomic distribution features in hepatocellular carcinoma (HCC) remain elusive. In this study, we found that N…
View article: Exosome-mediated miRNA delivery promotes liver cancer EMT and metastasis.
Exosome-mediated miRNA delivery promotes liver cancer EMT and metastasis. Open
The deregulation of exosomal microRNAs (miRNAs) plays an important role in the progression of hepatocarcinogenesis. In this study, we highlight exosomes as mediators involved in modulating miRNA profiles in liver cancer cells after inducti…
View article: Transarterial chemoembolization with pirarubicin-eluting microspheres in patients with unresectable hepatocellular carcinoma: Preliminary results
Transarterial chemoembolization with pirarubicin-eluting microspheres in patients with unresectable hepatocellular carcinoma: Preliminary results Open
View article: Accumulation and Genomic Distribution of DNA N6-Methyladenine Associated with Hepatocellular Carcinoma Development
Accumulation and Genomic Distribution of DNA N6-Methyladenine Associated with Hepatocellular Carcinoma Development Open
View article: Prognostic model for brain metastases from lung adenocarcinoma identified with epidermal growth factor receptor mutation status
Prognostic model for brain metastases from lung adenocarcinoma identified with epidermal growth factor receptor mutation status Open
Background Several indices have been developed to predict survival of brain metastases ( BM ) based on prognostic factors. However, such models were designed for general brain metastases from different kinds of cancers, and prognostic fact…
View article: Survival benefit of chemoembolization plus Iodine125 seed implantation in unresectable hepatitis B-related hepatocellular carcinoma with PVTT: a retrospective matched cohort study
Survival benefit of chemoembolization plus Iodine125 seed implantation in unresectable hepatitis B-related hepatocellular carcinoma with PVTT: a retrospective matched cohort study Open