Zhen-Yan Fu
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View article: Chinese visceral adiposity index predicts all-cause mortality in patients with type 2 diabetes, heart failure, and chronic kidney disease: a retrospective cohort study
Chinese visceral adiposity index predicts all-cause mortality in patients with type 2 diabetes, heart failure, and chronic kidney disease: a retrospective cohort study Open
Objective This study aimed to evaluate the prognostic value of the Chinese Visceral Adiposity Index (CVAI) for all-cause mortality in the high-risk population with coexisting type 2 diabetes mellitus (T2DM), heart failure (HF), and chronic…
View article: Varying oropharyngeal colostrum administration dosages on outcomes associated with very low birth weight infants: a randomised controlled trial protocol
Varying oropharyngeal colostrum administration dosages on outcomes associated with very low birth weight infants: a randomised controlled trial protocol Open
Introduction Oropharyngeal colostrum administration (OCA) confers immunological benefits to very low birth weight infants (VLBWIs) through nutrient absorption via oropharyngeal lymphatic tissue, potentially reducing complication rates and …
View article: Trends in dyslipidemia prevalence among Uyghur adults of different genders in China: a retrospective cohort study
Trends in dyslipidemia prevalence among Uyghur adults of different genders in China: a retrospective cohort study Open
Background To analyze the prevalence and epidemiological characteristics of dyslipidemia among adults of different genders in Xinjiang, China, providing a basis for promoting ideal lipid management among the Uyghur population. Methods In t…
View article: Serum ferritin associated with atherogenic lipid profiles in a high-altitude living general population
Serum ferritin associated with atherogenic lipid profiles in a high-altitude living general population Open
Background Serum ferritin (SF) levels are associated with metabolic syndrome and dyslipidemia. However, the association between SF and atherogenic lipid profiles in high-altitude living populations remains unclear. Methods In 2021, a cross…
View article: Synergistic effects of lipoprotein (a) and fibrinogen on carotid plaque in patients with coronary artery disease
Synergistic effects of lipoprotein (a) and fibrinogen on carotid plaque in patients with coronary artery disease Open
View article: Association of <i>HMGCR</i> rs17671591 and rs3761740 with lipidemia and statin response in Uyghurs and Han Chinese
Association of <i>HMGCR</i> rs17671591 and rs3761740 with lipidemia and statin response in Uyghurs and Han Chinese Open
Background Dyslipidemia plays a very important role in the occurrence and development of cardiovascular disease (CVD). Genetic factors, including single nucleotide polymorphisms (SNPs), are one of the main risks of dyslipidemia. 3-hydroxy-…
View article: A risk score for predicting in-stent restenosis in patients with premature acute myocardial infarction undergoing percutaneous coronary intervention with drug-eluting stent
A risk score for predicting in-stent restenosis in patients with premature acute myocardial infarction undergoing percutaneous coronary intervention with drug-eluting stent Open
View article: Development of the neonatal pain response variable set: a mixed methods consensus process
Development of the neonatal pain response variable set: a mixed methods consensus process Open
View article: Development of The Neonatal Pain Response Variable Set: A mixed methods consensus process
Development of The Neonatal Pain Response Variable Set: A mixed methods consensus process Open
Purpose While over 40 neonatal pain assessment scales have been published, owing to lack of consensus and standardized metrics, there are more than 100 assessment indicators with varying descriptors and quality differences. This study aims…
View article: Genetic Variability of SLCO1B3 and Its Influence on Lipid Levels and Statin Efficacy in Han and Uighur Populations
Genetic Variability of SLCO1B3 and Its Influence on Lipid Levels and Statin Efficacy in Han and Uighur Populations Open
Background Lowering plasma LDL cholesterol levels reduces the risk of atherosclerotic cardiovascular disease (ASCVD). Genetic factors, including single nucleotide polymorphisms (SNPs), affect lipid abnormalities. Statins are the main treat…
View article: Genetic polymorphism of the Dab2 gene and its association with Type 2 Diabetes Mellitus in the Chinese Uyghur population
Genetic polymorphism of the Dab2 gene and its association with Type 2 Diabetes Mellitus in the Chinese Uyghur population Open
Objective The human Disabled-2 (Dab2) protein is an endocytic adaptor protein, which plays an essential role in endocytosis of transmembrane cargo, including low-density lipoprotein cholesterol (LDL-C). As a candidate gene for dyslipidemia…
View article: Gefitinib Increases the Incidence of QT Prolongation in Patients with Non-Small Cell Lung Cancer
Gefitinib Increases the Incidence of QT Prolongation in Patients with Non-Small Cell Lung Cancer Open
Gefitinib (GEF) may increase the risk of corrected QT prolongation (QTc). We aimed to evaluate whether gefitinib increases the risk of corrected QT interval (QTc) prolongation and analyze the associated risk factors.A total of 122 cases of…
View article: New Loss-of-Function Mutations in PCSK9 Reduce Plasma LDL Cholesterol
New Loss-of-Function Mutations in PCSK9 Reduce Plasma LDL Cholesterol Open
Background: Lower plasma levels of LDL (low-density lipoprotein) cholesterol (LDL-C) can reduce the risk of atherosclerotic cardiovascular disease. The loss-of-function mutations in PCSK9 (proprotein convertase subtilisin/kexin type 9) hav…
View article: Prevalence of familial hypercholesterolemia and its association with coronary artery disease: A Chinese cohort study
Prevalence of familial hypercholesterolemia and its association with coronary artery disease: A Chinese cohort study Open
Background Familial hypercholesterolemia (FH) is underrecognized, and its association with coronary artery disease (CAD) remains limited, especially in China. We aimed to investigate the prevalence of FH and its relationship with CAD in a …
View article: Correlation of elevated serum uric acid with coronary artery disease in Xinjiang, China: A retrospective case-control study
Correlation of elevated serum uric acid with coronary artery disease in Xinjiang, China: A retrospective case-control study Open
Elevated serum uric acid (SUA) levels are associated with coronary artery disease (CAD). However, whether this association is independent of traditional cardiovascular risk factors remains controversial. Our study aimed to determine the co…
View article: Supplementary Material for: High systemic immune-inflammation index, predicting early allograft dysfunction, indicates high 90-day-mortality for acute-on-chronic liver failure after liver transplantation
Supplementary Material for: High systemic immune-inflammation index, predicting early allograft dysfunction, indicates high 90-day-mortality for acute-on-chronic liver failure after liver transplantation Open
Introduction: To investigate the relationship between systemic immune-inflammation index (SII) and early allograft dysfunction (EAD) and 90-day-mortality after liver transplantation (LT) in acute-on-chronic liver failure (ACLF). Methods: R…
View article: Genetic analysis of DNA methylation in dyslipidemia: a case-control study
Genetic analysis of DNA methylation in dyslipidemia: a case-control study Open
Background Coronary heart disease has become the leading cause of death in developed countries, and dyslipidemia is closely associated with the risk of cardiovascular disease. Dyslipidemia is caused by the abnormal regulation of several ge…
View article: Incidence of Deep Venous Thrombosis in Hospitalized COVID-19 Patients in Isolated De Martini Hospital Mogadishu Somalia
Incidence of Deep Venous Thrombosis in Hospitalized COVID-19 Patients in Isolated De Martini Hospital Mogadishu Somalia Open
Coronavirus (COVID-19) pandemic incidences of deep vein thrombosis (DVT) have been reported in considerable figures. This research aimed to assess the incidence of deep vein thrombosis (DVT) in COVID-19 patients admitted to De Martini Hosp…
View article: DMRT2 gene polymorphisms is associated with the coronary artery disease in Han population in Xinjiang, China
DMRT2 gene polymorphisms is associated with the coronary artery disease in Han population in Xinjiang, China Open
Background DMRT2 gene plays a significant role in human gonad and skeletal muscle, as well as affecting human immune, inflammatory and metabolic pathways. The main purpose of this study was to explore the relationship between single-nucleo…
