Zhengren Xu
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View article: Chemoenzymatic Synthesis of the Cyclopiane Family of Diterpenoid Natural Products
Chemoenzymatic Synthesis of the Cyclopiane Family of Diterpenoid Natural Products Open
A three‐stage chemoenzymatic synthesis of the cyclopiane family and related diterpenes is reported. Deoxyconidiogenol with a 6/5/5/5‐fused tetracyclic cyclopiane skeleton was first produced by an engineered E. coli host harboring the corre…
View article: Chemoenzymatic Synthesis of the Cyclopiane Family of Diterpenoid Natural Products
Chemoenzymatic Synthesis of the Cyclopiane Family of Diterpenoid Natural Products Open
A three‐stage chemoenzymatic synthesis of the cyclopiane family and related diterpenes is reported. Deoxyconidiogenol with a 6/5/5/5‐fused tetracyclic cyclopiane skeleton was first produced by an engineered E. coli host harboring the corre…
View article: Cofactor-independent C–C bond cleavage reactions catalyzed by the AlpJ family of oxygenases in atypical angucycline biosynthesis
Cofactor-independent C–C bond cleavage reactions catalyzed by the AlpJ family of oxygenases in atypical angucycline biosynthesis Open
Biosynthesis of atypical angucyclines involves unique oxidative B-ring cleavage and rearrangement reactions, which are catalyzed by AlpJ-family oxygenases, including AlpJ, JadG, and GilOII. Prior investigations established the essential re…
View article: Confirmation of the stereochemistry of spiroviolene
Confirmation of the stereochemistry of spiroviolene Open
We confirm the previously revised stereochemistry of spiroviolene by X-ray crystallographically characterizing a hydrazone derivative of 9-oxospiroviolane, which is synthesized by hydroboration/oxidation of spiroviolene followed by oxidati…
View article: Confirmation of the Stereochemistry of Spiroviolene
Confirmation of the Stereochemistry of Spiroviolene Open
We confirm the previously revised stereochemistry of spiroviolene by X-ray crystallographically characterizing a hydrazone derivative of 9-oxo-spiroviolane, which is synthesized from hydroboration-oxidation of spiroviolene followed by oxid…
View article: Crystal structure of the α-ketoglutarate-dependent non-heme iron oxygenase CmnC in capreomycin biosynthesis and its engineering to catalyze hydroxylation of the substrate enantiomer
Crystal structure of the α-ketoglutarate-dependent non-heme iron oxygenase CmnC in capreomycin biosynthesis and its engineering to catalyze hydroxylation of the substrate enantiomer Open
CmnC is an α-ketoglutarate (α-KG)-dependent non-heme iron oxygenase involved in the formation of the l -capreomycidine ( l -Cap) moiety in capreomycin (CMN) biosynthesis. CmnC and its homologues, VioC in viomycin (VIO) biosynthesis and Orf…
View article: Kristallstrukturbasierte Mutagenese der Cattleyene‐Synthase führt zur Bildung umgelagerter polycyclischer Diterpene
Kristallstrukturbasierte Mutagenese der Cattleyene‐Synthase führt zur Bildung umgelagerter polycyclischer Diterpene Open
Die Kristallstrukturen der Cattleyen‐Synthase (apo‐CyS) und der mit Geranylgeranylpyrophosphat (GGPP) komplexierten CyS wurden gelöst. Die CyS C59A ‐Variante zeigte eine erhöhte Produktion von Cattleyen und weiteren Diterpenen mit untersch…
View article: Crystal Structure Based Mutagenesis of Cattleyene Synthase Leads to the Generation of Rearranged Polycyclic Diterpenes
Crystal Structure Based Mutagenesis of Cattleyene Synthase Leads to the Generation of Rearranged Polycyclic Diterpenes Open
The crystal structures of cattleyene synthase (apo‐CyS), and CyS complexed with geranylgeranyl pyrophosphate (GGPP) were solved. The CyS C59A variant exhibited an increased production of cattleyene and other diterpenes with diverse skeleto…
View article: Biallelic Variants in Lanosterol Synthase (LSS) Cause Palmoplantar Keratoderma-Congenital Alopecia Syndrome Type 2
Biallelic Variants in Lanosterol Synthase (LSS) Cause Palmoplantar Keratoderma-Congenital Alopecia Syndrome Type 2 Open
View article: Thiocysteine lyases as polyketide synthase domains installing hydropersulfide into natural products and a hydropersulfide methyltransferase
Thiocysteine lyases as polyketide synthase domains installing hydropersulfide into natural products and a hydropersulfide methyltransferase Open
View article: Cascade Cyclization Reaction Initiated by Benzylic Carbocation of Indole: Scope and Mechanistic Insights
Cascade Cyclization Reaction Initiated by Benzylic Carbocation of Indole: Scope and Mechanistic Insights Open
During the course of the total synthesis of α-cyclopianic acid (α-CPA) and speradine C, our research group have developed a biomimetic cascade cyclization reaction initiated by the benzylic carbocation of indole.In this paper, the scope an…
View article: Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space Open
Natural products and their derivatives continue to be wellsprings of nascent therapeutic potential. However, many laboratories have limited resources for biological evaluation, leaving their previously isolated or synthesized compounds lar…
View article: Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research
Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research Open
Correction for ‘The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research’ by James B. McAlpine et al., Nat. Prod. Rep., 2018, DOI: 10.1039/c7np00064b.
