Zhihuan Zhou
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VAL-083 is effective in patients with newly-diagnosed MGMT-unmethylated glioblastoma: report of phase II study Open
VAL-083 (30 mg/m2/day) combined with radiation therapy was generally safe and well tolerated. Adverse events aligned with previous studies. This regimen, compared to standard-of-care TMZ, showed potential benefits in terms of disease progr…
View article: Deep learning model based on DCE-MRI: fusion of 3D features of tumor, peritumoral vessels and metastatic lymph nodes for prediction of pathological complete response to neoadjuvant therapy in breast cancer
Deep learning model based on DCE-MRI: fusion of 3D features of tumor, peritumoral vessels and metastatic lymph nodes for prediction of pathological complete response to neoadjuvant therapy in breast cancer Open
Objective The aim of this study is to develop a deep learning-based radiomic (DLR) model by fusing 3D features of tumor, peritumoral vessels, and metastatic lymph nodes from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), w…
CTIM-13. NEOADJUVANT TREATMENT OF RECURRENT HIGH-GRADE GLIOMAS WITH CAMRELIZUMAB IN COMBINATION WITH APATINIB: A PROSPECTIVE PHASE II CLINICAL STUDY Open
BACKGROUND High-grade gliomas exhibit recurrent and resistant to treatments, and require urgent therapeutic innovation. This phase II trial presents preliminary results of neoadjuvant camrelizumab (PD-1 inhibitor) combined with apatinib (V…
Use of a Pathomics Signature to Predict the Prognosis of Hepatocellular Carcinoma with Cirrhosis: A Multicentre Retrospective Study Open
Background: Hepatocellular carcinoma (HCC) is a highly aggressive and heterogeneous malignancy which predominantly arises in the setting of cirrhosis, and there is lack of models to predict prognosis in cirrhotic HCC. This study aims to de…
View article: Tangzhiqing Exacerbates Oxidized Low‐Density Lipoprotein‐Induced Cell Pyroptosis Through Activation of NLRP3 Inflammasome in Human Umbilical Vein Endothelial Cells
Tangzhiqing Exacerbates Oxidized Low‐Density Lipoprotein‐Induced Cell Pyroptosis Through Activation of NLRP3 Inflammasome in Human Umbilical Vein Endothelial Cells Open
Atherosclerosis (AS) is a chronic and progressive inflammatory condition affecting arterial walls. It is widely accepted that the deposition of low‐density lipoprotein (LDL) and its adverse impact on endothelial cells (ECs) play a pivotal …
The nuclear transcription factor ZmCCT positively regulates salt and low nitrogen stress response in Maize Open
Abiotic stresses such as drought, salinity, and low nitrogen negatively affect maize growth and development, leading to significant yield reductions. In previous studies, we successfully cloned the maize transcription factor gene ZmCCT and…
Connection between college students’ sports activities, depression, and anxiety: the mediating role of self-esteem Open
In conclusion, the findings provide a theoretical basis for developing physical activity programs aimed at enhancing college students' mental health, suggesting that future interventions should focus on increasing participation in physical…
View article: Association Between Visceral Fat Metabolism Score and Cataract Risk in US Adults: National Health and Nutrition Examination Survey 1999 to 2008
Association Between Visceral Fat Metabolism Score and Cataract Risk in US Adults: National Health and Nutrition Examination Survey 1999 to 2008 Open
METS-VF is significantly positively related to a higher cataract prevalence, and this relationship remains robust across various subgroups. Additionally, METS-VF demonstrates a stronger predictive ability for cataract than BMI, WC, and WHt…
The Relationship Between Social Support and Employment Anxiety Among College Students: The Mediating Role of Self-Efficacy Open
To investigate the effects of social support on employment anxiety and the mediating role of self-efficacy among college students. A total of 449 valid questionnaires were returned through a web-based survey using the Social Support Rating…
View article: AB048. Evidence of effectiveness of neoadjuvant camrelizumab and apatinib in patients with recurrent high-grade gliomas
AB048. Evidence of effectiveness of neoadjuvant camrelizumab and apatinib in patients with recurrent high-grade gliomas Open
This immuno-target combination neoadjuvant therapy in recurrent HGG demonstrated encouraging efficacy and revealed some evidence of efficacy, and worth to further investigate.
