Zhenwei Peng
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View article: Circular SNX25 encoded radioresistance augmenter facilitates DNA damage repair in hepatocellular carcinoma by targeting BAG6-GET4 interaction
Circular SNX25 encoded radioresistance augmenter facilitates DNA damage repair in hepatocellular carcinoma by targeting BAG6-GET4 interaction Open
Radiotherapy (RT) is a crucial treatment for hepatocellular carcinoma (HCC); however, resistance to radiation remains a major challenge to its effectiveness. Circular RNAs (circRNAs), traditionally considered stable non-coding RNAs, have r…
View article: An effector of phosphatidylinositol 3-kinase activity promotes <i>Rickettsia rickettsii</i> virulence by enhancing autophagy
An effector of phosphatidylinositol 3-kinase activity promotes <i>Rickettsia rickettsii</i> virulence by enhancing autophagy Open
To establish an intracellular niche conductive to growth, some bacterial pathogens deliver virulence factors that modulate phosphoinositides (PIPs) metabolism. PIPs are a family of lipids involved in signaling that regulates key cellular p…
View article: Genomic profiling and experimental validation of type VI secretion system-associated proteins in Klebsiella
Genomic profiling and experimental validation of type VI secretion system-associated proteins in Klebsiella Open
Klebsiella is widely distributed in nature and recognized for its dual role as a human commensal and an opportunistic pathogen capable of causing severe infections. Among its key virulence mechanisms, the Type VI Secretion System (T6SS) pl…
View article: Using Machine Learning to Predict Advanced-Stage Progression of Intermediate-Stage Hepatocellular Carcinoma after Transarterial Chemoembolization
Using Machine Learning to Predict Advanced-Stage Progression of Intermediate-Stage Hepatocellular Carcinoma after Transarterial Chemoembolization Open
The CatBoost machine learning model accurately predicted advanced-stage progression of intermediate-stage hepatocellular carcinoma after transarterial chemoembolization (TACE) and identified patients who benefited from post-TACE systemic t…
View article: SOX4 mediates cancer-associated fibroblasts related radioresistance in hepatocellular carcinoma
SOX4 mediates cancer-associated fibroblasts related radioresistance in hepatocellular carcinoma Open
Not applicable.
View article: Androgen receptor promotes arachidonic acid metabolism and angiogenic microenvironment in AFP-negative hepatocellular carcinoma
Androgen receptor promotes arachidonic acid metabolism and angiogenic microenvironment in AFP-negative hepatocellular carcinoma Open
View article: Transarterial intervention therapy plus systemic therapy for unresectable hepatocellular carcinoma: A systematic review and meta-analysis
Transarterial intervention therapy plus systemic therapy for unresectable hepatocellular carcinoma: A systematic review and meta-analysis Open
Recently, the combination of transarterial intervention therapy (transcatheter arterial chemoembolization [TACE] or hepatic arterial infusion chemotherapy [HAIC]) and systemic therapy for unresectable hepatocellular carcinoma (HCC) has yie…
View article: Gasdermin D aggravates a mouse model of radiation-induced liver disease by promoting chemokine secretion and neutrophil recruitment
Gasdermin D aggravates a mouse model of radiation-induced liver disease by promoting chemokine secretion and neutrophil recruitment Open
View article: Targeting the TRIM14/USP14 axis enhances radiotherapy efficacy by inducing GPX4 degradation and disrupting ferroptotic defense in HCC
Targeting the TRIM14/USP14 axis enhances radiotherapy efficacy by inducing GPX4 degradation and disrupting ferroptotic defense in HCC Open
Radiation resistance constitutes a formidable impediment in the treatment paradigm for hepatocellular carcinoma (HCC). Deubiquitinases (DUBs) exhibit notable efficacy in modulating cellular responses to stress and exogenous interventions, …
View article: Comprehensive genomic analysis of type VI secretion system diversity and associated proteins in Serratia
Comprehensive genomic analysis of type VI secretion system diversity and associated proteins in Serratia Open
The type VI secretion system (T6SS) is a contact-dependent contractile nanomachine widely distributed among Gram-negative bacteria, essential for interbacterial competition, host interactions and environmental adaptation. The T6SS encoded …
View article: Comprehensive analysis of the type VI secretion system in Neisseria: identification, distribution, and evolutionary insights
Comprehensive analysis of the type VI secretion system in Neisseria: identification, distribution, and evolutionary insights Open
View article: Can Epstein–Barr virus-deoxyribonucleic acid load after induction chemotherapy combined with American Joint Committee on Cancer stage determine the chemotherapy intensity of locally advanced nasopharyngeal carcinoma?
