Zhengyi Cao
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View article: A p53 peptide mucosal vaccine induces cellular and humoral immunity and anti-tumor effects in a murine colorectal cancer model
A p53 peptide mucosal vaccine induces cellular and humoral immunity and anti-tumor effects in a murine colorectal cancer model Open
Many patients with metastatic and recurrent colorectal cancer (CRC) have poor outcomes, due in part to resistance to current treatment approaches including immune checkpoint inhibitors, which have activity in only a subset of patients. Mis…
View article: Ultrasound-Guided Histotripsy Triggers the Release of Tumor-Associated Antigens from Breast Cancers
Ultrasound-Guided Histotripsy Triggers the Release of Tumor-Associated Antigens from Breast Cancers Open
Background/Objectives: There is increasing evidence to indicate that histotripsy treatment can enhance the host anti-tumor immune responses both locally at the targeting tumor site as well as systemically from abscopal effects. Histotripsy…
View article: Nanoemulsion is an effective antimicrobial for methicillin-resistant <i>Staphylococcus aureus</i> in infected swine skin burn wounds
Nanoemulsion is an effective antimicrobial for methicillin-resistant <i>Staphylococcus aureus</i> in infected swine skin burn wounds Open
Burns are one of the most common injuries in both civilian and combat settings and are difficult to treat. This is particularly true when the wounds are infected with antibiotic-resistant bacteria such as methicillin-resistant Staphylococc…
View article: A Study on the Dynamic Response of a Timber-Frame Beam–Bamboo Anchor-Supported Roadbed Slope under Train Load
A Study on the Dynamic Response of a Timber-Frame Beam–Bamboo Anchor-Supported Roadbed Slope under Train Load Open
In order to investigate the dynamic response of embankment slopes supported by wooden frame beams and bamboo anchor rods under train loading, this study conducted model tests on embankment slopes supported by wooden frame beams and bamboo …
View article: Experimental Study on the Deformation and Mechanical Properties of Bamboo Forest Slopes
Experimental Study on the Deformation and Mechanical Properties of Bamboo Forest Slopes Open
In this paper, model tests on a plain soil slope and a bamboo-rooted slope under slope top loading were carried out to analyze the slope surface displacement, the change in earth pressure, and the failure mode of the slope. Furthermore, th…
View article: A comprehensive analysis of miRNA/isomiRs profile of hydrosalpinx patients with interventional ultrasound sclerotherapy
A comprehensive analysis of miRNA/isomiRs profile of hydrosalpinx patients with interventional ultrasound sclerotherapy Open
Hydrosalpinx is a chronic inflammatory condition with high recurrence rate, and it is reported among female population having fallopian tubal factor infertility. Previously, we have reported that interventional ultrasound sclerotherapy imp…
View article: Effective Treatment of Skin Wounds Co-Infected with Multidrug-Resistant Bacteria with a Novel Nanoemulsion
Effective Treatment of Skin Wounds Co-Infected with Multidrug-Resistant Bacteria with a Novel Nanoemulsion Open
Infections, specifically polymicrobial, can cause serious consequences when it comes to wound treatment. Prolonged treatment with antibiotics can lead to an increased risk of bacterial resistance; co-infections can complicate treatment opt…
View article: HBP1-mediated transcriptional repression of AFP inhibits hepatoma progression
HBP1-mediated transcriptional repression of AFP inhibits hepatoma progression Open
View article: Additional file 2 of HBP1-mediated transcriptional repression of AFP inhibits hepatoma progression
Additional file 2 of HBP1-mediated transcriptional repression of AFP inhibits hepatoma progression Open
Additional file 2: Figure S2. HBP1 deletion aggravates DEN/CCl4-induced hepatic fibrosis. (A) Representative H.E. staining of liver sections from 12 weeks after DEN/CCl4 treatment in wild type or HBP1−/− mice. Scale bar, 100 μm. (B) Repres…
View article: Dendrimer-based posaconazole nanoplatform for antifungal therapy
Dendrimer-based posaconazole nanoplatform for antifungal therapy Open
We examined formulating a new antifungal agent, posaconazole (POS) and its derivatives, with different molecular vehicles. Several combinations of drug and carrier molecules were synthesized, and their antifungal activities were evaluated …
View article: Additional file 1 of HBP1-mediated transcriptional repression of AFP inhibits hepatoma progression
Additional file 1 of HBP1-mediated transcriptional repression of AFP inhibits hepatoma progression Open
Additional file 1: Figure S1. 5-FU promotes the suppression of HBP1 on AFP through enhancing HBP1 binding to AFP promoter. A-C. 5-FU promotes the suppression of HBP1 on AFP protein (A), mRNA (B) and promoter (C). HepG2 cells were transfect…
View article: HBP1-mediated transcriptional regulation of AFP and its impact on hepatoma
HBP1-mediated transcriptional regulation of AFP and its impact on hepatoma Open
Background: Hepatoma is a common malignancy of the liver. The abnormal high expression of alpha-fetoprotein (AFP) is intimately associated with hepatoma progress, but the mechanism of transcriptional regulation and singularly activation of…
View article: Functionalized nanoparticles with targeted antibody to enhance imaging of breast cancer in vivo
Functionalized nanoparticles with targeted antibody to enhance imaging of breast cancer in vivo Open
View article: Senescence: novel insight into DLX3 mutations leading to enhanced bone formation in Tricho-Dento-Osseous syndrome
Senescence: novel insight into DLX3 mutations leading to enhanced bone formation in Tricho-Dento-Osseous syndrome Open
The homeodomain transcription factor distal-less homeobox 3 gene (DLX3) is required for hair, tooth and skeletal development. DLX3 mutations have been found to be responsible for Tricho-Dento-Osseous (TDO) syndrome, characterized by kinky …
View article: A novel combination of intramuscular vaccine adjuvants, nanoemulsion and CpG produces an effective immune response against influenza A virus
A novel combination of intramuscular vaccine adjuvants, nanoemulsion and CpG produces an effective immune response against influenza A virus Open
The I.M. injection of NE02 adjuvanted rH5 elicits strong and broad immune responses against H5 antigens and effectively protects animals from lethal H5 challenge. Combining this adjuvant with CpG enhanced immune responses and provided impr…
View article: Acetylation of alpha-fetoprotein promotes hepatocellular carcinoma progression
Acetylation of alpha-fetoprotein promotes hepatocellular carcinoma progression Open
Alpha-fetoprotein (AFP) is a well-established biomarker for hepatocellular carcinoma (HCC). Here, we investigated the acetylation state of AFP in vivo. AFP acetylation was regulated by the acetyltransferase CBP and the deacetylase SIRT1. A…
View article: Chronic restraint stress induces esophageal fibrosis with enhanced oxidative stress in a murine model
Chronic restraint stress induces esophageal fibrosis with enhanced oxidative stress in a murine model Open
Although the underlying mechanism of stress remains unknown, it has been associated with the pathophysiology of gastroesophageal reflux diseases, the development of which appear to be accelerated by oxidative stress and fibrosis. The aim o…
View article: MDM2 promotes genome instability by ubiquitinating the transcription factor HBP1
MDM2 promotes genome instability by ubiquitinating the transcription factor HBP1 Open
Genome instability is a common feature of tumor cells, and the persistent presence of genome instability is a potential mechanism of tumorigenesis. The E3 ubiquitin ligase MDM2 is intimately involved in genome instability, but its mechanis…
View article: A positive feedback loop between Pim-1 kinase and HBP1 transcription factor contributes to hydrogen peroxide-induced premature senescence and apoptosis
A positive feedback loop between Pim-1 kinase and HBP1 transcription factor contributes to hydrogen peroxide-induced premature senescence and apoptosis Open
Oxidative stress can induce cell dysfunction and lead to a broad range of degenerative alterations, including carcinogenesis, aging, and other oxidative stress-related conditions. To avoid undergoing carcinogenesis in response to oxidative…
View article: Senescence: novel insight into DLX3 mutations leading to enhanced bone formation in Tricho-Dento-Osseous syndrome
Senescence: novel insight into DLX3 mutations leading to enhanced bone formation in Tricho-Dento-Osseous syndrome Open
The homeodomain transcription factor distal-less homeobox 3 gene ( DLX3 ) is required for hair, tooth and skeletal development. DLX3 mutations have been found to be responsible for Tricho-Dento-Osseous (TDO) syndrome, characterized by kink…
View article: Modified Nanoemulsions with Iron Oxide for Magnetic Resonance Imaging
Modified Nanoemulsions with Iron Oxide for Magnetic Resonance Imaging Open
A nanoemulsion (NE) is a surfactant-based, oil-in-water, nanoscale, high-energy emulsion with a mean droplet diameter of 400–600 nm. When mixed with antigen and applied nasally, a NE acts as a mucosal adjuvant and induces mucosal immune re…
View article: Screening of Nanoemulsion Formulations and Identification of NB-201 as an Effective Topical Antimicrobial for<i>Staphylococcus aureus</i>in a Mouse Model of Infected Wounds
Screening of Nanoemulsion Formulations and Identification of NB-201 as an Effective Topical Antimicrobial for<i>Staphylococcus aureus</i>in a Mouse Model of Infected Wounds Open
Despite advances in antimicrobial therapies, wound infection remains a global public health concern. We aimed to formulate and assess various nanoemulsions (NEs) for potential effectiveness as stable antimicrobial agents suitable for topic…
View article: HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis
HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis Open
View article: HER2+ peptide conjugated and pH responsive polyethylene glycol- poly(lactic-co-glycolic) acid (PEG-PLGA) nanoparticles tested in novel transgenic mouse tumor model
HER2+ peptide conjugated and pH responsive polyethylene glycol- poly(lactic-co-glycolic) acid (PEG-PLGA) nanoparticles tested in novel transgenic mouse tumor model Open
Event Abstract Back to Event HER2+ peptide conjugated and pH responsive polyethylene glycol- poly(lactic-co-glycolic) acid (PEG-PLGA) nanoparticles tested in novel transgenic mouse tumor model Yasmine Doleyres1, Zhengyi Cao2, Su He Wang2 a…
View article: Intranasal nanoemulsion-based inactivated respiratory syncytial virus vaccines protect against viral challenge in cotton rats
Intranasal nanoemulsion-based inactivated respiratory syncytial virus vaccines protect against viral challenge in cotton rats Open
Respiratory Syncytial Virus is a leading cause of bronchiolitis and pneumonia in infants, the elderly and individuals with compromised immune systems. Despite decades of research, there is currently no available vaccine for RSV. Our group …
View article: Effect of Chronic Uremia on the Cell Surface Expression of B7 Family Costimulatory Molecules in an HLA-A2 Transgenic Mouse Model of Chronic Kidney Disease.
Effect of Chronic Uremia on the Cell Surface Expression of B7 Family Costimulatory Molecules in an HLA-A2 Transgenic Mouse Model of Chronic Kidney Disease. Open
Uremia due to chronic kidney disease (CKD) in humans is associated with immune dysfunction, increased susceptibility to infections, immune-activation-associated inflammation, and poor responses to vaccines. The pathophysiologic basis of th…