View article: A prediction model based on platelet parameters, lipid levels, and angiographic characteristics to predict in-stent restenosis in coronary artery disease patients implanted with drug-eluting stents
A prediction model based on platelet parameters, lipid levels, and angiographic characteristics to predict in-stent restenosis in coronary artery disease patients implanted with drug-eluting stents Open
View article: FBXW7 gene polymorphism is associated with type 2 diabetes in the Uygur population in Xinjiang, China
FBXW7 gene polymorphism is associated with type 2 diabetes in the Uygur population in Xinjiang, China Open
Background FBXW7 gene expression is positively correlated with glycolipid metabolism and is associated with diabetes in animal models. In the current study, we focused on exploring whether genetic variants of the FBXW7 gene were associated…
View article: Correction to: Genetic polymorphism of IDOL gene was associated with the susceptibility of coronary artery disease in Han population in Xinjiang, China
Correction to: Genetic polymorphism of IDOL gene was associated with the susceptibility of coronary artery disease in Han population in Xinjiang, China Open
View article: Polymorphisms of rs2483205 and rs562556 in the PCSK9 gene are associated with coronary artery disease and cardiovascular risk factors
Polymorphisms of rs2483205 and rs562556 in the PCSK9 gene are associated with coronary artery disease and cardiovascular risk factors Open
View article: Genetic polymorphism of IDOL gene was associated with the susceptibility of coronary artery disease in Han population in Xinjiang, China
Genetic polymorphism of IDOL gene was associated with the susceptibility of coronary artery disease in Han population in Xinjiang, China Open
View article: Genetic variation of RNF145 gene and blood lipid levels in Xinjiang population, China
Genetic variation of RNF145 gene and blood lipid levels in Xinjiang population, China Open
View article: Correlation between SCAP Genetic Polymorphism and Coronary Artery Disease in a Han population in Xinjiang, China
Correlation between SCAP Genetic Polymorphism and Coronary Artery Disease in a Han population in Xinjiang, China Open
SREBP cleavage-activating protein (SCAP) plays a vital role in the modulation of cholesterol homeostasis, and cholesterol dysregulation is tightly associated with coronary artery disease (CAD). To investigate the correlation of the genetic…
View article: Polymorphisms of rs2483205 and rs562556 in Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Gene are Associated With Coronary Artery Disease
Polymorphisms of rs2483205 and rs562556 in Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Gene are Associated With Coronary Artery Disease Open
PCSK9 plays a pivotal role in lipid metabolism. The present study is to explore the potential novel single nucleotide polymorphisms (SNPs) of the PCSK9 gene which is associated with coronary artery disease (CAD) in the Han population who l…
View article: Genetic analysis of DNA methylation in dyslipidemia: a case-control study
Genetic analysis of DNA methylation in dyslipidemia: a case-control study Open
In our previous study, we explored the relationship between TBL2 gene DNA methylation and high-low-density lipoproteinemia (Hyper-LDL). However, Hyper-LDL is only one type of dyslipidemia. In order to expand the scope of clinical applicati…
View article: Meta-Analysis of the Association Between Body Mass Index and All-cause Mortality in Patients with Cardiogenic Shock
Meta-Analysis of the Association Between Body Mass Index and All-cause Mortality in Patients with Cardiogenic Shock Open
Background: the correlation between BMI and in-hospital mortality of patients with cardiogenic shock is still controversial. We hope to explore whether there is an "obesity paradox" in patients with cardiogenic shock through meta-analysis.…
View article: IDOL gene variant is associated with hyperlipidemia in Han population in Xinjiang, China
IDOL gene variant is associated with hyperlipidemia in Han population in Xinjiang, China Open
Hyperlipidemia is one of the main risk factors that contributed to atherosclerosis and coronary artery disease (CAD). In the present study, our objective was to explore whether some genetic variants of human IDOL gene were associated with …