Prevalence of dysphagia following posterior fossa tumor resection: a systematic review and meta‑analysis Open
Objective Dysphagia is common in individuals who have undergone posterior fossa tumor (PFT) resection and negatively impacts on the individual’s quality of life, nutritional status, and overall health. We aimed to quantitatively synthesize…
Integrating machine learning algorithms and multiple immunohistochemistry validation to unveil novel diagnostic markers based on costimulatory molecules for predicting immune microenvironment status in triple-negative breast cancer Open
Introduction Costimulatory molecules are putative novel targets or potential additions to current available immunotherapy, but their expression patterns and clinical value in triple-negative breast cancer (TNBC) are to be clarified. Method…
Headache alleviation with nasal irrigation following endoscopic endonasal surgery for pituitary adenomas Open
Background Headache is a common occurrence after endoscopic endonasal surgery (EES) for pituitary adenomas and significantly impacts the quality of life of patients. This study aims to investigate the effectiveness of nasal irrigation in r…
View article: Headache alleviation with nasal irrigation following endoscopic endonasal surgery for pituitary adenomas
Headache alleviation with nasal irrigation following endoscopic endonasal surgery for pituitary adenomas Open
Background Headache is very frequent following endoscopic endonasal surgery (EES) for pituitary adenomas, and affects the quality of life of patients, but was seldomly concerned before. This study aims to investigate the effect of nasal ir…
Integrated pyroptosis measurement and metabolomics to elucidate the effect and mechanism of tangzhiqing on atherosclerosis Open
Tangzhiqing formula (TZQ) is a traditional Chinese medicine prescribed to treat glucose and lipid metabolism disorders. A significant effect of TZQ on diabetes and hyperlipidemia has been demonstrated, but its effect on atherosclerosis (AS…
View article: SYST-04 PRELIMINARY REPORT OF A CLINICAL TRIAL EVALUATING THE SAFETY AND EFFICIENCY OF NEOADJUVANT CAMRELIZUMAB AND APATINIB IN PATIENTS WITH RECURRENT HIGH-GRADE GLIOMAS: A PROSPECTIVE, PHASE II, SINGLE-ARM STUDY
SYST-04 PRELIMINARY REPORT OF A CLINICAL TRIAL EVALUATING THE SAFETY AND EFFICIENCY OF NEOADJUVANT CAMRELIZUMAB AND APATINIB IN PATIENTS WITH RECURRENT HIGH-GRADE GLIOMAS: A PROSPECTIVE, PHASE II, SINGLE-ARM STUDY Open
High-grade glioma is the most common malignant primary brain tumor in the central nervous system. Multiple strategies such as surgery, radiotherapy, and chemotherapy have been used, but the prognosis of patients with high-grade glioma rema…
Management of dermatologic adverse events associated with tumor treating fields in patients with glioblastoma multiforme: A 27-case series Open
Data on tumor treating fields-related dermatologic adverse events is rarely reported, and published reports of management of scalp dermatologic adverse events are lacking. This case series summarizes a clinically individualized management …
Initial report of a clinical trial evaluating the safety and efficiency of neoadjuvant camrelizumab and apatinib in patients with recurrent high-grade gliomas Open
Background - and - Aim: High-grade glioma is the most common malignant primary brain tumor in the central nervous system. Multiple strategies such as surgery, radiotherapy, and chemotherapy have been used, but the prognosis of patients wit…
Factors Associated with Behaviors Toward End-of-life Care Among Chinese Oncology Nurses: A Cross-Sectional Study Open
The results may help provide a basis for converting behavior for EOL care among oncology nurses and design interventions to better improve quality of life for EOL patients with cancer in China.
Sinusitis Independently Predicts the Presence of Headache Following Endoscopic Transsphenoidal Resection for Pituitary Adenomas Open
Purpose Headache is common among patients with pituitary adenomas undergone endoscopic endonasal surgery (EES), but was seldomly concerned before. The present study aims to investigate the incidence and profile of risk factors of headache …
Risk Factors For Postoperative Cerebrospinal Fluid Leakage After Transsphenoidal Surgery For Pituitary Adenoma: A Meta-Analysis And Systematic Review Open
Objective: Postoperative cerebrospinal fluid (CSF) leakage represents a challenge even for experienced pituitary surgeons. We aimed to quantitatively synthesize data from studies regarding the risk factors for postoperative CSF leakage aft…
High preoperative albumin-bilirubin score predicts poor survival in patients with newly diagnosed high-grade gliomas Open
The preoperative ALBI score is a noninvasive and valuable prognostic marker for HGG patients.
Perioperative Nursing of a Case of Right Temporal Lobe Brain Abscess Ruptured into the Ventricle Open
Objective: To explore the perioperative nursing method of brain abscess breaking into the ventricle. Methods: By reviewing the clinical data of 1 case of right temporal lobe brain abscess into the ventricle, the effective nursing methods w…
Individualized Sellar Floor Reconstruction Method and Nursing Strategy for the Intraoperative Cerebrospinal Fluid Leakage Caused by Neuroendoscopic Transsphenoidal Pituitary Adenoma Resection Open
Objective: To explore the clinical effect of and the method and nursing strategy for sellar reconstruction for intraoperative cerebrospinal fluid (CSF) leakage in pituitary adenoma resection under neuroendoscopy. Methods: The data from 20 …