View article: Canvass: A Crowd-Sourced, Natural Product Screening Library for Exploring Biological Space
Canvass: A Crowd-Sourced, Natural Product Screening Library for Exploring Biological Space Open
Natural products and their derivatives continue to be wellsprings of nascent therapeutic potential. However, many laboratories have limited resources for biological evaluation, leaving their previously isolated or synthesized compounds lar…
View article: Canvass: A Crowd-Sourced, Natural Product Screening Library for Exploring Biological Space
Canvass: A Crowd-Sourced, Natural Product Screening Library for Exploring Biological Space Open
Natural products and their derivatives continue to be wellsprings of nascent therapeutic potential. However, many laboratories have limited resources for biological evaluation, leaving their previously isolated or synthesized compounds lar…
View article: Canvass: A Crowd-Sourced, Natural Product Screening Library for Exploring Biological Space
Canvass: A Crowd-Sourced, Natural Product Screening Library for Exploring Biological Space Open
Natural products and their derivatives continue to be wellsprings of nascent therapeutic potential. However, many laboratories have limited resources for biological evaluation, leaving their previously isolated or synthesized compounds lar…
View article: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research
The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research Open
With contributions from the global natural product (NP) research community, and continuing the Raw Data Initiative, this review collects a comprehensive demonstration of the immense scientific value of disseminating raw nuclear magnetic re…
View article: Metamorphosis of cycloalkenes for the divergent total synthesis of polycyclic indole alkaloids
Metamorphosis of cycloalkenes for the divergent total synthesis of polycyclic indole alkaloids Open
This review summarizes the divergent synthesis of monoterpene indole alkaloids using cycloalkene as the turning point of structural diversity.
View article: Discovery of the leinamycin family of natural products by mining actinobacterial genomes
Discovery of the leinamycin family of natural products by mining actinobacterial genomes Open
Significance Leinamycin (LNM) is a promising anticancer drug lead, yet no analog has been isolated since its discovery nearly 30 y ago. By mining bacterial genomes, we discovered 49 potential producers of LNM-type natural products, the str…
View article: New isofuranonaphthoquinones and isoindolequinones from Streptomyces sp. CB01883
New isofuranonaphthoquinones and isoindolequinones from Streptomyces sp. CB01883 Open
View article: CCDC 1426304: Experimental Crystal Structure Determination
CCDC 1426304: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Enantioselective Total Syntheses of (−)‐Rhazinilam, (−)‐Leucomidine B, and (+)‐Leuconodine F
Enantioselective Total Syntheses of (−)‐Rhazinilam, (−)‐Leucomidine B, and (+)‐Leuconodine F Open
A divergent total synthesis of three structurally distinct natural products from imine 9 was accomplished through an approach featuring: 1) a Pd‐catalyzed decarboxylative cross‐coupling, and 2) heteroannulation of 9 with bromoacetaldehyde …
View article: An Enantioselective Total Synthesis of (−)‐Isoschizogamine
An Enantioselective Total Synthesis of (−)‐Isoschizogamine Open
A concise enantioselective total synthesis of (−)‐isoschizogamine, a complex bridged polycyclic monoterpene indole alkaloid, was accomplished. N‐Alkylation of an enantio‐enriched imine with an alkyl iodide afforded an iminium salt, which, …
View article: Aqueous Titanium Trichloride Promoted Reductive Cyclization of <i>o</i>‐Nitrostyrenes to Indoles: Development and Application to the Synthesis of Rizatriptan and Aspidospermidine
Aqueous Titanium Trichloride Promoted Reductive Cyclization of <i>o</i>‐Nitrostyrenes to Indoles: Development and Application to the Synthesis of Rizatriptan and Aspidospermidine Open
Treatment of o ‐nitrostyrenes with aqueous TiCl 3 solution at room temperature afforded indoles through a formal reductive C(sp 2 )–H amination process. A range of functions such as halides (Cl, Br), carbonyl (ester, carbamate), cyano, hyd…
View article: Total Syntheses of (−)-Mersicarpine, (−)-Scholarisine G, (+)-Melodinine E, (−)-Leuconoxine, (−)-Leuconolam, (−)-Leuconodine A, (+)-Leuconodine F, and (−)-Leuconodine C: Self-Induced Diastereomeric Anisochronism (SIDA) Phenomenon for Scholarisine G and Leuconodines A and C
Total Syntheses of (−)-Mersicarpine, (−)-Scholarisine G, (+)-Melodinine E, (−)-Leuconoxine, (−)-Leuconolam, (−)-Leuconodine A, (+)-Leuconodine F, and (−)-Leuconodine C: Self-Induced Diastereomeric Anisochronism (SIDA) Phenomenon for Scholarisine G and Leuconodines A and C Open
Enantioselective total syntheses of title natural products from a common cyclohexenone derivative (S)-18 were reported. Ozonolysis of (S)-18 afforded a stable diketo ester (R)-17 that was subsequently converted to two skeletally different …
View article: CCDC 1061494: Experimental Crystal Structure Determination
CCDC 1061494: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1015233: Experimental Crystal Structure Determination
CCDC 1015233: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …