Zhengyu Cao
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View article: A Hypoxia‐Responsive Single‐Atom Sonozyme for Targeted Sonocatalytic Therapy in Alleviating Atherosclerotic Plaque
A Hypoxia‐Responsive Single‐Atom Sonozyme for Targeted Sonocatalytic Therapy in Alleviating Atherosclerotic Plaque Open
Sonocatalytic therapy (SCT) offers a non‐invasive and deep tissue‐penetrating approach to addressing the pathological challenges of atherosclerosis. However, its therapeutic efficacy remains limited by the lack of efficient sonosensitizers…
View article: Development and Validation of MRI Radiomics Model for Predicting Perineural Invasion in Rectal Cancer
Development and Validation of MRI Radiomics Model for Predicting Perineural Invasion in Rectal Cancer Open
Background This study aims to explore the application of multiparametric MRI (mp-MRI) based radiomics in evaluating the perineural invasion (PNI) status of rectal cancer. Methods A retrospective analysis was conducted on clinical and MRI d…
View article: Rational construction of PCL-PEG/CS/AST nanofiber for bone repair and regeneration
Rational construction of PCL-PEG/CS/AST nanofiber for bone repair and regeneration Open
Humerus greater tuberosity (HGT) avulsion fracture is one of the most common types of proximal humerus fractures. The presence of motion and gap lead to the failure of implants, due to the force pulling from the supraspinatus. In this work…
View article: Suppression of Epidermal Growth Factor Receptor by Erlotinib Attenuates Carvacrol-induced Skin Inflammation
Suppression of Epidermal Growth Factor Receptor by Erlotinib Attenuates Carvacrol-induced Skin Inflammation Open
Epidermal growth factor receptors (EGFRs) regulate the growth and repair process of epithelia, as well as carcinogenesis. Activation of TRPV3 by carvacrol stimulates skin inflammation and epidermal hyperplasia; the latter can be suppressed…
View article: Adipocyte microRNA-802 promotes adipose tissue inflammation and insulin resistance by modulating macrophages in obesity
Adipocyte microRNA-802 promotes adipose tissue inflammation and insulin resistance by modulating macrophages in obesity Open
Adipose tissue inflammation is now considered to be a key process underlying metabolic diseases in obese individuals. However, it remains unclear how adipose inflammation is initiated and maintained or the mechanism by which inflammation d…
View article: Scutellarein ameliorates dextran sulfate sodium-induced ulcerative colitis by inhibiting colonic epithelial cell proinflammation and barrier disruption
Scutellarein ameliorates dextran sulfate sodium-induced ulcerative colitis by inhibiting colonic epithelial cell proinflammation and barrier disruption Open
Introduction Scutellarein (Scu) is a natural occurring flavonoid found in multiple traditional Chinese medicines such as Oroxylum indicum (L.) Kurz and Scutellaria baicalensis , with various pharmacological activities including anti-inflam…
View article: Comparison of patient satisfaction and function outcomes between restricted kinematic alignment and mechanical alignment: An early follow-up study
Comparison of patient satisfaction and function outcomes between restricted kinematic alignment and mechanical alignment: An early follow-up study Open
Background Mechanical alignment (MA) is the gold standard for total knee arthroplasty (TKA). However, MA will inevitably modify the patient's native knee anatomy. Another alignment option is kinematic alignment (KA), which aims to restore …
View article: Author response: Adipocyte microRNA-802 promotes adipose tissue inflammation and insulin resistance by modulating macrophages in obesity
Author response: Adipocyte microRNA-802 promotes adipose tissue inflammation and insulin resistance by modulating macrophages in obesity Open
View article: Raffinose Ameliorates DSS-Induced Colitis in Mice by Modulating Gut Microbiota and Targeting the Inflammatory TLR4–MyD88–NF-κB Signaling Pathway
Raffinose Ameliorates DSS-Induced Colitis in Mice by Modulating Gut Microbiota and Targeting the Inflammatory TLR4–MyD88–NF-κB Signaling Pathway Open
This study aimed to explore the protective effects of raffinose (Raf) against inflammatory bowel disease in mice with colitis. Mice were administered 100, 200, or 400 mg/kg Raf for 21 d, followed by drinking-water containing 3% dextran sul…
View article: Discovery of pyridazinone derivatives bearing tetrahydroimidazo[1,2-a]pyrazine scaffold as potent inhibitors of transient receptor potential canonical 5 to ameliorate hypertension-induced renal injury in rats
Discovery of pyridazinone derivatives bearing tetrahydroimidazo[1,2-a]pyrazine scaffold as potent inhibitors of transient receptor potential canonical 5 to ameliorate hypertension-induced renal injury in rats Open
View article: Adipocyte <i>microRNA-802</i> promotes adipose tissue inflammation and insulin resistance by modulating macrophages in obesity
Adipocyte <i>microRNA-802</i> promotes adipose tissue inflammation and insulin resistance by modulating macrophages in obesity Open
Adipose tissue inflammation is now considered to be a key process underlying metabolic diseases in obese individuals. However, it remains unclear how adipose inflammation is initiated and maintained or the mechanism by which inflammation d…
View article: DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1
DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1 Open
The circadian-controlled DNA repair exhibits a strong diurnal rhythm. Disruption in circadian clock and DNA repair is closely linked with hepatocellular carcinoma (HCC) progression, but the mechanism remains unknown. Here, we show that pol…
View article: Gait Kinematic Analysis Facilitates Rapid Early Recovery Following Total Knee Arthroplasty
Gait Kinematic Analysis Facilitates Rapid Early Recovery Following Total Knee Arthroplasty Open
View article: Discovery of N-alkyl-N-benzyl thiazoles as novel TRPC antagonists for the treatment of glioblastoma multiforme
Discovery of N-alkyl-N-benzyl thiazoles as novel TRPC antagonists for the treatment of glioblastoma multiforme Open
View article: Influence of bifenthrin exposure at different gestational stages on the neural development
Influence of bifenthrin exposure at different gestational stages on the neural development Open
Perinatal exposure to bifenthrin (BF) alters neurodevelopment. However, the most susceptible time period to BF exposure and the possible mechanisms are not clear. In the current study, pregnant female mice were treated with BF (0.5 mg/kg/d…
View article: A new method for mandala image synthesis based on WGAN-GP
A new method for mandala image synthesis based on WGAN-GP Open
Mandala, as an ancient image art, has been found to have many unexpected applications in recent years, including use in art therapies, meditation induction and human body state assessment. Despite the omnipresent applications of convolutio…
View article: Total flavone of flowers of Abelmoschus manihot (L.) Medic inhibits the expression of adhesion molecules in primary mesenteric arterial endothelial cells and ameliorates dextran sodium sulphate-induced ulcerative colitis in mice
Total flavone of flowers of Abelmoschus manihot (L.) Medic inhibits the expression of adhesion molecules in primary mesenteric arterial endothelial cells and ameliorates dextran sodium sulphate-induced ulcerative colitis in mice Open
TFA efficaciously ameliorates UC possibly by inhibiting monocyte adhesion through blocking TNF-α-induced NF-κB activation, which in turn suppresses the upregulation of adhesive molecules in colon endothelial cells. Inhibiting the expressio…
View article: TRPM8 promotes hepatocellular carcinoma progression by inducing SNORA55 mediated nuclear-mitochondrial communication
TRPM8 promotes hepatocellular carcinoma progression by inducing SNORA55 mediated nuclear-mitochondrial communication Open
Transient receptor potential melastatin 8 (TRPM8) play crucial roles in solid tumors such as prostate and breast cancers. But the role of TRPM8 in hepatocellular carcinoma (HCC) and its underlying molecular mechanisms remain largely unknow…
View article: Scutellarein attenuates atopic dermatitis by selectively inhibiting transient receptor potential vanilloid 3 channels
Scutellarein attenuates atopic dermatitis by selectively inhibiting transient receptor potential vanilloid 3 channels Open
Background and Purpose Atopic dermatitis (AD) is one of the most common chronic inflammatory cutaneous diseases with unmet clinical needs. As a common ingredient found in several medicinal herbs with efficacy on cutaneous inflammatory dise…
View article: Synthesis of AC1903 analogs as potent transient receptor potential canonical channel 4/5 inhibitors and biological evaluation
Synthesis of AC1903 analogs as potent transient receptor potential canonical channel 4/5 inhibitors and biological evaluation Open
View article: Influence of perinatal deltamethrin exposure at distinct developmental stages on motor activity, learning and memory
Influence of perinatal deltamethrin exposure at distinct developmental stages on motor activity, learning and memory Open
View article: Antillatoxin-Stimulated Neurite Outgrowth Involves the Brain-Derived Neurotrophic Factor (BDNF) - Tropomyosin Related Kinase B (TrkB) Signaling Pathway
Antillatoxin-Stimulated Neurite Outgrowth Involves the Brain-Derived Neurotrophic Factor (BDNF) - Tropomyosin Related Kinase B (TrkB) Signaling Pathway Open
Voltage-gated sodium channel (VGSC) activators promote neurite outgrowth by augmenting intracellular Na+ concentration ([Na+]i) and upregulating N-methyl-d-aspartate receptor (NMDAR) function. NMDAR activat…
View article: Hypeisoxazole A, a Racemic Pair of Tetrahydroisoxazole-Fused Benzylisoquinoline Alkaloids from <i>Hypecoum erectum</i> and Structural Revision of Hypecoleptopine
Hypeisoxazole A, a Racemic Pair of Tetrahydroisoxazole-Fused Benzylisoquinoline Alkaloids from <i>Hypecoum erectum</i> and Structural Revision of Hypecoleptopine Open
(±)-Hypeisoxazole A (1), a racemic pair of rearranged benzylisoquinoline alkaloids possessing an unprecedented diindeno[2,1-c:2',1'-d] isoxazole scaffold, was isolated from the medicinal herb Hypecoum erectum, along with hype…
View article: Discovery of pyrroledione analogs as potent transient receptor potential canonical channel 5 inhibitors
Discovery of pyrroledione analogs as potent transient receptor potential canonical channel 5 inhibitors Open
View article: Sonodynamic Therapy Promotes Efferocytosis via CD47 Down-Regulation in Advanced Atherosclerotic Plaque
Sonodynamic Therapy Promotes Efferocytosis via CD47 Down-Regulation in Advanced Atherosclerotic Plaque Open
Atherosclerotic cerebrocardiovascular disease is the major cause of acute ischemic diseases in humans. Impaired efferocytosis contributes to the progression of atherosclerosis. Pathological and apoptotic cells fail to undergo effective pha…
View article: Sarco/endoplasmic reticulum Ca<sup>2+</sup>‐ATPase (SERCA2b) mediates oxidation‐induced endoplasmic reticulum stress to regulate neuropathic pain
Sarco/endoplasmic reticulum Ca<sup>2+</sup>‐ATPase (SERCA2b) mediates oxidation‐induced endoplasmic reticulum stress to regulate neuropathic pain Open
Background and Purpose Neuropathic pain is a widespread health problem with limited curative treatment. Decreased sarco/endoplasmic reticulum Ca 2+ ‐ATPase (SERCA) expression has been reported in dorsal root ganglion (DRG) of animals suffe…
View article: Neuronal Modulators from the Coral-Associated Fungi Aspergillus candidus
Neuronal Modulators from the Coral-Associated Fungi Aspergillus candidus Open
Three new p-terphenyl derivatives, named 4″-O-methyl-prenylterphenyllin B (1) and phenylcandilide A and B (17 and 18), and three new indole-diterpene alkaloids, asperindoles E–G (22-24), were isolated together with eighteen known analogues…
View article: Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine
Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine Open
The multimodal sensory channel transient receptor potential vanilloid-3 (TRPV3) is expressed in epidermal keratinocytes and implicated in chronic pruritus, allergy, and inflammation-related skin disorders. Gain-of-function mutations of TRP…
View article: Author response: Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine
Author response: Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine Open
View article: Surfactant cocamide monoethanolamide causes eye irritation by activating nociceptor TRPV1 channels
Surfactant cocamide monoethanolamide causes eye irritation by activating nociceptor TRPV1 channels Open
Background and Purpose Cocamide monoethanolamide (CMEA) is commonly used as a surfactant‐foam booster in cosmetic formulations. Upon contact with the eye or other sensitive skin areas, CMEA elicits stinging and lasting irritation. We hypot…