Can Epstein–Barr virus-deoxyribonucleic acid load after induction chemotherapy combined with American Joint Committee on Cancer stage determine the chemotherapy intensity of locally advanced nasopharyngeal carcinoma? Open
Background: Induction chemotherapy (IC) with docetaxel, cisplatin, and fluorouracil (TPF), combined with concurrent chemoradiotherapy (CCRT), has been shown to improve survival in patients with locally advanced nasopharyngeal carcinoma (LA…
View article: Comparison of thromboelastographic profiles and clinical characteristics in children with severe Mycoplasma pneumoniae pneumonia
Comparison of thromboelastographic profiles and clinical characteristics in children with severe Mycoplasma pneumoniae pneumonia Open
Background This study aimed to compare Thromboelastographic (TEG) profiles and clinical characteristics between severe Mycoplasma pneumoniae (MP) pneumonia patients with normal and abnormal TEG parameters. Methods The clinical data of 133 …
View article: In silico characterization of defense system hotspots in Acinetobacter spp.
In silico characterization of defense system hotspots in Acinetobacter spp. Open
View article: Longitudinal Body Composition Identifies Hepatocellular Carcinoma With Cachexia Following Combined Immunotherapy and Target Therapy (CHANCE2213)
Longitudinal Body Composition Identifies Hepatocellular Carcinoma With Cachexia Following Combined Immunotherapy and Target Therapy (CHANCE2213) Open
Background Cancer cachexia can impact prognosis, cause resistance to anticancer treatments and affect the tolerability of treatments. This study aims to identify hepatocellular carcinoma (HCC) with cachexia by characterizing longitudinal b…
View article: Chinese Expert Consensus on the Whole-Course Management of Hepatocellular Carcinoma (2023 Edition)
Chinese Expert Consensus on the Whole-Course Management of Hepatocellular Carcinoma (2023 Edition) Open
Background: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in China. Most HCC patients have the complications of chronic liver disease and need overall consideration and whole-course management, including diagnos…
View article: Preoperative MRI features for predicting response to postoperative adjuvant anti-PD-1 therapy in hepatocellular carcinoma
Preoperative MRI features for predicting response to postoperative adjuvant anti-PD-1 therapy in hepatocellular carcinoma Open
Biomarkers for predicting survival benefit of postoperative adjuvant anti-PD-1 therapy (PA-PD-1) in hepatocellular carcinoma (HCC) are scare and lack of clinical evidence currently. This study aimed to identify the value of preoperative MR…
View article: Application of New Acupuncture and Moxibustion Technology in Acne
Application of New Acupuncture and Moxibustion Technology in Acne Open
Acne is a common aesthetically damaging skin disease at present, with a high incidence rate, complex etiology, and serious symptoms, usually manifested as blackhead or white head acne, inflammatory papules, secondary pustules, nodules, cys…
View article: Survival in Patients With Recurrent Intermediate-Stage Hepatocellular Carcinoma
Survival in Patients With Recurrent Intermediate-Stage Hepatocellular Carcinoma Open
Importance Transarterial chemoembolization (TACE) is commonly used to treat patients with recurrent intermediate-stage hepatocellular carcinoma (HCC) and positive microvascular invasion (MVI); however, TACE alone has demonstrated unsatisfa…
View article: Knockout of integrin αvβ6 protects against renal inflammation in chronic kidney disease by reduction of pro-inflammatory macrophages
Knockout of integrin αvβ6 protects against renal inflammation in chronic kidney disease by reduction of pro-inflammatory macrophages Open
View article: Therapeutic targeting of PLK1 in <i>TERT</i> promoter‐mutant hepatocellular carcinoma
Therapeutic targeting of PLK1 in <i>TERT</i> promoter‐mutant hepatocellular carcinoma Open
Background Hotspot mutations in the promoter of telomerase reverse transcriptase ( TERT ) gene are the most common genetic variants in hepatocellular carcinoma (HCC) and associated with poor prognosis of the disease. However, no drug was c…
View article: Prognostic model and ceRNA network of m7G- and radiosensitivity-related genes in hepatocellular carcinoma
Prognostic model and ceRNA network of m7G- and radiosensitivity-related genes in hepatocellular carcinoma Open
The prognosis model of m7G- and radiosensitivity-related genes is constructed, and widely used in clinical prognosis, immunotherapy, and drug therapy. NCBP2, as a hub gene, may be a prognostic biomarker for HCC and is related to immunother…
View article: Anti-PD-1 antibody in combination with radiotherapy as first-line therapy for unresectable intrahepatic cholangiocarcinoma
Anti-PD-1 antibody in combination with radiotherapy as first-line therapy for unresectable intrahepatic cholangiocarcinoma Open
Background Unresectable intrahepatic cholangiocarcinoma (iCCA) has a poor prognosis despite treatment with standard combination chemotherapy. We aimed to evaluate the efficacy and safety of radiotherapy in combination with an anti-PD-1 ant…
View article: Relationships between Resident Activities and Physical Space in Shrinking Cities in China—The Case of Chaoyang City
Relationships between Resident Activities and Physical Space in Shrinking Cities in China—The Case of Chaoyang City Open
Shrinking cities suffer from a decreased level of resident activities. As a result, areas with low levels of resident activities may become breeding grounds for social issues. To ease and prevent social issues, it is important to deploy ph…
View article: Efficacy of radiation plus transarterial chemoembolization and lenvatinib in hepatocellular carcinoma with portal vein tumor thrombus
Efficacy of radiation plus transarterial chemoembolization and lenvatinib in hepatocellular carcinoma with portal vein tumor thrombus Open
Background We aimed to investigate the efficacy of a novel regimen, external beam radiation (RT) combined with trans arterial chemoembolization (TACE) and lenvatinib (LEN), in the treatment of hepatocellular carcinoma (HCC) with portal vei…
View article: The Transformation of Rural Areas Located in China’s Agricultural Heritage Systems under the Evolution of Urban–Rural Relationships
The Transformation of Rural Areas Located in China’s Agricultural Heritage Systems under the Evolution of Urban–Rural Relationships Open
The sustainable logic between the Agricultural Heritage System (AHS) and environmental synergy has been significantly changing with China’s urban–rural relationship shift from binary opposition to a stronger network exchange. During the pr…
View article: The importance, orientation and key content of township-level comprehensive spatial planning in China
The importance, orientation and key content of township-level comprehensive spatial planning in China Open
On the basis of fully understanding the key characteristics and problems of China’s township master plans, this article clarifies the requirements of the territorial spatial planning system reform for the governance system of townships and…
View article: The progression of hepatocyte pyroptosis exacerbates radiation-induced liver disease via the gasdermin D/signal transducer and activator of transcription 5a/CXCL1 axis
The progression of hepatocyte pyroptosis exacerbates radiation-induced liver disease via the gasdermin D/signal transducer and activator of transcription 5a/CXCL1 axis Open
Radiation-induced liver disease (RILD) severely impairs the outcome of patients exposed to irradiation (IR); however, the underlying mechanism is largely unknown. The N-terminus of gasdermin D (GSDMD-N) is mainly involved in driving the pr…
View article: Role of the Notch signaling pathway in regulating macrophage polarization in a rat model of fibrotic pigeon breeder’s lung
Role of the Notch signaling pathway in regulating macrophage polarization in a rat model of fibrotic pigeon breeder’s lung Open
Objectives: The Notch signaling pathway serves as the key regulator of the biological functions of macrophages and may affect the role of macrophages in the development of pigeon breeder’s lung (PBL). This study investigated the possible a…
View article: Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1–BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy
Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1–BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy Open
Radiotherapy is widely used in the management of advanced colorectal cancer (CRC). However, the clinical efficacy is limited by the safe irradiated dose. Sensitizing tumor cells to radiotherapy via interrupting DNA repair is a promi…